The influence of resistance exercise training prescription variables on skeletal muscle mass,strength,and physical function in healthy adults:An umbrella review

Purpose:The aim of this umbrella review was to determine the impact of resistance training(RT)and individual RT prescription variables on muscle mass,strength,and physical function in healthy adults.Methods:Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines,we systematically searched and screened eligible systematic reviews reporting the effects of differing RT prescription variables on muscle mass(or its proxies),strength,and/or physical function in healthy adults aged>18 years.Results:We identified 44 systematic reviews that met our inclusion criteria.The methodological quality of these reviews was assessed using A Measurement Tool to Assess Systematic Reviews;standardized effectiveness statements were generated.We found that RT was consistently a potent stimulus for increasing skeletal muscle mass(4/4 reviews provide some or sufficient evidence),strength(4/6 reviews provided some or sufficient evidence),and physical function(1/1 review provided some evidence).RT load(6/8 reviews provided some or sufficient evidence),weekly frequency(2/4 reviews provided some or sufficient evidence),volume(3/7 reviews provided some or sufficient evidence),and exercise order(1/1 review provided some evidence)impacted RT-induced increases in muscular strength.We discovered that 2/3 reviews provided some or sufficient evidence that RT volume and contraction velocity influenced skeletal muscle mass,while 4/7 reviews provided insufficient evidence in favor of RT load impacting skeletal muscle mass.There was insufficient evidence to conclude that time of day,periodization,inter-set rest,set configuration,set end point,contraction velocity/time under tension,or exercise order(only pertaining to hypertrophy)influenced skeletal muscle adaptations.A paucity of data limited insights into the impact of RT prescription variables on physical function.Conclusion:Overall,RT increased muscle mass,strength,and physical function compared to no exercise.RT intensity(load)and weekly frequency impacted RT-induced increases in muscular strength but not muscle hypertrophy.RT volume(number of sets)influenced muscular strength and hypertrophy.

Risk factors for running-related injuries:An umbrella systematic review

Purpose:This umbrella systematic review(SR) of SRs and meta-analysis seeks to comprehensively synthesize existing literature to identify and consolidate the diverse range of risk factors contributing to running-related injuries(RRIs).Methods:Systematic searches were conducted on June 28,2023,across Web of Science,SPORTDiscus,Scopus,PubMed,and Cochrane Library.We included SRs,whether accompanied by meta-analyses or not,that focused on investigating risk factors for RRIs within observational studies.The methodological quality of the SRs was evaluated using the Assessing the Methodological Quality of Systematic Reviews Ⅱ.To assess the extent of overlap across reviews,the corrected covered area metric was calculated.Results:From 1509 records retrieved,13 SRs were included.The degree of overlap between SRs was low(4%),and quality varied from critically low(n=8) to low(n=5).Two hundred seven outcomes assessed in 148 primary studies were identified as being associated with the occurrence of RRIs.The effect sizes of the associations for which risk measures were reported(n=131) were classified as large(n=30,23%),medium(n=38,29%),small(n=48,37%) or no effect(n=15,11%).Running/training characteristics,health and lifestyle factors,along with morphological and biomechanical aspects,exhibit large effect sizes in increasing the risk for RRIs.Conclusion:Drawing from the outcomes of the low-quality SRs and associations with large effect sizes,our findings indicate that running/training characteristics and health and lifestyle factors,as well as morphological and biomechanical aspects,are all implicated in elevating the risk of RRIs,emphasizing the multifactorial basis of injury incidence in running.Given the low quality and heterogeneity of SR,individual findings warrant cautious interpretation.

Assessing the effectiveness of internetbased interventions for mental health outcomes:an umbrella review

Internet-based interventions(IBIs)for behavioural health have been prevalent for over two decades,and a growing proportion of individuals with mental health concerns prefer these emerging digital alternatives.However,the effectiveness and acceptability of IBIs for various mental health disorders continue to be subject to scholarly debate.We performed an umbrella review of meta-analyses(MAs),conducting literature searches in PubMed,Web of Science,Embase,Cochrane and Ovid Medline from their inception to 17 January 2023.A total of 87MAs,reporting on 1683 randomised controlled trials and 295589 patients,were included.The results indicated that IBIs had a moderate effect on anxiety disorder(standardised mean difference(SMD)=0.53,95%CI 0.44 to 0.62)and post-traumatic stress disorder(PTSD)(SMD=0.63,95%CI 0.38 to 0.89).In contrast,the efficacy on depression(SMD=0.45,95%CI 0.39 to 0.52),addiction(SMD=0.23,95%CI 0.16 to 0.31),suicidal ideation(SMD=0.23,95%CI 0.16 to 0.30),stress(SMD=0.41,95%CI 0.33 to 0.48)and obsessive-compulsive disorder(SMD=0.47,95%CI 0.22 to 0.73)was relatively small.However,no significant effects were observed for personality disorders(SMD=0.07,95%CI-0.13 to 0.26).Our findings suggest a significant association between IBIs and improved mental health outcomes,with particular effectiveness noted in treating anxiety disorders and PTSD.However,it is noteworthy that the effectiveness of IBIs was impacted by high dropout rates during treatment.Furthermore,our results indicated that guided IBIs proved to be more effective than unguided ones,playing a positive role in reducing dropout rates and enhancing patient adherence rates.

Impact of citrus fruit and hesperidin intake on multiple health outcomes:An umbrella review

Citrus fruits are rich sources of several biologically active flavonoids such as hesperidin,naringin,and polymethoxylated flavones.We evaluated the evidence of associations between citrus fruit or hesperidin intake and multiple health outcomes.An umbrella review was conducted for studies performed in humans.Overall,246 articles were initially identified by searching in 4 databases.Twenty-two meta-analyses and systematic reviews with 28 health outcomes met the inclusion criteria.Citrus fruit intake had beneficial effects on all-cause mortality(relative risk[RR].0.90;95%confidence interval[95%CI],0.86 to 0.94),cardiovascular diseases(RR,0.78;95%CI,0.66 to 0.92),coronary heart disease(RR,0.91;95%CI,0.86 to 0.96),stroke(RR,0.74;95%CI,0.65 to 0.84),type 2 diabetes mellitus(RR,0.85;95%CI,0.78 to 0.92),and several cancers.Dose-response analyses indicated that each 100-g/d increase in citrus fruit intake could reduce the risks of all-cause mortality by 6%(RR,0.94;95%CI,0.88 to 1.00),stroke by 22%(RR,0.78;95%CI,0.69 to 0.90),and cardia gastric cancer by 40%(RR,0.60;95%CI,0.44 to 0.83).Citrus fruit intake also had beneficial effects on the lipid profile and body weight control(weighted mean difference,−1.28;95%CI,−1.82 to−0.74).Grapefruits could reduce the systolic blood pressure(weighted mean difference,−2.43,95%CI,−4.77 to−0.09).Hesperidin supplementation significantly improved inflammation.Citrus fruit intake was generally safe and beneficial for multiple health outcomes in humans.However,grapefruit and pomelo juice may affect the bioavailability of various medications,so care should be exercised before increasing the intake of these fruits or their juices.

Handgrip strength and health outcomes: Umbrella review of systematic reviews with meta-analyses of observational studies

Purpose:The aim of the present study was to assess both the credibility and strength of evidence arising from systematic reviews with meta-analyses of observational studies on handgrip strength and health outcomes.Methods:An umbrella review of systematic reviews with meta-analyses of observational studies was conducted.We assessed meta-analyses of observational studies based on random-effect summary effect sizes and their p values,95%prediction intervals,heterogeneity,small-study effects,and excess significance.We graded the evidence from convincing(Class I)to weak(Class IV).Results:From 504 articles returned in a search of the literature,8 systematic reviews were included in our review,with a total of 11 outcomes.Overall,nine of the 11 of the outcomes reported nominally significant summary results(p<0.05),with 4 associations surviving the application of the more stringent p value(p<106).No outcome presented convincing evidence.Three associations showed Class II evidence(i.e.,highly suggestive):(1)higher handgrip values at baseline were associated with a minor reduction in mortality risk in the general population(n=34 studies;sample size=1,855,817;relative risk=0.72,95%confidence interval(95%CI):0.670.78),(2)cardiovascular death risk in mixed populations(n=15 studies;relative risk=0.84,95%CI:0.780.91),and(3)incidence of disability(n=7 studies;relative risk=0.76,95%CI:0.660.87).Conclusion:The present results show that handgrip strength is a useful indicator for general health status and specifically for early all-cause and cardiovascular mortality,as well as disability.To further inform intervention strategies,future research is now required to fully understand mechanisms linking handgrip strength scores to these health outcomes.

Effect of pipe characteristics in umbrella arch method on controlling tunneling-induced settlements in soft grounds

Recent developments in tunneling have stimulated design practitioners to more effectively utilize the underground spaces.However,tunneling at shallow depth in soft grounds gives rise to concerns associated with tunnel instability.Umbrella arch method(UAM),as a pre-reinforcement approach of tunnels in complex geological conditions,is widely used to maintain the tunnel stability.Quantitative assessment of the impacts of the entire approach and forepoling pipe features on tunnel stability remains challenging due to the complex nature of the UAM application.This study aimed to assess the effect of pipe design parameters on reinforcing the tunnels excavated in soft grounds.This practical investigation considered the actual field conditions attributed to the tunneling procedure and UAM deployment.Then,the tunneling process was modeled and the tunnel excavation-induced settlements were calculated.The post-processed results confirmed that deploying the UAM substantially reduced the tunnel crown and ground surface settlements by 76%and 42%,respectively.Investigation of various design parameters of pipes underscored the significance of incorporating the optimum value for each individual parameter into design schemes to more effectively control the settlements.Additionally,contrasting the settlement reduction rates(SRRs)for pipe design variables showed that the tunnel stability is more sensitive to the changes in the values of diameter and length,compared to values of the installation angle and center-tocenter distance of the pipes.

Numerical analyses in the design of umbrella arch systems

Due to advances in numerical modelling, it is possible to capture complex support-ground interaction intwo dimensions and three dimensions for mechanical analysis of complex tunnel support systems,although such analysis may still be too complex for routine design calculations. One such system is theforepole element, installed within the umbrella arch temporary support system for tunnels, whichwarrants such support measures. A review of engineering literature illustrates that a lack of designstandards exists regarding the use of forepole elements. Therefore, when designing such support, designersmust employ complex numerical models combined with engineering judgement. With referenceto past developments by others and new investigations conducted by the authors on the Driskos tunnelin Greece and the Istanbul metro, this paper illustrates how advanced numerical modelling tools canfacilitate understanding of the influences of design parameters associated with the use of forepole elements.In addition, this paper highlights the complexity of the ground-support interaction whensimulated with two-dimensional （2D） finite element software using a homogenous reinforced region,and three-dimensional （3D） finite difference software using structural elements. This paper further illustratessequential optimisation of two design parameters （spacing and overlap） using numericalmodelling. With regard to capturing system behaviour in the region between forepoles for the purpose ofdimensioning spacing, this paper employs three distinctive advanced numerical models： particle codes,continuous finite element models with joint set and Voronoi blocks. Finally, to capture the behaviour/failure ahead of the tunnel face （overlap parameter）, 2D axisymmetric models are employed. Finally,conclusions of 2D and 3D numerical assessment on the Driskos tunnel are drawn. The data enriched casestudy is examined to determine an optimum design, based on the proposed optimisation of designparameters, of forepole elements related to the site-specific considerations. 2014 Institute of Rock and Soil Mechanics, Chinese Academy of Sciences. Production and hosting byElsevier B.V. All rights reserved.

High-Efficiency Solar Electricity of Umbrella by TRIZ Analysis

This investigation presents the strategy of high-efficiency solar electricity of umbrella by TRIZ (Theory of Inventive Problem Solving) analysis. According to the combined statistics of classical and new contradiction matrix, the invention principles can be used for designing tracking irradiance of surface plane of umbrella orientations including tilted angle (θ) and azimuth angle (&Oslash;). Three geographical sites are discussed by regions of Berlin, Taipei and Wellington located in north, near and south of tropic of cancer, respectively. The optimal design of azimuth surfaces of umbrella can be obtained by electricity gain at a fixed tilted angle.

A Generalized Information Criterion for Parameters under an Umbrella Order Restriction

The detection of the configuration of parameters is one of the most important problems in statistical studies. It is well known that the Akaike’s information criterion (AIC) is a key tool for this problem

Umbrella with Ultraviolet Radiation Protection

Background: Ultraviolet radiation (UVR) causes harm to the eye and skin in human. There are many ways to protect one from UVR. Umbrella is widely used due to its convenience as well as its ability to protect one from rain. However, there are limited numbers of studies on UVR protection of different types of umbrellas. Objective of study: To determine UVR protection efficacy of different umbrella designs. Methods: The experimental study was performed on five sunny days. Six manikins were placed in an open area, five of which were equipped with five different types of black canopy umbrellas. One manikin was placed without an umbrella as a control sample. Polysulfone film badges were attached in six different areas in each manikin for measuring the UVR from 10 am - 3 pm Results: All types of umbrellas provides 64.5% - 92.3% UVR photo protection efficacy. An umbrella with UV-filter coating on the inner surface provides maximum UVR photo protection efficacy. However, UVR proto protection efficacies of an umbrella with UV-filter coating on the inner surface and one with UV-filter coating on the outer surface and one without UV-filter coating are not statistically significant (p-value = 0.37). Umbrellas with a diameter of 122 cm and 152 cm provide comparable UVR photo protection efficacy while an umbrella with a diameter of 112 cm provides the least UVR photo protection efficacy. However, UVR photo protection efficacies of umbrellas with different diameter are not statistically significant (p-value = 0.36). The area of the body that received the most UVR photo protection is the forehead which is statistically significant when compared with other areas of the body (p-value < 0.001). The areas of the body that received the least UVR photo protection are the left ear and the back of the neck, which are statistically significant when compared with other areas of the body (p-value < 0.001). Conclusion: All types of umbrellas provide UVR photo protection efficacy. The study shows that umbrellas with different canvas material including both the UV-filter coating and different diameter of umbrellas could effectively protect the user from UVR without significant group difference in this study.

An umbrella review of Lianhua Qingwen combined with Western medicine for the treatment of coronavirus disease 2019

Objective:Lianhua Qingwen combined with Western medicine(LHQW+WM)has been proposed as a viable treatment for coronavirus disease 2019(COVID-19).Interestingly,umbrella reviews of systematic reviews(SRs),which provide the most comprehensive evidence,are the best evidence in evidence-based medicine.Therefore,an umbrella review of SRs that summarizes and evaluates the efficacy of LHQW+WM for COVID-19 is urgently required.Methods:Overall,6 databases were used to conduct a comprehensive literature search from inception to January 22,2022.The corrected covered area(CCA)was used to analyze the overlapping between SRs.Meta-analysis was conducted when that of the included SRs was inappropriate.A MeaSurement Tool to Assess Systematic Reviews(AMSTAR-2)was also employed to assess the quality of the included SRs.Results:In total,12 SRs were identified,which included 12 unique primary studies.The included SRs ranged in quality from moderate to critically low and had an extremely high CCA(36.4%).Compared to conventional treatment,LHQW+WM showed efficacy concerning fatigue recovery[risk ratio(RR)=1.69,95%confidence interval(CI):1.04-2.73,n=2,I2=0%],cough recovery(RR=1.65,95%CI:1.09-2.51,n=3,I2=39.1%),and overall effective rates(RR=1.17,95%CI:1.07-1.28,n=3,I2=17.5%).Conclusion:LHQW+WM may improve the clinical symptoms of patients with COVID-19;however,the results should be interpreted cautiously because of the rigorous processes in the included SRs.

Umbrella Arching and Compensation Grouting in Order to Protect Settlement-Sensitive Buildings over Large Shotcrete Excavations in Gravel

The Tunnel Oberau, with a length of 2.9 km, forms the core of the local bypass of Oberau. Between the two massifs Kirchbichl and Mühlberg, the tunnel is situated in the valley of the Gießenbach in alluvial gravel with only a small overlap underneath settlement-sensitive buildings. In this paper, the measures in the tunnel to minimize the settlements of the buildings during the shotcrete excavations are described. Basis for this planning were extensive 3D-FE-calculations. Furthermore, under two buildings a compensation grouting measure was carried out, in order to compensate the occurring settlements. This paper describes how the required time and the amount of injection material (grout) could be reduced during the compensation grouting in highly permeable gravel.

The Types of Tunnels Maintenance in Umbrella Arch Method

During tunneling in loose grounds, the ground deformation caused by drillings around the tunnel, leads to land subsidence and the adjacent tunnel which would affect tunnel structure and surrounding structures. In such situations it is necessary to improve the properties of the ground prior to drilling operations. In order to acquire tunnel face stability during excavation operations in areas with loose soil fault or areas with lack of adhesion, there are various methods such as split cross drilling, frame holder or auxiliary pre-holding methods such as umbrella arch method;pre-holding methods must provide safety when drilling and must be affordable, economically. In this study, we assessed the previous studies on methods and behaviors of umbrella arch strategy in reinforcing the concrete tunnels, reached the purpose with experimental and numerical methods and offered the latest design achievements, implementation progresses and analysis in relation with this method.

Pollutant exposure and health outcomes:protocol for a comprehensive umbrella review of meta-analyses and evidence mapping

Background:Many systematic reviews and meta-analyses(MAs)regarding the association between pollutant(e.g.,air pollution,noise pollution,and heavy metal pollution)exposure and health outcomes have been published recently,but there is still a lack of comprehensive research based on these MAs,and the evidence quality of these MAs are unknown.Therefore,we designed an umbrella review to address these gaps in knowledge.Methods:MAs that evaluated the association between pollutant exposure and health outcomes will be systematically searched through the PubMed and Embase databases in May 2021.Pairs of reviewers will conduct the study screening and data extraction independently,and cross-check the results.PRISMA and AMSTAR 2 will be used to evaluate the reporting and methodological quality of MAs included,respectively,and an evidence mapping method will be used to present the results.The corrected cover area(CCA)method will be used to assess the degree of overlap for included primary studies among MAs.The outcomes will be reanalyzed based on the random-effects model using the appropriate effect size,and the corresponding 95%confidence intervals will be reported.Meanwhile,sensitivity analysis and subgroup analysis will be used to explore heterogeneity.The GRADE method will be used to evaluate the evidence quality of outcome indicators.Stata 16.0 and Excel 2019 will be used for data analysis,and P<0.05 will be considered to indicate statistical significance.Results:The results of this umbrella review will be submitted to a peer-reviewed English journal for publication.Conclusion:We designed the first umbrella review to summarize evidence from MAs on the association between common pollutant exposure and health conditions.The results of this study will provide evidence for health policy makers to formulate appropriate health policies and researchers to conduct new studies.

Oral Contraceptives and Health Outcomes:an Umbrella Review of Systematic Reviews and Meta-analyses in Women and Offspring

Aim We herein provide an umbrella review of systematic reviews(SR)and meta-analyses(MAs)of studies of the association of oral contraceptives(OCs)with the risks of multiple health outcomes in women and their descendants.Methods Two investigators retrieved publications from four electronic databases,including PubMed,Embase,Web of Science,and the Cochrane Database of Systematic Reviews up to March 15,2021.For each association,random/fixed-effects summary effect size and 95%CIs were estimated.Heterogeneity and publication bias were also assessed.The method quality and evidence level for each publication were respectively assessed utilizing the AMSTAR and GRADE checklists.Results A total of 68 articles with 82 unique outcomes were included based on the eligibility criteria.Numerous lines of evidence indicated that OCs had effects on nearly all cardiovascular disease-related outcomes,especially for cerebral venous sinus thrombosis(OR=7.59,95%CI:3.82-15.09).Harmful associations were also found for vulvar vestibulitis(OR=2.31,95%CI:1.03-5.16),preterm birth(OR=1.17,95%CI:1.07-1.27),miscarriage(OR=1.13,95%CI:1.02-1.72),ulcerative colitis(OR=1.22,95%CI:1.06-1.41),Crohn's disease(OR=1.24,95%CI:1.09-1.40),alveolar osteitis(RR=1.86,95%CI:1.66-2.08),dry socket(RR=1.8,95%CI:1.33-2.43),and interstitial cystitis(OR=2.1,95%CI:1.26-3.49).However,oral contraceptives did not increase the risk of cancer except breast and cervical cancer.Maternal exposure to OCs was linked to an increased risk for the development of respiratory atopic disorders such as asthma(OR=1.1,95%CI:1.02-1.19)and rhinitis(OR=1.34,95%CI:1.07-1.68).Conclusion In summary,although their use obviously reduces the risk of pregnancy-and parturition-related morbidity and mortality for women,OCs were frequently related to more harm than benefit in terms of other health outcomes.This was true for both women and their descendants in this umbrella review.More large-scale prospective studies analysing different doses,structures,and durations of treatment with estrogen and progestin are needed to confirm these effects.

UMBRELLA 最美不是下雨天,是我独自撑起的那片“晴空”

一把伞，就像是一道屏障，把所有的悲伤、孤独、阳光、雨水都隔离开来，那一方小小的阴影下，就是一个独立的世界，任凭时移势迁，我自岿然。

Umbrella

Yesterday my father went to work by 1,but he left his umbrella(雨伞) in one of the compartments(火车车厢).He told the 2 about it and they began to look for the umbrella."3 compartment did you leave your umbrella in?" the conductor asked.But my fathercouldn't 4. The conductor found an

Umbrella

Yesterday my father went to work by 1 ,but he left his umbrella(雨伞)in one of thecompartments(火车车厢).He told the 2 aboutit and they began to look for time umbrella.

CFD simulation on performance of new type umbrella plate scrubber

A new type of umbrella plate scrubber was developed to address the pollution due to the dust,dioxide sulfur and other harmful gases,which were emitted from coal-burning boilers.The performance of the new device was studied through computational fluid dynamics(CFD)simulation and experiment methods.Initial work included experimental measurement of inlet-velocity,and gas phase simulation using Reynolds stress model(RSM).After gas phase was converged,particles were injected from the inlet of the new device.Discrete phase model(DPM)was used for particle trajectories determination.The pressure drop and the collection efficiency of the new device were predicted through simulation.The simulation results show that the pressure drop of the new devices is 230?250 Pa and the efficiency is 84%-86%,with the inlet velocity equal to 10.6 m/s and the dust concentration ranging from 2 to 22 g/m 3 .The CFD simulation results of the new device show good agreement with experimental data.The relative error of the pressure drop and the efficiency is approximately 4%and 10%respectively.The results obtained both from the numerical simulation and from the experiment demonstrate that CFD simulation is an effective method for this type of study.

Current treatment for male infertility:an umbrella review of systematic reviews and meta-analyses

This umbrella review aimed to summarize and provide a general evaluation of the effectiveness of current treatments for male infertility and assess the quality of evidence and possible biases.An umbrella review of systematic reviews and meta-analyses available in PubMed,Web of Science,and Scopus,covering studies published up to October 2023,was conducted.Sperm concentration,morphology,and motility were used as endpoints to evaluate the effectiveness of the treatments.Of 2998 studies,18 published meta-analyses were extracted,yielding 90 summary effects on sperm concentration(n=36),sperm morphology(n=26),and sperm motility(n=28)on 28 interventions.None of the meta-analyses were classified as having low methodological quality,whereas 12(66.7%)and 6(33.3%)had high and moderate quality,respectively.Of the 90 summary effects,none were rated high-evidence quality,whereas 53.3%(n=48),25.6%(n=23),and 21.1%(n=19)were rated moderate,low,and very low,respectively.Significant improvements in sperm concentration,morphology,and motility were observed with pharmacological interventions(N-acetyl-cysteine,antioxidant therapy,aromatase inhibitors,selective estrogen receptor modulators,hormones,supplements,and alpha-lipoic acid)and nonpharmacological interventions(varicocele repair and redo varicocelectomy).In addition,vitamin supplementation had no significant positive effects on sperm concentration,motility,or morphology.Treatments for male infertility are increasingly diverse;however,the current evidence is poor because of the limited number of patients.Further well-designed studies on single treatment and high-quality meta-analysis of intertreatment comparisons are recommended.