Cancer of the uncinate process of the pancreas:surgical anatomy and clinicopathological features

BACKGROUND:The clinicopathological features of uncinate process pancreatic cancer(UPPC) are poorly described.Furthermore the anatomy of the uncinate process and its division during surgery are central to pancreaticoduodenectomy for UPPC.We set out to describe the embryology and anatomy of the uncinate process and the clinicopathological features of UPPC.DATA SOURCES:All published case series of UPPC were reviewed and included in this review.RESULTS:The true incidence of UPPC is difficult to quantify,with the reported incidence ranging from 2.5% to 10.7% of pancreatic cancer.There are 5 published series of UPPC including 117 patients,72 males and 45 females,aged from 45-53 years to 61-84 years.The median survival was 5 or 5.5 months in 3 of the series,12.1 months in another based only on potentially resectable lesions and 17 months in another based only on resected cases.CONCLUSIONS:The number of reported series of UPPC is limited,with vague symptoms as the predominant presenting features of the disease.The prognosis is poor with synchronous venous resection demonstrating a survival advantage.

Clinical analysis of uncinate process carcinoma of the pancreas

OBJECTIVE: To analyse the clinical features of uncinate process carcinoma of the pancreas and the diagnosis and treatment of this malignancy. METHOD: Fifty-nine patients with pancreas uncinate process carcinoma treated from January 1998 to September 2002 at our hospital were analysed retrospectively. RESULTS: Major symptoms of these patients were upper abdominal pain accompanied with lumbar pain, body weight loss and jaundice. Thirty-seven patients received regional pancreaticoduodenectomy (RP), 16 partial resection of the superior mesenteric vein-portal vein (SMV-PV) or superior mesenteric artery (SMA) and reconstruction, 1 anhydrous alcohol injection in the celiac nerve plexus, regional chemotherapy via a chemotherapy pump, and liver biopsy, and 5 no operation. The survival of the patients after operation was 2-46 months (median 12.1 months). Eleven patients are still alive with a longest survival of 46 months. The 1- and 3-year survival rates were 37.7% and 5.6%. CONCLUSIONS: Pancreas uncinate process carcinoma invading the adjacent SMV/SMA-PV causes difficulty in early diagnosis and poor prognosis, which are related to its location, not tumor's aggressive nature. This carcinoma has a high resection rate of 89.8%.

Surgical treatment for uncinate process carcinoma of the pancreas

Objectives: To analyze the clinical features of unci- nate process carcinoma of the pancreas and to im- prove the resection rate. Methods: From January 1990 to June 1999, 10 pa- tients with pancreas uncinate process carcinoma re- ceived Whipple's operation. Portal vein (PV) resec- tion and reanastomosis were performed in 5 patients, and the resected length varied from 2.0 to 4.2 cm. Two patients underwent PV lateral wall partial resec- tion. Results: Among the 7 patients undergoing PV resec- tion, 1 died of hepatic failure 3 days after operation. One patient suffered from postoperative chylous asci- tes. These 6 patients survived 13 to 29 months post- operatively. Among the 3 patients without PV resec- tion, 2 survived 13 months and 14 months respective- ly. One patient was alive by the end of follow-up for 11. 5 months postoperatively. Conclusion: Although uncinate process carcinoma of the pancreas has a tendency to invade the adjacent PV and superior mesentery vein, it should not be simply regarded as a contraindication of radical resection.

Mucous gland cyst in uncinate process

To the Editor: Mucous gland cyst in nasal sinus is common, but large mucous gland cyst in uncinate process has not been reported home and abroad. We report a rare case of mucous gland cyst in uncinate process, to improve the awareness of mucous gland cyst in uncinate process.

鼻内镜下钩突尾端切除治疗前组鼻窦炎

钩突是鼻窦防御体系中的第1道门户,切除钩突是经典内镜鼻窦手术Messerklinger进路的第1个步骤。但钩突完整切除后,各鼻窦天然保护屏障消失,增加鼻腔、鼻窦黏膜再次发生炎性病变几率。故国内、外学者仍在不停思考如何维护鼻腔、鼻窦正常生理功能。我们于2007年2月-2009年2月采取鼻内镜下钩突尾端切除治疗前组鼻窦炎取得满意效果。

钩突黏液囊肿1例

1 临床资料 患者，女，43岁，左侧眉间间断性胀痛半年，偶有向左侧额颞区放射，无鼻塞，涕多，嗅觉减退等症状。鼻内镜下检查：左侧中鼻道区可见向外膨隆肿物，表面黏膜光滑，与鼻腔外侧壁融合，与中鼻甲无粘连，钩突近上颌窦口之尾部正常，

绕开钩突由筛泡径路的内镜精准术式的临床观察

目的探讨应用绕开钩突由筛泡径路的内镜精准术式在临床应用可行性及疗效。方法回顾性分析 2018年6月~2020年6月间30例行绕开钩突由筛泡径路的内镜精准术式患者的临床资料,详细分析和记录术中情况及总体疗效。结果由筛泡径路术式适合目前精准手术要求,特别适合有筛上颌窦气房、眶下气房及Haller气房等存在变异患者。术后随访6个月以上,临床症状逐步消失,病变均未复发。结论绕开钩突由筛泡径路的内镜精准术式可行,更能满足鼻腔生理需求,达到精准治疗的目的。

Impaired Parahippocampal Gyrus-Orbitofrontal Cortex Circuit Associated with Visuospatial Memory Deficit as a Potential Biomarker and Interventional Approach for Alzheimer Disease

The parahippocampal gyrus-orbitofrontal cortex(PHG-OFC)circuit in humans is homologous to the postrhinal cortex(POR)-ventral lateral orbitofrontal cortex(vlOFC)circuit in rodents.Both are associated with visuospatial malfunctions in Alzheimer’s disease(AD).However,the underlying mechanisms remain to be elucidated.In this study,we explored the relationship between an impaired POR-vlOFC circuit and visuospatial memory deficits through retrograde tracing and in vivo local field potential recordings in 5XFAD mice,and investigated alterations of the PHG-OFC circuit by multi-domain magnetic resonance imaging(MRI)in patients on the AD spectrum.We demonstrated that an impaired glutamatergic POR-vlOFC circuit resulted in deficient visuospatial memory in 5XFAD mice.Moreover,MRI measurements of the PHG-OFC circuit had an accuracy of 77.33%for the classification of amnestic mild cognitive impairment converters versus non-converters.Thus,the PHG-OFC circuit explains the neuroanatomical basis of visuospatial memory deficits in AD,thereby providing a potential predictor for AD progression and a promising interventional approach for AD.