OBJECTIVE: To analyse the clinical features of uncinate process carcinoma of the pancreas and the diagnosis and treatment of this malignancy. METHOD: Fifty-nine patients with pancreas uncinate process carcinoma treate...OBJECTIVE: To analyse the clinical features of uncinate process carcinoma of the pancreas and the diagnosis and treatment of this malignancy. METHOD: Fifty-nine patients with pancreas uncinate process carcinoma treated from January 1998 to September 2002 at our hospital were analysed retrospectively. RESULTS: Major symptoms of these patients were upper abdominal pain accompanied with lumbar pain, body weight loss and jaundice. Thirty-seven patients received regional pancreaticoduodenectomy (RP), 16 partial resection of the superior mesenteric vein-portal vein (SMV-PV) or superior mesenteric artery (SMA) and reconstruction, 1 anhydrous alcohol injection in the celiac nerve plexus, regional chemotherapy via a chemotherapy pump, and liver biopsy, and 5 no operation. The survival of the patients after operation was 2-46 months (median 12.1 months). Eleven patients are still alive with a longest survival of 46 months. The 1- and 3-year survival rates were 37.7% and 5.6%. CONCLUSIONS: Pancreas uncinate process carcinoma invading the adjacent SMV/SMA-PV causes difficulty in early diagnosis and poor prognosis, which are related to its location, not tumor's aggressive nature. This carcinoma has a high resection rate of 89.8%.展开更多
Objectives: To analyze the clinical features of unci- nate process carcinoma of the pancreas and to im- prove the resection rate. Methods: From January 1990 to June 1999, 10 pa- tients with pancreas uncinate process c...Objectives: To analyze the clinical features of unci- nate process carcinoma of the pancreas and to im- prove the resection rate. Methods: From January 1990 to June 1999, 10 pa- tients with pancreas uncinate process carcinoma re- ceived Whipple's operation. Portal vein (PV) resec- tion and reanastomosis were performed in 5 patients, and the resected length varied from 2.0 to 4.2 cm. Two patients underwent PV lateral wall partial resec- tion. Results: Among the 7 patients undergoing PV resec- tion, 1 died of hepatic failure 3 days after operation. One patient suffered from postoperative chylous asci- tes. These 6 patients survived 13 to 29 months post- operatively. Among the 3 patients without PV resec- tion, 2 survived 13 months and 14 months respective- ly. One patient was alive by the end of follow-up for 11. 5 months postoperatively. Conclusion: Although uncinate process carcinoma of the pancreas has a tendency to invade the adjacent PV and superior mesentery vein, it should not be simply regarded as a contraindication of radical resection.展开更多
文摘OBJECTIVE: To analyse the clinical features of uncinate process carcinoma of the pancreas and the diagnosis and treatment of this malignancy. METHOD: Fifty-nine patients with pancreas uncinate process carcinoma treated from January 1998 to September 2002 at our hospital were analysed retrospectively. RESULTS: Major symptoms of these patients were upper abdominal pain accompanied with lumbar pain, body weight loss and jaundice. Thirty-seven patients received regional pancreaticoduodenectomy (RP), 16 partial resection of the superior mesenteric vein-portal vein (SMV-PV) or superior mesenteric artery (SMA) and reconstruction, 1 anhydrous alcohol injection in the celiac nerve plexus, regional chemotherapy via a chemotherapy pump, and liver biopsy, and 5 no operation. The survival of the patients after operation was 2-46 months (median 12.1 months). Eleven patients are still alive with a longest survival of 46 months. The 1- and 3-year survival rates were 37.7% and 5.6%. CONCLUSIONS: Pancreas uncinate process carcinoma invading the adjacent SMV/SMA-PV causes difficulty in early diagnosis and poor prognosis, which are related to its location, not tumor's aggressive nature. This carcinoma has a high resection rate of 89.8%.
文摘Objectives: To analyze the clinical features of unci- nate process carcinoma of the pancreas and to im- prove the resection rate. Methods: From January 1990 to June 1999, 10 pa- tients with pancreas uncinate process carcinoma re- ceived Whipple's operation. Portal vein (PV) resec- tion and reanastomosis were performed in 5 patients, and the resected length varied from 2.0 to 4.2 cm. Two patients underwent PV lateral wall partial resec- tion. Results: Among the 7 patients undergoing PV resec- tion, 1 died of hepatic failure 3 days after operation. One patient suffered from postoperative chylous asci- tes. These 6 patients survived 13 to 29 months post- operatively. Among the 3 patients without PV resec- tion, 2 survived 13 months and 14 months respective- ly. One patient was alive by the end of follow-up for 11. 5 months postoperatively. Conclusion: Although uncinate process carcinoma of the pancreas has a tendency to invade the adjacent PV and superior mesentery vein, it should not be simply regarded as a contraindication of radical resection.
