Efficacy and economic analysis of Ex- PRESS implantation versus trabeculectomy in uncontrolled glaucoma： a systematic review and Meta-analysis

AIM：To systematically review the current evidence based on the efficacy and cost of Ex-PRESS implantation and trabeculectomy（Trab）for uncontrolled glaucoma.·METHODS：Clinical trials were identified by electronic databases（Pub Med,EMBASE,ISI Web of science and Cochrane library）,and data,such as intraocular pressure（IOP）,the complete and qualified success rate,the postoperative complications and the cost,were exacted from these relevant studies.Weighted mean difference（WMD）,odds ratio（OR）and 95%confidence intervals（CIs）were calculated and were pooled using a randomeffects model.·RESULTS：Eleven relevant publications and two abstracts met the inclusion criteria.The efficacy of ExPRESS was similar to that of Trab in the percentage of IOP reduction（IOPR%）at 1,2y（WMD：-2.01;95%CI：-7.92-3.90;=0.50 and WMD：2.89;95%CI：-8.05-13.83;=0.60,respectively）.Ex-PRESS possessed a significant higher complete and qualified success rate（OR：1.59;95%CI：1.07-2.35;=0.02 and OR：1.74;95%CI：1.06-2.86;=0.03,respectively）.Moreover,Ex-PRESS exerted a significantly lower frequency of hypotony and hyphema than Trab（OR：0.39;95%CI：0.21-0.72;=0.003 and OR：0.27;95%CI：0.10-0.69;=0.003,respectively）.However,there was no consistent result on the cost between the two groups according to the previous three studies.·C ONCLUSION：Both Trab and Ex-PRESS have equivalent efficacy in lowering IOP,yet Ex-PRESS had a lower risk of hypotony and hyphema than Trab.Nevertheless,whether the cost of Ex-PRESS was less than that of Trab should be further investigated to ensure evidence-based conclusion in the long run.

The Impact of Some Uncontrolled Landfill Sites on the Ecosystems of Surrounding Areas of Eastern and Western Parts of Georgia

The most visible uncontrolled landfill sites were selected in the western and eastern parts of the territory of Georgia. Particularly, in eastern Georgia the regions of Mtskheta-Mtianeti and Kvemo Kartli have been researched;and in western Georgia Imereti and Samtskhe-Javakheti correspondingly. Both chemical and microbiological analyses were conducted in the samples taken from their adjacent territories. In case the landfill site is located near the river, during field works using portable equipment main physical-chemical indicators of surface waters were determined. After processing of the obtained results the corresponding estimations were provided. The risks due to the environmental pollution and negative impacts on population health were assessed.

Gap acceptance behavior of drivers at uncontrolled T-intersections under mixed traffic conditions

Explicit traffic control measures are absent in uncontrolled intersections which make them susceptible to frequent conflicts and resulting collisions between vehicles. In developing countries like India, drivers at such intersections do not yield to higher priority movements which cause more crashes between vehicles. The objective of this study is to analyze and model the gap acceptance behavior of minor street drivers at uncontrolled T-intersections considering their aggressive nature. Three intersections in the northeast region of India have been selected as the case study area. Preliminary analysis of the data revealed that drivers behave aggressively, not because they have to wait for a long time at the stop line, but because of their lack of respect for traffic rules. Binary logit models are developed for minor road right turning vehicles which show that gap acceptance behavior is influenced by gap duration, clearing time and aggressive nature of drivers. The equations obtained were used to estimate the critical gaps for aggressive and non-aggressive drivers. Critical gaps are also calculated using an existing method called clearing behavior approach. It is also shown that the estimation of critical gap is more realistic if clearing time and aggressive behavior of drivers are considered.

Impact of uncontrolled blood pressure on diagnostic accuracy of coronary flow reserve for detecting significant coronary stenosis in hypertensive patients

Background Impaired coronary flow reserve （CFR） in patients with hypertension may be caused by epicardial coronary stenosis or microvascular dysfunction. Antihypertensive treatment has been shown to improve coronary microvascular dysfunction. The aim of this study was to evaluate the impact of uncontrolled blood pressure （BP） on diagnostic accuracy of CFR for detecting significant coronary stenosis. Methods A total of 98 hypertensive patients scheduled for coronary angiography （CAG） due to chest pain were studied. Of them, 45 patients had uncontrolled BP （defined as the office BP 〉140/90 mmHg （1 mmHg=0.133 kPa） in general hypertensive patients, or ≥130/80 mmHg in hypertensive individuals with diabetes mellitus）, and the remaining 53 patients had well-controlled BP. CFR was measured in the left anterior descending coronary artery （LAD） during adenosine triphosphate-induced hyperemia by non-invasive transthoracic Doppler echocardiography （TTDE） within 48 hours prior to CAG. Significant LAD stenosis was defined as 〉70% luminal narrowing. Diagnostic accuracy of CFR for detecting significant coronary stenosis was analyzed with a receiver operating characteristic analysis. Results CFR was significantly lower in patients with uncontrolled BP than in those with well-controlled BP （2.1±0.6 vs. 2.6±0.9, P〈0.01）. Multivariate linear regression analysis of the study showed that the value of CFR was independently associated with the angiographically determined degree of LAD stenosis （β= -0.445, P 〈0.0001） and the presence of uncontrolled BP （β= -0.272, P=0.014）. With a receiver operating characteristic analysis, CFR 〈2.2 was the optimal cut-off value for detecting LAD stenosis in all hypertensive patients （AUC 0.83, 95% CI 0.75-0.91） with a sensitivity of 75%, a specificity of 78%, and an accuracy of 77%. A significant reduction of diagnostic specificity was observed in patients with uncontrolled BP compared with those with well-controlled BP （67% vs. 93%, P=0.031）. Conclusions CFR measurement by TTDE is valuable in the diagnosis of significant coronary stenosis in hypertensive patients. However, the diagnostic specificity is reduced in patients with uncontrolled BP.

A novel face recognition in uncontrolled environment based on block 2D-CS-LBP features and deep residual network

Purpose-In order to solve the problem that the performance of the existing local feature descriptors in uncontrolled environment is greatly affected by illumination,background,occlusion and other factors,we propose a novel face recognition algorithm in uncontrolled environment which combines the block central symmetry local binary pattern(CS-LBP)and deep residual network(DRN)model.Design/methodology/approach-The algorithm first extracts the block CSP-LBP features of the face image,then incorporates the extracted features into the DRN model,and gives the face recognition results by using a well-trained DRN model.The features obtained by the proposed algorithm have the characteristics of both local texture features and deep features that robust to illumination.Findings-Compared with the direct usage of the original image,the usage of local texture features of the image as the input of DRN model significantly improves the computation efficiency.Experimental results on the face datasets of FERET,YALE-B and CMU-PIE have shown that the recognition rate of the proposed algorithm is significantly higher than that of other compared algorithms.Originality/value-The proposed algorithm fundamentally solves the problem of face identity recognition in uncontrolled environment,and it is particularly robust to the change of illumination,which proves its superiority.

Dataset of Large Gathering Images for Person Identification and Tracking

This paper presents a large gathering dataset of images extracted from publicly filmed videos by 24 cameras installed on the premises of Masjid Al-Nabvi,Madinah,Saudi Arabia.This dataset consists of raw and processed images reflecting a highly challenging and unconstraint environment.The methodology for building the dataset consists of four core phases;that include acquisition of videos,extraction of frames,localization of face regions,and cropping and resizing of detected face regions.The raw images in the dataset consist of a total of 4613 frames obtained fromvideo sequences.The processed images in the dataset consist of the face regions of 250 persons extracted from raw data images to ensure the authenticity of the presented data.The dataset further consists of 8 images corresponding to each of the 250 subjects(persons)for a total of 2000 images.It portrays a highly unconstrained and challenging environment with human faces of varying sizes and pixel quality(resolution).Since the face regions in video sequences are severely degraded due to various unavoidable factors,it can be used as a benchmark to test and evaluate face detection and recognition algorithms for research purposes.We have also gathered and displayed records of the presence of subjects who appear in presented frames;in a temporal context.This can also be used as a temporal benchmark for tracking,finding persons,activity monitoring,and crowd counting in large crowd scenarios.

Factors associated with intensification of antihypertensive drug therapy in patients with poorly controlled hypertension

Objective To assess antihypertensive management of older patients with poor blood pressure(BP)control.Methods Physicians,voluntary participating in the study,included six consecutive hypertensive patients during routine visits.Hypertension had to have been previously recognized and averaged office BP was>140 and/or>90 mmHg in spite of>6 weeks of antihypertensive therapy.The physicians completed a questionnaire on patients'history of cardiovascular(CV)risk factors,comorbidities,home BP monitoring,anthropometric data and the pharmacotherapy.Results Mean age of the 6462 patients was 61 years,7%were>80 years,51%were female.Mean士SD office BP values were 158士13/92土10 mmHg.The most commonly prescribed antihypertensive drugs were:diuretics(67%),ACE inhibitors(64%),calcium channel blockers(58%)and卩-blockers(54%),and their use increased with age.On monotherapy or dual therapy,43%of the patients and 40%had their latest treatment modification within six months.Home BP monitoring was a factor that accelerated the modification of the therapy.Older patients had to have less chance on faster modification of antihypertensive therapy in spite of presence of diabetes and higher systolic BP.Conclusions Our study suggests that a large number of outpatients with poor BP control receive suboptimal antihypertensive therapy,especially in primary care.In older patients,higher BP values in the office settings are more frequently accepted by physicians even in case of higher CV risk.Regular home BP monitoring hastens the decision to intensify of antihypertensive treatment.

Measurement of the Effective Dose Radiation at Radiology Departments of Some Hospitals in Duhok Governorate

During operating of the X-ray machines, if the protection of X-ray rooms is insufficient, not only the patient but also clinical staffs as well as public are exposed to high X-ray dosage and they are affected from X-ray related to the dose level. In the present survey, by testing the radiological leakage and scatter from X-rays machines in radiology departments of 7 randomly selected hospitals in Duhok governorate, the effects dose of X-ray to the both control panel area and the patients waiting or visiting area who are located near the radiography room, were measured. The dose was recorded for a range of peak kilovoltage (kVp) and mAs values to find efficiency of shielding materials (barriers) of radiography rooms for different X-rays level. The measurements were performed at one meter above the ground surface which was the same height of X-rays tube by using Gamma Scout dosimeter. From the measurement results, it was seen that the most hospitals barriers (doors and walls) were not appropriate to the standards except 2 hospitals. The maximum effective doses were measured in uncontrolled area of Khazer hospital which was 82.48 ± 0.73 mSv·yr-1 that was much more than the reference dose limits and in controlled area of Haval Banda Zaroka hospital which was 12.98 ± 0.16 mSv·yr-1. In result, the knowledge about the radiation dose affecting the radiologists and public in the selected hospitals was obtained, and by informing the radiologists and the hospitals managements, the necessary regulations would be planned.

Psychological flexibility, occupational burnout and eating behavior among working women

Background: Occupational burnout is associated with diminished psychological flexibility and higher emotional (EE) and uncontrolled eating (UE). Psychological flexibility could be a mediating factor between burnout and eating behaviour. Objectives: To investigate differences in eating behaviour between those with different levels of psychological flexibility, and the association of the interaction between psychological flexibility and occupational burnout with eating behaviour. Design: The participants were working women (n = 263), who took part in the randomized controlled health intervention trial. Analyses were performed in a cross-sectional setting at baseline. Methods: Eating behaviour was measured using the Three Factor Eating Behaviour Questionnaire-18 [which evaluates EE, UE and cognitive restraint (CR)], psychological flexibility using Acceptance and Action Questionnaire-II and occupational burnout using Bergen Burnout Indicator-15. Participants were divided into four groups based on the quartile points of psychological flexibility. Results: The EE of those who were inflexible was higher than that of those whose flexibility was high moderate (p = 0.013) and who were flexible (p = 0.001). The UE of those who were inflexible was higher than the UE in the other groups with higher flexibility [low moderate (p = 0.034), high moderate (p een occupational burnout and EE and UE. Multivariate analysis of variances revealed that the combination of psychological flexibility and burnout had a stronger association with the variances of EE and UE than psychological flexibility alone. Conclusions: Persons who are psychologically inflexible have higher EE and UE. Future studies should investigate if increasing psychological flexibility helps decrease EE and UE.

Analysis of occupation time of vehicles at urban unsignalized intersections in non-lane-based mixed traffic conditions

In India, traffic flow on roads is highly mixed in nature with wide variations in the static and dynamic characteristics of vehicles. At unsignalized intersections, vehicles generally do not follow lane discipline and ignore the rules of priority. Drivers generally become more aggressive and tend to cross the uncontrolled intersections without considering the conflicting traffic. All these conditions cause a very complex traffic situation at unsignal- ized intersections which have a great impact on the capacity and performance of traffic intersections. A new method called additive conflict flow （ACF） method is suitable to determine the capacity of unsignalized inter- sections in non-lane-based mixed traffic conditions as prevailing in India. Occupation time is the key parameter for ACF method, which is defined as the time spent by a vehicle in the conflict area at the intersection. Data for this study were collected at two three-legged unsignalized intersections （one is uncontrolled and other one is semi- controlled） in Mangalore city, India using video-graphic technique during peak periods on three consecutive week days. The occupation time of vehicles at these intersections were studied and compared. The data on conflicting traffic volume and occupation time by each subject vehicle at the conflict area were extracted from the videos using image processing software. The subject vehicles were divided into three categories： two wheelers,cars, and auto-rickshaws. Mathematical relationships were developed to relate the occupation time of different cate- gories of vehicles with the conflicting flow of vehicles for various movements at both the intersections. It was found that occupation time increases with the increasing con- flicting traffic and observed to be higher at the uncontrolled intersection compared to the semicontrolled intersec- tion. The segregated turning movements and the presence of mini roundabout at the semicontrolled intersection reduces the conflicts of vehicular movements, which ulti- mately reduces the occupation time. The proposed methodology will be useful to determine the occupation time for various movements at unsignalized intersections. The models developed in the study can be used by practitioners and traffic engineers to estimate the capacity of unsignalized intersections in non-lane-based discipline and mixed traffic conditions.

Environmental Impact of Casablanca Landfill on Groundwater Quality, Morocco

The Casablanca landfill is one among many uncontrolled dumping sites in Morocco with no bottom liner. About 4000 tons/day of solid wastes from mixed urban and industrial origins are placed directly on the fifteen old sandstone quarries. At the site of this landfill, the groundwaters circulate deeply (10 m) in the fractured aquiferous quartzites, the site has never been sealed before its opening. The aim of this study is the characterization the groundwater quality around the landfill, to delimit the contaminated zone and the factors controlling the extent of groundwater contamination. To evaluate groundwater pollution due to this landfill, piezometric level and geochemical analyses have been carried out on 19 wells. The results of geochemical analyses show an important qualitative degradation of the groundwater, especially in the parts situated in the down gradient area and in direct proximity to the landfill. In these polluted zones, we have observed the following values: higher than 11 mS/cm in electric conductivity, 1400 mg/L in bicarbonates, 275 mg/L in chemical oxygen demand, 2616 and 100 mg/L respectively in chlorides and sulfate, 269.5 mg/L in nitrates, 50 - 100 mg/L in cadmium, and 40 - 230 μg/L in chromium. These concentrations widely exceed the standard values for potable and irrigation water. Several determining factors in the evolution of groundwater contamination have been highlighted, such as: depth of the water table, permeability of unsaturated zone and lineaments, effective infiltration, absence of a system for leachate drainage. So, to reduce the pollution risks of the groundwater, it is necessary to set a system of collection, drainage and treatment of landfill leachates and to emplace an impermeable surface at the site of landfill, in order to limit the infiltration of leachate.

Prevalence of Chronic Kidney Disease in Patients with Cardiovascular Disease

Background: Chronic kidney disease (CKD) is a worldwide public health alarming problem. Although both heart and kidneys are separated by a quite distance within the body and they perform varied functions, there is a close physiological relationship between them. The diseases in the kidneys can trigger a disease in the heart and vice versa. High blood pressure is the most significant risk factor for the development and progression of chronic kidney disease (CKD). Lowering blood pressure is a goal to prevent CKD progress. Chronic abnormalities in cardiac function (e.g., chronic congestive heart failure) causing, chronic kidney disease and anemia appear to act together in a vicious circle in which each condition causes or exacerbates the other progressive chronic kidney disease. Objective: To assess the prevalence of chronic kidney disease in patients with cardiovascular disease at Shebin El-Kom Teaching Hospital and Menoufia University Hospital Cardiology Outpatient Clinic, Menoufia Governorate, Egypt. Methods: This is a cross-sectional study that was conducted in Shebin El-Kom Teaching Hospital Cardiology Outpatient Clinic, Menoufia University Cardiology Outpatient Clinic from April 2019 to July 2019. This study included 200 patients with cardiovascular disease or hypertension for more than 6 months. All patients were subjected to detailed history taking, clinical examination, laboratory investigation, echo and abdominal ultrasound. Results: This study included 200 patients with cardiovascular disease or hypertension for more than 6 months, which showed that: 63 (31.5%) were diagnosed as chronic kidney disease, 24 (38%) known to be CKD, 39 (62%) not known diagnosed in our study. Uncontrolled hypertension, congestive heart failure, diuretics and ACEI or ARBS with diuretics together are significant risk factors for renal impairment;uncontrolled hypertension and diuretics are the most predictors for renal impairment. Conclusion: Uncontrolled hypertension is the most preventable cause of renal impairment;RAAS not cause renal impairment but lead to decreased GFR in CKD patients. We should be careful with ACEI or ARBS with diuretics or diuretics only and control congestive heart disease to avoid kidney injury and chronic cardiorenal.

Subsoil Natural Physico-chemical Reactor: The Property of Deep Abiogenic Methane-Containing High-Thermobaric Fluid to Form Coal Seams

For the first time,the property of deep abiogenic methane-containing high-thermobaric fluid to decompose organic residues in the Earth’s crust and form coal seams was established.

Deadlock-free Supervisor Design for Robotic Manufacturing Cells With Uncontrollable and Unobservable Events

In this paper,a deadlock prevention policy for robotic manufacturing cells with uncontrollable and unobservable events is proposed based on a Petri net formalism.First,a Petri net for the deadlock control of such systems is defined.Its admissible markings and first-met inadmissible markings(FIMs)are introduced.Next,place invariants are designed via an integer linear program(ILP)to survive all admissible markings and prohibit all FIMs,keeping the underlying system from reaching deadlocks,livelocks,bad markings,and the markings that may evolve into them by firing uncontrollable transitions.ILP also ensures that the obtained deadlock-free supervisor does not observe any unobservable transition.In addition,the supervisor is guaranteed to be admissible and structurally minimal in terms of both control places and added arcs.The condition under which the supervisor is maximally permissive in behavior is given.Finally,experimental results with the proposed method and existing ones are given to show its effectiveness.

Contained local compression on peri-ascending aortic area for postoperative bleeding control:a case report

After type A acute aortic dissection(AAD)repair or modified Bentall procedure,uncontrollable bleeding from the anastomotic sites of the fragile dissected tissues or aortic root area is a critical situation to a cardiac surgeon.For postoperative care,lots of blood transfusion with strict monitoring on the patient all night and subsequent reoperation for the bleeding control is usually needed.We managed to make contained local compression of upper half of the heart,from upper part of the right ventricle to just above the innominate vein,using bovine pericardium with closing both sides of transverse sinus in two cases of uncontrolled postoperative bleeding(bleeding from distal anastomotic site in type-A AAD and valve sitting site in modified Bentall procedure).Even though reoperations for the removal of packed gauges were done in both cases 2 days later,postoperative courses at intensive care unit were very smooth with little need for transfusion.This kind of contained local compression trial could be a useful strategy for dealing with the malignant uncontrollable bleeding from the fragile aortic tissue or root area after acute dissection or aortic root repair.

Chaotic motions of the L-mode to H-mode transition model in tokamak

The chaotic dynamics of the transport equation for the L-mode to H-mode near the plasma in a tokamak is studied in detail with the Melnikov method. The transport equations represent a system with external and parametric excitation. The critical curves separating the chaotic regions and nonchaotic regions are presented for the system with periodically external excitation and linear parametric excitation, or cubic parametric excitation, respectively. The results obtained here show that there exist uncontrollable regions in which chaos always take place via heteroclinic bifurcation for the system with linear or cubic parametric excitation. Especially, there exists a controllable frequency, excited at which chaos does not occur via homoclinic bifurcation no matter how large the excitation amplitude is for the system with cubic parametric excitation. Some complicated dynamical behaviors are obtained for this class of systems.

Adaptive practical output tracking of a class of nonlinear systems

Focus is laid on the adaptive practical output-tracking problem of a class of nonlinear systems with high-order lower-triangular structure and uncontrollable unstable linearization. Using the modified adaptive addition of a power integrator technique as a basic tool, a new smooth adaptive state feedback controller is designed. This controller can ensure all signals of the closed-loop systems are globally bounded and output tracking error is arbitrary small.

DOE在SMT新产品导入中的效应及案例分析

引言 电子产品的SMT新品导入及生产过程中，必然会遇到产品的结构设计、各种新型制程工艺、特殊或非标元器件、相关的辅材导入等验证要求，以及生产制程参数优化、产品缺陷分析与改善等问题。为了搞好相关验证并解决以上问题，从而获得恰当的制程工艺参数及产品品质，

Cancer,Mankind’s Challenge

Cancer, or malignant tumour, is a group of diseases defined by the uncontrollable growth of the transformed cells, and their capabilities of invasion into surrounding healthy tissues and metastasis to remote sites in the body of organisms[1, 2].

Analyzing variations in spatial critical gaps at two-way stop controlled intersections using parametric and non-parametric techniques

At two-way stop controlled(TWSC)intersections drivers on minor stream are generally at risk because of the difficulty in judging safe gap between major stream vehicles.Any misjudgment by the driver while choosing gap may result in a collision with major stream vehicle.This paper provides important insights for determining and analyzing spatial critical gaps of drivers at high speed and medium speed TWSC intersections.The critical gap line(CGL)fitted for the accepted and rejected gaps using parametric(binary logit model-BLM)and non-parametric(support vector machines-SVM)techniques gives critical gap values at 15 th,50 th and 85 th percentile speeds.The evaluation of spatial critical gap with respect to major road vehicle(conflicting vehicle)speed makes it easier to understand the impact of variation in speed on spatial gaps accepted by the drivers on the minor road.The logit models developed revealed that the probability of accepting gap decreases with increase in the speed of the conflicting vehicle and it increases with increase in the distance of conflicting vehicle.The spatial critical gaps estimated using support vector machines were found in close approximation with those estimated using binary logit model.The study results showed that SVMs have very good potential to be an alternative tool for the estimation of driver's critical gap.The spatial critical gaps corresponding to 15 th,50 th and 85 th percentile speeds for medium speed intersections were 32 m,38 m and 46 m respectively and for high speed intersections these values were 64 m,76 m and 104 m respectively.The increase in the magnitude of gap value with respect to the percentile speed clearly states the effect of speed on spatial gaps.The insights from the study can be used to suggest various measures to improve the safety of crossing drivers at uncontrolled intersections.