Polyamines, putrescine (PUT), spermidine (SPD) and spermine (SPM) are implicated in plants’ responses under conditions of abiotic stress. Previous research in other crops has indicated that polyamines and changes in ...Polyamines, putrescine (PUT), spermidine (SPD) and spermine (SPM) are implicated in plants’ responses under conditions of abiotic stress. Previous research in other crops has indicated that polyamines and changes in their concentrations are associated with drought tolerance under conditions of water-deficit stress;however, no information exists on cotton (Gossypium hirsutum L.). Growth chamber experiments were conducted with two cotton cultivars differing in drought tolerance, ST5288B2F (drought-sensitive) and Siokra L23 (drought-tolerant) in order to investigate the distribution of free polyamines, the effect of water-deficit stress on the polyamine metabolism of cotton reproductive units and their subtending leaves as well as the possible relationship between polyamines and drought tolerance in cotton. Our results showed that cotton ovaries contained significantly higher levels of total free polyamines compared to their subtending leaves under both control and water stress conditions. Water-deficit stress significantly increased PUT concentrations in ST5288B2F, while SPM levels significantly decreased in Siokra L23. The results indicated that water-deficit stress significantly affected cotton polyamine metabolism in reproductive structures and their subtending leaves;however, no clear relationship between drought-tolerance and changes in polyamine accumulation was established. Further research is needed to elucidate the mechanism according to which water-deficit stress affects polyamine metabolism.展开更多
In recent years, graphical processing unit (GPU)-accelerated intelligent algorithms have been widely utilized for solving combination optimization problems, which are NP-hard, These intelligent algorithms involves a...In recent years, graphical processing unit (GPU)-accelerated intelligent algorithms have been widely utilized for solving combination optimization problems, which are NP-hard, These intelligent algorithms involves a common operation, namely reduction, in which the best suitable candidate solution in the neighborhood is selected. As one of the main procedures, it is necessary to optimize the reduction on the GPU. In this paper, we propose an enhanced warp-based reduction on the GPU. Compared with existing block-based reduction methods, our method exploit efficiently the potential of implementation at warp level, which better matches the characteristics of current GPU architecture. Firstly, in order to improve the global memory access performance, the vectoring accessing is utilized. Secondly, at the level of thread block reduction, an enhanced warp-based reduction on the shared memory are presented to form partial results. Thirdly, for the configuration of the number of thread blocks, the number of thread blocks can be obtained by maximizing the size of thread block and the maximum size of threads per stream multi-processor on GPU. Finally, the proposed method is evaluated on three generations of NVIDIA GPUs with the better performances than previous methods.展开更多
Current minimally invasive interventions for ureteric stones involve either ESWL or Ureteroscopy and stone localization is mandatory for successful treatment in both. Objectives: To avoid doing KUB radiograph before E...Current minimally invasive interventions for ureteric stones involve either ESWL or Ureteroscopy and stone localization is mandatory for successful treatment in both. Objectives: To avoid doing KUB radiograph before ESWL routinely by correlating the stone attenuation value on CT KUB with stone visualization at fluoroscopy. Methods: This is a prospective cross sectional hospital based, Multicentric study carried out on 1010 patients with ureteric stones in Sudan from August 2014 to March 2016. Results: Mean stone density in HU was 704.45 ± 300 (SD) ranging (81 - 1873) HU. All of the stones were localized using fluoroscopy and only 26.5% of them were not seen under fluoroscopy. I.V contrast was used mostly, and also mainly in the upper ureter. More than 80% of the application of contrast through the ureteric catheter was in the lower ureteric stones. 91.2% of patients with stone density ≤ 400 HU failed to appear at fluoroscopy and therefore 400 HU attenuation value can be used as a cut-off level to request doing KUB before ESWL and Ureteroscopy. Conclusion: the ureteric stones with density ≤400 HU the likelihood of being non-visualized at fluoroscopy is 91.2% therefore if the stone has ≤400 HU at CT KUB it is mandatory to do KUB before treatment above that it is most likely to be seen at fluoroscopy and no need to request KUB for them before ESWL or URS. 1) Inclusion Criteria: All patients diagnosed by CT scan to have ureteric stones for ESWL or Ureteroscopy. 2) Exclusion Criteria: Patients for whom treatment of ureteric stone by ESWL or ureteroscopy is not indicated like severe infection or poor kidney function where nephrectomy is needed.展开更多
Unit nurse managers in Malawi experience many challenges in the course of performing their roles. This affects their performance and service delivery including the quality of nursing care to patients. This study was c...Unit nurse managers in Malawi experience many challenges in the course of performing their roles. This affects their performance and service delivery including the quality of nursing care to patients. This study was conducted to determine the factors that hindered performance of unit managers in relation to expected quality of nursing services at two referral facilities (Kamuzu and Queen Elizabeth Central hospitals) in Malawi. These two central hospitals have the same structural settings and both offer specialized tertiary health services. A quantitative descriptive design was used to guide the planning and implementation of the study. Purposive sampling was used to select the two major hospitals in Malawi and all available 37 unit nurse managers during the time of the study at the two hospitals participated in the study. Data were collected using semi-structured questionnaires after seeking consent from the participants and were analyzed using SPSS version 16.0. The major roles identified by the unit managers were supervision (75.6%, n = 28) and coordination (70.3%, n = 26). Other roles such as team leader, liaison officer, research allocator, monitor and facilitator were rated by very few participants. Findings of the study showed that performance of unit nurse managers was affected by inadequate material (86.4%, n = 32) and human resources (94.5%, n = 35) and lack of managerial skills (5.4%, n = 2). In addition, the unit managers perceived their role to be stressful (38.9%, n = 14) and challenging (47.2%, n = 17). Therefore, there is a need to provide adequate material and human resources to the wards of the two central hospitals to enable the unit managers perform their duties efficiently.展开更多
The organization of the compartment of mesenchymal stem cells is still obscure. Two types of human stromal precursor cells are known. Both of them are analyzed in in vitro system: mesenchymal multipotent stromal cells...The organization of the compartment of mesenchymal stem cells is still obscure. Two types of human stromal precursor cells are known. Both of them are analyzed in in vitro system: mesenchymal multipotent stromal cells (MMSC) and fibroblast colony forming units (CFU-F). The aim of this study was to compare the main characteristics of MMSC and CFU-F derived from the bone marrow of 24 healthy donors. Growth and differentiation parameters, as well as relative expression levels of different genes were analyzed in MMSC and CFU-F. MMSC were cultivated for 5 passages. CFU-F concentration was determined for each bone marrow sample. The data obtained demonstrated the heterogeneity and hierarchical organization of both studied populations of stromal precursor cells-MMSC and CFU-F. These two types of stromal precursor cells turned to be different in most parameters studied. Altogether MMSC seemed to be more immature cells than CFU-F and took up the higher position in hierarchical tree of mesenchymal stem cells. The rate of differentiation and proliferative potential decreased with the donor’s age in both populations MMSC and CFU-F.展开更多
文摘Polyamines, putrescine (PUT), spermidine (SPD) and spermine (SPM) are implicated in plants’ responses under conditions of abiotic stress. Previous research in other crops has indicated that polyamines and changes in their concentrations are associated with drought tolerance under conditions of water-deficit stress;however, no information exists on cotton (Gossypium hirsutum L.). Growth chamber experiments were conducted with two cotton cultivars differing in drought tolerance, ST5288B2F (drought-sensitive) and Siokra L23 (drought-tolerant) in order to investigate the distribution of free polyamines, the effect of water-deficit stress on the polyamine metabolism of cotton reproductive units and their subtending leaves as well as the possible relationship between polyamines and drought tolerance in cotton. Our results showed that cotton ovaries contained significantly higher levels of total free polyamines compared to their subtending leaves under both control and water stress conditions. Water-deficit stress significantly increased PUT concentrations in ST5288B2F, while SPM levels significantly decreased in Siokra L23. The results indicated that water-deficit stress significantly affected cotton polyamine metabolism in reproductive structures and their subtending leaves;however, no clear relationship between drought-tolerance and changes in polyamine accumulation was established. Further research is needed to elucidate the mechanism according to which water-deficit stress affects polyamine metabolism.
基金Supported by National Nature Science Foundation of China(61472289)the Nature Science Foundation of Hubei Province(2015CFB254)
文摘In recent years, graphical processing unit (GPU)-accelerated intelligent algorithms have been widely utilized for solving combination optimization problems, which are NP-hard, These intelligent algorithms involves a common operation, namely reduction, in which the best suitable candidate solution in the neighborhood is selected. As one of the main procedures, it is necessary to optimize the reduction on the GPU. In this paper, we propose an enhanced warp-based reduction on the GPU. Compared with existing block-based reduction methods, our method exploit efficiently the potential of implementation at warp level, which better matches the characteristics of current GPU architecture. Firstly, in order to improve the global memory access performance, the vectoring accessing is utilized. Secondly, at the level of thread block reduction, an enhanced warp-based reduction on the shared memory are presented to form partial results. Thirdly, for the configuration of the number of thread blocks, the number of thread blocks can be obtained by maximizing the size of thread block and the maximum size of threads per stream multi-processor on GPU. Finally, the proposed method is evaluated on three generations of NVIDIA GPUs with the better performances than previous methods.
文摘Current minimally invasive interventions for ureteric stones involve either ESWL or Ureteroscopy and stone localization is mandatory for successful treatment in both. Objectives: To avoid doing KUB radiograph before ESWL routinely by correlating the stone attenuation value on CT KUB with stone visualization at fluoroscopy. Methods: This is a prospective cross sectional hospital based, Multicentric study carried out on 1010 patients with ureteric stones in Sudan from August 2014 to March 2016. Results: Mean stone density in HU was 704.45 ± 300 (SD) ranging (81 - 1873) HU. All of the stones were localized using fluoroscopy and only 26.5% of them were not seen under fluoroscopy. I.V contrast was used mostly, and also mainly in the upper ureter. More than 80% of the application of contrast through the ureteric catheter was in the lower ureteric stones. 91.2% of patients with stone density ≤ 400 HU failed to appear at fluoroscopy and therefore 400 HU attenuation value can be used as a cut-off level to request doing KUB before ESWL and Ureteroscopy. Conclusion: the ureteric stones with density ≤400 HU the likelihood of being non-visualized at fluoroscopy is 91.2% therefore if the stone has ≤400 HU at CT KUB it is mandatory to do KUB before treatment above that it is most likely to be seen at fluoroscopy and no need to request KUB for them before ESWL or URS. 1) Inclusion Criteria: All patients diagnosed by CT scan to have ureteric stones for ESWL or Ureteroscopy. 2) Exclusion Criteria: Patients for whom treatment of ureteric stone by ESWL or ureteroscopy is not indicated like severe infection or poor kidney function where nephrectomy is needed.
文摘Unit nurse managers in Malawi experience many challenges in the course of performing their roles. This affects their performance and service delivery including the quality of nursing care to patients. This study was conducted to determine the factors that hindered performance of unit managers in relation to expected quality of nursing services at two referral facilities (Kamuzu and Queen Elizabeth Central hospitals) in Malawi. These two central hospitals have the same structural settings and both offer specialized tertiary health services. A quantitative descriptive design was used to guide the planning and implementation of the study. Purposive sampling was used to select the two major hospitals in Malawi and all available 37 unit nurse managers during the time of the study at the two hospitals participated in the study. Data were collected using semi-structured questionnaires after seeking consent from the participants and were analyzed using SPSS version 16.0. The major roles identified by the unit managers were supervision (75.6%, n = 28) and coordination (70.3%, n = 26). Other roles such as team leader, liaison officer, research allocator, monitor and facilitator were rated by very few participants. Findings of the study showed that performance of unit nurse managers was affected by inadequate material (86.4%, n = 32) and human resources (94.5%, n = 35) and lack of managerial skills (5.4%, n = 2). In addition, the unit managers perceived their role to be stressful (38.9%, n = 14) and challenging (47.2%, n = 17). Therefore, there is a need to provide adequate material and human resources to the wards of the two central hospitals to enable the unit managers perform their duties efficiently.
文摘The organization of the compartment of mesenchymal stem cells is still obscure. Two types of human stromal precursor cells are known. Both of them are analyzed in in vitro system: mesenchymal multipotent stromal cells (MMSC) and fibroblast colony forming units (CFU-F). The aim of this study was to compare the main characteristics of MMSC and CFU-F derived from the bone marrow of 24 healthy donors. Growth and differentiation parameters, as well as relative expression levels of different genes were analyzed in MMSC and CFU-F. MMSC were cultivated for 5 passages. CFU-F concentration was determined for each bone marrow sample. The data obtained demonstrated the heterogeneity and hierarchical organization of both studied populations of stromal precursor cells-MMSC and CFU-F. These two types of stromal precursor cells turned to be different in most parameters studied. Altogether MMSC seemed to be more immature cells than CFU-F and took up the higher position in hierarchical tree of mesenchymal stem cells. The rate of differentiation and proliferative potential decreased with the donor’s age in both populations MMSC and CFU-F.