Ⅰ.听录音,选出与你所听到的句子意思相同或相近的选项。1. A. He has small eyes. B. His eyes are not big. C. He has big eyes.2. A. I can carry this heavy desk. B. I can' t carry this heavy desk. C. I can carry this li...Ⅰ.听录音,选出与你所听到的句子意思相同或相近的选项。1. A. He has small eyes. B. His eyes are not big. C. He has big eyes.2. A. I can carry this heavy desk. B. I can' t carry this heavy desk. C. I can carry this light desk.3. A. The basket is full. You can' t carry it. B. The basket is full. You can' t put展开更多
The cancer cell metastasis is a major death reason for patients with non-small cell lung cancer(NSCLC).Although researchers have disclosed that interleukin 17(IL-17)can increase matrix metalloproteinases(MMPs)inductio...The cancer cell metastasis is a major death reason for patients with non-small cell lung cancer(NSCLC).Although researchers have disclosed that interleukin 17(IL-17)can increase matrix metalloproteinases(MMPs)induction causing NSCLC cell metastasis,the underlying mechanism remains unclear.In the study,we found that IL-17 receptor A(IL-17RA),p300,p-STAT3,Ack-STAT3,and MMP19 were up-regulated both in NSCLC tissues and NSCLC cells stimulated with IL-17.p300,STAT3 and MMP19 overexpression or knockdown could raise or reduce IL-17-induced p-STAT3,Ack-STAT3 and MMP19 level as well as the cell migration and invasion.Mechanism investigation revealed that STAT3 and p300 bound to the same region(−544 to−389 nt)of MMP19 promoter,and p300 could acetylate STAT3-K631 elevating STAT3 transcriptional activity,p-STAT3 or MMP19 expression and the cell mobility exposed to IL-17.Meanwhile,p300-mediated STAT3-K631 acetylation and its Y705-phosphorylation could interact,synergistically facilitating MMP19 gene transcription and enhancing cell migration and invasion.Besides,the animal experiments exhibited that the nude mice inoculated with NSCLC cells by silencing p300,STAT3 or MMP19 gene plus IL-17 treatment,the nodule number,and MMP19,Ack-STAT3,or p-STAT3 production in the lung metastatic nodules were all alleviated.Collectively,these outcomes uncover that IL-17-triggered NSCLC metastasis involves up-regulating MMP19 expression via the interaction of STAT3-K631 acetylation by p300 and its Y705-phosphorylation,which provides a new mechanistic insight and potential strategy for NSCLC metastasis and therapy.展开更多
I.单项选择1. John plays football, if not better than, David.A. as well B. as well as C. so well D. so well as2.a teacher,so he must decide what to do and what not to do.A. Being B. As C...I.单项选择1. John plays football, if not better than, David.A. as well B. as well as C. so well D. so well as2.a teacher,so he must decide what to do and what not to do.A. Being B. As C. He is D. Because3. He demanded that the books to the school library at once.A. return B. should returnC. be returned D. would be展开更多
文摘Ⅰ.听录音,选出与你所听到的句子意思相同或相近的选项。1. A. He has small eyes. B. His eyes are not big. C. He has big eyes.2. A. I can carry this heavy desk. B. I can' t carry this heavy desk. C. I can carry this light desk.3. A. The basket is full. You can' t carry it. B. The basket is full. You can' t put
基金National Natural Science Foundation of China(Grants Numbers 81902878 and 81971468).
文摘The cancer cell metastasis is a major death reason for patients with non-small cell lung cancer(NSCLC).Although researchers have disclosed that interleukin 17(IL-17)can increase matrix metalloproteinases(MMPs)induction causing NSCLC cell metastasis,the underlying mechanism remains unclear.In the study,we found that IL-17 receptor A(IL-17RA),p300,p-STAT3,Ack-STAT3,and MMP19 were up-regulated both in NSCLC tissues and NSCLC cells stimulated with IL-17.p300,STAT3 and MMP19 overexpression or knockdown could raise or reduce IL-17-induced p-STAT3,Ack-STAT3 and MMP19 level as well as the cell migration and invasion.Mechanism investigation revealed that STAT3 and p300 bound to the same region(−544 to−389 nt)of MMP19 promoter,and p300 could acetylate STAT3-K631 elevating STAT3 transcriptional activity,p-STAT3 or MMP19 expression and the cell mobility exposed to IL-17.Meanwhile,p300-mediated STAT3-K631 acetylation and its Y705-phosphorylation could interact,synergistically facilitating MMP19 gene transcription and enhancing cell migration and invasion.Besides,the animal experiments exhibited that the nude mice inoculated with NSCLC cells by silencing p300,STAT3 or MMP19 gene plus IL-17 treatment,the nodule number,and MMP19,Ack-STAT3,or p-STAT3 production in the lung metastatic nodules were all alleviated.Collectively,these outcomes uncover that IL-17-triggered NSCLC metastasis involves up-regulating MMP19 expression via the interaction of STAT3-K631 acetylation by p300 and its Y705-phosphorylation,which provides a new mechanistic insight and potential strategy for NSCLC metastasis and therapy.
文摘I.单项选择1. John plays football, if not better than, David.A. as well B. as well as C. so well D. so well as2.a teacher,so he must decide what to do and what not to do.A. Being B. As C. He is D. Because3. He demanded that the books to the school library at once.A. return B. should returnC. be returned D. would be
