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Comparison of Positron Emission Tomography Using 2-[^18F]-fluoro-2-deoxy-D-glucose and 3-deoxy-3-[^18F]-fluorothymidine in Lung Cancer Imaging 被引量:8
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作者 Fu-Li Wang Ye-Ying Tan +4 位作者 Xiang-Min Gu Tian-Ran Li Guang-Ming Lu Gang Liu Tian-Long Huo 《Chinese Medical Journal》 SCIE CAS CSCD 2016年第24期2926-2935,共10页
Background: The detection of solitary pulmonary nodules (SPNs) that may potentially develop into a malignant lesion is essential for early clinical interventions. However, grading classification based on computed t... Background: The detection of solitary pulmonary nodules (SPNs) that may potentially develop into a malignant lesion is essential for early clinical interventions. However, grading classification based on computed tomography (CT) imaging results remains a significant challenge. The 2-[^18F]-fluoro-2-deoxy-D-glucose (^18F-FDG) positron emission tomography (PET)/CT imaging produces both false-positive and false-negative findings for the diagnosis of SPNs. In this study, we compared 18F-FDG and 3-deoxy-3-[^18F]-fluorothymidine (^18F-FLT) in lung cancer PET/CT imaging. Methods: The binding ratios of the two tracers to A549 lung cancer cells were calculated. The mouse lung cancer model was established (n = 12), and micro-PET/CT analysis using the two tracers was performed. Images using the two tracers were collected from 55 lung cancer patients with SPNs. The correlation among the cell-tracer binding ratios, standardized uptake values (SUVs), and Ki-67 proliferation marker expression were investigated. Results: The cell-tracer binding ratio for the A549 cells using the ^18F-FDG was greater than the ratio using 18F-FLT (P 〈 0.05). The Ki-67 expression showed a significant positive correlation with the ^18F-FLT binding ratio (r = 0.824, P〈 0.01). The tumor-to-nontumor uptake ratio of ^18F-FDG imaging in xenografts was higher than that of ^18F-FLT imaging. The diagnostic sensitivity, specificity, and the accuracy of ^18F-FDG for lung cancer were 89%, 67%, and 73%, respectively. Moreover, the diagnostic sensitivity, specificity, and the accuracy of ^18F-FLT for lung cancer were 71%, 79%, and 76%, respectively. There was an obvious positive correlation between the lung cancer Ki-67 expression and the mean maximum SUV of ^18F-FDG and ^18F-FLT (r = 0.658, P〈 0.05 and r = 0.724, P〈 0.01, respectively). Conclusions: The ^18F-FDG uptake ratio is higher than that of ^18F-FLT in A549 cells at the cellular level.^18F-FLT imaging might be superior for the quantitative diagnosis of lung tumor tissue and could distinguish lung cancer nodules from other SPNs. 展开更多
关键词 2-[^18F]-fluoro-2-deoxy-D-glucosc 2-[^18F ]-fluoro-2-deoxy-D-glucose and 3-deoxy-3-[^18F]-fluorothymidine Computed Tomography Lung Cancer Positron Emission Tomography Solitary Pulmonary Nodules Standardized uplake Value
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