AIM: To compare the effect of propofol versus urapidil on hemodynamics and intraocular pressure during anesthesia and extubation for ophthalmic patients. METHODS: Eighty-two surgical patients (Class: ASA I-II) were ra...AIM: To compare the effect of propofol versus urapidil on hemodynamics and intraocular pressure during anesthesia and extubation for ophthalmic patients. METHODS: Eighty-two surgical patients (Class: ASA I-II) were randomly assigned to propofol (n = 41) and urapidil groups (n = 41). Their gender, age, body mass, operation time and dosage of anesthetics had no significant difference between the two groups (P > 0.05). The patients of propofol and urapidil groups were given propofol (1.5mg/kg) and urapidil (2.5mg/kg) respectively; and two drugs were all diluted with normal saline to 8mL. Then the drugs were given to patients by slow intravenous injection. After treatment, the patients were conducted immediate suction, tracheal extubation, and then patients wore oxygen masks for 10 minutes. By double-blind methods, before the induction medication, at the suction, and 5, 10 minutes after the extubation, we recorded the systolic and diastolic blood pressure (BP), heart rate (HR), pH, PaO2, PaCO2, SaO(2) and intraocular pressure (TOP) respectively. The complete recovery time of the patients with restlessness (on the command they could open eyes and shaking hands) was also recorded during the extubation. The data were analyzed by using a professional SPSS 15.0 statistical software. RESULTS: The incidence of cough, restlessness and glossocoma was significantly lower in the propofol group than that in the urapidil group after extubation (P < 0.05). There were no episodes of hypotension, laryngospasm, or severe respiratory depression. There was no statistical difference in recovery time between two groups (P > 0.05). In propofol group, the BP and HR during extubation and thereafter had no significant difference compared with those before induction, while they were significantly lower than those before giving propofol (P < 0.05), and had significant difference compared with those in urapidil group (P < 0.05). Compared to preinduction, the BP of urapidil group showed no obvious increase during aspiration and extubation. The HR of urapidil group had little changes after being given urapidil, and it was obviously increased compared with that before induction. The stimulation of aspiration and extubation caused less cough and agitation in propofol group than that in urapidil group (P < 0.05). The IOP of propofol group showed no obvious increase during extubation compared with that in preinduction, while in the urpidil group, extubation caused IOP significantly increased (P < 0.05). The changes in these indicators between the two groups had no significant difference (P > 0.05). CONCLUSION: Compared to urapidil, propofol is superior for preventing the cardiovascular and stress responses and IOP increases during emergence and extubation for the ophthalmic patients. Moreover, it has no effects on patient's recovery.展开更多
Objective：To investigate the influences of urapidil and nicardipine on rabbit sinus function, atrio-ventricular node function and hemodynamics. Methods：Thirty-two Angora＇ s rabbits were selected and randomly divide...Objective：To investigate the influences of urapidil and nicardipine on rabbit sinus function, atrio-ventricular node function and hemodynamics. Methods：Thirty-two Angora＇ s rabbits were selected and randomly divided into four groups. U1 group：urapidil 0.25 mg/kg; U2 group：urapidil 0.5 mg/kg; N1 group：nicardipine 10 μg/kg; N2 group： nicardipine 20 μg/kg. All these medicine were administrated within 30 seconds. Measurements were taken before and after the administration of urapidil or nicardipine for the following data： mean blood pressure（MAP）, heart rate（HR）, sino-atrial conduction time（SACT）, maximal sinoatrial recovery time（SNRTmax） corrected sinus node recovery time（CSNRT）, index of sinus node recovery time（SNRTI）, Wenckebach A-V conduction frequency （WB）, and P-R interval. Results：Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine. No significant changes could be found in the rest of the parameters. Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group（P 〈 0.01）; the MAP decreased（P 〈 0.01） and the HR increased drastically（P〈 0.01）. Conclusions：Neither urapidil（0.25 mg/kg, 0,5 mg/kg） nor nicardipine（10 μg/kg, 20 μg/kg） has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function. Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.展开更多
目的:系统评价乌拉地尔在男性良性前列腺增生(BPH)患者下尿路症状(LUTS)治疗中的潜在价值。方法:从PubMed、MEDLINE、Web of science、中国知网、万方数据库中鉴定和收集随机对照试验(RCT)或临床观察性研究。利用RevMan软件进行固定效...目的:系统评价乌拉地尔在男性良性前列腺增生(BPH)患者下尿路症状(LUTS)治疗中的潜在价值。方法:从PubMed、MEDLINE、Web of science、中国知网、万方数据库中鉴定和收集随机对照试验(RCT)或临床观察性研究。利用RevMan软件进行固定效应模型和随机效应模型的Meta分析。计算合并效应尺度以加权均数差及其95%可信区间(95%CI)表示。结果:共纳入3项短期(1个月内)观察性研究和1项RCT,共142例患者。发现乌拉地尔显著改善了患者的IPSS(MD=-5.57,95%CI:-7.98~-3.16,P<0.00001)、夜尿频率(MD=-0.7,95%CI:-1.16~-0.24,P=0.003)、残余尿率(MD=-6.97;95%CI:-12.57~-1.37,P=0.01)、平均尿流率(MD=2.04;95%CI:0.52~3.56,P=0.008)和最大尿流率(MD=4.29;95%CI:0.58~8.01,P=0.02),而残余尿量(MD=-35.93;95%CI:-78.62~6.76,P=0.10)在患者服药前后无统计学差异。结论:乌拉地尔是一种有效的缓解BPH患者LUTS的药物。但由于目前的RCT研究数量及质量有限,仍需高质量、大规模的RCT研究进一步证实这一结论。展开更多
目的研究对比乌拉地尔与硝酸甘油在老年高血压合并糖尿病患者发生急性心力衰竭时的疗效。方法将82名老年高血压合并糖尿病并发急性心力衰竭患者,采用数字表法将患者分为硝酸甘油组及乌拉地尔治疗组。观察不同时段2组患者血压、心率的变...目的研究对比乌拉地尔与硝酸甘油在老年高血压合并糖尿病患者发生急性心力衰竭时的疗效。方法将82名老年高血压合并糖尿病并发急性心力衰竭患者,采用数字表法将患者分为硝酸甘油组及乌拉地尔治疗组。观察不同时段2组患者血压、心率的变化情况,反映心功能指标的N末端B型利钠肽原(N terminal B type natriuretic peptide,NT-pro BNP)、射血分数等指标变化情况,观察血糖、血脂浓度及肝、肾功能的情况。结果乌拉地尔组对收缩压的控制及NT-pro BNP的改善明显优于硝酸甘油组。乌拉地尔组在治疗第7天,射血分数较硝酸甘油组明显升高,左室舒张末期容积减小。对心率及糖脂代谢无不良影响。治疗过程中乌拉地尔无不良事件发生。结论乌拉地尔在平稳降压,通过减轻心脏后负荷,从而改善心功能。对糖耐量、血脂代谢无不良影响。药效安全、可靠,未出现耐药反应。展开更多
A reverse flow injection chemiluminescence(CL) method for the determination of urapidil was firstly described. It was found that the CL intensity from the Luminol ClO - system could be enhanced in the presence of urap...A reverse flow injection chemiluminescence(CL) method for the determination of urapidil was firstly described. It was found that the CL intensity from the Luminol ClO - system could be enhanced in the presence of urapidil. The increase of CL emission was correlated with urapidil mass concentration in the range from 0.2 to 100 μg/mL, the detection limit was 0.01 μg/mL and the relative standard deviation was 1.3%( ρ =4 μg/mL, n =11), a sampling frequency of 150 h -1 was attained. The method was applied to the determination of leucoge in pharmaceutical preparations with recovery of 101.0% and 101.3% .展开更多
基金National Natural Science Foundation of China (No.39580683)
文摘AIM: To compare the effect of propofol versus urapidil on hemodynamics and intraocular pressure during anesthesia and extubation for ophthalmic patients. METHODS: Eighty-two surgical patients (Class: ASA I-II) were randomly assigned to propofol (n = 41) and urapidil groups (n = 41). Their gender, age, body mass, operation time and dosage of anesthetics had no significant difference between the two groups (P > 0.05). The patients of propofol and urapidil groups were given propofol (1.5mg/kg) and urapidil (2.5mg/kg) respectively; and two drugs were all diluted with normal saline to 8mL. Then the drugs were given to patients by slow intravenous injection. After treatment, the patients were conducted immediate suction, tracheal extubation, and then patients wore oxygen masks for 10 minutes. By double-blind methods, before the induction medication, at the suction, and 5, 10 minutes after the extubation, we recorded the systolic and diastolic blood pressure (BP), heart rate (HR), pH, PaO2, PaCO2, SaO(2) and intraocular pressure (TOP) respectively. The complete recovery time of the patients with restlessness (on the command they could open eyes and shaking hands) was also recorded during the extubation. The data were analyzed by using a professional SPSS 15.0 statistical software. RESULTS: The incidence of cough, restlessness and glossocoma was significantly lower in the propofol group than that in the urapidil group after extubation (P < 0.05). There were no episodes of hypotension, laryngospasm, or severe respiratory depression. There was no statistical difference in recovery time between two groups (P > 0.05). In propofol group, the BP and HR during extubation and thereafter had no significant difference compared with those before induction, while they were significantly lower than those before giving propofol (P < 0.05), and had significant difference compared with those in urapidil group (P < 0.05). Compared to preinduction, the BP of urapidil group showed no obvious increase during aspiration and extubation. The HR of urapidil group had little changes after being given urapidil, and it was obviously increased compared with that before induction. The stimulation of aspiration and extubation caused less cough and agitation in propofol group than that in urapidil group (P < 0.05). The IOP of propofol group showed no obvious increase during extubation compared with that in preinduction, while in the urpidil group, extubation caused IOP significantly increased (P < 0.05). The changes in these indicators between the two groups had no significant difference (P > 0.05). CONCLUSION: Compared to urapidil, propofol is superior for preventing the cardiovascular and stress responses and IOP increases during emergence and extubation for the ophthalmic patients. Moreover, it has no effects on patient's recovery.
文摘Objective：To investigate the influences of urapidil and nicardipine on rabbit sinus function, atrio-ventricular node function and hemodynamics. Methods：Thirty-two Angora＇ s rabbits were selected and randomly divided into four groups. U1 group：urapidil 0.25 mg/kg; U2 group：urapidil 0.5 mg/kg; N1 group：nicardipine 10 μg/kg; N2 group： nicardipine 20 μg/kg. All these medicine were administrated within 30 seconds. Measurements were taken before and after the administration of urapidil or nicardipine for the following data： mean blood pressure（MAP）, heart rate（HR）, sino-atrial conduction time（SACT）, maximal sinoatrial recovery time（SNRTmax） corrected sinus node recovery time（CSNRT）, index of sinus node recovery time（SNRTI）, Wenckebach A-V conduction frequency （WB）, and P-R interval. Results：Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine. No significant changes could be found in the rest of the parameters. Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group（P 〈 0.01）; the MAP decreased（P 〈 0.01） and the HR increased drastically（P〈 0.01）. Conclusions：Neither urapidil（0.25 mg/kg, 0,5 mg/kg） nor nicardipine（10 μg/kg, 20 μg/kg） has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function. Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.
文摘目的:系统评价乌拉地尔在男性良性前列腺增生(BPH)患者下尿路症状(LUTS)治疗中的潜在价值。方法:从PubMed、MEDLINE、Web of science、中国知网、万方数据库中鉴定和收集随机对照试验(RCT)或临床观察性研究。利用RevMan软件进行固定效应模型和随机效应模型的Meta分析。计算合并效应尺度以加权均数差及其95%可信区间(95%CI)表示。结果:共纳入3项短期(1个月内)观察性研究和1项RCT,共142例患者。发现乌拉地尔显著改善了患者的IPSS(MD=-5.57,95%CI:-7.98~-3.16,P<0.00001)、夜尿频率(MD=-0.7,95%CI:-1.16~-0.24,P=0.003)、残余尿率(MD=-6.97;95%CI:-12.57~-1.37,P=0.01)、平均尿流率(MD=2.04;95%CI:0.52~3.56,P=0.008)和最大尿流率(MD=4.29;95%CI:0.58~8.01,P=0.02),而残余尿量(MD=-35.93;95%CI:-78.62~6.76,P=0.10)在患者服药前后无统计学差异。结论:乌拉地尔是一种有效的缓解BPH患者LUTS的药物。但由于目前的RCT研究数量及质量有限,仍需高质量、大规模的RCT研究进一步证实这一结论。
文摘目的研究对比乌拉地尔与硝酸甘油在老年高血压合并糖尿病患者发生急性心力衰竭时的疗效。方法将82名老年高血压合并糖尿病并发急性心力衰竭患者,采用数字表法将患者分为硝酸甘油组及乌拉地尔治疗组。观察不同时段2组患者血压、心率的变化情况,反映心功能指标的N末端B型利钠肽原(N terminal B type natriuretic peptide,NT-pro BNP)、射血分数等指标变化情况,观察血糖、血脂浓度及肝、肾功能的情况。结果乌拉地尔组对收缩压的控制及NT-pro BNP的改善明显优于硝酸甘油组。乌拉地尔组在治疗第7天,射血分数较硝酸甘油组明显升高,左室舒张末期容积减小。对心率及糖脂代谢无不良影响。治疗过程中乌拉地尔无不良事件发生。结论乌拉地尔在平稳降压,通过减轻心脏后负荷,从而改善心功能。对糖耐量、血脂代谢无不良影响。药效安全、可靠,未出现耐药反应。
文摘A reverse flow injection chemiluminescence(CL) method for the determination of urapidil was firstly described. It was found that the CL intensity from the Luminol ClO - system could be enhanced in the presence of urapidil. The increase of CL emission was correlated with urapidil mass concentration in the range from 0.2 to 100 μg/mL, the detection limit was 0.01 μg/mL and the relative standard deviation was 1.3%( ρ =4 μg/mL, n =11), a sampling frequency of 150 h -1 was attained. The method was applied to the determination of leucoge in pharmaceutical preparations with recovery of 101.0% and 101.3% .
