Equal access to social infrastructures is a fundamental prerequisite for sustainable development,but has long been a great challenge worldwide.Previous studies have primarily focused on the accessibility to social inf...Equal access to social infrastructures is a fundamental prerequisite for sustainable development,but has long been a great challenge worldwide.Previous studies have primarily focused on the accessibility to social infras-tructures in urban areas across various scales,with less attention to rural areas,where inequality can be more severe.Particularly,few have investigated the disparities of accessibility to social infrastructures between urban and rural areas.Here,using the Changsha-Zhuzhou-Xiangtan urban agglomeration,China,as an example,we investigated the inequality of accessibility in both urban and rural areas,and further compared the urban-rural difference.Accessibility was measured by travel time of residents to infrastructures.We selected four types of social infrastructures including supermarkets,bus stops,primary schools,and health care,which were funda-mentally important to both urban and rural residents.We found large disparities in accessibility between urban and rural areas,ranging from 20 min to 2 h.Rural residents had to spend one to two more hours to bus stops than urban residents,and 20 min more to the other three types of infrastructures.Furthermore,accessibility to multiple infrastructures showed greater urban-rural differences.Rural residents in more than half of the towns had no access to any infrastructure within 15 min,while more than 60%of the urban residents could access to all infrastructures within 15 min.Our results revealed quantitative accessibility gap between urban and rural areas and underscored the necessity of social infrastructures planning to address such disparities.展开更多
This paper provides a method of the process of computation called the cumulative method, it is based upon repeated cumulative process. The cumulative method is being adapted to the purposes of computation, particularl...This paper provides a method of the process of computation called the cumulative method, it is based upon repeated cumulative process. The cumulative method is being adapted to the purposes of computation, particularly multiplication and division. The operations of multiplication and division are represented by algebraic formulas. An advantage of the method is that the cumulative process can be performed on decimal numbers. The present paper aims to establish a basic and useful formula valid for the two fundamental arithmetic operations of multiplication and division. The new cumulative method proved to be more flexible and made it possible to extend the multiplication and division based on repeated addition/subtraction to decimal numbers.展开更多
Landslide susceptibility assessment is an essential tool for disaster prevention and management. In areas with multiple fault zones, the impact of fault zone on slope stability cannot be disregarded. This study perfor...Landslide susceptibility assessment is an essential tool for disaster prevention and management. In areas with multiple fault zones, the impact of fault zone on slope stability cannot be disregarded. This study performed qualitative analysis of fault zones and proposed a zoning method to assess the landslide susceptibility in Chengkou County, Chongqing Municipality, China. The region within a distance of 1 km from the faults was designated as sub-zone A, while the remaining area was labeled as sub-zone B. To accomplish the assessment, a dataset comprising 388 historical landslides and 388 non-landslide points was used to train the random forest model. 10-fold cross-validation was utilized to select the training and testing datasets for the model. The results of the models were analyzed and discussed, with a focus on model performance and prediction uncertainty. By implementing the proposed division strategy based on fault zone, the accuracy, precision, recall, F-score, and AUC of both two sub-zones surpassed those of the whole region. In comparison to the results obtained for the whole region, sub-zone B exhibited an increase in AUC by 6.15%, while sub-zone A demonstrated a corresponding increase of 1.66%. Moreover, the results of 100 random realizations indicated that the division strategy has little effect on the prediction uncertainty. This study introduces a novel approach to enhance the prediction accuracy of the landslide susceptibility mapping model in areas with multiple fault zones.展开更多
BACKGROUND Cell division cyclin 25C(CDC25C)is a protein that plays a critical role in the cell cycle,specifically in the transition from the G2 phase to the M phase.Recent research has shown that CDC25C could be a pot...BACKGROUND Cell division cyclin 25C(CDC25C)is a protein that plays a critical role in the cell cycle,specifically in the transition from the G2 phase to the M phase.Recent research has shown that CDC25C could be a potential therapeutic target for cancers,particularly for hepatocellular carcinoma(HCC).However,the specific regulatory mechanisms underlying the role of CDC25C in HCC tumorigenesis and development remain incompletely understood.AIM To explore the impact of CDC25C on cell proliferation and apoptosis,as well as its regulatory mechanisms in HCC development.METHODS Hepa1-6 and B16 cells were transduced with a lentiviral vector containing shRNA interference sequences(LV-CDC25C shRNA)to knock down CDC25C.Subsequently,a xenograft mouse model was established by subcutaneously injecting transduced Hepa1-6 cells into C57BL/6 mice to assess the effects of CDC25C knockdown on HCC development in vivo.Cell proliferation and migration were evaluated using a Cell Counting Kit-8 cell proliferation assays and wound healing assays,respectively.The expression of endoplasmic reticulum(ER)stress-related molecules(glucose-regulated protein 78,X-box binding protein-1,and C/EBP homologous protein)was measured in both cells and subcutaneous xenografts using quantitative real-time PCR(qRT-PCR)and western blotting.Additionally,apoptosis was investigated using flow cytometry,qRT-PCR,and western blotting.RESULTS CDC25C was stably suppressed in Hepa1-6 and B16 cells through LV-CDC25C shRNA transduction.A xenograft model with CDC25C knockdown was successfully established and that downregulation of CDC25C expression significantly inhibited HCC growth in mice.CDC25C knockdown not only inhibited cell proliferation and migration but also significantly increased the ER stress response,ultimately promoting ER stress-induced apoptosis in HCC cells.CONCLUSION The regulatory mechanism of CDC25C in HCC development may involve the activation of ER stress and the ER stress-induced apoptosis signaling pathway.展开更多
Rice production is crucial for food security in China,and its relationship with rural labor migration has been studied extensively.Labor migration in rural China has taken new forms in recent years.There has been a di...Rice production is crucial for food security in China,and its relationship with rural labor migration has been studied extensively.Labor migration in rural China has taken new forms in recent years.There has been a discernible trend wherein adult children have started migrating to cities while their elderly parents return to villages to re-engage in on-farm work.The phenomenon has notably shaped the intergenerational division of labor(IDL)within households.However,it remains to be seen how farmers adjust their rice production systems in response to the IDL.The age of 60 years for employment injury insurance is the eligibility threshold for off-farm employment and is used to obtain a source of exogenous variation in the IDL.Based on a representative household survey of 1,752 rice farmers in the Hubei Province of Central China,our fuzzy regression discontinuity analysis reveals that farmers in IDL households are more likely to adopt ratoon rice(RR)than single cropping rice(SR)or double cropping rice(DR).The effect of the IDL varies under different levels of operational scales and specialized agricultural service availability.Further analysis suggests that farmers’arrangements are associated with two potential mechanisms of downward intergenerational transfer.Monetary transfer for urban housing purchases increases RR in IDL households,and time transfer for intergenerational childcare significantly promotes SR in IDL households.This study enhances the understanding of the relationship between rural labor migration and rice production in China,providing a reference for adjusting rice production systems to ensure food security.展开更多
The Zambezi Delta basin is a passive marginal basin located on the East African coast that has good oil and gas exploration potential.Due to the special geological evolutionary background of the Beira High in the Zamb...The Zambezi Delta basin is a passive marginal basin located on the East African coast that has good oil and gas exploration potential.Due to the special geological evolutionary background of the Beira High in the Zambezi Delta basin,it has a low gravity anomaly,and the existing seismic survey lines do not cover the whole basin;therefore,it is difficult to interpret the structural characteristics of the whole basin based solely on gravity or seismic data.Based on satellite altimetry gravity anomaly data,this study infers the distribution characteristics of faults in the Zambezi Delta basin by using the normalized vertical derivative of the total horizontal derivative(NVDR-THDR)technique.Then,constrained by seismic data,the gravity anomaly at the Moho interface is extracted by using the fast forward method of the double-interface model of the gravity anomaly,and this anomaly is then removed from the Bouguer gravity anomaly to obtain the sedimentary layer gravity anomaly.The thickness of the sedimentary strata is obtained by inversing the sedimentary basement depth of the whole basin.Then,uplifts and depressions are divided based on a sedimentary layer thickness of 3 km.This research demonstrates that the Zambezi Delta basin mainly features nearly SN-trending and NE-trending faults and that these faults exhibit east-west partitioning.The nearly SN-trending strike-slip faults controlled the sedimentary development of the basin,and the NE-trending tensile faults may have acted as migration channels for oil,gas and magma.The“overcompensation”effect of the Moho interface gravity anomaly on the gravity anomaly of the sedimentary layer is caused by the depression of the Moho interface beneath the Beira High,which results in a low gravity anomaly value for the Beira High.The pattern of uplifts and depressions trends NE and has the structural characteristics of east-west blocks.展开更多
There are significant differences between urban and rural bed-and-breakfasts(B&Bs)in terms of customer positioning,economic strength and spatial carrier.Accurately identifying the differences in spatial characteri...There are significant differences between urban and rural bed-and-breakfasts(B&Bs)in terms of customer positioning,economic strength and spatial carrier.Accurately identifying the differences in spatial characteristics and influencing factors of each type,is essential for creating urban and rural B&B agglomeration areas.This study used density-based spatial clustering of applications with noise(DBSCAN)and the multi-scale geographically weighted regression(MGWR)model to explore similarities and differences in the spatial distribution patterns and influencing factors for urban and rural B&Bs on the Jiaodong Peninsula of China from 2010 to 2022.The results showed that:1)both urban and rural B&Bs in Jiaodong Peninsula went through three stages:a slow start from 2010 to 2015,rapid development from 2015 to 2019,and hindered development from 2019 to 2022.However,urban B&Bs demonstrated a higher development speed and agglomeration intensity,leading to an increasingly evident trend of uneven development between the two sectors.2)The clustering scale of both urban and rural B&Bs continued to expand in terms of quantity and volume.Urban B&B clusters characterized by a limited number,but a higher likelihood of transitioning from low-level to high-level clusters.While the number of rural B&B clusters steadily increased over time,their clustering scale was comparatively lower than that of urban B&Bs,and they lacked the presence of high-level clustering.3)In terms of development direction,urban B&B clusters exhibited a relatively stable pattern and evolved into high-level clustering centers within the main urban areas.Conversely,rural B&Bs exhibited a more pronounced spatial diffusion effect,with clusters showing a trend of multi-center development along the coastline.4)Transport emerged as a common influencing factor for both urban and rural B&Bs,with the density of road network having the strongest explanatory power for their spatial distribution.In terms of differences,population agglomeration had a positive impact on the distribution of urban B&Bs and a negative effect on the distribution of rural B&Bs.Rural B&Bs clustering was more influenced by tourism resources compared with urban B&Bs,but increasing tourist stay duration remains an urgent issue to be addressed.The findings of this study could provide a more precise basis for government planning and management of urban and rural B&B agglomeration areas.展开更多
Administrative regions are an important environment for the operation of China's market economy.The relevant economic subjects cannot predict the policy of adjustment of administrative divisions and carry out cons...Administrative regions are an important environment for the operation of China's market economy.The relevant economic subjects cannot predict the policy of adjustment of administrative divisions and carry out conscious migration behavior,adjustment of administrative divisions can be regarded as a quasi-natural experiment.The three cities of Hefei,Wuhu,and Ma'anshan,which are directly related to the adjustment of the administrative division of Chaohu,are taken as the treatment group,and the seven adjacent cities of Lu'an,Huainan,Chuzhou,Bengbu,Anqing,Chizhou,and Tongling are taken as the control group.Differences-in-Differences method and relevant control variables affecting the upgrading of industrial structure are used to test.The test results show that"Partitions of Chaohu"has a significant industrial structure upgrading effect by promoting the optimization of spatial layout,the cross-regional flow of production factors and the effective management of Chaohu Lake Basin.At the same time,the increase of total retail sales of consumer goods,urban fixed assets investment,public utility expenses in science,education,culture and health,and population plays a significant positive role in promoting the upgrading of industrial structure,while foreign direct investment plays a certain inhibition role in the upgrading of industrial structure.In order to meet the ever-developing space demands and enhance the impact on surrounding areas,the Hefei metropolitan area should be driven by technological innovation,strengthen the integration of industrial chains,improve the business environment and transportation network,and continuously promote the upgrading of industrial structure and the formation and development of new productive forces.展开更多
In this work, we present a general theoretical study leading to analytical expression of the seasonal temperature at the near surface that is expected to evaluate any area seasonal temperature of the world using the l...In this work, we present a general theoretical study leading to analytical expression of the seasonal temperature at the near surface that is expected to evaluate any area seasonal temperature of the world using the least square method to fit the hourly data to the theoretical curve of the temperature. It is shown that the temperature is globally the result of two contributions: the contribution of the revolution movement of the terrestrial globe on its elliptical orbit around the sun, the contribution of the spin-orbit coupling for the rotation movement of the terrestrial globe around its polar axis and its revolution movement. The orbital behavior of the temperature is used to find the seasonal divisions of the climate for the local area considered. The whole expression of the temperature is very useful for the meteorological needs. The contribution of the human activities and natural instabilities are the results of discrepancies which increase errors (standard deviations).展开更多
The environmental impact issues,such as global warming and expansion of the urban zone,seem more serious and have become the biggest defining challenges of the 21st century.Climate change can lead to water shortages,d...The environmental impact issues,such as global warming and expansion of the urban zone,seem more serious and have become the biggest defining challenges of the 21st century.Climate change can lead to water shortages,desertification,land degradation,air pollution,rising sea levels,accelerated deforestation,and exacerbated economic pressures.Global urban growth greatly impacts changes in sociability,humanity,and the environment of the Earth.The human presence,especially in cities,seriously affects resource use and waste disposal,and they are consuming natural resources faster than the planet can sustain during urbanization,changing how people live.China,with a population of 1.3 billion,has seen tens of millions of people living in the countryside migrate to cities,especially megacities,since the 1980s.As a result of its decision to industrialize and urbanize to boost the economy,China has become the world’s second-largest consumer of energy.In recent years,China’s government has quickly recognized the lessons of“limits to growth”and has taken action by initiating the construction process in Dongtan,Shanghai,China.They are making efforts to build urban-rural integration communities to promote sustainable development.Based on a literature review focusing on Dongtan,research questions are raised according to the research objective:(1)What are the challenges of sustainable development in urban-rural integration?(2)What practices has Dongtan implemented for sustainable development,or how is sustainable development being applied to Dongtan?(3)What are the social,political,environmental,and economic concerns regarding the sustainable development of Dongtan?The sustainable urban-rural integration concerns the ecological,economic,environmental,and psychological aspects of urban-rural integration design and management.The overall objective is to promote sustainable development in economic,social,ecological,and spatial dimensions.It will be a liveable,complete community that makes economic,environmental,and social sense locally while also contributing to national and global sustainable development.It will serve as a compelling model for how to build sustainable urban-rural integration worldwide.展开更多
There is a considerable urban-rural divide in economic wellbeing in China. Since it was established as an urban-rural reform zone in 2007, Chengdu has seen significant reduction in the disparity in its urban and rural...There is a considerable urban-rural divide in economic wellbeing in China. Since it was established as an urban-rural reform zone in 2007, Chengdu has seen significant reduction in the disparity in its urban and rural household incomes. From 2007 to 2010, Chengdu adopted urban-rural coordination policy by defining rural land property rights and establishing a rural land market. After 2010, Chengdu adopted an urban- rural integration strategy and allowed villager and business enterprises to participate in land consolidation. The transition from urban-rural division to urban-rural integration involves reducing systematic costs. The degree of urban-rural integration depends on the extent of the reduction in systematic costs.展开更多
Color metasurface holograms are powerful and versatile platforms for modulating the amplitude,phase,polarization,and other properties of light at multiple operating wavelengths.However,the current color metasurface ho...Color metasurface holograms are powerful and versatile platforms for modulating the amplitude,phase,polarization,and other properties of light at multiple operating wavelengths.However,the current color metasurface holography can only realize static manipulation.In this study,we propose and demonstrate a multiplexing metasurface technique combined with multiwavelength code-division multiplexing(CDM)to realize dynamic manipulation.Multicolor code references are utilized to record information within a single metasurface and increase the information capacity and security for anticracks.A total of 48 monochrome images consisting of pure color characters and multilevel color video frames were reconstructed in dual polarization channels of the birefringent metasurface to exhibit high information density,and a video was displayed via sequential illumination of the corresponding code patterns to verify the ability of dynamic manipulation.Our approach demonstrates significant application potential in optical data storage,optical encryption,multiwavelengthversatile diffractive optical elements,and stimulated emission depletion microscopy.展开更多
Urban-rural integration (URI) is a global challenge that is highly related to inequalities, poverty, economic growth, and other Sustainable Development Goals (SDGs). Existing research has evaluated the extent of URI a...Urban-rural integration (URI) is a global challenge that is highly related to inequalities, poverty, economic growth, and other Sustainable Development Goals (SDGs). Existing research has evaluated the extent of URI and explored its influencing factors, but urban-rural linkages are seldom incorporated in evaluation systems, and geographical factors are rarely recognized as the influencing factors. We construct a URI framework including regional economy, rural development, urban-rural linkage, and urban-rural gap. Based on a dataset consisting of 1,669 counties in China in 2020, we reveal the spatial pattern of URI and find a high correlation between the spatial pattern of URI and the relief degree of land surface (RDLS). Using structural equation modeling, we discover that topography has direct ( − 0.18, p < 0.001) and indirect ( − 0.17, p < 0.001) effects on URI. The indirect negative effects are mediated through the infrastructure, and the combination of localized advantages and modern technical conditions could mitigate the negative impact of topography. Finally, we identify 742 counties as lagging regions in URI, which can be clustered into eight types. Our findings could facilitate policy designing for those countries striving for integrated and sustainable development of urban and rural areas.展开更多
Quantum key distribution(QKD) generates information-theoretical secure keys between two parties based on the physical laws of quantum mechanics. The phase-matching(PM) QKD protocol allows the key rate to break the qua...Quantum key distribution(QKD) generates information-theoretical secure keys between two parties based on the physical laws of quantum mechanics. The phase-matching(PM) QKD protocol allows the key rate to break the quantum channel secret key capacity limit without quantum repeaters, and the security of the protocol is demonstrated by using equivalent entanglement. In this paper, the wavelength division multiplexing(WDM) technique is applied to the PM-QKD protocol considering the effect of crosstalk noise on the secret key rate. The performance of PM-QKD protocol based on WDM with the influence of adjacent classical channels and Raman scattering is analyzed by numerical simulations to maximize the total secret key rate of the QKD, providing a reference for future implementations of QKD based on WDM techniques.展开更多
Since China’s reform and opening up in 1978,the acceleration of industrialization and urbanization in China had led to dramatic changes in the pattern of urban-rural land use.In this paper,we focused on the rural ind...Since China’s reform and opening up in 1978,the acceleration of industrialization and urbanization in China had led to dramatic changes in the pattern of urban-rural land use.In this paper,we focused on the rural industrialized areas in central China(Xinxiang County and Changyuan City of Henan Province).We used the average nearest neighbor index,spatial statistical analysis,and a structural equation model to analyze the spatiotemporal evolution and influencing factors of urban-rural construction land based on multisource spatial data and survey data.The results showed that:1)from 1975 to 2019,the spatial distribution of urban-rural construction land in rural industrialized areas had evolved from homogeneous distribution to local agglomeration.In terms of comparative analysis of cases,the spatial distribution of urban-rural construction land in Changyuan City had shown a trend from diffusion to agglomeration,and Xinxiang County had overall shown a spatial change from homogenization to agglomeration and then to regional integration development.2)The hot spots with increased urban-rural construction land significantly expanded,and they had a high degree of spatial overlap with industrial development.Among them,Xinxiang County was concentrated in central and marginal areas,and Changyuan was mainly concentrated in central urban areas.3)From the evolution of spatial proximity of urban-rural construction land,rural industrialized areas generally decline,showing the characteristics of internal differentiation in the rate of change.4)Industrial development,social economy,the policy environment,and urban development played a positive role in promoting the expansion of urban-rural construction land in rural industrialized areas.To promote the optimal use of regional land and the integrated development of urban-rural areas,we should combine the advantages of regional endowment,formulate development strategies according to local conditions,and adjust the way that land is used in a timely manner.展开更多
The development of rural areas usually has a positive impact on the urban-rural integration. This study explores an innovative approach to stimulate rural development by proposing qualified villages as central village...The development of rural areas usually has a positive impact on the urban-rural integration. This study explores an innovative approach to stimulate rural development by proposing qualified villages as central villages that can provide basic urban services for their residents and residents of neighboring villages. This approach can contribute to overcoming the various problems that rural areas faced at the social, economic, and environmental levels. It seeks to achieve spatial sustainability of rural areas, representing a new approach by integrating urban development methods to revitalize rural villages. The study analyzed 15 villages belonging to Abbasiya District of AL Kufa City in the Najaf Governorate of Iraq. Based on the GIS techniques and the analysis of urban service indicators(village population, percentage of urban building materials used in villages, distance between village and health centers, distance between village and main roads, nature of economic activity, distance between village and educational institutions, distance between village and drinking water sources, number of communication towers, and distance between village and urban administrative center), this study proposed that Abu Gharb and Albu Ghraib can served as central villages in Abbasiya District in the future. This study establishes a new rural spatial structure to achieve rural sustainable development, improves the development status of rural areas, and provides a theoretical basis for the government and relevant institutions to use urban service indicators, achieving rural sustainable development and formulating relevant development policies in Abbasiya District.展开更多
The continuous growth of recoverable reserves in a waterflooding oilfield has a significant impact on the patterns of production evolution. A new production evolution model is established by improving the Weng Cycle m...The continuous growth of recoverable reserves in a waterflooding oilfield has a significant impact on the patterns of production evolution. A new production evolution model is established by improving the Weng Cycle model. With the new model, the statistical correspondence between the production decline stage and the reserve-production imbalance is clarified,and the correlation of water cut with the recovery percent of recoverable reserves is discussed, providing quantitative basis of reservoir engineering for dividing development stages of oilfield and defining mature oilfields. According to the statistics of oilfields in eastern China, the time point corresponding to the reserve-production balance coefficient dropping to less than 1dramatically is well correlated the beginning point of production decline, thus the time when the reserve-production balance coefficient drops dramatically can be taken as the initiation point of production decline stage. The research results show that the water cut and the recovery percent of recoverable reserves have a good statistical match in the high water cut stage, and it is more rational to take both the start point of production decline stage and the water cut of 90%(or the recovery percent of recoverable reserves of 80%) as the critical criteria for defining a mature oilfield. Five production evolution patterns can be summarized as follows: growth–peak plateau–stepped decline, growth–stepped stabilizing–stepped decline, growth–stepped stabilizing–rapid decline, growth–peak plateau–rapid decline, and growth–continuous decline.展开更多
The PBFT (Practical Byzantine Fault Tolerance, PBFT) consensus algorithm, which addressed the issue of malicious nodes sending error messages to disrupt the system operation in distributed systems, was challenging to ...The PBFT (Practical Byzantine Fault Tolerance, PBFT) consensus algorithm, which addressed the issue of malicious nodes sending error messages to disrupt the system operation in distributed systems, was challenging to support massive network nodes, the common participation over all nodes in the consensus mechanism would lead to increased communication complexity, and the arbitrary selection of master nodes would also lead to inefficient consensus. This paper offered a PBFT consensus method (Role Division-based Practical Byzantine Fault Tolerance, RD-PBFT) to address the above problems based on node role division. First, the nodes in the system voted with each other to divide the high reputation group and low reputation group, and determined the starting reputation value of the nodes. Then, the mobile node in the group was divided into roles according to the high reputation value, and a total of three roles were divided into consensus node, backup node, and supervisory node to reduce the number of nodes involved in the consensus process and reduced the complexity of communication. In addition, an adaptive method was used to select the master nodes in the consensus process, and an integer value was introduced to ensure the unpredictability and equality of the master node selection. Experimentally, it was verified that the algorithm has lower communication complexity and better decentralization characteristics compared with the PBFT consensus algorithm, which improved the efficiency of consensus.展开更多
Chengdu's development strategy of“western control”has laid a solid ecological background for 8 western districts,cities and counties and cultivated good ecological resources.The integrated urban-rural developmen...Chengdu's development strategy of“western control”has laid a solid ecological background for 8 western districts,cities and counties and cultivated good ecological resources.The integrated urban-rural development in the new era will realize the balanced development of urban and rural areas and give full play to the value of rural ecological resources through the“powerful combination”of urban and rural areas.To realize the urban-rural integration and high-quality rural development in Chengdu“western control”area,it is necessary to enhance the awareness of ecological resources and ecological products,and carry out unified planning of ecological infrastructure,ecological material products and ecological service products in the whole“western control”area.Meantime,ecological restoration must be carried out scientifically,and scene design for value transformation of ecological products should be implemented innovatively.展开更多
The tango of life begins with the very first cell division.New research reveals that to dance their way through development,dividing cells must pass along not just DNA but molecular“memories”that guide their destini...The tango of life begins with the very first cell division.New research reveals that to dance their way through development,dividing cells must pass along not just DNA but molecular“memories”that guide their destinies.When this handoff gets fumbled,the dance falls apart.展开更多
基金supported by funding from the National Natural Science Foundation of China(Grant No.U21A2010)the National Science Fund for Distinguished Young Scholars(Grant No.42225104)the National Key Research and Development Program(Grant No.2022YFF130110O).
文摘Equal access to social infrastructures is a fundamental prerequisite for sustainable development,but has long been a great challenge worldwide.Previous studies have primarily focused on the accessibility to social infras-tructures in urban areas across various scales,with less attention to rural areas,where inequality can be more severe.Particularly,few have investigated the disparities of accessibility to social infrastructures between urban and rural areas.Here,using the Changsha-Zhuzhou-Xiangtan urban agglomeration,China,as an example,we investigated the inequality of accessibility in both urban and rural areas,and further compared the urban-rural difference.Accessibility was measured by travel time of residents to infrastructures.We selected four types of social infrastructures including supermarkets,bus stops,primary schools,and health care,which were funda-mentally important to both urban and rural residents.We found large disparities in accessibility between urban and rural areas,ranging from 20 min to 2 h.Rural residents had to spend one to two more hours to bus stops than urban residents,and 20 min more to the other three types of infrastructures.Furthermore,accessibility to multiple infrastructures showed greater urban-rural differences.Rural residents in more than half of the towns had no access to any infrastructure within 15 min,while more than 60%of the urban residents could access to all infrastructures within 15 min.Our results revealed quantitative accessibility gap between urban and rural areas and underscored the necessity of social infrastructures planning to address such disparities.
文摘This paper provides a method of the process of computation called the cumulative method, it is based upon repeated cumulative process. The cumulative method is being adapted to the purposes of computation, particularly multiplication and division. The operations of multiplication and division are represented by algebraic formulas. An advantage of the method is that the cumulative process can be performed on decimal numbers. The present paper aims to establish a basic and useful formula valid for the two fundamental arithmetic operations of multiplication and division. The new cumulative method proved to be more flexible and made it possible to extend the multiplication and division based on repeated addition/subtraction to decimal numbers.
基金Postdoctoral Research Foundation of China (2021M700608)Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission (cstc2021jcyj-bsh0047)+1 种基金Scientific Project Supported by the Bureau of Planning and Natural Resources, Chongqing (2301DH09002)Sichuan Transportation Science and Technology Project (2018ZL-01)。
文摘Landslide susceptibility assessment is an essential tool for disaster prevention and management. In areas with multiple fault zones, the impact of fault zone on slope stability cannot be disregarded. This study performed qualitative analysis of fault zones and proposed a zoning method to assess the landslide susceptibility in Chengkou County, Chongqing Municipality, China. The region within a distance of 1 km from the faults was designated as sub-zone A, while the remaining area was labeled as sub-zone B. To accomplish the assessment, a dataset comprising 388 historical landslides and 388 non-landslide points was used to train the random forest model. 10-fold cross-validation was utilized to select the training and testing datasets for the model. The results of the models were analyzed and discussed, with a focus on model performance and prediction uncertainty. By implementing the proposed division strategy based on fault zone, the accuracy, precision, recall, F-score, and AUC of both two sub-zones surpassed those of the whole region. In comparison to the results obtained for the whole region, sub-zone B exhibited an increase in AUC by 6.15%, while sub-zone A demonstrated a corresponding increase of 1.66%. Moreover, the results of 100 random realizations indicated that the division strategy has little effect on the prediction uncertainty. This study introduces a novel approach to enhance the prediction accuracy of the landslide susceptibility mapping model in areas with multiple fault zones.
基金Supported by Natural Science Foundation of Guangxi Zhuang Autonomous Region,China,No.2023GXNSFAA026070 and No.2018GXNSFAA281071.
文摘BACKGROUND Cell division cyclin 25C(CDC25C)is a protein that plays a critical role in the cell cycle,specifically in the transition from the G2 phase to the M phase.Recent research has shown that CDC25C could be a potential therapeutic target for cancers,particularly for hepatocellular carcinoma(HCC).However,the specific regulatory mechanisms underlying the role of CDC25C in HCC tumorigenesis and development remain incompletely understood.AIM To explore the impact of CDC25C on cell proliferation and apoptosis,as well as its regulatory mechanisms in HCC development.METHODS Hepa1-6 and B16 cells were transduced with a lentiviral vector containing shRNA interference sequences(LV-CDC25C shRNA)to knock down CDC25C.Subsequently,a xenograft mouse model was established by subcutaneously injecting transduced Hepa1-6 cells into C57BL/6 mice to assess the effects of CDC25C knockdown on HCC development in vivo.Cell proliferation and migration were evaluated using a Cell Counting Kit-8 cell proliferation assays and wound healing assays,respectively.The expression of endoplasmic reticulum(ER)stress-related molecules(glucose-regulated protein 78,X-box binding protein-1,and C/EBP homologous protein)was measured in both cells and subcutaneous xenografts using quantitative real-time PCR(qRT-PCR)and western blotting.Additionally,apoptosis was investigated using flow cytometry,qRT-PCR,and western blotting.RESULTS CDC25C was stably suppressed in Hepa1-6 and B16 cells through LV-CDC25C shRNA transduction.A xenograft model with CDC25C knockdown was successfully established and that downregulation of CDC25C expression significantly inhibited HCC growth in mice.CDC25C knockdown not only inhibited cell proliferation and migration but also significantly increased the ER stress response,ultimately promoting ER stress-induced apoptosis in HCC cells.CONCLUSION The regulatory mechanism of CDC25C in HCC development may involve the activation of ER stress and the ER stress-induced apoptosis signaling pathway.
基金supported by the National Natural Science Foundation of China(42207529)the China Postdoctoral Science Foundation(2022M721289).
文摘Rice production is crucial for food security in China,and its relationship with rural labor migration has been studied extensively.Labor migration in rural China has taken new forms in recent years.There has been a discernible trend wherein adult children have started migrating to cities while their elderly parents return to villages to re-engage in on-farm work.The phenomenon has notably shaped the intergenerational division of labor(IDL)within households.However,it remains to be seen how farmers adjust their rice production systems in response to the IDL.The age of 60 years for employment injury insurance is the eligibility threshold for off-farm employment and is used to obtain a source of exogenous variation in the IDL.Based on a representative household survey of 1,752 rice farmers in the Hubei Province of Central China,our fuzzy regression discontinuity analysis reveals that farmers in IDL households are more likely to adopt ratoon rice(RR)than single cropping rice(SR)or double cropping rice(DR).The effect of the IDL varies under different levels of operational scales and specialized agricultural service availability.Further analysis suggests that farmers’arrangements are associated with two potential mechanisms of downward intergenerational transfer.Monetary transfer for urban housing purchases increases RR in IDL households,and time transfer for intergenerational childcare significantly promotes SR in IDL households.This study enhances the understanding of the relationship between rural labor migration and rice production in China,providing a reference for adjusting rice production systems to ensure food security.
基金The Petrochina Basic Prospective Science and Technology Research Project–Overseas deepwater ultra-deepwater oil and gas exploration technology research topic,under contract No.2021DJ2403。
文摘The Zambezi Delta basin is a passive marginal basin located on the East African coast that has good oil and gas exploration potential.Due to the special geological evolutionary background of the Beira High in the Zambezi Delta basin,it has a low gravity anomaly,and the existing seismic survey lines do not cover the whole basin;therefore,it is difficult to interpret the structural characteristics of the whole basin based solely on gravity or seismic data.Based on satellite altimetry gravity anomaly data,this study infers the distribution characteristics of faults in the Zambezi Delta basin by using the normalized vertical derivative of the total horizontal derivative(NVDR-THDR)technique.Then,constrained by seismic data,the gravity anomaly at the Moho interface is extracted by using the fast forward method of the double-interface model of the gravity anomaly,and this anomaly is then removed from the Bouguer gravity anomaly to obtain the sedimentary layer gravity anomaly.The thickness of the sedimentary strata is obtained by inversing the sedimentary basement depth of the whole basin.Then,uplifts and depressions are divided based on a sedimentary layer thickness of 3 km.This research demonstrates that the Zambezi Delta basin mainly features nearly SN-trending and NE-trending faults and that these faults exhibit east-west partitioning.The nearly SN-trending strike-slip faults controlled the sedimentary development of the basin,and the NE-trending tensile faults may have acted as migration channels for oil,gas and magma.The“overcompensation”effect of the Moho interface gravity anomaly on the gravity anomaly of the sedimentary layer is caused by the depression of the Moho interface beneath the Beira High,which results in a low gravity anomaly value for the Beira High.The pattern of uplifts and depressions trends NE and has the structural characteristics of east-west blocks.
基金Under the auspices of National Social Science Foundation of China (No.21BJY202)。
文摘There are significant differences between urban and rural bed-and-breakfasts(B&Bs)in terms of customer positioning,economic strength and spatial carrier.Accurately identifying the differences in spatial characteristics and influencing factors of each type,is essential for creating urban and rural B&B agglomeration areas.This study used density-based spatial clustering of applications with noise(DBSCAN)and the multi-scale geographically weighted regression(MGWR)model to explore similarities and differences in the spatial distribution patterns and influencing factors for urban and rural B&Bs on the Jiaodong Peninsula of China from 2010 to 2022.The results showed that:1)both urban and rural B&Bs in Jiaodong Peninsula went through three stages:a slow start from 2010 to 2015,rapid development from 2015 to 2019,and hindered development from 2019 to 2022.However,urban B&Bs demonstrated a higher development speed and agglomeration intensity,leading to an increasingly evident trend of uneven development between the two sectors.2)The clustering scale of both urban and rural B&Bs continued to expand in terms of quantity and volume.Urban B&B clusters characterized by a limited number,but a higher likelihood of transitioning from low-level to high-level clusters.While the number of rural B&B clusters steadily increased over time,their clustering scale was comparatively lower than that of urban B&Bs,and they lacked the presence of high-level clustering.3)In terms of development direction,urban B&B clusters exhibited a relatively stable pattern and evolved into high-level clustering centers within the main urban areas.Conversely,rural B&Bs exhibited a more pronounced spatial diffusion effect,with clusters showing a trend of multi-center development along the coastline.4)Transport emerged as a common influencing factor for both urban and rural B&Bs,with the density of road network having the strongest explanatory power for their spatial distribution.In terms of differences,population agglomeration had a positive impact on the distribution of urban B&Bs and a negative effect on the distribution of rural B&Bs.Rural B&Bs clustering was more influenced by tourism resources compared with urban B&Bs,but increasing tourist stay duration remains an urgent issue to be addressed.The findings of this study could provide a more precise basis for government planning and management of urban and rural B&B agglomeration areas.
文摘Administrative regions are an important environment for the operation of China's market economy.The relevant economic subjects cannot predict the policy of adjustment of administrative divisions and carry out conscious migration behavior,adjustment of administrative divisions can be regarded as a quasi-natural experiment.The three cities of Hefei,Wuhu,and Ma'anshan,which are directly related to the adjustment of the administrative division of Chaohu,are taken as the treatment group,and the seven adjacent cities of Lu'an,Huainan,Chuzhou,Bengbu,Anqing,Chizhou,and Tongling are taken as the control group.Differences-in-Differences method and relevant control variables affecting the upgrading of industrial structure are used to test.The test results show that"Partitions of Chaohu"has a significant industrial structure upgrading effect by promoting the optimization of spatial layout,the cross-regional flow of production factors and the effective management of Chaohu Lake Basin.At the same time,the increase of total retail sales of consumer goods,urban fixed assets investment,public utility expenses in science,education,culture and health,and population plays a significant positive role in promoting the upgrading of industrial structure,while foreign direct investment plays a certain inhibition role in the upgrading of industrial structure.In order to meet the ever-developing space demands and enhance the impact on surrounding areas,the Hefei metropolitan area should be driven by technological innovation,strengthen the integration of industrial chains,improve the business environment and transportation network,and continuously promote the upgrading of industrial structure and the formation and development of new productive forces.
文摘In this work, we present a general theoretical study leading to analytical expression of the seasonal temperature at the near surface that is expected to evaluate any area seasonal temperature of the world using the least square method to fit the hourly data to the theoretical curve of the temperature. It is shown that the temperature is globally the result of two contributions: the contribution of the revolution movement of the terrestrial globe on its elliptical orbit around the sun, the contribution of the spin-orbit coupling for the rotation movement of the terrestrial globe around its polar axis and its revolution movement. The orbital behavior of the temperature is used to find the seasonal divisions of the climate for the local area considered. The whole expression of the temperature is very useful for the meteorological needs. The contribution of the human activities and natural instabilities are the results of discrepancies which increase errors (standard deviations).
文摘The environmental impact issues,such as global warming and expansion of the urban zone,seem more serious and have become the biggest defining challenges of the 21st century.Climate change can lead to water shortages,desertification,land degradation,air pollution,rising sea levels,accelerated deforestation,and exacerbated economic pressures.Global urban growth greatly impacts changes in sociability,humanity,and the environment of the Earth.The human presence,especially in cities,seriously affects resource use and waste disposal,and they are consuming natural resources faster than the planet can sustain during urbanization,changing how people live.China,with a population of 1.3 billion,has seen tens of millions of people living in the countryside migrate to cities,especially megacities,since the 1980s.As a result of its decision to industrialize and urbanize to boost the economy,China has become the world’s second-largest consumer of energy.In recent years,China’s government has quickly recognized the lessons of“limits to growth”and has taken action by initiating the construction process in Dongtan,Shanghai,China.They are making efforts to build urban-rural integration communities to promote sustainable development.Based on a literature review focusing on Dongtan,research questions are raised according to the research objective:(1)What are the challenges of sustainable development in urban-rural integration?(2)What practices has Dongtan implemented for sustainable development,or how is sustainable development being applied to Dongtan?(3)What are the social,political,environmental,and economic concerns regarding the sustainable development of Dongtan?The sustainable urban-rural integration concerns the ecological,economic,environmental,and psychological aspects of urban-rural integration design and management.The overall objective is to promote sustainable development in economic,social,ecological,and spatial dimensions.It will be a liveable,complete community that makes economic,environmental,and social sense locally while also contributing to national and global sustainable development.It will serve as a compelling model for how to build sustainable urban-rural integration worldwide.
文摘There is a considerable urban-rural divide in economic wellbeing in China. Since it was established as an urban-rural reform zone in 2007, Chengdu has seen significant reduction in the disparity in its urban and rural household incomes. From 2007 to 2010, Chengdu adopted urban-rural coordination policy by defining rural land property rights and establishing a rural land market. After 2010, Chengdu adopted an urban- rural integration strategy and allowed villager and business enterprises to participate in land consolidation. The transition from urban-rural division to urban-rural integration involves reducing systematic costs. The degree of urban-rural integration depends on the extent of the reduction in systematic costs.
基金the National Key R&D Program of China(2021YFA1401200)Beijing Outstanding Young Scientist Program(BJJWZYJH01201910007022)+2 种基金National Natural Science Foundation of China(No.U21A20140,No.92050117)Beijing Municipal Science&Technology Commission,Administrative Commission of Zhongguancun Science Park(No.Z211100004821009)X.Li acknowledges the support from Beijing Institute of Technology Research Fund Program for Young Scholars(XSQD-201904005).
文摘Color metasurface holograms are powerful and versatile platforms for modulating the amplitude,phase,polarization,and other properties of light at multiple operating wavelengths.However,the current color metasurface holography can only realize static manipulation.In this study,we propose and demonstrate a multiplexing metasurface technique combined with multiwavelength code-division multiplexing(CDM)to realize dynamic manipulation.Multicolor code references are utilized to record information within a single metasurface and increase the information capacity and security for anticracks.A total of 48 monochrome images consisting of pure color characters and multilevel color video frames were reconstructed in dual polarization channels of the birefringent metasurface to exhibit high information density,and a video was displayed via sequential illumination of the corresponding code patterns to verify the ability of dynamic manipulation.Our approach demonstrates significant application potential in optical data storage,optical encryption,multiwavelengthversatile diffractive optical elements,and stimulated emission depletion microscopy.
基金the National Natural Science Foundation of China(Grants No.T2261129477 and 41971220)the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA23070300).
文摘Urban-rural integration (URI) is a global challenge that is highly related to inequalities, poverty, economic growth, and other Sustainable Development Goals (SDGs). Existing research has evaluated the extent of URI and explored its influencing factors, but urban-rural linkages are seldom incorporated in evaluation systems, and geographical factors are rarely recognized as the influencing factors. We construct a URI framework including regional economy, rural development, urban-rural linkage, and urban-rural gap. Based on a dataset consisting of 1,669 counties in China in 2020, we reveal the spatial pattern of URI and find a high correlation between the spatial pattern of URI and the relief degree of land surface (RDLS). Using structural equation modeling, we discover that topography has direct ( − 0.18, p < 0.001) and indirect ( − 0.17, p < 0.001) effects on URI. The indirect negative effects are mediated through the infrastructure, and the combination of localized advantages and modern technical conditions could mitigate the negative impact of topography. Finally, we identify 742 counties as lagging regions in URI, which can be clustered into eight types. Our findings could facilitate policy designing for those countries striving for integrated and sustainable development of urban and rural areas.
基金supported by the State Key Laboratory of Information Photonics and Optical Communications (Beijing University of Posts and Telecommunications) (Grant No. IPOC2021ZT10)the National Natural Science Foundation of China (Grant No. 11904333)+1 种基金the Fundamental Research Funds for the Central Universities (Grant No. 2019XDA02)BUPT Innovation and Entrepreneurship Support Program (Grant No. 2022-YC-T051)。
文摘Quantum key distribution(QKD) generates information-theoretical secure keys between two parties based on the physical laws of quantum mechanics. The phase-matching(PM) QKD protocol allows the key rate to break the quantum channel secret key capacity limit without quantum repeaters, and the security of the protocol is demonstrated by using equivalent entanglement. In this paper, the wavelength division multiplexing(WDM) technique is applied to the PM-QKD protocol considering the effect of crosstalk noise on the secret key rate. The performance of PM-QKD protocol based on WDM with the influence of adjacent classical channels and Raman scattering is analyzed by numerical simulations to maximize the total secret key rate of the QKD, providing a reference for future implementations of QKD based on WDM techniques.
基金Under the auspices of National Natural Science Foundation of China(No.42271225)Research Program Fund for Humanities and Social Sciences of the Ministry of Education of China(No.22YJA790050)+2 种基金Henan Provincial Planning Fund for Philosophy and Social Sciences(No.2022BJJ011)Postgraduate Cultivating Innovation Action Plan of Henan University(No.SYLYC2022014)Henan University of Economics and Law Huang Tingfang/Xinhe Young Scholars Program(No.13)。
文摘Since China’s reform and opening up in 1978,the acceleration of industrialization and urbanization in China had led to dramatic changes in the pattern of urban-rural land use.In this paper,we focused on the rural industrialized areas in central China(Xinxiang County and Changyuan City of Henan Province).We used the average nearest neighbor index,spatial statistical analysis,and a structural equation model to analyze the spatiotemporal evolution and influencing factors of urban-rural construction land based on multisource spatial data and survey data.The results showed that:1)from 1975 to 2019,the spatial distribution of urban-rural construction land in rural industrialized areas had evolved from homogeneous distribution to local agglomeration.In terms of comparative analysis of cases,the spatial distribution of urban-rural construction land in Changyuan City had shown a trend from diffusion to agglomeration,and Xinxiang County had overall shown a spatial change from homogenization to agglomeration and then to regional integration development.2)The hot spots with increased urban-rural construction land significantly expanded,and they had a high degree of spatial overlap with industrial development.Among them,Xinxiang County was concentrated in central and marginal areas,and Changyuan was mainly concentrated in central urban areas.3)From the evolution of spatial proximity of urban-rural construction land,rural industrialized areas generally decline,showing the characteristics of internal differentiation in the rate of change.4)Industrial development,social economy,the policy environment,and urban development played a positive role in promoting the expansion of urban-rural construction land in rural industrialized areas.To promote the optimal use of regional land and the integrated development of urban-rural areas,we should combine the advantages of regional endowment,formulate development strategies according to local conditions,and adjust the way that land is used in a timely manner.
文摘The development of rural areas usually has a positive impact on the urban-rural integration. This study explores an innovative approach to stimulate rural development by proposing qualified villages as central villages that can provide basic urban services for their residents and residents of neighboring villages. This approach can contribute to overcoming the various problems that rural areas faced at the social, economic, and environmental levels. It seeks to achieve spatial sustainability of rural areas, representing a new approach by integrating urban development methods to revitalize rural villages. The study analyzed 15 villages belonging to Abbasiya District of AL Kufa City in the Najaf Governorate of Iraq. Based on the GIS techniques and the analysis of urban service indicators(village population, percentage of urban building materials used in villages, distance between village and health centers, distance between village and main roads, nature of economic activity, distance between village and educational institutions, distance between village and drinking water sources, number of communication towers, and distance between village and urban administrative center), this study proposed that Abu Gharb and Albu Ghraib can served as central villages in Abbasiya District in the future. This study establishes a new rural spatial structure to achieve rural sustainable development, improves the development status of rural areas, and provides a theoretical basis for the government and relevant institutions to use urban service indicators, achieving rural sustainable development and formulating relevant development policies in Abbasiya District.
基金Supported by the National Natural Science Foundation of China (72088101)。
文摘The continuous growth of recoverable reserves in a waterflooding oilfield has a significant impact on the patterns of production evolution. A new production evolution model is established by improving the Weng Cycle model. With the new model, the statistical correspondence between the production decline stage and the reserve-production imbalance is clarified,and the correlation of water cut with the recovery percent of recoverable reserves is discussed, providing quantitative basis of reservoir engineering for dividing development stages of oilfield and defining mature oilfields. According to the statistics of oilfields in eastern China, the time point corresponding to the reserve-production balance coefficient dropping to less than 1dramatically is well correlated the beginning point of production decline, thus the time when the reserve-production balance coefficient drops dramatically can be taken as the initiation point of production decline stage. The research results show that the water cut and the recovery percent of recoverable reserves have a good statistical match in the high water cut stage, and it is more rational to take both the start point of production decline stage and the water cut of 90%(or the recovery percent of recoverable reserves of 80%) as the critical criteria for defining a mature oilfield. Five production evolution patterns can be summarized as follows: growth–peak plateau–stepped decline, growth–stepped stabilizing–stepped decline, growth–stepped stabilizing–rapid decline, growth–peak plateau–rapid decline, and growth–continuous decline.
文摘The PBFT (Practical Byzantine Fault Tolerance, PBFT) consensus algorithm, which addressed the issue of malicious nodes sending error messages to disrupt the system operation in distributed systems, was challenging to support massive network nodes, the common participation over all nodes in the consensus mechanism would lead to increased communication complexity, and the arbitrary selection of master nodes would also lead to inefficient consensus. This paper offered a PBFT consensus method (Role Division-based Practical Byzantine Fault Tolerance, RD-PBFT) to address the above problems based on node role division. First, the nodes in the system voted with each other to divide the high reputation group and low reputation group, and determined the starting reputation value of the nodes. Then, the mobile node in the group was divided into roles according to the high reputation value, and a total of three roles were divided into consensus node, backup node, and supervisory node to reduce the number of nodes involved in the consensus process and reduced the complexity of communication. In addition, an adaptive method was used to select the master nodes in the consensus process, and an integer value was introduced to ensure the unpredictability and equality of the master node selection. Experimentally, it was verified that the algorithm has lower communication complexity and better decentralization characteristics compared with the PBFT consensus algorithm, which improved the efficiency of consensus.
基金Sponsored by Sichuan Landscape and Recreation Research Center Project(JGYQ2019008)。
文摘Chengdu's development strategy of“western control”has laid a solid ecological background for 8 western districts,cities and counties and cultivated good ecological resources.The integrated urban-rural development in the new era will realize the balanced development of urban and rural areas and give full play to the value of rural ecological resources through the“powerful combination”of urban and rural areas.To realize the urban-rural integration and high-quality rural development in Chengdu“western control”area,it is necessary to enhance the awareness of ecological resources and ecological products,and carry out unified planning of ecological infrastructure,ecological material products and ecological service products in the whole“western control”area.Meantime,ecological restoration must be carried out scientifically,and scene design for value transformation of ecological products should be implemented innovatively.
文摘The tango of life begins with the very first cell division.New research reveals that to dance their way through development,dividing cells must pass along not just DNA but molecular“memories”that guide their destinies.When this handoff gets fumbled,the dance falls apart.