Humic Acid Effects on Reducing Corn Leaf Burn Caused by Foliar Spray of Urea-Ammonium Nitrate at Different Humic Acid/Urea-Ammonium Nitrate Ratios

Technologies for reducing corn leaf burn caused by foliar spray of urea-ammonium nitrate (UAN) during the early growing season are limited. A field experiment was carried out to evaluate the effects of humic acid on corn leaf burn caused by foliar spray of undiluted UAN solution on corn canopy at Jackson, TN in 2018. Thirteen treatments of the mixtures of UAN and humic acid were evaluated at V6 of corn with different UAN application rates and different UAN/humic acid ratios. Leaf burn during 1 2, 3, 4, 5, 6, 7, and 14 days after UAN foliar spray significantly differed between with or without humic acid addition. The addition of humic acid to UAN significantly reduced leaf burn at each UAN application rate (15, 25, and 35 gal/acre). The reduction of leaf burn was enhanced as the humic acid/UAN ratio went up from 10% to 30%. Leaf burn due to foliar application of UAN became severer with higher UAN rates. The linear regression of leaf burn 14 days after application with humic acid/UAN ratio was highly significant and negative. However, the linear regression of leaf burn 14 days after application with the UAN application rate was highly significant and positive. In conclusion, adding humic acid to foliar-applied UAN is beneficial for reducing corn leaf burn during the early growing season.

Cys C、C1q、β_(2)-MG、Urea、UA检测对初诊多发性骨髓瘤患者合并肾损伤的诊断价值

目的探讨肾功能指标胱抑素C(cystatin C,Cys C)、补体C1q(complement C1q)、β_(2)-微球蛋白(β_(2)-microglobulin,β_(2)-MG)、尿素(Urea)、尿酸(uric acid,UA)对初诊多发性骨髓瘤(multiplemyeloma,MM)患者合并肾损伤(renal impairment,RI)的诊断价值。方法回顾性分析2021年8月~2022年12月首都医科大学附属北京积水潭医院血液科收治的93例初诊MM患者的病例资料,按照血肌酐水平将MM患者分为RI组[血肌酐>176.80mmol/L(2mg/dl),n=19]及非RI组[血肌酐≤176.80mmol/L(2mg/dl),n=74],对RI组和非RI组的临床资料及实验室指标进行分析。采用单因素和多因素Logistic回归分析评价MM患者发生RI的危险因素,应用受试者工作特征(receiver operating characteristic,ROC)曲线评估危险因素对MM患者发生RI的预测价值。结果93例初诊MM患者发生RI者占25.68%,RI组轻链型占比最高(36.84%,7/19),IgG-λ型和IgA-κ型比例最低(10.53%,2/19);非RI组IgA-κ型比例最高(29.73%,22/74),IgG-λ型比例最低(12.16%,9/74)。DS分期中,RI组19例全部为Ⅲ期,非RI组72例全部为Ⅲ期。ISS分期中,RI组Ⅲ期最多(68.42%,13/19),非RI组中Ⅰ期最多(41.89%,31/74)。RISS分期中,RI组Ⅱ期和Ⅲ期最多(36.84%,7/19),非RI组Ⅱ期最多(58.11%,43/74)。DS分期和ISS分期组间差异有统计学意义(P<0.05)。RI组中Cys C、β_(2)-MG、Urea、UA水平均高于非RI组,差异均有统计学意义(P<0.05)。单因素分析结果显示,Cys C、Urea、β_(2)-MG水平异常升高是MM患者发生RI的危险因素(P<0.05),C1q对MM患者发生RI没有影响(P>0.05);多因素Logistic回归分析结果显示,Cys C、Urea、β_(2)-MG水平异常升高均是MM患者发生RI的独立影响因素(P<0.05)。Cys C、Urea、β_(2)-MG预测MM患者发生RI的敏感度分别为88.9%、50.0%、94.4%,特异性分别为90.4%、100.0%、84.9%;Cys C、Urea、β_(2)-MG联合检测预测MM患者发生RI的敏感度为100.0%,特异性为87.7%。结论Cys C、Urea、β_(2)-MG均能较好地预测初诊MM患者发生RI的可能性,3项指标联合检测对MM患者发生RI具有更高的预测价值。

Concentration of α-Linoleic Acid of Perilla Oil by Gradient Cooling Urea Inclusion

In this study, production of ct-linoleic acid concentrated from crude perilla oil by gradient cooling urea inclusion was optimized. The fatty acid composition was determined after ethyl esterification by gas chromatography （GC）. In this process, orthogonal experiment was carried out. Under optimum conditions, the maximum amount of α-linoleic acid （91.5%） was obtained at a urea to fatty acid ratio of 3, a solvent to fatty acids ratio of 7, a reaction temperature of 348 K and a crystallization time of 690 min. A simple method of gradient cooling urea inclusion was used to purify α-linolenic acid by using urea to form inclusion complexes with the saturated and the less unsaturated fatty acids, which enhanced the purity of α-linoleic acid ethyl ester by above 90%.

Effects of urea enhanced with different weathered coal-derived humic acid components on maize yield and fate of fertilizer nitrogen

Humic acid(HA) is a readily available and low-cost material that is used to enhance crop production and reduce nitrogen(N) loss. However, there is little consensus on the efficacy of different HA components. In the current study, a soil column experiment was conducted using the ^(15)N tracer technique in Dezhou City, Shandong Province, China, to compare the effects of urea with and without the addition of weathered coal-derived HA components on maize yield and the fate of fertilizerderived N(fertilizer N). The HA components were incorporated into urea by blending different HA components into molten urea to obtain the three different types of HA-enhanced urea(HAU). At harvest, the aboveground dry biomass of plants grown with HAU was enhanced by 11.50–21.33% when compared to that of plants grown with U. More significantly, the grain yields under the HAU treatments were 5.58–18.67% higher than the yield under the urea treatment. These higher yields were due to an increase in the number of kernels per plant rather than the weight of individual kernels. The uptake of fertilizer N under the HAU treatments was also higher than that under the urea treatment by 11.49–29.46%, while the unaccounted N loss decreased by 12.37–30.05%. More fertilizer-derived N was retained in the 0–30 cm soil layer under the HAU treatments than that under the urea treatment, while less N was retained in the 30–90 cm soil layer. The total residual amount of fertilizer N in the soil column, however, did not differ significantly between the treatments. Of the three HAU treatments investigated, the one with an HA fraction derived from extraction with pH values ranging from 6 to 7, resulted in the best improvement in all assessment targets. This is likely due to the abundance of the COO/C–N=O group in this HA component.

Optical nonlinearity in measurement of urea and uric acid in blood

The Z-scan technique is a simple and effective tool for determining nonlinear optical properties of materials. This technique is utilized in meas-urement of urea and uric acid in blood. The nonlinear refractive index of urea and uric acid are found to vary linearly with concentration. Hence by calculating the nonlinear refractive index it is possible to measure their concentra-tion in the sample. The results of this method are found to be in good agreement with the conventional colorimetric method.

Effect of Combined Application of Humic Acid and Urea on the Wheat Growth and Yield

This paper aims to research the effects of combined application of humic acid and urea on the wheat yield and yield component,and establish rational fertilizer application scheme of wheat. Split plot experiment was adopted. Two types of phosphorus fertilizer( adding humic acid or not) was assigned to the main plot,and four types of top dressing modes( different amount of urea and humic acid urea) were used in subplots. Effects of combined application of humic acid and urea on the wheat yield and yield component were researched. 375 kg / ha ordinary DAP + 150 kg / ha urea was used as base fertilizer; topdressing of 300 kg / ha urea humate could effectively promote the plant height,leaf area coefficient and aboveground dry matter amount. Adding humic acid in urea in topdressing significantly enhanced the wheat yield and economic coefficient of wheat. Adding humic acid in urea in topdressing has better effects of yield increasing than base fertilizer,and can be used for large scale extension.

Density Functional Theory Study of Infrared and Ultraviolet Spectra of Urea L-Malic Acid

Urea L-malic acid, a new second order nonlinear optical crystal, was studied using density functional theory （DFT）. PBEPBE/6-31＋G（d,p） method, the optimal method for comparing the results from the several DFT methods, was chosen to study the molecular structure. Infrared and ultraviolet-visible spectra were obtained and compared with experiments. The ultraviolet-visible spectrum was also analyzed by the molecular orbital population. The geometries, and the infrared and ultraviolet-visible spectra in water were studied using DFT methods in combination with the polarized continuum model to predict the perturbations by the solvent effect.

Synthesis and Antibacterial Activity of Urea and Thiourea Derivatives of Anacardic Acid Mixture Isolated from A Natural Product Cashew Nut Shell Liquid (CNSL)

Synthesis and antibacterial activity of some novel urea and thiourea derivatives (8a - 8k, 9a - 9f) of anacardic acid prepared from commercially available anacardic acid which is obtained from natural product Cashew Nut Shell Liquid (CNSL). Compounds (8a - 8k, 9a - 9f) were tested for Gram positive and Gram negative bacterial cultures. Most of the compounds were showed active compared with standard drug ampicilline.

The Synthesis and Anion Binding of Novel Cholic Acid-based Molecular Clefts Containing Unsymmetrically Disubstituted Urea Unit

A novel type of chiral molecular clefts consisting of a rigid deoxycholic acid methyl ester backbone and chiral unsymmetrically disubstituted urea side chain have been designed and synthesized. All these new receptors 3a^c and the corresponding key intermediates 1a^c and 2a^c are new compounds, their structures were confirmed by 1HNMR, IR, MS spectra and elemental analysis. These molecular clefts showed binding ability for halide anions.

Synthesis and Antibacterial Activity of Urea and hiourea Derivatives at C-8 Alkyl Chain of Anacardic Acid Mixture Isolated from a Natural Product Cashew Nut Shell Liquid (CNSL)

Synthesis and antibacterial activity of some novel urea and thiourea derivatives (7a-7k, 8a-8f) of anacardic acid prepared from commercially available anacardic acid which is obtained from natural product Cashew Nut Shell Liquid (CNSL). Compounds (7a-7k, 8a-8f) were tested for Gram positive and Gram negative bac- terial cultures. Most of the compounds were showed active compared with standard drug ampicilline.

HA/AA-UREA缓释保水剂的制备

以腐殖酸（HA）、中和度75%的丙烯酸（AA）、尿素（UREA）为原料,过硫酸钾为引发剂,N,N＇-亚甲基双丙烯酰胺为交联剂,采用水溶液聚合法制备具有互穿网络结构的功能性缓释保水材料。并采用FTIR、SEM、DSC和压力势法等对产物的结构和性能进行表征和测试,探讨了单体配比、尿素用量、反应温度、引发剂用量及交联剂用量对产品吸水性能及缓释性能的影响。结果表明：在聚合温度为80℃、引发剂用量为1%（即其质量占单体AA质量的百分数,下同）、交联剂用量为0.2%、HA用量为14.3%、UREA用量为50%的条件下,制得的高吸水性树脂吸自来水能力最高可达310 g/g,且具有良好的保水性能,可利用水分占总吸水量的93.81%,氮元素28 d累积释放率71.50%。

不同土壤及水分对稳定型尿素硝酸铵溶液调控氮素的影响及其肥效研究

为验证稳定型尿素硝酸铵溶液(YUAN,脲酶、硝化抑制剂用量均占UAN的0.06%)在夏玉米栽培中的应用效果,采用室内培养与田间试验,探究不同土壤[褐土(S1)和红壤(S2)]、不同土壤田间持水量[40%(W1)、60%(W2)和80%(W3)]以及夏玉米种植条件下[不施氮(CK)、追施普通尿素(CN)、优化CN(CNU)、追施普通尿素硝酸铵溶液(UAN)、追施稳定型尿素硝酸铵溶液(UANa和UANb)],稳定型尿素硝酸铵溶液(YUAN)对其所含氮素的调控效果及肥效。结果表明,YUAN处理下,土壤铵态氮含量平均上升和下降速率均慢于UAN处理,铵态氮含量在下降期内显著高于UAN处理。铵态氮含量在S1中的平均上升速率(41.63 mg·kg^(-1)·d^(-1))和下降速率(25.50 mg·kg^(-1)·d^(-1))均大于在S2中的平均上升速率(35.79 mg·kg^(-1)·d^(-1))和下降速率(16.74 mg·kg^(-1)·d^(-1)),0~56 d内二者铵态氮含量整体达到显著差异,说明YUAN的氮素在S2中转化的慢,其对氮素的调控效果更佳。在W1、W2和W3土壤田间持水量条件下,0~91 d内YUAN处理铵态氮含量整体显著高于UAN处理,土壤硝态氮含量峰值出现的时间分别为7、91和21 d(分别为933.70、1128.80和1507.10 mg·kg^(-1)),说明W2田间持水量条件下YUAN调控氮素的效果较优。与CN相比,UANa处理玉米产量提升690 kg·hm^(-2),增产率为8.73%,氨挥发减少67.10%。与UAN相比,UANa处理玉米产量提升779 kg·hm^(-2),增产率为9.97%,氨挥发减少60.64%。在0~20 cm土层内,硝态氮含量以CN和UANa处理较高,二者之间差异不显著,但显著高于其他处理,其他处理之间差异不显著;在180~200 cm土层内,施肥处理中以UANa处理硝态氮含量最低,分别较CN、CNU、UAN和UANb处理降低46.60%、26.08%、40.59%和27.07%,其中UANa处理显著低于CN和UAN处理。本研究结果为稳定型尿素硝酸铵溶液氮肥的推广应用奠定了理论基础与技术支撑。

The relationship between serum levels of uric acid and prognosis of infection in critically ill patients

Serum uric acid level is associated with some chronic diseases and prognosis of severe infection. This study aimed to investigate the relationship between serum uric acid （SUA） and prognosis of infection in critically ill patients. The data from 471 patients with infection admitted from January 2003 to April 2010 were analyzed retrospectively at Huashan Hospital Affiliated to Fudan University, Shanghai, China. The data of SUA, serum creatinine, blood urea nitrogen （BUN） and other relevant examinations within 24 hours after admission were recorded and the levels of SUA in those patients were described, then Student＇s t test was used to evaluate the relationship between SUA and pre-existing disorders. Different levels of SUA were graded for further analysis. The Chi-square test was used to examine the difference in the prognosis of infection. The mean initial level of SUA within 24 hours after admission was 0.232±0.131 mmol/L and the median was 0.199 mmol/L. Remarkable variations in the initial levels of SUA were observed in patients with pre-existing hypertension （t=-3.084, P=0.002）, diabetes mellitus （t=-2.487, P=0.013）, cerebral infarction （t=-3.061, P=0.002）, renal insufficiency （t=-4.547, P〈0.001）, central nervous system infection （t=5.096, P〈0.001） and trauma （t=2.875, P=0.004）. SUAwas linearly correlated with serum creatinine and BUN （F=159.470 and 165.059, respectively, P〈0.001）. No statistical correlation was found between the initial levels of SUA and prognosis of infection （X^2=60.892, P=0.100）. The current study found no direct correlation between the initial levels of SUA after admission and prognosis of infection in critically ill patients.

An efficient Biginelli one-pot synthesis of new benzoxazole-substituted dihydropyrimidinones and thiones catalysed by trifluoro acetic acid under solvent-free conditions

An efficient synthesis of benzoxazole-substituted 3,4-dihydropyrimidinones （DHPMs） using trifluoro acetic acid as the catalyst for the first time from an aldehyde, 13-keto ester and benzoxazole-substituted urea/thiourea under solvent-free conditions is described. Compared to the classical Biginelli reaction conditions, this new method consistently has the advantage of excellent yields （80-91%） and short reaction time （40-130 min） at reflux temperature. 2009 M. Adharvana Chad. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

A Commercially Available Skin Care Lotion with a pH of 4.5 and 10% Urea Improves Skin Surface pH, Stratum Corneum Hydration and Epidermal Barrier Function in Subjects with Dry Skin and Atopic Diathesis

OBJECTIVE: The physiological skin surface pH is crucial for several epidermal barrier functions, like stratum corneum integrity, cohesion and restoration. Alterations of the “normal” acidic nature of the skin surface have been shown to correlate with specific skin conditions like aged or inflamed skin and are leading to impaired skin barrier function and formation. It is previously demonstrated that topical acidification in atopic dermatitis improves stratum corneum function, skin barrier structure and clinical signs in dermatitis. Against this background, we examined the impact of a slightly acidic skin care product containing urea on stratum corneum hydration, skin surface pH and epidermal barrier function in subjects with dry skin and atopic diathesis. METHODS: Stratum corneum hydration, skin surface pH and transepidermal water loss were biophysically measured before and after a 4-week treatment period with the test product (pH 4.5, 10% urea) compared to the reference product in 25 volunteers. In addition, dynamic epidermal barrier parameters like stratum corneum integrity, cohesion and recovery were investigated by using a previously described tape stripping approach. RESULTS: It was shown that the test product (pH 4.5, 10% urea) significantly elevated stratum corneum hydration and improved the acidic nature of the skin surface by lowering the skin surface pH to a greater extent compared to the reference product. After the 4-week treatment period a significant faster barrier restoration was detected on the test site treated with the test product compared to the reference product. Moreover, the test product strengthens the skin barrier integrity and cohesion. CONCLUSION: The present marketed skin care lotion was shown to increase epidermal barrier function after 4 weeks of application. Balancing and controlling the skin surface pH in subjects with dry and atopic-prone skin by application of the herein tested o/w emulsion with a given pH of 4.5, in combination with a 10% urea content seems to be effective and beneficial. The results are important for the formulation of topical products for dry and atopic-prone skin.

玛咖灵芝片缓解小鼠体力疲劳的研究

研究玛咖灵芝片对改善小鼠体力劳动过度的疲倦状态,增加体力和身体机能的作用.本次实验采用清洁级雄性ICR小鼠作为动物模型,以体重为划分依据随机分组,包括低、中、高剂量组和阴性对照组4组.其中低、中、高剂量组分别给予剂量为0.38、0.75、2.25 g/kg·bw的玛咖灵芝片药剂进行灌胃;阴性对照组为20 mL/kg·bw的蒸馏水灌胃.每天给药1次,共给药30 d.实验期间,小鼠每日进行负重游泳实验,与此同时,使用比色法对血清中尿素、肝糖原和血乳酸的含量进行检测.比色法检测结果显示,与阴性对照组相比较,玛咖灵芝片不同剂量组的小鼠负重游泳的时间明显延长(P<0.05).另外,玛咖灵芝片不同剂量组的小鼠负重游泳后,其血浆尿素浓度均明显低于阴性对照组(P<0.05),肝脏糖原含量均显著高于阴性对照组(P<0.05),血乳酸浓度均显著低于阴性对照组(P<0.05).玛咖灵芝片可通过提高肝糖原含量和阻止血乳酸堆积的方式有效改善小鼠体力劳动过度的疲倦状态,增加体力和身体机能.

超声监测结合BUN、UA水平预测PE并发FGR孕产妇不良结局价值

目的:探讨超声胎儿监测结合血尿素氮(BUN)和尿酸(UA)水平预测子痫前期(PE)并发胎儿生长受限(FGR)患者不良结局价值。方法:回顾性收集2020年1月-2023年5月本院就诊的PE患者,其中并发FGR 106例为观察组,未并发FGR患者106例为对照组,比较两组血BUN、UA水平,超声胎儿静脉导管收缩期峰值速度(PSV)、舒张期峰值速度(EDV)、平均时间最大血流速度(Vmax),统计新生儿及孕妇不良结局。结果:观察组血BUN(5.03±1.22mmol/L)、UA(435.54±52.13mmol/L)高于对照组(4.01±1.30 mmol/L、391.60±60.88 mmol/L),PSV(0.85±0.12cm/s)、EDV(0.78±0.11cm/s)、Vmax(0.81±0.13cm/s)低于对照组(0.89±0.11 cm/s、0.96±0.14 cm/s、0.98±0.12 cm/s),新生儿不良结局总发生率(67.9%)高于对照组(15.1%),孕妇不良妊娠结局总发生率(38.7%)高于对照组(20.8%);观察组发生新生儿不良结局患者血BUN、UA高于未发生新生儿不良结局患者,而超声胎儿静脉血流参数均低于未发生新生儿不良结局患者(均P<0.05)。血BUN、UA、PSV、EDV、Vmax及联合预测新生儿不良结局的曲线下面积分别为0.735、0.760、0.643、0.809、0.670和0.706,联合预测的灵敏性达到100.0%。结论:PE并发FGR患者BUN、UA水平异常升高,超声胎儿静脉血流参数异常降低,上述超声及血指标预测新生儿不良结局有一定临床指导价值。

Localization and Associative Strength of Acid Polysaccharides in Coccoliths of <i>Pleurochrysis haptonemofera</i>(Haptophyta) Predicted from Their Extractability from Partially Decalcified Coccoliths

The coccolithophorids have calcified scales called coccoliths on their surface that include abundant acid polysaccharides. To determine the localization and associative strength of acid polysaccharides Ph-PS-1, -2, and -3 incoccoliths of Pleurochrysis haptonemofera, we analyzed the acid polysaccharides extracted with urea from partially decalcified coccoliths. On treatment of coccoliths with8.0 Murea at pH8.0 inboiling water, Ph-PS-2 was not extracted, but parts of Ph-PS-1 and -3 were from the surface without the crystal morphology being affected. When coccoliths were partially decalcified at various pHs (pH 8.0 - 5.0), Ph-PS-1, -3, and -2 were extracted with urea in that order as the calcite crystals dissolved. Detection of the acid polysaccharides using fluorescein-isothiocyanate-labeled lectin (ConA) and anti-Ph-PS-2 antibodies demonstrated that Ph-PS-2 exists on the surfaces of both untreated and urea-treated coccoliths. Moreover, NaClO-treatment under moderate conditions extracted only Ph-PS-1, -3, and part of Ph-PS-2 from coccoliths, without separation of the crystal units, suggesting that at least some part of Ph-PS-2 acts as a glue connecting crystal units and/or a crystal unit and a base plate inside coccoliths. These results suggest that Ph-PS-2 exists not only on the surface but also inside of the coccoliths, most of it being strongly bound to coccoliths, while Ph-PS-1 and -3 are weakly associated close to the coccolith surface, in that order from the surface. This strongly supports a scheme in which PS-2 type acid polysaccharides play an important role in the crystal nucleation and PS-3 type functions during crystal growth.

目标导向液体治疗在腹腔镜肝脏手术中的应用效果

目的探讨对腹腔镜肝脏手术患者实施目标导向液体治疗(GDFT)后获得的临床效果。方法选取2020年3月至2023年8月烟台市烟台山医院收治的62例腹腔镜肝脏手术患者作为研究对象,按照随机数字表法分为参照组(31例)与研究组(31例),参照组采用常规方法治疗,研究组采用GDFT治疗。比较两组的简易精神状态检查量表(MMSE)评分、血流动力学指标水平、尿素氮(BUN)水平、乳酸(Lac)水平。结果术前1 d,两组患者MMSE评分比较,差异无统计学意义(P>0.05);术后1、3 d,研究组患者MMSE评分高于参照组,差异有统计学意义(P<0.05)。研究组患者切肝时(T_(2))及手术完毕时(T_(3))心脏指数(CI)高于参照组;T_(2)时中心静脉压(CVP)水平高于参照组,T_(3)时CVP水平低于参照组,差异有统计学意义(P<0.05);入室时(T_(0))、T_(3)时及术后24 h,两组患者BUN水平比较,差异无统计学意义(P>0.05);T_(0)时,两组患者Lac水平比较,差异无统计学意义(P>0.05);T_(3)及术后24 h,研究组患者Lac水平低于参照组,差异有统计学意义(P<0.05)。结论临床对腹腔镜肝脏手术患者合理给予GDFT治疗,对于患者重要脏器血流灌注稳定性以及患者的血流动力学水平维持表现出的作用明显,可以保护患者的脑组织,对于患者的术后认知功能改善有促进作用。

KIM-1表达水平对高尿酸肾结石患者CR、UREA、GFR、Cys-C的影响

目的研究肾损伤分子-1(KIM-1)表达水平对高尿酸肾结石患者肌酐(CR)、尿素(UREA)、肾小球滤过率(GFR)和胱抑素C(Cys-C)的影响。方法选取94例肾结石患者,根据尿酸水平分为高尿酸血症(HUA)组46例和正常血尿酸组(非HUA组)48例,另外选取健康成人30例作为对照组。检测三组尿液KIM-1及肾功能指标CR、UREA、GFR和Cys-C的水平,采用Pearson法分析不同血尿酸水平的肾结石患者KIM-1表达与肾功能指标之间的相关性。结果HUA组尿液KIM-1水平高于非HUA组和对照组(t分别=14.34、13.82,P均<0.05),非HUA组和对照组KIM-1比较,差异无统计学意义(t=0.33,P>0.05)。HUA组CR、UREA和Cys-C水平均高于非HUA组和对照组,GFR水平低于非HUA组和对照组(t分别=14.90、10.48、21.69、13.25、11.36、21.34、-18.42、-13.59,P均<0.05),非HUA组和对照组之间CR、UREA、Cys-C、GFR比较,差异均无统计学意义(t分别=1.70、1.73、1.03、0.49,P均>0.05)。Pearson相关性结果显示,KIM-1水平与CR、UREA和Cys-C水平均呈正相关(r分别=0.52、0.46、0.65,P均<0.05),与GFR水平呈负相关(r=-0.52,P<0.05)。结论高尿酸水平的肾结石患者尿液KIM-1水平明显升高。KIM-1影响肾功能指标的表达,并与高尿酸水平肾结石患者的肾功能下降程度相关。