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Tanshinone ⅡA improves functional recovery in spinal cord injury-induced lower urinary tract dysfunction 被引量:9
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作者 Yong-dong Yang Xing Yu +2 位作者 Xiu-mei Wang Xiao-hong Mu Feng He 《Neural Regeneration Research》 SCIE CAS CSCD 2017年第2期267-275,共9页
Tanshinone ⅡA, extracted from Salvia miltiorrhiza Bunge, exerts neuroprotective effects through its anti-inflammatory, anti-oxidative and anti-apoptotic properties. This study intravenously injected tanshinone ⅡA 20... Tanshinone ⅡA, extracted from Salvia miltiorrhiza Bunge, exerts neuroprotective effects through its anti-inflammatory, anti-oxidative and anti-apoptotic properties. This study intravenously injected tanshinone ⅡA 20 mg/kg into rat models of spinal cord injury for 7 consecutive days. Results showed that tanshinone ⅡA could reduce the inflammation, edema as well as compensatory thickening of the bladder tissue, improve urodynamic parameters, attenuate secondary injury, and promote spinal cord regeneration. The number of hypertrophic and apoptotic dorsal root ganglion(L6–S1) cells was less after treatment with tanshinone ⅡA. The effects of tanshinone ⅡA were similar to intravenous injection of 30 mg/kg methylprednisolone. These findings suggested that tanshinone ⅡA improved functional recovery after spinal cord injury-induced lower urinary tract dysfunction by remodeling the spinal pathway involved in lower urinary tract control. 展开更多
关键词 nerve regeneration spinal cord injury tanshinone IIA spinal pathway lower urinary tract dysfunction neurogenic bladder dorsal root ganglion detrusor-sphincter dyssynergia urodynamics neural regeneration
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