Objective:To investigate the changes of serumβ2 microglobulin(β2-MG),cystatin C(CysC)and urine microalbumin(mAlb)levels in patients with ureteral calculi before and after extracorporeal shock wave lithotripsy and th...Objective:To investigate the changes of serumβ2 microglobulin(β2-MG),cystatin C(CysC)and urine microalbumin(mAlb)levels in patients with ureteral calculi before and after extracorporeal shock wave lithotripsy and their clinical significance.Methods Sixty-eight patients with ureteral calculi admitted to the hospital between June 2018 and June 2019 were selected as the observation group.35 volunteers who received physical elimination in the hospital during the same period were selected as the control group.Levels ofβ2-MG,Cys C and urine mAlb in the observation group were compared before and after treatment,and compared with those in the control group.Changes in serumβ2-MG,Cys C and urine mAlb levels and renal function indicators[blood urea nitrogen(BUN),serum creatinine(SCr)]in patients with different prognosis in the observation group after treatment were analyzed.The value of serumβ2-MG,Cys C and urine mAlb levels in the diagnosis and treatment of ureteral calculi was analyzed with ROC curve.The correlations between serumβ2-MG,Cys C and urine mAlb levels and renal function indexes were analyzed.Results Serumβ2-MG,Cys C and urine mAlb levels in the observation group before treatment were significantly higher than those in the same group after treatment or those in the control group(P<0.05).Serumβ2-MG,Cys C and urine mAlb levels,BUN and SCr in patients with residual stones were significantly higher than those in patients without(P<0.05).ROC curve analysis showed that the sensitivity and the area under the curve of combined detection of serumβ2-MG,Cys C and urine mAlb levels for evaluating the curative effect of extracorporeal shock wave lithotripsy on ureteral calculi were significantly higher/larger than those of single detection of the three(P<0.05).Partial correlation analysis showed that serumβ2-MG,Cys C and urine mAlb levels were positively correlated with BUN and SCr(P<0.05).Conclusion There are obvious changes of serumβ2-MG,Cys C and urine mAlb levels in patients with ureteral calculi before and after extracorporeal shock wave lithotripsy.The combined detection of the three indexes is helpful for the early diagnosis of ureteral calculi and the evaluation of renal function after lithotripsy.They can provide reference for protecting renal function in patients with ureteral calculi treated by extracorporeal shock wave lithotripsy.展开更多
Urineβ_2-microglobulin (β_2-m) was measured in 433 persons with low-level, long-term environmental exposure to Cd, and in 124 control persons from unpolluted area. In 152 of the exposed persons, and some of the cont...Urineβ_2-microglobulin (β_2-m) was measured in 433 persons with low-level, long-term environmental exposure to Cd, and in 124 control persons from unpolluted area. In 152 of the exposed persons, and some of the controls, the urine β-m exceeded the limit. Of the 433 exposed persons, 74 cases with both urine Cd and β_2-m exceeding the limit were matched by the control. This study suggests that after the stratification of the degrees of renal tubular injury according to the fractional β_2-m excretion (FE β_2-m) and coordination of clinical examination, FE β_2-m could contribute to identifying renal tubular dysfunction due to Cd exposure and kidney lesion when both Cd exposure and original nephropathy exist.展开更多
目的探讨糖化血红蛋白(HbA1c)、β2-微球蛋白(β2-MG)、尿微量白蛋白/肌酐比值(UACR)与老年高血压患者血压变异性严重程度的关系。方法回顾性选取2019年4月至2022年9月成都市第三人民医院收治的167例原发性高血压患者作为高血压组、另...目的探讨糖化血红蛋白(HbA1c)、β2-微球蛋白(β2-MG)、尿微量白蛋白/肌酐比值(UACR)与老年高血压患者血压变异性严重程度的关系。方法回顾性选取2019年4月至2022年9月成都市第三人民医院收治的167例原发性高血压患者作为高血压组、另外选取同期健康体检非高血压疾病志愿者80名作为对照组。对比两组研究对象的HbA1c、β2-MG、UACR、24 h平均收缩压(24 h SBP)、24 h平均舒张压(24 h DBP)、24 h平均收缩压变异率(24 h SBPV)、24 h平均舒张压变异率(24 h DBPV)、空腹血糖、餐后2 h血糖(2 h PG)、血肌酐、尿素氮、甘油三酯、总胆固醇、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。并根据高血压分级标准将高血压组分为不同等级进行分层分析(>2级患者121例,≤2级46例)。采用Pearson分析法分析HbA1c、β2-MG、UACR与血压变异性参数的关系。结果高血压组患者的HbA1c、β2-MG、UACR、24 h SBP、24 h DBP、24 h SBPV、空腹血糖测定值均显著高于对照组,差异均有统计学意义(P<0.05);高血压组患者的24 h DBPV、2 h PG、血肌酐、尿素氮、甘油三酯、总胆固醇、HDL-C、LDL-C测定值与对照组比较,差异均无统计学意义(P>0.05)。>2级的原发性高血压患者的β2-MG、UACR、24 h SBP、24 h DBP、24 h SBPV、血肌酐测定值均显著高于≤2级的原发性高血压患者,差异均有统计学意义(P<0.05);≤2级与>2级的原发性高血压患者的HbA1c、24 h DBPV、空腹血糖、2 h PG、尿素氮、甘油三酯、总胆固醇、HDL-C、LDL-C测定值比较,差异均无统计学意义(P>0.05)。原发性高血压患者β2-MG、UACR测定值与24 h SBPV、24 h DBPV均呈正相关(P<0.05)。结论原发性高血压患者的HbA1c、β2-MG、UACR高于非高血压患者,β2-MG、UACR测定值与原发性高血压患者的血压水平及血压变异性呈正相关。展开更多
目的探讨血清胱抑素C(Cys-C)、β2-微球蛋白(β2-MG)、尿微量蛋白/尿肌酐(mAlb/Cr)联合检测在原发性肾病综合征(PNS)患儿急性肾损伤(AKI)诊断中的临床价值。方法回顾性分析潜江市中心医院肾病风湿科2018年1月至2022年1月期间收治的60例...目的探讨血清胱抑素C(Cys-C)、β2-微球蛋白(β2-MG)、尿微量蛋白/尿肌酐(mAlb/Cr)联合检测在原发性肾病综合征(PNS)患儿急性肾损伤(AKI)诊断中的临床价值。方法回顾性分析潜江市中心医院肾病风湿科2018年1月至2022年1月期间收治的60例PNS患儿病例资料,其中男35例、女25例,年龄(9.24±2.51)岁,根据是否出现AKI分为AKI组(27例)和非AKI组(33例)。对比两组患儿临床资料[性别、年龄、体质量指数(BMI)、血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、血肌酐(Scr)、血清白蛋白(ALB)、尿酸(UA)、24 h尿蛋白(24 h Up)、血红蛋白(Hb)、β2-MG、CysC、mAlb/Cr]。采用多元logistic回归方程分析PNS患儿发生AKI的危险因素,采用受试者工作特征曲线(ROC)分析Cys-C、β2-MG及mAlb/Cr联合检测诊断PNS患儿发生AKI的临床价值。采用t检验、χ^(2)检验。结果AKI组患儿Scr[(87.04±13.32)μmol/L]、UA[(275.53±58.14)μmol/L]、24 h Up[(150.24±37.83)mg/24 h]、Cys-C[(2.25±0.53)mg/L]、β2-MG[(1.46±0.25)mg/L]、mAlb/Cr水平[(36.70±10.35)μg/mg]均高于非AKI组[(71.95±11.91)μmol/L、(221.07±43.56)μmol/L、(120.52±28.62)mg/24 h、(1.62±0.32)mg/L、(1.18±0.21)mg/L、(22.32±6.51)μg/mg],ALB水平[(34.72±2.34)g/L]低于非AKI组[(37.39±2.72)g/L],差异均有统计学意义(均P<0.05)。Cys-C、β2-MG及mAlb/Cr升高均为PNS患儿发生AKI的危险因素(均P<0.05)。Cys-C、β2-MG及mAlb/Cr联合检测诊断PNS患儿发生AKI的曲线下面积(AUC)、灵敏度及特异度(0.885、88.89%、81.82%)均优于单一指标检测(均P<0.05)。结论Cys-C、β2-MG及mAlb/Cr联合检测诊断PNS患儿发生AKI具有较好的应用价值。展开更多
基金Science and technology department of Sichuan province(No.2017JY05012)
文摘Objective:To investigate the changes of serumβ2 microglobulin(β2-MG),cystatin C(CysC)and urine microalbumin(mAlb)levels in patients with ureteral calculi before and after extracorporeal shock wave lithotripsy and their clinical significance.Methods Sixty-eight patients with ureteral calculi admitted to the hospital between June 2018 and June 2019 were selected as the observation group.35 volunteers who received physical elimination in the hospital during the same period were selected as the control group.Levels ofβ2-MG,Cys C and urine mAlb in the observation group were compared before and after treatment,and compared with those in the control group.Changes in serumβ2-MG,Cys C and urine mAlb levels and renal function indicators[blood urea nitrogen(BUN),serum creatinine(SCr)]in patients with different prognosis in the observation group after treatment were analyzed.The value of serumβ2-MG,Cys C and urine mAlb levels in the diagnosis and treatment of ureteral calculi was analyzed with ROC curve.The correlations between serumβ2-MG,Cys C and urine mAlb levels and renal function indexes were analyzed.Results Serumβ2-MG,Cys C and urine mAlb levels in the observation group before treatment were significantly higher than those in the same group after treatment or those in the control group(P<0.05).Serumβ2-MG,Cys C and urine mAlb levels,BUN and SCr in patients with residual stones were significantly higher than those in patients without(P<0.05).ROC curve analysis showed that the sensitivity and the area under the curve of combined detection of serumβ2-MG,Cys C and urine mAlb levels for evaluating the curative effect of extracorporeal shock wave lithotripsy on ureteral calculi were significantly higher/larger than those of single detection of the three(P<0.05).Partial correlation analysis showed that serumβ2-MG,Cys C and urine mAlb levels were positively correlated with BUN and SCr(P<0.05).Conclusion There are obvious changes of serumβ2-MG,Cys C and urine mAlb levels in patients with ureteral calculi before and after extracorporeal shock wave lithotripsy.The combined detection of the three indexes is helpful for the early diagnosis of ureteral calculi and the evaluation of renal function after lithotripsy.They can provide reference for protecting renal function in patients with ureteral calculi treated by extracorporeal shock wave lithotripsy.
文摘Urineβ_2-microglobulin (β_2-m) was measured in 433 persons with low-level, long-term environmental exposure to Cd, and in 124 control persons from unpolluted area. In 152 of the exposed persons, and some of the controls, the urine β-m exceeded the limit. Of the 433 exposed persons, 74 cases with both urine Cd and β_2-m exceeding the limit were matched by the control. This study suggests that after the stratification of the degrees of renal tubular injury according to the fractional β_2-m excretion (FE β_2-m) and coordination of clinical examination, FE β_2-m could contribute to identifying renal tubular dysfunction due to Cd exposure and kidney lesion when both Cd exposure and original nephropathy exist.
文摘目的探讨糖化血红蛋白(HbA1c)、β2-微球蛋白(β2-MG)、尿微量白蛋白/肌酐比值(UACR)与老年高血压患者血压变异性严重程度的关系。方法回顾性选取2019年4月至2022年9月成都市第三人民医院收治的167例原发性高血压患者作为高血压组、另外选取同期健康体检非高血压疾病志愿者80名作为对照组。对比两组研究对象的HbA1c、β2-MG、UACR、24 h平均收缩压(24 h SBP)、24 h平均舒张压(24 h DBP)、24 h平均收缩压变异率(24 h SBPV)、24 h平均舒张压变异率(24 h DBPV)、空腹血糖、餐后2 h血糖(2 h PG)、血肌酐、尿素氮、甘油三酯、总胆固醇、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。并根据高血压分级标准将高血压组分为不同等级进行分层分析(>2级患者121例,≤2级46例)。采用Pearson分析法分析HbA1c、β2-MG、UACR与血压变异性参数的关系。结果高血压组患者的HbA1c、β2-MG、UACR、24 h SBP、24 h DBP、24 h SBPV、空腹血糖测定值均显著高于对照组,差异均有统计学意义(P<0.05);高血压组患者的24 h DBPV、2 h PG、血肌酐、尿素氮、甘油三酯、总胆固醇、HDL-C、LDL-C测定值与对照组比较,差异均无统计学意义(P>0.05)。>2级的原发性高血压患者的β2-MG、UACR、24 h SBP、24 h DBP、24 h SBPV、血肌酐测定值均显著高于≤2级的原发性高血压患者,差异均有统计学意义(P<0.05);≤2级与>2级的原发性高血压患者的HbA1c、24 h DBPV、空腹血糖、2 h PG、尿素氮、甘油三酯、总胆固醇、HDL-C、LDL-C测定值比较,差异均无统计学意义(P>0.05)。原发性高血压患者β2-MG、UACR测定值与24 h SBPV、24 h DBPV均呈正相关(P<0.05)。结论原发性高血压患者的HbA1c、β2-MG、UACR高于非高血压患者,β2-MG、UACR测定值与原发性高血压患者的血压水平及血压变异性呈正相关。
文摘目的探讨血清胱抑素C(Cys-C)、β2-微球蛋白(β2-MG)、尿微量蛋白/尿肌酐(mAlb/Cr)联合检测在原发性肾病综合征(PNS)患儿急性肾损伤(AKI)诊断中的临床价值。方法回顾性分析潜江市中心医院肾病风湿科2018年1月至2022年1月期间收治的60例PNS患儿病例资料,其中男35例、女25例,年龄(9.24±2.51)岁,根据是否出现AKI分为AKI组(27例)和非AKI组(33例)。对比两组患儿临床资料[性别、年龄、体质量指数(BMI)、血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、血肌酐(Scr)、血清白蛋白(ALB)、尿酸(UA)、24 h尿蛋白(24 h Up)、血红蛋白(Hb)、β2-MG、CysC、mAlb/Cr]。采用多元logistic回归方程分析PNS患儿发生AKI的危险因素,采用受试者工作特征曲线(ROC)分析Cys-C、β2-MG及mAlb/Cr联合检测诊断PNS患儿发生AKI的临床价值。采用t检验、χ^(2)检验。结果AKI组患儿Scr[(87.04±13.32)μmol/L]、UA[(275.53±58.14)μmol/L]、24 h Up[(150.24±37.83)mg/24 h]、Cys-C[(2.25±0.53)mg/L]、β2-MG[(1.46±0.25)mg/L]、mAlb/Cr水平[(36.70±10.35)μg/mg]均高于非AKI组[(71.95±11.91)μmol/L、(221.07±43.56)μmol/L、(120.52±28.62)mg/24 h、(1.62±0.32)mg/L、(1.18±0.21)mg/L、(22.32±6.51)μg/mg],ALB水平[(34.72±2.34)g/L]低于非AKI组[(37.39±2.72)g/L],差异均有统计学意义(均P<0.05)。Cys-C、β2-MG及mAlb/Cr升高均为PNS患儿发生AKI的危险因素(均P<0.05)。Cys-C、β2-MG及mAlb/Cr联合检测诊断PNS患儿发生AKI的曲线下面积(AUC)、灵敏度及特异度(0.885、88.89%、81.82%)均优于单一指标检测(均P<0.05)。结论Cys-C、β2-MG及mAlb/Cr联合检测诊断PNS患儿发生AKI具有较好的应用价值。
