目的:探讨经靶向导管注入尼可地尔与重组人尿激酶原(rh-proUK)联合经皮冠状动脉介入术(PCI)治疗冠状动脉慢性完全闭塞(chronic total occlusion,CTO)的效果及对远期预后的影响。方法:收集2021年9月至2023年1月于我院成功进行PCI术的237...目的:探讨经靶向导管注入尼可地尔与重组人尿激酶原(rh-proUK)联合经皮冠状动脉介入术(PCI)治疗冠状动脉慢性完全闭塞(chronic total occlusion,CTO)的效果及对远期预后的影响。方法:收集2021年9月至2023年1月于我院成功进行PCI术的237例CTO患者为研究对象,开展回顾性研究。根据治疗方法不同进行分组,将经靶向导管注入尼可地尔联合PCI术治疗的患者纳入尼可地尔组(n=78),将经靶向导管注入rh-proUK联合PCI术治疗的患者纳入rh-proUK组(n=78),将经靶向导管注入尼可地尔与rh-proUK联合PCI术治疗的患者纳入联合组(n=81)。比较3组微循环指标[靶血管心肌梗死溶栓试验(TIMI)血流分级、TIMI心肌灌注分级(TMPG)、校正TIMI血流帧数(cTFC)]、心肌损伤指标[肌酐、肌酸激酶同工酶(CK-MB)、N末端脑钠肽前体(NT-proBNP)、肌钙蛋白(IcTnI)]、心功能[左心室舒张末期内径(LVED)、室壁运动积分指数(WMSI)、左心室射血分数(LVEF)]、心肌微循环血流灌注情况[心肌灌注定量分析常数(k)]及不良心血管事件发生率。结果:联合组TMPG 3级占比高于尼可地尔组、rh-proUK组,cTFC低于尼可地尔组、rh-proUK组(P<0.05);术后24h联合组CK-MB、肌酐、IcTnI、NT-proBNP均低于尼可地尔组、rh-proUK组(P<0.05);术后3个月联合组LVEF高于尼可地尔组、rh-proUK组,LVED低于尼可地尔组、rh-proUK组(P<0.05);术后7d联合组基础态、负荷态心肌微循环血流灌注k值高于尼可地尔组、rh-proUK组(P<0.05);3组术后6个月、12个月不良心血管事件总发生率比较无显著差异(P>0.05)。结论:经靶向导管注入尼可地尔与rh-proUK联合PCI术治疗CTO患者可促进术后心肌微循环改善,有助于缓解术后心肌损伤、恢复心功能,改善远期预后。展开更多
目的分析基于英国生物样本数据库(UK Biobank)开展的关于心血管疾病的研究热点和发展趋势,为研究者开展心血管疾病相关研究提供科学参考。方法在Web of Science核心集数据库中检索2016年至2022年期间基于UK Biobank数据库开展的关于心...目的分析基于英国生物样本数据库(UK Biobank)开展的关于心血管疾病的研究热点和发展趋势,为研究者开展心血管疾病相关研究提供科学参考。方法在Web of Science核心集数据库中检索2016年至2022年期间基于UK Biobank数据库开展的关于心血管疾病研究的文献,运用Citespace 6.1.R 2和VOSviewer 1.6.18软件分别从国家、机构、关键词等方面对心血管疾病的研究热点和发展趋势进行可视化分析。结果研究共纳入284篇文献,整体发文量处于增长趋势;发文量排在第1位的作者是S.PETERSEN,发文量最多的国家是英国,发文量最多的机构是英国牛津大学;关键词突现分析提示,近5年研究趋势主要集中在危险因素分析(adiposity,body mass index)、全基因组关联研究(genome-wide association study)与疾病预后分析(therapy,all-cause mortality)等方面的研究。另外,以“smoking”为代表的危险因素探讨、基因表达(loci,expression)和以孟德尔随机化为代表的偏倚控制方法探讨(Mendelian randomization,bias)是现阶段基于UK Biobank数据库开展的有关脑血管疾病的研究热点。结论当前基于UK Biobank数据库的心血管疾病研究处于快速发展期,英国与美国在该领域开展的研究较多,近5年该领域研究趋势和热点主要集中在心血管疾病的危险因素分析、基因表达、疾病预后分析与偏倚控制方法等方面。展开更多
The outward student mobility has been recognized as an instrument for the internationalization of higher education(IHE)world-widely and in the UK.This paper intends to critically review the existing literature in orde...The outward student mobility has been recognized as an instrument for the internationalization of higher education(IHE)world-widely and in the UK.This paper intends to critically review the existing literature in order to identify the current trend and issues of the UK outward student mobility under the IHE.It points out that the focus of current international educational activities is attracting foreign/inward students out of the economic impetus in the UK.Consequently,the outward student mobility is given the less recognition than the inward one in the UK policy-making and researches,which could lead the imbalanced gains for UK-domiciled students.Thus,it suggests that both the UK government education sectors and institutions should more develop the outward student mobility;moreover,future researches could investigate more about outward students’personal development.展开更多
Objective:Discussion and analysis of the effect of the early application of Tirofiban on acute ischemic stroke(AIS)after intravenous thrombolysis with urokinase.Method:The subjects of this study are 40 patients with A...Objective:Discussion and analysis of the effect of the early application of Tirofiban on acute ischemic stroke(AIS)after intravenous thrombolysis with urokinase.Method:The subjects of this study are 40 patients with AIS admitted at the Yibin Fourth People’s Hospital,of which were computer-randomized into a control group(20 cases,with regular urokinase intravenous thrombolysis therapy)and a research group(20 cases,combined with early Tirofiban treatment)from January 2018 to December 2022.The intervention outcomes between these two groups were compared and analyzed.Result:The blood platelet-related parameters before treatment had no statistical difference between the two groups(P>0.05),but the research group was higher than that of the control group after treatment(P<0.05).The Barthel index before treatment in both groups had no statistical difference(P>0.05),but the research group was higher than that of the control group after treatment(P<0.05).Conclusion:Early Tirofiban treatment for patients with AIS after intravenous thrombolysis with urokinase could effectively regulate the blood platelet-related parameters,hence improving treatment benefits and living capacity for patients,with definite clinical benefits.展开更多
This paper focuses on media consumption,especially Chinese-language media consumption,among Chinese people living in the UK within the current global media landscape.This research project employs an explanatory sequen...This paper focuses on media consumption,especially Chinese-language media consumption,among Chinese people living in the UK within the current global media landscape.This research project employs an explanatory sequential mixed-methods approach,utilizing a questionnaire survey,focus groups,and semi-structured in-depth interviews to gather both quantitative and qualitative data.The findings indicate that Chinese people in the UK predominantly consume media through social platforms on mobile devices.Notably,their approach to accessing news reflects a trend of independent choice driven by personal information preferences.This study suggests that shifts in the media consumption of Chinese individuals in the UK are influenced by changing media environments in China,and their media habits evolve as they gradually adapt to the host society.While Chinese-language media offer platforms for Chinese individuals in the UK to create virtual communities to meet various needs,this research argues that while it may help them adapt to the host society more quickly,it does not necessarily encourage full integration.展开更多
文摘目的:探讨经靶向导管注入尼可地尔与重组人尿激酶原(rh-proUK)联合经皮冠状动脉介入术(PCI)治疗冠状动脉慢性完全闭塞(chronic total occlusion,CTO)的效果及对远期预后的影响。方法:收集2021年9月至2023年1月于我院成功进行PCI术的237例CTO患者为研究对象,开展回顾性研究。根据治疗方法不同进行分组,将经靶向导管注入尼可地尔联合PCI术治疗的患者纳入尼可地尔组(n=78),将经靶向导管注入rh-proUK联合PCI术治疗的患者纳入rh-proUK组(n=78),将经靶向导管注入尼可地尔与rh-proUK联合PCI术治疗的患者纳入联合组(n=81)。比较3组微循环指标[靶血管心肌梗死溶栓试验(TIMI)血流分级、TIMI心肌灌注分级(TMPG)、校正TIMI血流帧数(cTFC)]、心肌损伤指标[肌酐、肌酸激酶同工酶(CK-MB)、N末端脑钠肽前体(NT-proBNP)、肌钙蛋白(IcTnI)]、心功能[左心室舒张末期内径(LVED)、室壁运动积分指数(WMSI)、左心室射血分数(LVEF)]、心肌微循环血流灌注情况[心肌灌注定量分析常数(k)]及不良心血管事件发生率。结果:联合组TMPG 3级占比高于尼可地尔组、rh-proUK组,cTFC低于尼可地尔组、rh-proUK组(P<0.05);术后24h联合组CK-MB、肌酐、IcTnI、NT-proBNP均低于尼可地尔组、rh-proUK组(P<0.05);术后3个月联合组LVEF高于尼可地尔组、rh-proUK组,LVED低于尼可地尔组、rh-proUK组(P<0.05);术后7d联合组基础态、负荷态心肌微循环血流灌注k值高于尼可地尔组、rh-proUK组(P<0.05);3组术后6个月、12个月不良心血管事件总发生率比较无显著差异(P>0.05)。结论:经靶向导管注入尼可地尔与rh-proUK联合PCI术治疗CTO患者可促进术后心肌微循环改善,有助于缓解术后心肌损伤、恢复心功能,改善远期预后。
基金Guangdong University Teaching Quality Assurance and Reform Project“The English Teaching Team Construction”(No.2020SZL03).
文摘The outward student mobility has been recognized as an instrument for the internationalization of higher education(IHE)world-widely and in the UK.This paper intends to critically review the existing literature in order to identify the current trend and issues of the UK outward student mobility under the IHE.It points out that the focus of current international educational activities is attracting foreign/inward students out of the economic impetus in the UK.Consequently,the outward student mobility is given the less recognition than the inward one in the UK policy-making and researches,which could lead the imbalanced gains for UK-domiciled students.Thus,it suggests that both the UK government education sectors and institutions should more develop the outward student mobility;moreover,future researches could investigate more about outward students’personal development.
文摘Objective:Discussion and analysis of the effect of the early application of Tirofiban on acute ischemic stroke(AIS)after intravenous thrombolysis with urokinase.Method:The subjects of this study are 40 patients with AIS admitted at the Yibin Fourth People’s Hospital,of which were computer-randomized into a control group(20 cases,with regular urokinase intravenous thrombolysis therapy)and a research group(20 cases,combined with early Tirofiban treatment)from January 2018 to December 2022.The intervention outcomes between these two groups were compared and analyzed.Result:The blood platelet-related parameters before treatment had no statistical difference between the two groups(P>0.05),but the research group was higher than that of the control group after treatment(P<0.05).The Barthel index before treatment in both groups had no statistical difference(P>0.05),but the research group was higher than that of the control group after treatment(P<0.05).Conclusion:Early Tirofiban treatment for patients with AIS after intravenous thrombolysis with urokinase could effectively regulate the blood platelet-related parameters,hence improving treatment benefits and living capacity for patients,with definite clinical benefits.
文摘This paper focuses on media consumption,especially Chinese-language media consumption,among Chinese people living in the UK within the current global media landscape.This research project employs an explanatory sequential mixed-methods approach,utilizing a questionnaire survey,focus groups,and semi-structured in-depth interviews to gather both quantitative and qualitative data.The findings indicate that Chinese people in the UK predominantly consume media through social platforms on mobile devices.Notably,their approach to accessing news reflects a trend of independent choice driven by personal information preferences.This study suggests that shifts in the media consumption of Chinese individuals in the UK are influenced by changing media environments in China,and their media habits evolve as they gradually adapt to the host society.While Chinese-language media offer platforms for Chinese individuals in the UK to create virtual communities to meet various needs,this research argues that while it may help them adapt to the host society more quickly,it does not necessarily encourage full integration.
