The InSight(Interior Exploration using Seismic Investigations,Geodesy,and Heat Transport)mission has recorded continuous ambient noise signals with many spectral peaks since its landing in 2018.The majority of these p...The InSight(Interior Exploration using Seismic Investigations,Geodesy,and Heat Transport)mission has recorded continuous ambient noise signals with many spectral peaks since its landing in 2018.The majority of these peaks are modes produced by instrumental vibrations and are associated with environmental factors,such as temperature and wind energy fluctuations.Understanding how these modes react under various conditions is crucial because it aids in identifying their origins.In this study,we analyzed the three-component spectra of InSight recordings from sols 184–738 and obtained the horizontal-to-vertical spectral ratio(HVSR,also known as H/V)curves for different time intervals.The primary modes,such as those at 3.3 and 4.1 Hz,exhibited different behaviors,suggesting diverse origins.Some modes were sensitive to low temperature and some were sensitive to high temperature.Additionally,we investigated the influence of wind and temperature on the H/V curve.The peak frequency was mainly affected by temperature,whereas the H/V value was not associated with the temperature or wind only.Characterizing these modes and elucidating their origins are significant for processing signals from InSight and can provide valuable guidance for designing future planetary seismometers.展开更多
Glaucoma is a leading cause of irreve rsible blindness wo rldwide,and previous studies have shown that,in addition to affecting the eyes,it also causes abnormalities in the brain.However,it is not yet clear how the pr...Glaucoma is a leading cause of irreve rsible blindness wo rldwide,and previous studies have shown that,in addition to affecting the eyes,it also causes abnormalities in the brain.However,it is not yet clear how the primary visual cortex(V1)is altered in glaucoma.This study used DBA/2J mice as a model for spontaneous secondary glaucoma.The aim of the study was to compare the electrophysiological and histomorphological chara cteristics of neurons in the V1between 9-month-old DBA/2J mice and age-matched C57BL/6J mice.We conducted single-unit recordings in the V1 of light-anesthetized mice to measure the visually induced responses,including single-unit spiking and gamma band oscillations.The morphology of layerⅡ/Ⅲneurons was determined by neuronal nuclear antigen staining and Nissl staining of brain tissue sections.Eighty-seven neurons from eight DBA/2J mice and eighty-one neurons from eight C57BL/6J mice were examined.Compared with the C57BL/6J group,V1 neurons in the DBA/2J group exhibited weaker visual tuning and impaired spatial summation.Moreove r,fewer neuro ns were observed in the V1 of DBA/2J mice compared with C57BL/6J mice.These findings suggest that DBA/2J mice have fewer neurons in the VI compared with C57BL/6J mice,and that these neurons have impaired visual tuning.Our findings provide a better understanding of the pathological changes that occur in V1 neuron function and morphology in the DBA/2J mouse model.This study might offer some innovative perspectives regarding the treatment of glaucoma.展开更多
The Z curve is a very useful method for visual-izing and analyzing DNA sequences. It is a three-dimensional space curve that constitutes a unique representation of a given DNA se-quence. It becomes more and more impor...The Z curve is a very useful method for visual-izing and analyzing DNA sequences. It is a three-dimensional space curve that constitutes a unique representation of a given DNA se-quence. It becomes more and more important to study non-coding regions in the recent years. Using Z curve method, 15 disease-related ncRNAs and some snoRNAs and miRNAs sequences are selected from the NONCODE database in this paper, which relate to Alzheimer Disease. The corresponding Z curves of the studied ncRNAs, sequences have been mapped and compared. The statistical features of the Z curves are ob-tained. These features indicate that the ncRNAs sequences playing same roles in the celluar process have almost the same Z-curves. And the base content in these sequences is almost same too.展开更多
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB 41000000).
文摘The InSight(Interior Exploration using Seismic Investigations,Geodesy,and Heat Transport)mission has recorded continuous ambient noise signals with many spectral peaks since its landing in 2018.The majority of these peaks are modes produced by instrumental vibrations and are associated with environmental factors,such as temperature and wind energy fluctuations.Understanding how these modes react under various conditions is crucial because it aids in identifying their origins.In this study,we analyzed the three-component spectra of InSight recordings from sols 184–738 and obtained the horizontal-to-vertical spectral ratio(HVSR,also known as H/V)curves for different time intervals.The primary modes,such as those at 3.3 and 4.1 Hz,exhibited different behaviors,suggesting diverse origins.Some modes were sensitive to low temperature and some were sensitive to high temperature.Additionally,we investigated the influence of wind and temperature on the H/V curve.The peak frequency was mainly affected by temperature,whereas the H/V value was not associated with the temperature or wind only.Characterizing these modes and elucidating their origins are significant for processing signals from InSight and can provide valuable guidance for designing future planetary seismometers.
基金supported by the STI 2030-Major Projects 2022ZD0208500(to DY)the National Natural Science Foundation of China,Nos.82072011(to YX),82121003(to DY),82271120(to YS)+2 种基金Sichuan Science and Technology Program,No.2022ZYD0066(to YS)a grant from Chinese Academy of Medical Science,No.2019-12M-5-032(to YS)the Fundamental Research Funds for the Central Universities,No.ZYGX2021YGLH219(to KC)。
文摘Glaucoma is a leading cause of irreve rsible blindness wo rldwide,and previous studies have shown that,in addition to affecting the eyes,it also causes abnormalities in the brain.However,it is not yet clear how the primary visual cortex(V1)is altered in glaucoma.This study used DBA/2J mice as a model for spontaneous secondary glaucoma.The aim of the study was to compare the electrophysiological and histomorphological chara cteristics of neurons in the V1between 9-month-old DBA/2J mice and age-matched C57BL/6J mice.We conducted single-unit recordings in the V1 of light-anesthetized mice to measure the visually induced responses,including single-unit spiking and gamma band oscillations.The morphology of layerⅡ/Ⅲneurons was determined by neuronal nuclear antigen staining and Nissl staining of brain tissue sections.Eighty-seven neurons from eight DBA/2J mice and eighty-one neurons from eight C57BL/6J mice were examined.Compared with the C57BL/6J group,V1 neurons in the DBA/2J group exhibited weaker visual tuning and impaired spatial summation.Moreove r,fewer neuro ns were observed in the V1 of DBA/2J mice compared with C57BL/6J mice.These findings suggest that DBA/2J mice have fewer neurons in the VI compared with C57BL/6J mice,and that these neurons have impaired visual tuning.Our findings provide a better understanding of the pathological changes that occur in V1 neuron function and morphology in the DBA/2J mouse model.This study might offer some innovative perspectives regarding the treatment of glaucoma.
文摘The Z curve is a very useful method for visual-izing and analyzing DNA sequences. It is a three-dimensional space curve that constitutes a unique representation of a given DNA se-quence. It becomes more and more important to study non-coding regions in the recent years. Using Z curve method, 15 disease-related ncRNAs and some snoRNAs and miRNAs sequences are selected from the NONCODE database in this paper, which relate to Alzheimer Disease. The corresponding Z curves of the studied ncRNAs, sequences have been mapped and compared. The statistical features of the Z curves are ob-tained. These features indicate that the ncRNAs sequences playing same roles in the celluar process have almost the same Z-curves. And the base content in these sequences is almost same too.
