就近年来白细胞介素6/非受体酪氨酸蛋白激酶/信号转导和转录激活因子3(interleukin-6/janus activated kinase/signal transducer and activator of transcription 3,IL-6/JAK/STAT3)信号通路在多种消化系统肿瘤中发挥的效应、中药单体...就近年来白细胞介素6/非受体酪氨酸蛋白激酶/信号转导和转录激活因子3(interleukin-6/janus activated kinase/signal transducer and activator of transcription 3,IL-6/JAK/STAT3)信号通路在多种消化系统肿瘤中发挥的效应、中药单体及其活性成分、中药复方对与IL-6/JAK/STAT3信号通路调控有关的消化系统肿瘤中的防治作用进行综述,探究中医药在延缓、阻抑甚至逆转炎-癌转化中发挥的作用,为防治肿瘤提供更有力的理论指导。展开更多
The macrophage migration inhibitory factor has been implicated in a number ofimmune and inflammatory processes. MIF presents particular opportunities for drug design anddevelopment with potential therapeutic applicati...The macrophage migration inhibitory factor has been implicated in a number ofimmune and inflammatory processes. MIF presents particular opportunities for drug design anddevelopment with potential therapeutic applications. Drug design strategies taking intoconsideration of specific stereochemical and tautomeric requirements in the interaction of MIF withsubstrates and inhibitors allow several novel structures to be designed. Our investigationssuccessfully explored the tautomeric and stereochemical aspects of new compounds of the2-phenylpyruvic acid type, both experimentally, through synthesis and structural investigations andcomputationally, through molecular mechanics and quantum mechanics calculations.展开更多
文摘就近年来白细胞介素6/非受体酪氨酸蛋白激酶/信号转导和转录激活因子3(interleukin-6/janus activated kinase/signal transducer and activator of transcription 3,IL-6/JAK/STAT3)信号通路在多种消化系统肿瘤中发挥的效应、中药单体及其活性成分、中药复方对与IL-6/JAK/STAT3信号通路调控有关的消化系统肿瘤中的防治作用进行综述,探究中医药在延缓、阻抑甚至逆转炎-癌转化中发挥的作用,为防治肿瘤提供更有力的理论指导。
文摘The macrophage migration inhibitory factor has been implicated in a number ofimmune and inflammatory processes. MIF presents particular opportunities for drug design anddevelopment with potential therapeutic applications. Drug design strategies taking intoconsideration of specific stereochemical and tautomeric requirements in the interaction of MIF withsubstrates and inhibitors allow several novel structures to be designed. Our investigationssuccessfully explored the tautomeric and stereochemical aspects of new compounds of the2-phenylpyruvic acid type, both experimentally, through synthesis and structural investigations andcomputationally, through molecular mechanics and quantum mechanics calculations.