期刊文献+
共找到869篇文章
< 1 2 44 >
每页显示 20 50 100
VAV家族在膀胱尿路上皮癌中的表达及其与预后的关系
1
作者 黄翔 蔡宏佳 张能 《现代医药卫生》 2024年第1期10-13,19,共5页
目的研究VAV家族(VAV1、VAV2、VAV3)在膀胱尿路上皮癌中的表达情况,分析VAV1、VAV2、VAV3与膀胱尿路上皮癌患者预后的关系。方法通过TCGA数据库下载膀胱尿路上皮癌及正常膀胱尿路上皮组织的数据,使用R语言提取数据后进行分析,获取VAV1、... 目的研究VAV家族(VAV1、VAV2、VAV3)在膀胱尿路上皮癌中的表达情况,分析VAV1、VAV2、VAV3与膀胱尿路上皮癌患者预后的关系。方法通过TCGA数据库下载膀胱尿路上皮癌及正常膀胱尿路上皮组织的数据,使用R语言提取数据后进行分析,获取VAV1、VAV2、VAV3在膀胱尿路上皮癌及正常膀胱尿路上皮组织中的表达情况,以及根据患者结局绘制生存曲线图。进一步对在膀胱尿路上皮癌组织中进行免疫组织化学验证。结果VAV1在膀胱尿路上皮癌组织及正常膀胱尿路上皮组织中表达比较,差异无统计学意义(P>0.05),VAV2、VAV3在膀胱尿路上皮癌组织中表达高于正常膀胱尿路上皮组织,差异有统计学意义(P<0.05),与膀胱的分化程度无明显相关性(P>0.05)。VAV1、VAV2的表达与患者生存时间无明显相关性(P>0.05),VAV3表达越高,患者生存时间越短(P<0.0001)。结论VAV2、VAV3可能参与膀胱尿路上皮癌的变化进展,VAV3可能与患者不良预后有关。 展开更多
关键词 膀胱尿路上皮癌 vav1 vav2 vav3 预后
下载PDF
Vav^(Cre)介导的荧光报告系统对小鼠小胶质细胞的标记效率
2
作者 李冰冰 李佳倬 +2 位作者 朱盼盼 王一婷 谢华锋 《郑州大学学报(医学版)》 CAS 北大核心 2024年第4期450-454,共5页
目的:探讨Vav^(Cre)介导的荧光报告系统对小胶质细胞的标记效率。方法:将Vav^(Cre)/Rosa26REYFP fl/fl雄鼠与C57BL/6雌鼠杂交获得Vav^(Cre)/Rosa26REYFP^(fl/-)和Rosa26REYFP^(fl/-)子代。以发现雌鼠阴道栓的时间标记为E0.5,流式细胞术... 目的:探讨Vav^(Cre)介导的荧光报告系统对小胶质细胞的标记效率。方法:将Vav^(Cre)/Rosa26REYFP fl/fl雄鼠与C57BL/6雌鼠杂交获得Vav^(Cre)/Rosa26REYFP^(fl/-)和Rosa26REYFP^(fl/-)子代。以发现雌鼠阴道栓的时间标记为E0.5,流式细胞术检测EYFP在E7.5~E8.25、E10~E10.5、E12~E12.5、E14~E14.5小鼠胚胎和新生小鼠小胶质细胞中的表达。结果:Vav^(Cre)/Rosa26REYFP^(fl/-)组E10~E10.5、E12~E12.5、E14~E14.5胚胎和新生小鼠小胶质细胞中EYFP阳性率高于Rosa26REYFP^(fl/-)组(P<0.001),且均>95.000%。Vav^(Cre)/Rosa26REYFP^(fl/-)E7.5~E8.25小鼠胚胎中EYFP阳性率为(0.059±0.009)%。结论:以Vav^(Cre)介导的荧光报告系统可以稳定、高效地标记小鼠小胶质细胞,可以用于动态监测小胶质细胞的发育。 展开更多
关键词 小胶质细胞 vav^(Cre) Rosa26REYFP 小鼠
下载PDF
VAV变风量空调系统施工技术
3
作者 钱玉龙 《广东土木与建筑》 2024年第6期106-107,111,共3页
以某工程为例,对VAV变风量空调系统施工技术进行研究,通过采用BIM技术对风管的形状、构造及布置进行深化设计,优化了系统布置,降低了能耗;采用DDC数字控制的变风量空调系统,实现与计算机联网一体化智能控制,通过VAV末端,实施对空调房间... 以某工程为例,对VAV变风量空调系统施工技术进行研究,通过采用BIM技术对风管的形状、构造及布置进行深化设计,优化了系统布置,降低了能耗;采用DDC数字控制的变风量空调系统,实现与计算机联网一体化智能控制,通过VAV末端,实施对空调房间的智能控制,消除了送风温度的变化对室内温度的影响,达到节能的目的。 展开更多
关键词 vav变风量空调系统 避免冷凝水滴漏和污染吊顶 DDC数字控制 楼宇智能化 状态反馈系统解耦 系统消音优化
下载PDF
深圳中信金融中心VAV空调系统的研究与应用
4
作者 王丙亮 李世鲲 +2 位作者 陈铭 乔哲明 陈咏华 《安装》 2024年第5期19-21,共3页
近年来,VAV空调系统在越来越多的项目中得到应用。本文对深圳中信金融中心项目的VAV空调系统进行研究,分析了VAV系统的工作原理、控制方法、设备选型和系统调试等要点,可提高空调的舒适性和节能效果,为类似项目提供参考。
关键词 vav空调系统 变风量末端 系统调试
下载PDF
Entropy Assessment on Environmental Influence of Condense Heat in Recovery System in Air-Conditioning Refrigerating Machine 被引量:2
5
作者 TANG Wen-wu1,2,WANG Han-qing1,2(1.School of Energy Science and Engineering,Central South University,Changsha,Hunan 410083,China 2.School of Civil Engineering,Hunan University of Technology,Zhuzhou,Hunan 412008,China) 《湖南大学学报(自然科学版)》 EI CAS CSCD 北大核心 2009年第S1期96-101,共6页
This paper presented an entropy evaluation method for the influences of condense heat recovery system on the environment.Aiming at the damage of the condense heat to the environment,an entropy of resource loss and an ... This paper presented an entropy evaluation method for the influences of condense heat recovery system on the environment.Aiming at the damage of the condense heat to the environment,an entropy of resource loss and an emission entropy from the condense heat recovery system in the air conditioning refrigerating machine were introduced.For the evaluation of the entropies,we developed a new algorithm for the parameter identification,called the composite influence coefficient,based on the Least Squares Support Vector Machine method.By simulation,the numerical experiments shows that the Least Squares Support Vector Machine method is one of the powerful methods for the parameter identification to compute the damage entropy of the condense heat,with the largest training error being-0.025(the relative error being-3.56%),and the biggest test error being 0.015(the relative error being 2.5%). 展开更多
关键词 air-conditioning refrigerating MACHINE condense HEAT ENTROPY evaluation LS-SVM
下载PDF
Impact of summer office set air-conditioning temperature on energy consumption and thermal comfort 被引量:3
6
作者 刘红 马小磊 高亚峰 《Journal of Central South University》 SCIE EI CAS 2009年第S1期6-11,共6页
To explore the relationship between summer office set air-conditioning temperature and energy consumption related to air conditioning use to provide human thermal comfort,a comparison experiment was conducted in three... To explore the relationship between summer office set air-conditioning temperature and energy consumption related to air conditioning use to provide human thermal comfort,a comparison experiment was conducted in three similar offices at temperatures of 24,26 and 28 ℃ respectively. A thermal comfort questionnaire survey was conducted. It is demonstrated that air-conditioner energy consumption at the set temperature of 28 ℃ is 113% and 271% lower than at 26 ℃ and 24 ℃,respectively. A linear relationship exists between air-conditioner energy consumption and the indoor and outdoor temperature difference. When comfortably dressed,over 80% of research participants accept the set temperature of 28 ℃. The regression analysis leads to a neutral temperature of 26.2 ℃ and an acceptable temperature of 28.2 ℃ for over 80% of the research participants subjects,indicating that the current 26 ℃ set temperature for offices in summer,required by Chinese General Office of the State Council,can be increased to 28 ℃. Moreover,analysis of predicted mean vote(PMV) index shows that a set temperature of 27 ℃,not 26 ℃,is sufficiently comfortable for office staff wearing long-sleeve shirts,long pants and leather shoes. 展开更多
关键词 air-conditioning TEMPERATURE thermal COMFORT air-conditIONER energy consumption NEUTRAL TEMPERATURE acceptable TEMPERATURE
下载PDF
Selection of Weather Parameters for Air-Conditioning System Design for Buildings with Long Thermal Lag 被引量:1
7
作者 GE Lian-feng1,2,LEI Ming3,CHEN You-ming1,2(1.College of Civil Engineering,Hunan University,Changsha,Hunan 410082,China 2.Key Laboratory of Building Safety and Energy Efficiency,MOE,China (3.Aviation Theory Department,Aviation University of Air Force,Changchun,Jilin 130022,China) 《湖南大学学报(自然科学版)》 EI CAS CSCD 北大核心 2009年第S1期79-82,共4页
Two building factors-a longer thermal lag of more than one hour for building envelops and a lag of indoor radiation to convert into cooling load-have impact on the instantaneous heat input and instantaneous cooling lo... Two building factors-a longer thermal lag of more than one hour for building envelops and a lag of indoor radiation to convert into cooling load-have impact on the instantaneous heat input and instantaneous cooling load.So the two factors should be taken into account when selecting the weather parameters for air-conditioning system design.This paper developed a new statistic method for the rational selection of coincident solar irradiance,dry-bulb and wet-bulb temperatures.The method was applied to historic weather records of 25 years in Hong Kong to generate coincident design weather data.And the results show that traditional design solar irradiance,dry-bulb and wet-bulb temperatures may be significantly overestimated in many conditions,and the design weather data for the three different constructions is not kept constant. 展开更多
关键词 building construction THERMAL LAG system capacity design WEATHER data air-conditioning
下载PDF
The Experiment and Simulation of Solid Desiccant Dehumidification for Air-Conditioning System in a Tropical Humid Climate 被引量:1
8
作者 Juntakan Taweekun Visit Akvanich 《Engineering(科研)》 2013年第1期146-153,共8页
The aim of this research was to study and design a solid desiccant dehumidification system suitable for tropical climate to reduce the latent load of air-conditioning system and improve the thermal comfort. Different ... The aim of this research was to study and design a solid desiccant dehumidification system suitable for tropical climate to reduce the latent load of air-conditioning system and improve the thermal comfort. Different dehumidifiers such as desiccant column and desiccant wheel were investigated. The ANSYS and TRASYS software were used to predict the results of dehumidifiers and the desiccant cooling systems, respectively. The desiccant bed contained approximately 15 kg of silica-gel, with 3 mm average diameter. Results indicated that the pressure drop and the adsorption rate of desiccant column are usually higher than those of the desiccant wheel. The feasible and practical adsorption rate of desiccant wheel was 0.102 kgw/h at air flow rate 1.0 kg/min, regenerated air temperature of 55?C and at a wheel speed of 2.5 rpm. The humidity ratio of conditioning space and cooling load of split-type air conditioner was decreased to 0.002 kgw/kgda (14%) and 0.71 kWth (19.26%), respectively. Consequently, the thermal comfort was improved from 0.5 PMV (10.12% PPD) to 0.3 PMV (7.04% PPD). 展开更多
关键词 SOLID DESICCANT DEHUMIDIFICATION air-conditioning System TROPICAL Humid CLIMATE
下载PDF
An Energy-Saving Control Strategy on Central Air-Conditioning System 被引量:1
9
作者 Sheng Xing 1 , Yin Juan 2 , Shang Jingfu 3 , Yu Yang 4 , Wu Zhangxian 5 1. State Grid Information & Telecommunication Co., Ltd. 2. China Huadian Finance Corporation Limited 3. State Grid AC Engineering Construction Company 4. Northeast China Electric Power Dispatching & Communication Center 5. North China Electric Power University 《Electricity》 2011年第4期62-66,共5页
An energy-saving control strategy based on predictive control for central air-conditioning systems is proposed in this paper. The cold load model is developed to describe the dynamic characteristics of temperature con... An energy-saving control strategy based on predictive control for central air-conditioning systems is proposed in this paper. The cold load model is developed to describe the dynamic characteristics of temperature control systems, and then parameters in the cold load model and in the central air-conditioning system model are estimated. Generalized predictive control (GPC) is used to establish an optimization model to minimize the consumption of energy and the control error of temperature. The simulated annealing (SA) algorithm, combined with quadratic programming, is adopted to solve the optimal problem. Contrasted with the simulation of traditional PID control, the results prove the effectiveness of this proposed strategy. 展开更多
关键词 central air-conditioning predictive control energy saving time-delay system simulated annealing
下载PDF
血管结构异常的先天性心脏病患儿中Vav2基因突变的筛查和功能分析 被引量:1
10
作者 陈颖慧 冯奕源 +3 位作者 冯炜琦 吴逸卓 鲁亚南 于昱 《心血管病学进展》 CAS 2023年第8期757-763,共7页
目的通过全外显子组测序筛查血管结构异常类先天性心脏病(CHD)致病候选基因Vav2的新发突变c.701C>T:p.P234L,探究Vav2及其新发罕见突变对内皮细胞功能的影响,探索CHD发生的可能分子机制。方法分析117例血管结构异常类CHD患儿及200例... 目的通过全外显子组测序筛查血管结构异常类先天性心脏病(CHD)致病候选基因Vav2的新发突变c.701C>T:p.P234L,探究Vav2及其新发罕见突变对内皮细胞功能的影响,探索CHD发生的可能分子机制。方法分析117例血管结构异常类CHD患儿及200例正常儿童的外周血全外显子组测序数据筛查Vav2突变。构建Vav2野生型及突变型表达质粒,转染人脐静脉内皮细胞(HUVEC),通过qRT-PCR和Western blot检测Vav2、下游Rac1 mRNA和蛋白的表达水平;通过CCK-8、划痕试验和成管实验检测Vav2及突变对HUVEC增殖、迁移和成管能力的影响。结果在血管结构异常类CHD患儿中发现的Vav2罕见突变c.701C>T:p.P234L,在对照组中未出现且从未被报道。与野生型对比,P234L突变能降低Vav2蛋白表达,CCK-8、划痕试验和成管实验发现该突变影响Vav2促进HUVEC增殖、迁移和成管等血管生成相关的功能,但该突变不影响下游Rac1本底mRNA和蛋白表达。结论Vav2的错义突变影响Vav2蛋白表达,进而损害Vav2在HUVEC中促进增殖、迁移和成管等血管生成相关的功能,可能是影响下游Rac1激活而非本底表达导致的。Vav2是血管发育过程的关键分子,可能参与调控血管结构异常类CHD发生,P234L突变导致Vav2功能受损,进一步提供了Vav2在血管结构异常类CHD中可能的致病分子机制。 展开更多
关键词 血管发育 血管结构异常 先天性心脏病 vav2 错义突变 人脐静脉内皮细胞
下载PDF
VAVs基因家族在肝癌中的表达及临床意义
11
作者 蔡慧欣 项思博 杨文军 《肝胆胰外科杂志》 CAS 2023年第6期366-373,共8页
目的探究VAVs家族基因在肝细胞癌(HCC)患者中的表达水平及其在预后中的临床价值,并基于阳性作用基因建立肝癌的预后预测模型。方法从肿瘤基因组图谱(TCGA)数据库中下载并提取342例HCC癌组织和50例癌旁组织中VAVs家族基因mRNA测序表达数... 目的探究VAVs家族基因在肝细胞癌(HCC)患者中的表达水平及其在预后中的临床价值,并基于阳性作用基因建立肝癌的预后预测模型。方法从肿瘤基因组图谱(TCGA)数据库中下载并提取342例HCC癌组织和50例癌旁组织中VAVs家族基因mRNA测序表达数据及其临床信息。比较TCGA中VAVs mRNA在HCC癌组织和癌旁组织中的表达差异,并比较温州医科大学附属第一医院20例HCC患者的癌组织及癌旁组织中VAVs蛋白的表达差异。根据VAVs mRNA表达量中位值分为高表达组(n=171)和低表达组(n=171),比较两组的临床病理特征差异,采用Kaplan-Meier法分析比较两组的生存差异。采用单因素和多因素Cox分析筛选HCC患者预后的危险因素。基于VAV2 mRNA构建HCC生存预后列线图模型,采用受试者工作特征(ROC)曲线及校正曲线来评估模型的预测准确性。结果对TCGA数据库分析显示,VAV2 mRNA在HCC癌组织中的表达量高于癌旁组织(P<0.05);本中心免疫组化结果表明,VAV2蛋白在HCC癌组织中的表达量高于癌旁组织(P<0.05)。TCGA数据库分析结果显示,VAV2 mRNA表达水平与HCC患者的性别、肝癌临床分期显著相关(P<0.05),在女性、肝癌临床分期中的Ⅲ期、T分期中的T3期的患者中表达上调(P<0.05)。VAV2 mRNA高表达组的生存时间显著短于VAV2低表达组(P<0.05)。Cox分析显示,VAV2 mRNA表达水平(HR=1.031,95%CI 1.009-1.054,P<0.05)和肝癌临床分期(HR=1.626,95%CI 1.083-2.442,P<0.05)是HCC患者预后的独立危险因素。基于VAV2 mRNA和肝癌临床分期建立的HCC患者生存预后列线图,C指数为0.731。患者1、2、3年ROC曲线下面积(AUC)分别为0.772、0.683、0.650,校准曲线图表明第1年实际观测值与预测值具有较好的一致性。结论VAV2 mRNA的高表达与HCC患者疾病发展及不良预后相关。基于VAV2和肝癌临床分期建立的列线图具有一定的区分度和准确度。 展开更多
关键词 肝癌 vavs家族基因 肿瘤基因组图谱(TCGA) 预后模型 vav2 临床分期
下载PDF
电针对佐剂性关节炎大鼠膝关节滑膜VEGF/Vav2/Rac1信号通路的影响 被引量:1
12
作者 孙晓莹 龙轶映 +6 位作者 赵凌云 吴庆泽 瞿启睿 祁芳 刘梨 艾坤 张亮 《湖南中医药大学学报》 CAS 2023年第10期1830-1837,共8页
目的观察电针对佐剂性关节炎(adjuvant arthritis,AA)大鼠膝关节滑膜组织内血管内皮生长因子(vascular endothelial growth factor,VEGF)、鸟嘌呤核苷酸交换因子2(vav guanine nucleotide exchange factor 2,Vav2)和Ras相关C3肉毒素底物... 目的观察电针对佐剂性关节炎(adjuvant arthritis,AA)大鼠膝关节滑膜组织内血管内皮生长因子(vascular endothelial growth factor,VEGF)、鸟嘌呤核苷酸交换因子2(vav guanine nucleotide exchange factor 2,Vav2)和Ras相关C3肉毒素底物1(Ras-related C3 botulinum toxin substrate 1,Rac1)表达的影响,探究电针干预类风湿关节炎(rheumatoid arthritis,RA)血管新生的可能机制。方法将40只SPF级SD雄性大鼠随机分成4组(空白组、模型组、西药组和电针组),每组10只。除空白组,其他3组采用尾根部皮下注射完全弗氏佐剂制成AA大鼠模型。造模后第2天开始干预,电针组进行电针干预,以左侧足三里与关元穴配穴,右侧足三里与同侧阿是穴配穴,每次20 min,每天干预1次,共干预21次;西药组给予甲氨蝶呤灌胃给药,每周1次,共干预3次。观察各组体质量、关节红肿等一般情况,每3天测量1次大鼠后双侧足跖容积。干预结束后,通过大鼠一般情况、体质量、足跖容积分析各组大鼠足跖肿胀程度,HE染色观察AA大鼠膝关节滑膜组织的病理形态学,免疫组织化学法检测膝关节滑膜组织内CD31表达变化,Western blot法检测大鼠膝关节滑膜组织VEGF、Vav2和Rac1蛋白表达量。结果与空白组相比,模型组大鼠第21天足跖容积均明显增大(P<0.01),膝关节滑膜组织出现显著性病理改变,CD31表达量明显升高(P<0.05),VEGF、Vav2、Rac1蛋白表达量显著升高(P<0.01)。与模型组相比,西药组足跖容积在第21天显著减小(P<0.01),膝关节滑膜组织病理改变明显改善,VEGF、Vav2表达量明显下降(P<0.05),Rac1蛋白表达量显著下降(P<0.01);电针组足跖容积在第21天显著减小(P<0.01),膝关节滑膜组织病理改变明显改善,VEGF、Rac1表达量明显下降(P<0.05),Vav2蛋白表达量显著下降(P<0.01)。结论电针改善RA的作用机制可能与抑制VEGF/Vav2/Rac1信号通路,进而抑制血管新生有关。 展开更多
关键词 佐剂性关节炎 电针 血管内皮生长因子 鸟嘌呤核苷酸交换因子2 Ras相关C3肉毒素底物1 血管新生
下载PDF
Application of Fuzzy Comprehensive Evaluation to Air-conditioning Competitive Power Analysis
13
作者 LU Congda LIU Gaojin JIANG Shaofei LV Chaoqun (The MOE Key Laboratory of Mechanical Manufacture and Automation,Zhejiang University of Technology,Hangzhou 310032,China 《武汉理工大学学报》 CAS CSCD 北大核心 2006年第S2期463-467,共5页
As the conceptual design of air-conditioning is done using the theory of Quality Function Deployment (QFD),cus- tomer requirements should be understood and the product competitive power be analyzed as exactly as possi... As the conceptual design of air-conditioning is done using the theory of Quality Function Deployment (QFD),cus- tomer requirements should be understood and the product competitive power be analyzed as exactly as possible for new product de- signing.Lots of information in the process of this research is fuzzy and uncertain,but traditional QFD can not deal with it well. Fuzzy theory can solve the problem.So a fuzzy model for analyzing product competitive power is formulated in this paper to im- prove traditional QFD,after that it is applied to analyze air-conditioning competitive power.When air-conditioning competitive power is analyzed using this model,firstly the importance weight of the customer requirements o fair-conditioning is determined us- ing the Analytic Hierarchy Process (AHP) weighting process,then air-conditloning competitive power is evaluated using fuzzy comprehensive evaluation.It is proved that the model is feasible and has good applicability. 展开更多
关键词 air-conditioning COMPETITIVE power QFD AHP FUZZY COMPREHENSIVE evaluation
下载PDF
Application of Dual Throttling Air-Conditioning System to Explosion-Proof Frequency Converter
14
作者 张于峰 高岩 盛颖 《Transactions of Tianjin University》 EI CAS 2015年第2期95-103,共9页
An explosion-proof dual throttling air-conditioning system was put forward to solve the heat dissipation and internal dewing problems of explosion-proof frequency converter in the underground coal mine. This study inv... An explosion-proof dual throttling air-conditioning system was put forward to solve the heat dissipation and internal dewing problems of explosion-proof frequency converter in the underground coal mine. This study investigated the feasibility and benefits of explosion-proof dual throttling cooling and dehumidification air-conditioning system applied to the explosion-proof frequency converter. The physical model of dual throttling air-conditioning system was established and its performance parameter was described by mathematical method. The design calculation of the system has also been done. The experimental result showed that the system reached the steady state at the refrigeration mode after running 45 min, and the maximum internal temperature of the flame-proof cavity was 31.0 ℃. The system reached the steady state at the dehumidification mode after running 37 min. The maximum internal relative humidity and temperature of the flame-proof cavity were 33.4% and 36.3 ℃, respectively. Therefore, the proposed system had excellent ability of heat dissipation and avoided internal dewing. Compared with water cooling system, it was more energy-saving and economical. The airflow field of dual throttling air-conditioning system was also studied by CFD simulation. It was found that the result of CFD numerical simulation was highly consistent with the experimental data. 展开更多
关键词 EXPLOSION-PROOF CONVERTER DUAL throttling air-conditioning CFD energy SAVING heat DISSIPATION dewing
下载PDF
Simulation of Artificial Intelligence for Automotive Air-conditioning System
15
作者 袁晓梅 陈佑华 陈芝久 《Journal of Donghua University(English Edition)》 EI CAS 2002年第1期40-43,共4页
The artificial intelligence is applied to the simulation of the automotive air-conditioning system ( AACS )According to the system's characteristics a model of AACS, based on neural network, is developed. Differen... The artificial intelligence is applied to the simulation of the automotive air-conditioning system ( AACS )According to the system's characteristics a model of AACS, based on neural network, is developed. Different control methods of AACS are discussed through simulation based on this model. The result shows that the neural- fuzzy control is the best one compared with the on-off control and conventional fuzzy control method.It can make the compartment's temperature descend rapidly to the designed temperature and the fluctuation is small. 展开更多
关键词 NEURAL network AUTOMOTIVE air-conditioning system(AACS) Simulation Modeling.
下载PDF
Vav1 promotes inflammation and neuronal apoptosis in cerebral ischemia/reperfusion injury by upregulating microglial and NLRP3 inflammasome activation 被引量:3
16
作者 Jing Qiu Jun Guo +3 位作者 Liang Liu Xin Liu Xianhui Sun Huisheng Chen 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第11期2436-2442,共7页
Microglia,which are the resident macrophages of the central nervous system,are an important part of the inflammatory response that occurs after cerebral ischemia.Vav guanine nucleotide exchange factor 1(Vav1) is a gua... Microglia,which are the resident macrophages of the central nervous system,are an important part of the inflammatory response that occurs after cerebral ischemia.Vav guanine nucleotide exchange factor 1(Vav1) is a guanine nucleotide exchange factor that is related to microglial activation.However,how Vav1 participates in the inflammato ry response after cerebral ischemia/reperfusion inj ury remains unclea r.In this study,we subjected rats to occlusion and repe rfusion of the middle cerebral artery and subjected the BV-2 mic roglia cell line to oxygen-glucose deprivatio n/reoxygenation to mimic cerebral ischemia/repe rfusion in vivo and in vitro,respectively.We found that Vav1 levels were increased in the brain tissue of rats subjected to occlusion and reperfusion of the middle cerebral arte ry and in BV-2 cells subjected to oxygen-glucose deprivation/reoxygenation.Silencing Vav1 reduced the cerebral infarct volume and brain water content,inhibited neuronal loss and apoptosis in the ischemic penumbra,and im p roved neurological function in rats subjected to occlusion and repe rfusion of the middle cerebral artery.Further analysis showed that Vav1 was almost exclusively localized to microglia and that Vav1 downregulation inhibited microglial activation and the NOD-like receptor pyrin 3(NLRP3) inflammasome in the ischemic penumbra,as well as the expression of inflammato ry facto rs.In addition,Vov1 knoc kdown decreased the inflammatory response exhibited by BV-2 cells after oxygen-glucose deprivation/reoxyge nation.Taken together,these findings show that silencing Vav1 attenuates inflammation and neuronal apoptosis in rats subjected to cerebral ischemia/repe rfusion through inhibiting the activation of mic roglia and NLRP3 inflammasome. 展开更多
关键词 apoptosis cerebral ischemia/reperfusion inflammatory cytokines microglia microglial activation middle cerebral artery occlusion neuroprotection NLRP3 inflammasome oxygen-glucose deprivation/reoxygenation vav1
下载PDF
Research on the Arrangement of Dew Point Temperature Detectors of Capillary Plane Radiation Air-Conditioning
17
作者 Xuelai Liu Jie Wu 《Journal of Power and Energy Engineering》 2014年第4期76-81,共6页
Based on analysis of the reason and process of condensation on ceiling radiant cooling panels, two kinds of arrangement of detectors are put forward. The physical model is established, the results show that detectors ... Based on analysis of the reason and process of condensation on ceiling radiant cooling panels, two kinds of arrangement of detectors are put forward. The physical model is established, the results show that detectors are arranged as the form of triangle is more suitable. It can not only satisfy the use requirement but also it is economical and practical. Finally we can conclude that the inlet water temperature 0.5&deg;C higher than dew point temperature is safe and reliable. 展开更多
关键词 CAPILLARY PLANE RADIATION air-conditioning DEW POINT Temperature Detectors Arrangement
下载PDF
Analysis of Solar Direct-Driven Organic Rankine Cycle Powered Vapor Compression Cooling System Combined with Electric Motor for Office Building Air-Conditioning
18
作者 Xiang Xiao Wei Zhao +4 位作者 Wei Wang Wei Zhang Xianbiao Bu Lingbao Wang Huashan Li 《Energy Engineering》 EI 2021年第1期89-101,共13页
Solar energy powered organic Rankine cycle vapor compression cycle(ORC-VCC)is a good alternative to convert solar heat into a cooling effect.In this study,an ORC-VCC system driven by solar energy combined with electri... Solar energy powered organic Rankine cycle vapor compression cycle(ORC-VCC)is a good alternative to convert solar heat into a cooling effect.In this study,an ORC-VCC system driven by solar energy combined with electric motor is proposed to ensure smooth operation under the conditions that solar radiation is unstable and discontinuous,and an office building located in Guangzhou,China is selected as a case study.The results show that beam solar radiation and generation temperature have considerable effects on the system performance.There is an optimal generation temperature at which the system achieves optimum performance.Also,as a key indicator,the cooling power per square meter collector should be considered in the hybrid solar cooling system in design process.Compared to the vapor compression cooling system,the hybrid cooling system can save almost 68.23%of electricity consumption. 展开更多
关键词 Solar cooling organic Rankine cycle vapor compression cycle hybrid solar cooling system office building air-conditioning
下载PDF
Analysis of Fresh Air Volume of Air-conditioning System for Railway Vehicles
19
作者 PU Dong GAO Fei 《International Journal of Plant Engineering and Management》 2018年第3期172-178,共7页
The relevant standard requirements both in domestic and abroad provide the basis for designing air-conditioning system of railway vehicles present. However, there are great differences in the fresh air volume indicato... The relevant standard requirements both in domestic and abroad provide the basis for designing air-conditioning system of railway vehicles present. However, there are great differences in the fresh air volume indicators among different standards requirements, and the requirements of each vehicle procurement contracts are also different. The design of air-conditioning become difficult above these. In this paper, the fresh air volume of different type railway vehicles is analyzed from health and equipment electricity consumption according to the railway vehicles air-conditioning system standard requirements in domestic and abroad. Some advises for designing air-conditioning system of railway vehicles through the fresh air volume calculation and comparison for domestic air-conditioning system of railway vehicles was provided. 展开更多
关键词 railway vehicle air-conditioning system fresh air volume
下载PDF
上海某综合体项目冷热源及VAV系统设计应用
20
作者 姜秀鹏 《建筑节能(中英文)》 CAS 2023年第5期73-78,102,共7页
基于上海市一个已经完成的综合体项目,对冷热源部分免费冷却系统、办公区域变风量VAV系统进行了性能比较及计算分析,并从节能、控制策略角度对过渡季及冬季,利用冷水机组所配置冷却塔对循环水进行散热,通过板式换热器所产生的冷水进行... 基于上海市一个已经完成的综合体项目,对冷热源部分免费冷却系统、办公区域变风量VAV系统进行了性能比较及计算分析,并从节能、控制策略角度对过渡季及冬季,利用冷水机组所配置冷却塔对循环水进行散热,通过板式换热器所产生的冷水进行自然冷却、新风冷却进行了研究。尤其对免费冷却时间段区间统计、冷却塔和板式换热器热工性能核算、末端设备实际换热量校核、变风量系统新风量计算,结合本项目进行了技术和计算理论分析。此外,本项目不足之处是在冬季冷却塔开启时,会有部分时间段冷却塔排风遇到空气产生白雾现象,对其进行了原理分析和解决技术措施探讨。根据实际项目设计要点进行详细探讨以供业内人士在综合体建筑空调采暖系统设计时参考。 展开更多
关键词 冷热源 免费冷却 间接冷却 变风量系统 热回收 再热
下载PDF
上一页 1 2 44 下一页 到第
使用帮助 返回顶部