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Versatile and controlled quantum teleportation network
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作者 周瑶瑶 梅鹏娴 +4 位作者 刘艳红 吴量 李雁翔 闫智辉 贾晓军 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第3期415-423,共9页
A quantum teleportation network involving multiple users is essential for future quantum internet.So far,controlled quantum teleportation has been demonstrated in a three-user network.However,versatile and controlled ... A quantum teleportation network involving multiple users is essential for future quantum internet.So far,controlled quantum teleportation has been demonstrated in a three-user network.However,versatile and controlled quantum teleportation network involving more users is in demand,which satisfies different combinations of users for practical requirements.Here we propose a highly versatile and controlled teleportation network that can switch among various combinations of different users.We use a single continuous-variable six-partite Greenberger-Horne-Zeilinger(GHZ)state to realize such a task by choosing the different measurement and feedback operations.The controlled teleportation network,which includes one sub-network,two sub-networks and three sub-networks,can be realized for different application of user combinations.Furthermore,the coherent feedback control(CFC)can manipulate and improve the teleportation performance.Our approach is flexible and scalable,and would provide a versatile platform for demonstrations of complex quantum communication and quantum computing protocols. 展开更多
关键词 quantum teleportation coherent feedback control versatile controlled transformation
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四川大白菜细菌性软腐病新病原菌Pectobacterium versatile的鉴定
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作者 韩帅 张河庆 +1 位作者 吴婕 席亚东 《植物保护》 CAS CSCD 北大核心 2023年第6期79-86,114,共9页
为明确引起四川理县大白菜软腐病的病原菌种类,从理县梭罗沟村田间采集具有典型软腐症状的大白菜病样,采用组织分离、致病力测定、生理生化分析、形态学和分子生物学方法进行鉴定。结果表明,分离获得的5株细菌在NA培养基上形成的菌落呈... 为明确引起四川理县大白菜软腐病的病原菌种类,从理县梭罗沟村田间采集具有典型软腐症状的大白菜病样,采用组织分离、致病力测定、生理生化分析、形态学和分子生物学方法进行鉴定。结果表明,分离获得的5株细菌在NA培养基上形成的菌落呈圆形、半透明、乳白色、中心突起、边缘平滑,在半选择性培养基CVP上培养48 h后产生凹陷。5株菌均能使大白菜、胡萝卜、马铃薯和芹菜的离体组织腐烂,接种于白菜苗后叶片呈湿腐萎蔫症状。通过大白菜叶柄接种部位形成的病斑长径来比较菌株致病力强弱,各菌株的致病力有显著差异。基于看家基因pgi、rpoS、mdh、proA、mtlD和icdA(NCBI登录号为OL963562~OL963571)的多基因联合系统发育树,分离菌株与Pectobacterium versatile聚为一簇,dnaX-leuS-recA(NCBI登录号为OL963572~OL963576)的多位点序列分析(MLSA)进一步支持以上结果,且准确性更高。分离菌株的生理生化特征与P.versatile模式菌株一致,综上将其鉴定为P.versatile。这是我国首次报道P.versatile引起大白菜软腐病。 展开更多
关键词 Pectobacterium versatile 软腐病 病原鉴定 多位点序列分析
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A versatile nano-TiO_(2) decorated gel separator with derived multi-scale nanofibers towards dendrite-blocking and polysulfide-inhibiting lithium-metal batteries 被引量:3
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作者 Huijuan Zhao jing Yan +2 位作者 Nanping Deng Weimin Kang Bowen Cheng 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2021年第4期190-201,共12页
In this study,a versatile fluorine-bearing gel membrane with multi-scale nanofibers was rationally designed and synthesized via facile one-step blend electrospinning of nano-titanium dioxide(TiO_(2))particles and fluo... In this study,a versatile fluorine-bearing gel membrane with multi-scale nanofibers was rationally designed and synthesized via facile one-step blend electrospinning of nano-titanium dioxide(TiO_(2))particles and fluorinated poly-m-phenyleneisophthalamide(PMIA)polymer solution.The prepared multiscale TiO_(2)-assisted gel separator presented relatively high porosity,small aperture,giving rise to superior affinity to electrolyte and sufficient active sites to accelerate lithium ions migration.Meanwhile,the asfabricated multifunctional GPE also rendered outstanding heat-resistance and well-distributed lithiumions flux,and the mutual overlaps between the coarse fibers and the fine fibers within the multi-scale nanofiber membrane provided a strong skeleton support,which in turn laid a solid footing stone for high-security and dendrite-proof batteries.Particularly,the nano-TiO_(2) particles within PMIA membrane acted as"gatekeepers",which can not only resist the growth of lithium dendrites,but also intercept the dissolved polysulfide on cathode side.Based on these merits,the gel PMIA-based lithium cobalt(LCO)/lithium battery obtained the remarkably improved rate capability and cycle performances on account of superior ionic conductivity,steady anodic stability window and weakened polarization behavior.Meanwhile,the resultant lithium-sulfur cell also delivered the outstanding cycling stability with the aid of the greatly prevented"shuttle effect"of dissolved lithium polysulfides based on the physical trapping and chemical binding of the prepared GPE to polysulfides species.This work proved that the addition of functional inorganic nanoparticles similar with TiO_(2) in multi-scale gel PMIA membrane can enhance the lithium ions transport capability,resist the growth of lithium dendrites as well as inhibit the shuttle effect of polysulfides,which would prompt a great development for dendrite-blocking and polysulfideinhibiting lithium-metal cells. 展开更多
关键词 versatile gel polymer electrolyte Multi-scale nanofibers Thermostability Dendrite-blocking and polysulfide-inhibiting Lithium-metal batteries
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Theoretical derivation and simulation of a versatile electrostatic trap for cold polar molecules 被引量:1
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作者 李胜强 《Chinese Physics B》 SCIE EI CAS CSCD 2016年第11期222-229,共8页
We propose a versatile electrostatic trap scheme using several charged spherical electrodes and a bias electric held.We hrst give the two-ball scheme and derive the analytical solution of the electric held.In order to... We propose a versatile electrostatic trap scheme using several charged spherical electrodes and a bias electric held.We hrst give the two-ball scheme and derive the analytical solution of the electric held.In order to make a comparison,we also give the numerical solution calculated by the hnite element software(Ansoft Maxwell).Considering the loading of cold polar molecules into the trap,we give the three-ball scheme.We hrst give the analytical and numerical solutions of the distribution of the electric held.Then we simulate the dynamic process of the loading and trapping cold molecules using the classical Monte Carlo method.We analyze the influence of the velocity of the incident molecular beam and the loading time on the loading efficiency.After that,we give the temperature of the trapped cold molecules.Our study shows that the loading efficiency can reach 82%,and the corresponding temperature of the trapped molecules is about 24.6 mK.At last,we show that the single well divides into two ones by increasing the bias electric held or decreasing the voltages applied to the spherical electrodes. 展开更多
关键词 spherical polar trapped derivation electrostatic versatile trapping Maxwell Stark contour
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High Speed Versatile Reed-Solomon Decoder for Correcting Errors and Erasures
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作者 王华 范光荣 +1 位作者 王平勤 匡镜明 《Journal of Beijing Institute of Technology》 EI CAS 2008年第1期81-86,共6页
A new Chien search method for shortened Reed-Solomon (RS) code is proposed, based on this, a versatile RS decoder for correcting both errors and erasures is designed. Compared with the traditional RS decoder, the we... A new Chien search method for shortened Reed-Solomon (RS) code is proposed, based on this, a versatile RS decoder for correcting both errors and erasures is designed. Compared with the traditional RS decoder, the weighted coefficient of the Chien search method is calculated sequentially through the three pipelined stages of the decoder. And therefore, the computation of the errata locator polynomial and errata evaluator polynomial needs to be modified. The versatile RS decoder with minimum distance 21 has been synthesized in the Xilinx Virtex-Ⅱ series field programmable gate array (FPGA) xe2v1000-5 and is used by coneatenated coding system for satellite communication. Results show that the maximum data processing rate can be up to 1.3 Gbit/s. 展开更多
关键词 Reed-Solomon code Berlekamp-Massey algorithm error correction codes versatile Reed-Solomon decoder
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Cultivating Versatile Foreign Language Talents for China——Exclusive interview with Wang Zonghu,Dean of the School of Foreign Languages of Capital Normal University
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作者 Wang Lili 《China's Foreign Trade》 2019年第4期18-21,共4页
When entering the School of Foreign Languages of Capital Normal University,you can sense the strong academic and teaching atmosphere.As for talent cultivation,Wang Zonghu,Dean of the School of Foreign Languages of Cap... When entering the School of Foreign Languages of Capital Normal University,you can sense the strong academic and teaching atmosphere.As for talent cultivation,Wang Zonghu,Dean of the School of Foreign Languages of Capital Normal University has quite clear objectives:“I hope to cultivate versatile talents with profound cultural connotation,adequate knowledge of history,culture,politics,economy,military and foreign affairs,international view and patriotism.” 展开更多
关键词 INTERVIEW versatile Foreign
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Versatile Plastic Bottles Blowing Machine
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《China's Foreign Trade》 1994年第9期56-56,共1页
The versatile plastic bottle blowing machine, developed and produced by the Anhui Tongda Science and Technology Development Corp. under the Sino-foreign joint venture Guobao Group, has been exported to Britain, Icelan... The versatile plastic bottle blowing machine, developed and produced by the Anhui Tongda Science and Technology Development Corp. under the Sino-foreign joint venture Guobao Group, has been exported to Britain, Iceland, Paraguay, Thailand, Pakistan, Bangladesh and the Commonwealth of Independent States. At an 展开更多
关键词 PET versatile Plastic Bottles Blowing Machine
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Zhong Jianhua a Versatile Cultural Administrator
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作者 Sun Shuzhu 《China & The World Cultural Exchange》 2000年第5期12-13,共2页
关键词 Zhong Jianhua a versatile Cultural Administrator
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Difluoromethyl phenoxathiinium salt: A new general and versatile difluoromethylating reagent with divergent ·CF_(2)H, CF_(2)H^(+), and :CF_(2) reactivities
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作者 Yuan-Qing Gu Hong-Xin Long +2 位作者 Dan-Dan Zhang Mei-Feng Ruan Guo-Kai Liu 《Science China Chemistry》 SCIE EI CAS CSCD 2024年第3期953-962,共10页
Development of practical and versatile electrophilic difluoromethylating reagent is still a grand challenge so far due to its inherent instability or low reactivity.Herein,we report the design and synthesis of difluor... Development of practical and versatile electrophilic difluoromethylating reagent is still a grand challenge so far due to its inherent instability or low reactivity.Herein,we report the design and synthesis of difluoromethyl phenoxathiinium tetrafluoroborate(PT-CF_(2)H^(+)BF_(4)^(-)) as a novel difluoromethylating reagent,which proves to be a bench-stable,general,powerful and versatile reagent with divergent·CF_(2)H,CF_(2)H^(+),and:CF_(2) reactivities.Making use of this reagent,we demonstrated a vast array of difluoromethyl radical transfer reactions via diverse pathways involving photocatalyst-free visible-light induction,visible-light photoredox catalysis and visible-light mediation single electron transfer of EDA complex.Moreover,the green and highly effective CF_(2)H^(+) and:CF_(2) transfer reactions were also readily accomplished. 展开更多
关键词 difluoromethyl phenoxathiinium salt versatile difluoromethylating reagent difluoromethyl radical difluoromthyl cation DIFLUOROCARBENE
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Recent advances of versatile reagents as controllable building blocks in organic synthesis
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作者 Shaomin Chen Luigi Vaccaro Yanlong Gu 《Chinese Chemical Letters》 SCIE CAS CSCD 2024年第2期24-43,共20页
Diversity-oriented synthesis is a powerful and interesting synthetic tool for the rapid construction of structurally complex and privileged scaffolds from readily accessible starting materials.To date,diversity-orient... Diversity-oriented synthesis is a powerful and interesting synthetic tool for the rapid construction of structurally complex and privileged scaffolds from readily accessible starting materials.To date,diversity-oriented synthesis mostly relies on the employment of versatile reagents.Versatile reagents can be regulated as controllable and flexible building blocks for multipurpose utilizations.Over the past decade,a variety of multifunctional reagents have been developed.However,most versatile reagents usually need multi-step synthesis,thus restricting their wide application to a large extent.In terms of the practicalities and universalities,we prefer to pay more attention to the utilization of simple and practical versatile reagents with multiple reactivities,mainly including atropaldehyde acetals,aryl methyl ketones,vinylene carbonate,vinyl azides,aryldiazonium salts,rongalite,halodifluoromethyl compounds.Most importantly,these versatile reagents can also play different roles simultaneously in the same reaction,in which their different reactivities are converged into the final target products.Such strategy can not only offer more possibilities for the synthesis of several active pharmaceutical ingredients,but also minimize the occurrence of some side reactions by lessening the varieties of materials.Also,a perspective is given at the end of this review. 展开更多
关键词 versatile reagents Divergent synthesis Dual synthons Bond cleavage Tandem reactions
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Versatile memristor implemented in van der Waals CuInP_(2)S_(6) 被引量:1
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作者 Yiqun Liu Yonghuang Wu +5 位作者 Bolun Wang Hetian Chen Di Yi Kai Liu Ce-Wen Nan Jing Ma 《Nano Research》 SCIE EI CSCD 2023年第7期10191-10197,共7页
Memristors are playing an increasingly important role in developing in-memory computing.Versatile memristors which offer both volatile and non-volatile performances can be employed as both memories and selectors,displ... Memristors are playing an increasingly important role in developing in-memory computing.Versatile memristors which offer both volatile and non-volatile performances can be employed as both memories and selectors,displaying unique advantages for developing novel electronic circuits.Herein,the remarkable multifunctional memristor with switchable operating modes between volatile and non-volatile by regulating compliance currents is implemented in Ag/CIPS/Au(CIPS:CuInP_(2)S_(6))device.Diode-like volatile memristor performances with the rectification ratio of 10^(3) and an endurance of 500 switching cycles were obtained.Meanwhile,significant non-volatile memory performances with on/off ratio of 10^(3)and retention up to 10^(4)s were also developed,which enables it to be utilized as selectors and memories simultaneously.Moreover,such versatile memristor can emulate the short-term plasticity(STP)and long-term plasticity(LTP)of artificial synapse,demonstrating its advantages in neuromorphic computing applications. 展开更多
关键词 CuInP_(2)S_(6)(CIPS) versatile memristor conductive filament synaptic plasticity
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scPlant:A versatile framework for single-cell transcriptomic data analysis in plants 被引量:1
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作者 Shanni Cao Zhaohui He +7 位作者 Ruidong Chen Yuting Luo Liang-Yu Fu Xinkai Zhou Chao He Wenhao Yan Chen-Yu Zhang Dijun Chen 《Plant Communications》 SCIE CSCD 2023年第5期1-14,共14页
Single-cell transcriptomics has been fully embraced in plant biological research and is revolutionizing our understanding of plant growth,development,and responses to external stimuli.However,single-cell tran-scriptom... Single-cell transcriptomics has been fully embraced in plant biological research and is revolutionizing our understanding of plant growth,development,and responses to external stimuli.However,single-cell tran-scriptomic data analysis in plants is not trivial,given that there is currently no end-to-end solution and that integration of various bioinformatics tools involves a large number of required dependencies.Here,we pre-sent scPlant,a versatile framework for exploring plant single-cell atlases with minimuminput data provided by users.The scPlant pipeline is implemented with numerous functions for diverse analytical tasks,ranging from basic data processing to advanced demands such as cell-type annotation and deconvolution,trajec-tory inference,cross-species data integration,and cell-type-specific gene regulatory network construc-tion.In addition,a variety of visualization tools are bundled in a built-in Shiny application,enabling explo-ration of single-cell transcriptomic data on the fly. 展开更多
关键词 versatile PLANT INTEGRATION
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A multi-layer modelling approach for mining versatile ports of a global maritime transportation network
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作者 Peng Peng Christophe Claramunt +2 位作者 Shifen Cheng Yu Yang Feng Lu 《International Journal of Digital Earth》 SCIE EI 2023年第1期2129-2151,共23页
International ports play critical roles in maintaining transportation flows and sustaining the effectiveness of global maritime logistics.Although the concept of versatile ports has been introduced to represent the sp... International ports play critical roles in maintaining transportation flows and sustaining the effectiveness of global maritime logistics.Although the concept of versatile ports has been introduced to represent the specific patterns that these ports play at the regional and global levels,there is still a need for the design and development of computational approaches that support these notions.This paper introduces a flexible multi-layer network approach for an international maritime network whose interest is that it offers a flexible model that favours the identification of the different transportation flows and versatile ports.The model is complemented by a series of structural indices complemented by a new overlap measure that evaluates the specific role of a given port across various transportation trades.The whole approach is implemented and experimented with using massive AIS maritime data that supports the automatic generation of the multi-layer network,and derivation of the structural measures while maintaining a flexible view of the maritime network.The experiments applied to the global maritime transportation network identify key versatile ports and highlight significant differences at the regional and trade flow levels. 展开更多
关键词 versatile port multilayer network aggregated network maritime transportation vessel trajectory data
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Versatile Recyclable Kevlar Nanofibrous Aerogels Enabled by Destabilizing Dynamic Balance Strategy
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作者 Lishan Li Jing Lyu +2 位作者 Qingqing Cheng Chen Fu Xuetong Zhang 《Advanced Fiber Materials》 SCIE EI 2023年第3期1050-1062,共13页
Aerogels are of great interest in diverse fields including thermal insulation,environmental protection,liquid separation,electromagnetic shielding,etc.However,the development of renewable and recyclable aerogels,espec... Aerogels are of great interest in diverse fields including thermal insulation,environmental protection,liquid separation,electromagnetic shielding,etc.However,the development of renewable and recyclable aerogels,especially synthetic pol-ymer-based ones,remains an enormous challenge,which seriously hinders the practical application of aerogels.Herein,utilizing Kevlar nanofibers(KNFs)as representative synthetic polymer building blocks,a destabilizing dynamic balance(DDB)strategy is proposed to fabricate recyclable aerogels with high reprocessing consistency.More specifically,aprotic esters(e.g.,di-tert-butyl decarbonate,DiBoc)and alkalis(e.g.,potassium tert-butoxide,t-BuOK)are introduced to trigger the destabilizing dynamic balance between deprotonation–protonation of KNFs,resulting in a reversible sol–gel transition.Meanwhile,the duration of sol–gel transition(i.e.,gelation)time,adjustable from 10^(–2)to 10^(3)min,is compatible with versatile processing methods,such as static mould casting,dynamic wet spinning,dynamic blade coating and dynamic 3D printing.These unique advantages enable the fabrication of various KNF aerogel products(i.e.,continuous fibers,continuous films,large-sized monoliths and 3D-printed articles)with low density(33–165 mg/cm3),high compressive modulus(up to 52 MPa),high specific surface area(360–404 m^(2)/g)and low thermal conductivity(0.027–0.050 W/m·K).Notably,these properties are comparable or superior to that of previously reported KNF aerogels and far superior to that of recyclable aerogels.Compared with direct fabrication from raw materials,the DDB strategy reduces the cost by 50.5%and 82.5%when products are made from recycled aerogels and wet gels,respectively.Such cost reduction further increases with the number of recycling cycles,which is calculated as$275 per kilogram KNF aerogel with 5 cycles.This work develops extraordinary KNF aerogels those can be recycled and reused,as well as provides a strategy that can be applied to design more recyclable aerogels. 展开更多
关键词 AEROGEL KEVLAR RECYCLABILITY versatile processing Dynamic balance
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间充质干细胞命运的调控机制
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作者 范志朋 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2024年第6期1237-1238,共2页
Mesenchymal intricate stem cells(MSCs)represent a versatile population of multipotent progenitor cells with remarkable capacity for selfrenewal and differentiation[1].The fate commitment of MSCs is orchestrated by a c... Mesenchymal intricate stem cells(MSCs)represent a versatile population of multipotent progenitor cells with remarkable capacity for selfrenewal and differentiation[1].The fate commitment of MSCs is orchestrated by a complex interplay of intrinsic and extrinsic factors,encompassing signaling pathways,transcriptional regulators,epigenetic modifiers,and microenvironmental cues[2-5]. 展开更多
关键词 间充质干细胞 versatile PROGENITOR
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Leggings: The new fashion staple
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《China Textile》 2024年第1期54-55,共2页
Leggings have been a staple in the fashion industry for decades,consistently remaining one of the most popular and versatile items of clothing.They have achieved viral status and continue to be a highly sought-after f... Leggings have been a staple in the fashion industry for decades,consistently remaining one of the most popular and versatile items of clothing.They have achieved viral status and continue to be a highly sought-after fashion item,transcending age and cultural barriers.The body-hugging style of leggings has remained in vogue,attracting young people of all ages and backgrounds.With their enduring popularity,it’s likely that leggings will remain a fashion staple for years to come. 展开更多
关键词 FASHION versatile LIKELY
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Versatile on-chip light coupling and(de)multiplexing from arbitrary polarizations to controlled waveguide modes using an integrated dielectric metasurface 被引量:12
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作者 YUAN MENG ZHOUTIAN LIU +10 位作者 ZHENWEI XIE RIDE WANG TIANCHENG QI FUTAI HU HYUNSEOK KIM QIRONG XIAO XING FU QIANG WU SANG-HOON BAE MALI GONG XIAOCONG YUAN 《Photonics Research》 SCIE EI CSCD 2020年第4期564-576,共13页
Metasurfaces have found broad applicability in free-space optics,while its potential to tailor guided waves remains barely explored.By synergizing the Jones matrix model with generalized Snell’s law under the phase-m... Metasurfaces have found broad applicability in free-space optics,while its potential to tailor guided waves remains barely explored.By synergizing the Jones matrix model with generalized Snell’s law under the phase-matching condition,we propose a universal design strategy for versatile on-chip mode-selective coupling with polarization sensitivity,multiple working wavelengths,and high efficiency concurrently.The coupling direction,operation frequency,and excited mode type can be designed at will for arbitrary incident polarizations,outperforming previous technology that only works for specific polarizations and lacks versatile mode controllability.Here,using silicon-nanoantenna-patterned silicon-nitride photonic waveguides,we numerically demonstrate a set of chip-scale optical couplers around 1.55μm,including mode-selective directional couplers with high coupling efficiency over 57%and directivity about 23 d B.Polarization and wavelength demultiplexer scenarios are also proposed with 67%maximum efficiency and an extinction ratio of 20 d B.Moreover,a chip-integrated twisted light generator,coupling free-space linear polarization into an optical vortex carrying 1 h orbital angular momentum(OAM),is also reported to validate the mode-control flexibility.This comprehensive method may motivate compact wavelength/polarization(de)multiplexers,multifunctional mode converters,on-chip OAM generators for photonic integrated circuits,and high-speed optical telecommunications. 展开更多
关键词 versatile on-chip light arbitrary polarizations waveguide modes an integrated dielectric metasurface
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A versatile photodetector assisted by photovoltaic and bolometric effects 被引量:5
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作者 Wei Jiang Tan Zheng +14 位作者 Binmin Wu Hanxue Jiao Xudong Wang Yan Chen Xiaoyu Zhang Meng Peng Hailu Wang Tie Lin Hong Shen Jun Ge Weida Hu Xiaofeng Xu Xiangjian Meng Junhao Chu Jianlu Wang 《Light(Science & Applications)》 SCIE EI CAS CSCD 2020年第1期494-502,共9页
The advent of low-dimensional materials with peculiar structure and superb band properties provides a new canonical form for the development of photodetectors.However,the limited exploitation of basic properties makes... The advent of low-dimensional materials with peculiar structure and superb band properties provides a new canonical form for the development of photodetectors.However,the limited exploitation of basic properties makes it difficult for devices to stand out.Here,we demonstrate a hybrid heterostructure with ultrathin vanadium dioxide film and molybdenum ditelluride nanoflake.Vanadium dioxide is a classical semiconductor with a narrow bandgap,a high temperature coefficient of resistance,and phase transformation.Molybdenum ditelluride,a typical two-dimensional material,is often used to construct optoelectronic devices.The heterostructure can realize three different functional modes:(i)the p-n junction exhibits ultrasensitive detection(450 nm-2μm)with a dark current down to 0.2 pA and a response time of 17μs,(ii)the Schottky junction works stably under extreme conditions such as a high temperature of 400 K,and(iii)the bolometer shows ultrabroad spectrum detection exceeding 10μm.The flexible switching between the three modes makes the heterostructure a potential candidate for next-generation photodetectors from visible to longwave infrared radiation(LWIR).This type of photodetector combines versatile detection modes,shedding light on the hybrid application of novel and traditional materials,and is a prototype of advanced optoelectronic devices. 展开更多
关键词 RESISTANCE dioxide versatile
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Towards a versatile point-of-care systemcombining femtosecond laser generatedmicrofluidic channels and direct laserwritten microneedle arrays 被引量:4
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作者 Anika Trautmann Gian-Luca Roth +2 位作者 Benedikt Nujiqi Thomas Walther Ralf Hellmann 《Microsystems & Nanoengineering》 EI CSCD 2019年第1期606-614,共9页
Microneedle-based microfluidic systems have a great potential to become well-accepted medical devices for simple,accurate,and painless drug delivery and lab-on-a-chip diagnostics.In this work,we report on a novel hybr... Microneedle-based microfluidic systems have a great potential to become well-accepted medical devices for simple,accurate,and painless drug delivery and lab-on-a-chip diagnostics.In this work,we report on a novel hybrid approach combining femtosecond direct laser written microneedles with femtosecond laser generated microfluidic channels providing an important step towards versatile medical point-of-care systems.Hollow microneedle arrays are fabricated by a laser system designed for two-photon polymerization applications.Compression tests of two different types of truncated cone-shaped microneedle arrays prepared from OrmoComp^(■)give information about the microneedle mechanical strength,and the results are compared to skin insertion forces.Three-dimensional microchannels are directly created inside PMMA bulk material by an ultrashort pulse laser system with vertical channels having adjustable cross-sectional areas,which allow attaching of microneedles to the microfluidic system.A comprehensive parameter study varying pulse duration and repetition rate is performed on two-photon polymerization to identify an optimal laser power range for fabricating microneedles using the same pulse duration and repetition rate as for microchannels.This addresses the advantage of a single laser system process that overcomes complex fabrication methods.A proof of concept flow test with a rhodamine B dye solution in distilled water demonstrates that the combination of microneedles and microchannels qualifies for microfluidic injection and extraction applications. 展开更多
关键词 ARRAYS versatile NEEDLE
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A Versatile Surface Bioengineering Strategy Based on Mussel-Inspired and Bioclickable Peptide Mimic 被引量:4
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作者 Yu Xiao Wenxuan Wang +10 位作者 Xiaohua Tian Xing Tan Tong Yang Peng Gao Kaiqing Xiong Qiufen Tu Miao Wang Manfred FMaitz Nan Huang Guoqing Pan Zhilu Yang 《Research》 EI CAS 2020年第1期1233-1244,共12页
In this work,we present a versatile surface engineering strategy by the combination of mussel adhesive peptide mimicking and bioorthogonal click chemistry.The main idea reflected in this work derived from a novel muss... In this work,we present a versatile surface engineering strategy by the combination of mussel adhesive peptide mimicking and bioorthogonal click chemistry.The main idea reflected in this work derived from a novel mussel-inspired peptide mimic with a bioclickable azide group(i.e.,DOPA_(4)-azide).Similar to the adhesion mechanism of the mussel foot protein(i.e.,covalent/noncovalent comediated surface adhesion),the bioinspired and bioclickable peptide mimic DOPA_(4)-azide enables stable binding on a broad range of materials,such as metallic,inorganic,and organic polymer substrates.In addition to the material universality,the azide residues of DOPA_(4)-azide are also capable of a specific conjugation of dibenzylcyclooctyne-(DBCO-)modified bioactive ligands through bioorthogonal click reaction in a second step.To demonstrate the applicability of this strategy for diversified biofunctionalization,we bioorthogonally conjugated several typical bioactive molecules with DBCO functionalization on different substrates to fabricate functional surfaces which fulfil essential requirements of biomedically used implants.For instance,antibiofouling,antibacterial,and antithrombogenic properties could be easily applied to the relevant biomaterial surfaces,by grafting antifouling polymer,antibacterial peptide,and NO-generating catalyst,respectively.Overall,the novel surface bioengineering strategy has shown broad applicability for both the types of substrate materials and the expected biofunctionalities.Conceivably,the“clean”molecular modification of bioorthogonal chemistry and the universality of mussel-inspired surface adhesion may synergically provide a versatile surface bioengineering strategy for a wide range of biomedical materials. 展开更多
关键词 materials AZIDE versatile
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