VIH系统的探讨

针对高速公路监控系统 ,介绍了一种新型的高速公路———视频信息高速公路 (VIH )的构思及其技术设计 ,包括VIH网关和闭路电视 (CCTV)网关 ,数字化视频系统 (DVS)、开放式数据配送结构和VIH网络系统的建设 ,通过对国内外研究现状进行了分析 ,探讨了我国发展VIH的技术要求和建议 。

Explanatory Factors for the Variation in HIV Prevalence between Regions of Côte d’Ivoire: An Ecological Study

Introduction: No study has analyzed the reasons for the difference in HIV prevalence between Ivorian regions ranging from 1.3% in the central-western region to 4.1% in Abidjan among men. Objective: To analyze explanatory factors for the difference in HIV prevalence observed in men in Côte d’Ivoire’s regions. Methodology: Assessment of the relationship between HIV prevalence per region and risk factors explored in the 2012 Côte d’Ivoire Demographic and Health Surveys (DHS). A multivariate analysis was conducted to assess the relationship between HIV prevalence and each variable. Results: The explanatory power of the variation of HIV prevalence between regions was 98%. There was a significant association between HIV prevalence and union (r = −0.38;p = 0.008;95% CI (−0.53 to −0.23)), condom use (r = −0.01;p = 0.19;95% CI (−0.03 to −0.01)), practice of Christian religion (r = −0.1;p = 0.017;95% CI (−0.16 to −0.05)), and schooling (r = −0.01;p = 0.25;95% CI (−0.04 to 0.02)). There was a paradoxical association between HIV prevalence and mean age at first sexual intercourse (r = −0.1;p = 0.017;95% CI (−0.16 to −0.05)) and sexual infections (r = −0.48;p = 0.016;95% CI (−0.75 to −0.22)). Conclusion: The explanatory factors for the difference in HIV prevalence observed in men in the regions of the country were union, condom use, mean age at first sexual intercourse, sexual infection, sexual activity, and multiple sexual partnerships. However, only union and condom use were effective in reducing HIV prevalence by preventing new infections.

梅毒与人类免疫缺陷病毒感染

虽然梅毒是认识较多的性传播疾病(STD)之一,但仍有许多尚需学习的方面,研究证明梅毒和人类免疫缺陷病毒(HIV)感染之间有复杂的关系,说明目前对梅毒的了解还是不够的。梅毒能否促使HIV 的传播横剖面流行病学调查表明,既往有患梅毒证据者与发生HIV 感染的危险性有明显关联。在肯尼亚及扎伊尔的研究证明,梅毒血清学试验阳性或有生殖器溃疡史者,与发生HIV 感染的可能性相关;与HIV 感染的相关因素包括:嫖娼、未割包皮、出国旅行及生殖器溃疡史。HIV 感染与梅毒有类似的关联,旧金山一项前瞻性研究表明,采男性同性恋者血标本检测HIV 抗体,其中过去有梅毒治疗史者,HIV 血清阳性的危险性显著升高(机会比率3.6,95%置信区间1.9～6.2)。对去某一STD 门诊部就诊的异性恋患者用配对逻辑斯谛回归分析法评价其HIV 感染的危险因子,发现RPR 试验阳性;原先有单纯疱疹病毒Ⅱ型感染的血清学证据等,均证明与HIV 感染的危险性有明显相关。一期梅毒可引起上皮或粘膜表面的破坏。

基于生物信息学分析结直肠癌诊断标志物与治疗靶点

基于生物信息学分析结直肠癌诊断标志物与治疗靶点,选取2018年1月至2019年12月收治的结直肠癌患者300例,其中结肠癌174例,直肠癌126例。采用细针获取组织标本,进行Transwell细胞侵袭实验,采用贝伐单抗联合依立替康、甲酰四氢叶酸、氟尿嘧啶化疗。观察不同时间SW480发生EMT情况,比较结直肠癌患者TGF-Β诱导12h、24h、48h CDH1、VIH、miR-138、miR-139-5p、穿过基质胶细胞个数及临床疗效。结果显示,24h可见部分结直肠癌发生形态学变化,48h发生明显的形态学改变,72h形态改变更加明显。结肠癌、直肠癌患者12h、24h、48hCDH1、VIH基因表达比较差异无统计学意义(P>0.05)。结肠癌、直肠癌患者12h、24h、48hmiR-138、miR-139-5p表达比较差异无统计学意义(P>0.05)。结肠癌、直肠癌患者穿过基质胶细胞个数比较差异无统计学意义(P>0.05)。300例患者的临床总有效率为72.67%,完全缓解率为24.67%、部分缓解率为37.33%、病情稳定率为10.67%。结果表明,分析结直肠癌生物信息学寻找治疗靶点,有利于临床制定有效治疗方案。