介绍了VSMP(Voice Service Management Platform,语音业务管理平台)平台以及统计查询系统在该平台中的主要功能。分析了该平台中统计查询系统的现状和存在的问题,提出采用基于配置的方式和面向对象的思想对该系统进行改进,使得系统的开...介绍了VSMP(Voice Service Management Platform,语音业务管理平台)平台以及统计查询系统在该平台中的主要功能。分析了该平台中统计查询系统的现状和存在的问题,提出采用基于配置的方式和面向对象的思想对该系统进行改进,使得系统的开发更加方便、快捷,统计结果的呈现更加灵活和人性化。展开更多
Polychlorinated dibenzothiophenes（PCDTs） are a group of important persistent organic pollutants.In the present study,geometrical optimization and electrostatic potential calculations have been performed for all 135 ...Polychlorinated dibenzothiophenes（PCDTs） are a group of important persistent organic pollutants.In the present study,geometrical optimization and electrostatic potential calculations have been performed for all 135 PCDTs congeners at the B3LYP/6-31G＊ level of theory.By means of the VSMP（variable selection and modeling based on prediction） program,one optimal descriptor（molecular polarizability,α） was selected to develop a QSRR model for the prediction of gas chromatographic retention indices（GC-RI） of PCDTs.The estimated correlation coefficients（r2） and LOO-validated correlation coefficients（q2）,all more than 0.99,were built by multiple linear regression,which shows a good estimation ability and stability of the models.A prediction power for the external samples was validated by the model built from the training set with 17 polychlorinated dibenzothiophenes.展开更多
Using a novel freshwater photobacteria — Q67 as an indication organism and the VeritasTM luminometer with 96-well microplate as the testing equipment to determine luminous intensity of photobacteria,the familiar 29 s...Using a novel freshwater photobacteria — Q67 as an indication organism and the VeritasTM luminometer with 96-well microplate as the testing equipment to determine luminous intensity of photobacteria,the familiar 29 substituted benzenes of the median inhibition toxicities（pEC50）were determined,respectively.The quantum chemical parameters of 29 substituted benzenes in the ideal gas state at 298.15 K and 1.013×105 Pa have been calculated at the B3LYP/6-31G＊ level using Gaussian 03 program.The Quantitative linear relationship（N1）between the pEC50 and two descriptors of 29 substituted benzenes was developed using the variable selection and modeling based on prediction（VSMP）.Model N1 showed good estimation ability and stability（r = 0.8777,q = 0.8482）,which exhibited the difference between empirical and predicted values of 2,3-dimethylphenol was greater（0.5）,so it was given up.Using VSMP to select the optimal descriptors,a 2-variable multiple linear regression model（called model N2）was developed for the pEC50 of substituted benzenes.The r and q for model N2 based on 28 substituted benzenes are 0.8991 and 0.8735,respectively.In order to validate the model,28 substituted benzenes were divided into a training set consisting of 20 compounds and a test set with 8 compounds.The result showed that some main structural factors influencing the pEC50 of substituted benzenes are the lowest unoccupied orbital（ELUMO）and total energy（EHF）.展开更多
在72只乌拉坦麻醉,切断双侧颈迷走神经,制动和人工呼吸的家兔上,用局部给药的方法,观察到促甲状腺激素释放激素(TRH)作用于延髓腹侧面加压区(VSMp)可使血压呈具有剂量-效应关系的明显增高,这种作用主要是由局部的α_1受体介导的,似乎与...在72只乌拉坦麻醉,切断双侧颈迷走神经,制动和人工呼吸的家兔上,用局部给药的方法,观察到促甲状腺激素释放激素(TRH)作用于延髓腹侧面加压区(VSMp)可使血压呈具有剂量-效应关系的明显增高,这种作用主要是由局部的α_1受体介导的,似乎与α_2、β受体无关。在 VSMp 预先给予纳络酮,可显著增强 TRH 的升压效应。预先在延髓腹侧面减压区(VSMd)给予酚妥拉明,可使 TRH 在同侧 VSMp 的升压效应显著增强。预先在一侧孤束核区微量注射甘氨酸,可显著增强 TRH 在同侧 VSMp 的升压效应。展开更多
文摘介绍了VSMP(Voice Service Management Platform,语音业务管理平台)平台以及统计查询系统在该平台中的主要功能。分析了该平台中统计查询系统的现状和存在的问题,提出采用基于配置的方式和面向对象的思想对该系统进行改进,使得系统的开发更加方便、快捷,统计结果的呈现更加灵活和人性化。
基金Sponsored by the NSF of Guangxi Province (No. 2011XNSFA018059)Guangxi Key Laboratory Research Fund of Environmental Engineering and Protection Assessment (No. 0801Z026)+1 种基金Major Science of Water Pollution Control and Management (No. 2008ZX07317-02)the Guangxi Zhuang Autonomous Region Department of Education Research (No. 201010LX174) Funding
文摘Polychlorinated dibenzothiophenes（PCDTs） are a group of important persistent organic pollutants.In the present study,geometrical optimization and electrostatic potential calculations have been performed for all 135 PCDTs congeners at the B3LYP/6-31G＊ level of theory.By means of the VSMP（variable selection and modeling based on prediction） program,one optimal descriptor（molecular polarizability,α） was selected to develop a QSRR model for the prediction of gas chromatographic retention indices（GC-RI） of PCDTs.The estimated correlation coefficients（r2） and LOO-validated correlation coefficients（q2）,all more than 0.99,were built by multiple linear regression,which shows a good estimation ability and stability of the models.A prediction power for the external samples was validated by the model built from the training set with 17 polychlorinated dibenzothiophenes.
基金Sponsored by the Water Pollution Control and Management of Major Special Technology (2008ZX07317-02-03E)the Ministry of Education of Guangxi Zhuang Autonomous Region (200911MS108)Guangxi Key Laboratory of Environmental Engineering,Protection and Assessment (Nos.0801Z026,0801Z027)
文摘Using a novel freshwater photobacteria — Q67 as an indication organism and the VeritasTM luminometer with 96-well microplate as the testing equipment to determine luminous intensity of photobacteria,the familiar 29 substituted benzenes of the median inhibition toxicities（pEC50）were determined,respectively.The quantum chemical parameters of 29 substituted benzenes in the ideal gas state at 298.15 K and 1.013×105 Pa have been calculated at the B3LYP/6-31G＊ level using Gaussian 03 program.The Quantitative linear relationship（N1）between the pEC50 and two descriptors of 29 substituted benzenes was developed using the variable selection and modeling based on prediction（VSMP）.Model N1 showed good estimation ability and stability（r = 0.8777,q = 0.8482）,which exhibited the difference between empirical and predicted values of 2,3-dimethylphenol was greater（0.5）,so it was given up.Using VSMP to select the optimal descriptors,a 2-variable multiple linear regression model（called model N2）was developed for the pEC50 of substituted benzenes.The r and q for model N2 based on 28 substituted benzenes are 0.8991 and 0.8735,respectively.In order to validate the model,28 substituted benzenes were divided into a training set consisting of 20 compounds and a test set with 8 compounds.The result showed that some main structural factors influencing the pEC50 of substituted benzenes are the lowest unoccupied orbital（ELUMO）and total energy（EHF）.
文摘在72只乌拉坦麻醉,切断双侧颈迷走神经,制动和人工呼吸的家兔上,用局部给药的方法,观察到促甲状腺激素释放激素(TRH)作用于延髓腹侧面加压区(VSMp)可使血压呈具有剂量-效应关系的明显增高,这种作用主要是由局部的α_1受体介导的,似乎与α_2、β受体无关。在 VSMp 预先给予纳络酮,可显著增强 TRH 的升压效应。预先在延髓腹侧面减压区(VSMd)给予酚妥拉明,可使 TRH 在同侧 VSMp 的升压效应显著增强。预先在一侧孤束核区微量注射甘氨酸,可显著增强 TRH 在同侧 VSMp 的升压效应。
