Objectives To analyze the changes of vasoactive substances originated from endo- theiium in patients with unstable angina pectoris treated by modified thrombolytic therapy and explore the mech- anisms of the drug to t...Objectives To analyze the changes of vasoactive substances originated from endo- theiium in patients with unstable angina pectoris treated by modified thrombolytic therapy and explore the mech- anisms of the drug to treat unstable angina pectoris. Methods 120 patients with unstable angina pectoris who were not well responsed to common medication were studied. Their ECG stress tests were abnormal and there were ischemic changes in Holter. Urokinase 300,000 U was added in 100 ml normal saline and in- jected within 30 min once a day for 3 days. 300 mg as- pirin was administrated a day before and during uroki- nase applications. Before and after urokinase treat- ments , endothelin-1 , plasma tissue plasminogen activa- tor and its inhibitor-lwere determined. Results Compared with pretreatments, after treatments, the ac- tivities of tissue plasminogen activator increased, endo- thelin-1 and the inhibitor-1 decreased. The changes were significant. Conclusions Modified thrombolytic therapy can regulate the vasoactive substances origina- ted endotheiium in patients with unstable angina pecto- ris . The major substances include endothelin-1, plasma tissue plasminogen activator and inhibitor-1. This mechanism may suggest that urokinase can treat coro- nary heart disease effectively.展开更多
TCM holds that angina pectoris is apathogenic state induced by stagnant heart-qi,stagnancy of qi and blood, or obstruction ofthe heart orifice due to blood stasis or turbidphlegm. Based on TCM differentiation,
Over the last 20 years, it has emerged that, while surgical revascularisation of extensive ischaemic heart disease may have prognostic advantages, the main issues considered regarding individual management are usually...Over the last 20 years, it has emerged that, while surgical revascularisation of extensive ischaemic heart disease may have prognostic advantages, the main issues considered regarding individual management are usually those of symptomatic improvement only. The major impetus towards invasive intervention is therefore failure of prophylactic anti-anginal therapy. On the other hand, many patients, especially the elderly, now present the clinical problem of ongoing angina without residual invasive options. There is an ongoing need for more effective anti-anginal therapies. Of the currently available major classes of prophylactic anti-anginal agents, neither nitrates, β-blockers nor calcium antagonists generally produce marked improvements in exercise duration. Three areas of new therapeutic development in anti-anginal therapy are worthy of note. These involve the sinus node inhibitor ivabradine, high dose allopurinol (xanthine oxidase inhibitor) and a new class of “metabolic modulators” represented by perhexiline, trimetazidine and probably ranolazine. The current review addresses the therapeutic potential of these agents. Notably, all of these “new” drugs are potentially suitable for management of angina in the setting of impaired left ventricular systolic function, and they may also be utilized in patients with angina independent of the presence of coronary disease (for example in hypertrophic cardiomyopathy). The current evidence for efficacy and potential future development in this area are reviewed.展开更多
Objective： To observe the therapeutic effect and effect on plasm endothelin （ET） and nitric oxide （NO） of acupuncture in treating variant angina pectoris. Methods： Sixty-two patients with variant angina pectoris...Objective： To observe the therapeutic effect and effect on plasm endothelin （ET） and nitric oxide （NO） of acupuncture in treating variant angina pectoris. Methods： Sixty-two patients with variant angina pectoris were randomly divided into the acupuncture group of 32 cases and the control group of 30 cases. The patients in control group were treated by nitrate, Ca^2＋ antagonist and aspirin for 4 weeks. The patients in acupuncture group were treated by needling Neiguan （PC 6）, Sanyinjiao （SP 6）, Zusanli （ST 36）, Xinshu （BL 15） Taichong （LR 3） and Shenmen （HT 7） on the basis of western medicine.Results： In acupuncture group, 24 cases were markedly effective, 6 cases were effective and 2 cases got no effect. In control group, 20 cases were markedly effective, 5cases were effective and 5 cases got no effect. The therapeutic effect of acupuncture treatment was significantly prior to that of control treatment （x^2 = 95.4, P 〈 0. 05）. In acupuncture group, posttreatment plasm NO, 86.9±23.15 μmol/L, was markedly higher than pretreatment NO, 63.8±22. 07μmol/L. There was significant difference between them （t= 2.925, P〈 0.01）. In the two groups, plasm ET reduced after treatment. There was significant difference in plasm ET between posttreatment and pretreatment in the two groups （P 〈 0.01）. There was significant difference in reduced plasm ET after treatment between acupuncture group and control group （P 〈 0. 05）. Conclusion： Acupuncture in assistant treating variant angina pectoris could improve the clinical symptoms obviously and reduce the level of plasm ET and NO.展开更多
Objective： To clarify the clinical efficacy of needle-embedding therapy for stable angina pectoris. Methods： Seventy-six patients with stable angina pectoris were divided into needle-embedding therapy group （group ...Objective： To clarify the clinical efficacy of needle-embedding therapy for stable angina pectoris. Methods： Seventy-six patients with stable angina pectoris were divided into needle-embedding therapy group （group A） and basic treatment group （group B） according to the random number table, with 38 patients in each group. Needle-embedding therapy combined with basic treatment was adopted in group A, and needle-embedding was given once every other day, the needles were retained for 24 h each time and three times of treatment were given each week. basic treatment was applied solely in group B. Four weeks of treatment which means one course were given in two groups, efficacy observation and evaluation were carried out after 1 course of treatment. Results： After treatment, the total effective rate of clinical efficacy was 89.47% in group A and 71.05% in group B （p 〈 0.05）, and the total effective rate of electrocardiograph （ECG） efficacy was 84.21% in group A and 63.16% in group B （p〈0.05）. After treatment, the score of limitation of motion, score of the sta- ble state of angina pectoris and the score of angina pectoris attack in group A increased by 0.7%, 34,5% and 16.9% respectively when compared with the scores before treatment （t= 1.623, p 〈0.0l; t=3.867, p 〈 0.01 ; t = 1.958, p 〈 0.05）, and according to the comparison of the score of satisfaction with treatment and the score of disease perception before and after treatment, the difference was not statistically significant （t=4.972, p 〉 0.05; t=0.999, p 〉 0.05）. According to the comparison of the score of limitation of motion, score of angina pectoris attack, score of satisfaction with treatment and the score of disease per- ception in group B before and after treatment, the differences were not statistically significant （t = 1.726, p 〉 0.05; t = 1.594, p 〉 0.05; t = 4.385, p 〉 0.05; t = 0.999, p 〉 0.05）. The score of： the stable state of angina pectoris increased by 4.9% （t = 1.780, p 〈 0.05）. Conclusion： Needle-embedding in acupoint therapy can effectively improve the clinical efficacy, ECG efficacy and the score of Seattle angina questionnaire （SAQ） of stable angina pectoris.展开更多
To As one of the most common cardiovascular diseases,coronary heart disease has a high morbidity and mortality.In recent years,non-drug therapy has been put on equal importance with drug therapy due to its simple oper...To As one of the most common cardiovascular diseases,coronary heart disease has a high morbidity and mortality.In recent years,non-drug therapy has been put on equal importance with drug therapy due to its simple operation and fast onset.Cognitive behavioral therapy,as a kind of non-drug therapy,has been widely used to improve the physical and mental symptoms of patients with coronary heart disease.This article reviews the origin,concept,theoretical basis,characteristics,technology,and current research status of cognitive behavioral therapy in patients with coronary heart disease,in order to provide a reference for the clinical development of cognitive behavioral therapy.展开更多
文摘Objectives To analyze the changes of vasoactive substances originated from endo- theiium in patients with unstable angina pectoris treated by modified thrombolytic therapy and explore the mech- anisms of the drug to treat unstable angina pectoris. Methods 120 patients with unstable angina pectoris who were not well responsed to common medication were studied. Their ECG stress tests were abnormal and there were ischemic changes in Holter. Urokinase 300,000 U was added in 100 ml normal saline and in- jected within 30 min once a day for 3 days. 300 mg as- pirin was administrated a day before and during uroki- nase applications. Before and after urokinase treat- ments , endothelin-1 , plasma tissue plasminogen activa- tor and its inhibitor-lwere determined. Results Compared with pretreatments, after treatments, the ac- tivities of tissue plasminogen activator increased, endo- thelin-1 and the inhibitor-1 decreased. The changes were significant. Conclusions Modified thrombolytic therapy can regulate the vasoactive substances origina- ted endotheiium in patients with unstable angina pecto- ris . The major substances include endothelin-1, plasma tissue plasminogen activator and inhibitor-1. This mechanism may suggest that urokinase can treat coro- nary heart disease effectively.
文摘TCM holds that angina pectoris is apathogenic state induced by stagnant heart-qi,stagnancy of qi and blood, or obstruction ofthe heart orifice due to blood stasis or turbidphlegm. Based on TCM differentiation,
文摘Over the last 20 years, it has emerged that, while surgical revascularisation of extensive ischaemic heart disease may have prognostic advantages, the main issues considered regarding individual management are usually those of symptomatic improvement only. The major impetus towards invasive intervention is therefore failure of prophylactic anti-anginal therapy. On the other hand, many patients, especially the elderly, now present the clinical problem of ongoing angina without residual invasive options. There is an ongoing need for more effective anti-anginal therapies. Of the currently available major classes of prophylactic anti-anginal agents, neither nitrates, β-blockers nor calcium antagonists generally produce marked improvements in exercise duration. Three areas of new therapeutic development in anti-anginal therapy are worthy of note. These involve the sinus node inhibitor ivabradine, high dose allopurinol (xanthine oxidase inhibitor) and a new class of “metabolic modulators” represented by perhexiline, trimetazidine and probably ranolazine. The current review addresses the therapeutic potential of these agents. Notably, all of these “new” drugs are potentially suitable for management of angina in the setting of impaired left ventricular systolic function, and they may also be utilized in patients with angina independent of the presence of coronary disease (for example in hypertrophic cardiomyopathy). The current evidence for efficacy and potential future development in this area are reviewed.
文摘Objective： To observe the therapeutic effect and effect on plasm endothelin （ET） and nitric oxide （NO） of acupuncture in treating variant angina pectoris. Methods： Sixty-two patients with variant angina pectoris were randomly divided into the acupuncture group of 32 cases and the control group of 30 cases. The patients in control group were treated by nitrate, Ca^2＋ antagonist and aspirin for 4 weeks. The patients in acupuncture group were treated by needling Neiguan （PC 6）, Sanyinjiao （SP 6）, Zusanli （ST 36）, Xinshu （BL 15） Taichong （LR 3） and Shenmen （HT 7） on the basis of western medicine.Results： In acupuncture group, 24 cases were markedly effective, 6 cases were effective and 2 cases got no effect. In control group, 20 cases were markedly effective, 5cases were effective and 5 cases got no effect. The therapeutic effect of acupuncture treatment was significantly prior to that of control treatment （x^2 = 95.4, P 〈 0. 05）. In acupuncture group, posttreatment plasm NO, 86.9±23.15 μmol/L, was markedly higher than pretreatment NO, 63.8±22. 07μmol/L. There was significant difference between them （t= 2.925, P〈 0.01）. In the two groups, plasm ET reduced after treatment. There was significant difference in plasm ET between posttreatment and pretreatment in the two groups （P 〈 0.01）. There was significant difference in reduced plasm ET after treatment between acupuncture group and control group （P 〈 0. 05）. Conclusion： Acupuncture in assistant treating variant angina pectoris could improve the clinical symptoms obviously and reduce the level of plasm ET and NO.
基金Supported by Youth Fund of National Natural Science Foundation of China:81704142special funds of basic scientific research expenses of central public wel-fare research institutes:YZ-1612Nature Science Foundation of Hubei Province:2016CFB215
文摘Objective： To clarify the clinical efficacy of needle-embedding therapy for stable angina pectoris. Methods： Seventy-six patients with stable angina pectoris were divided into needle-embedding therapy group （group A） and basic treatment group （group B） according to the random number table, with 38 patients in each group. Needle-embedding therapy combined with basic treatment was adopted in group A, and needle-embedding was given once every other day, the needles were retained for 24 h each time and three times of treatment were given each week. basic treatment was applied solely in group B. Four weeks of treatment which means one course were given in two groups, efficacy observation and evaluation were carried out after 1 course of treatment. Results： After treatment, the total effective rate of clinical efficacy was 89.47% in group A and 71.05% in group B （p 〈 0.05）, and the total effective rate of electrocardiograph （ECG） efficacy was 84.21% in group A and 63.16% in group B （p〈0.05）. After treatment, the score of limitation of motion, score of the sta- ble state of angina pectoris and the score of angina pectoris attack in group A increased by 0.7%, 34,5% and 16.9% respectively when compared with the scores before treatment （t= 1.623, p 〈0.0l; t=3.867, p 〈 0.01 ; t = 1.958, p 〈 0.05）, and according to the comparison of the score of satisfaction with treatment and the score of disease perception before and after treatment, the difference was not statistically significant （t=4.972, p 〉 0.05; t=0.999, p 〉 0.05）. According to the comparison of the score of limitation of motion, score of angina pectoris attack, score of satisfaction with treatment and the score of disease per- ception in group B before and after treatment, the differences were not statistically significant （t = 1.726, p 〉 0.05; t = 1.594, p 〉 0.05; t = 4.385, p 〉 0.05; t = 0.999, p 〉 0.05）. The score of： the stable state of angina pectoris increased by 4.9% （t = 1.780, p 〈 0.05）. Conclusion： Needle-embedding in acupoint therapy can effectively improve the clinical efficacy, ECG efficacy and the score of Seattle angina questionnaire （SAQ） of stable angina pectoris.
文摘To As one of the most common cardiovascular diseases,coronary heart disease has a high morbidity and mortality.In recent years,non-drug therapy has been put on equal importance with drug therapy due to its simple operation and fast onset.Cognitive behavioral therapy,as a kind of non-drug therapy,has been widely used to improve the physical and mental symptoms of patients with coronary heart disease.This article reviews the origin,concept,theoretical basis,characteristics,technology,and current research status of cognitive behavioral therapy in patients with coronary heart disease,in order to provide a reference for the clinical development of cognitive behavioral therapy.
