Application of Endoscopic Vein Harvesting in Obese Patients Undergoing Coronary Artery Bypass Grafting

This study aims to evaluate the clinical outcomes of endoscopic vein harvesting （EVH） for coronary artery bypass grafting （CABG） in obese patients. Totally, 153 obese patients who underwent EVH （n=81） or standard bridging technique （SBT, n=72） in CABG surgery from May 2012 to October 2014 in our hospital were enrolled in this retrospective non-randomized controlled study. The general situation of operation, postoperative complications and short medium-term outcomes were analyzed. The baseline characteristics were similar between these two groups （P〉0.05）. There were no statistical differences in total operation time （226±28 min vs. 224±30 min, P〉0.05）, number of damaged vessels （0.12±0.05 vs. 0.16±0.06, P〉0.05） and short medium-term outcomes including revascularization rate （1.25% vs. 2.78%, P〉0.05）, vessel dysfunction rate （11.25% vs. 11.11%, P〉0.05） and mortality （0.00% vs. 0.00%, P〉0.05）. Use of EVH was associated with significant reduction of total harvesting time （41±6 min vs. 63±11 min, P〈0.05）, incision length （4.4±1.1 cm vs. 18.2±4.5 cm, P〈0.05） and postoperative lower extremity complications （P〈0.05）. EVH can reduce the risk of wound complications, whereas does not influence short- and medium-term outcomes in obese patients. It can be considered a reliable procedure of harvesting vessel conduits for obese patients undergoing CABG.

A Comparative Analysis on Surgical Outcomes and Complications of Endoscopic and Open Vein Harvesting Techniques

Objective: The great saphenous vein (GSV) is commonly used as a conduit for grafting during CABG surgery, and open GSV harvesting (OVH), commonly used with long incision to expose the vein. However, endoscopic vein harvesting (EVH) is an alternative approach, utilizing specialized instruments and small incisions to harvest the vein. Methods: A retrospective analysis was conducted on a cohort of patients who underwent Coronary artery bypass graft (CABG) requiring great saphenous vein (GSV) harvesting which was done by EVH or OVH procedures. Demographic variables, including age and gender, were assessed for both groups. Intraoperative variables such as the number of grafts, cardiopulmonary bypass time, X clamp time, and type of procedure were analyzed. Postoperative variables, including infection and bleeding rates, were also evaluated. Results: The study included 30 patients each undergoing Coronary artery bypass graft (CABG) with need of great saphenous vein harvesting which was done by EVH and OVH. Demographic variables were well-matched between the two groups in terms of age, while a significant difference in gender distribution was observed. Obesity and smoking were more prevalent in the OVH group, and EVH was associated with a higher mean number of grafts compared to OVH. Conversion to an open technique occurred in a portion of the EVH cases, and infection rates did not significantly differ between the EVH and OVH groups. However, the incidence of postoperative bleeding was significantly higher in the EVH group. Conclusion: This study provides valuable insights into the demographic, intraoperative, and postoperative variables associated with EVH and OVH techniques. EVH demonstrated advantages in terms of reduced infection rates compared to OVH. However, the higher incidence of postoperative bleeding associated with EVH raises concerns about potential risks.

ANGIOGRAPHIC STUDY ON THE PATENCY OF SINGLE VERSUS SEQUENTIAL VENOUS GRAFT BEFORE REDO CORONARY ARTERY BYPASS SURGERY

Objective:To compare the long-term patency and longevity of the single and sequential ve-nous graft.Methods:The coronary arterial angiographic data for 300 redo coronary bypass grafting(CABG) were collected.Among them 106 cases had both single(159) and sequential(118) grafts.Results:The oc-clusive and narrowness rate for the single grafts versus sequential grafts were:1 year,2% vs 2%;5 years,3% vs 4%;10years,18% vs 19%;15 years,60% vs 68%;and 23 years,76% vs 81% ,respectively.The differences were not significant in general.Conclusion:Sequential anastomosis itself does not has any adverse affects on short-term and long-term patency of the venous graft and its longevity in CABG operations in general.

Consideration of the Necessity of Prophylactic Bypass Grafting for Anomalous Origin of the Right Coronary Artery—Based on a Case with Concomitant Left Main Trunk Disease Resuscitated from Cardiopulmonary Arrest

Anomalous origin of the right coronary artery is a rare congenital anomaly, but is associated with sudden death. Originating from the opposite sinus of Valsalva, an interarterial?course and an intramural course are especially considered as the risk factor for fatal cardiac events. Surgical indication remains controversial because many patients are asymptomatic. A 52-year-old man with anomalous origin of the right coronary artery with an interarterial?course concomitant with the left main trunk disease was resuscitated from cardiopulmonary arrest. It was likely to be attributed to the left main trunk disease, but anatomical structure of the right coronary artery suggests its possible involvement. Prophylactic bypass grafting for the right coronary artery was performed using saphenous vein graft without ligating native vessel to prevent future cardiac events, as well as revascularization of the left main trunk disease. All grafts were patent in one-year follow-up coronary angiography. Any cardiac event has not occurred.

经内窥镜大隐静脉获取术在冠状动脉旁路移植术中应用的学习曲线

【目的】探讨内窥镜获取大隐静脉在冠状动脉旁路移植术中的应用并探讨学习曲线,重点关注初学者易发生的问题及对早期临床结果的影响。【方法】回顾性分析2013年7月至2014年4月在郑州大学第一附属医院心外科接受不停跳冠状动脉旁路移植术并使用内窥镜技术获取大隐静脉的83例患者的临床资料,按照手术时间的先后顺序分为A组(初学组20例)、B组(熟悉组20例)、C组(进步组20例)、D组(成熟组23例),分析各组之间患者围术期及随访结果差异,明确学习曲线周期。【结果】该组患者年龄为(60.22±8.06)岁,体质量为(69.77±11.66)kg,其中合并高血压24例、糖尿病26例、亚急性脑梗14例。A组相对于后三组获取大隐静脉长度与时间比值明显较小(P<0.001),静脉主干损伤数量明显较多(P=0.006),并且随访1年时静脉桥通畅率较低,但差异无统计学意义。【结论】内窥镜获取大隐静脉之前技术操作培训是必要的,能有效规避初学者造成的血管损伤,实际获取的过程中大概需要亲自操作20例,并认真总结技术技巧就可以较为熟练地进行相关操作。

内窥镜采集大隐静脉对微创冠状动脉旁路移植术患者手术切口及生活质量的影响

目的 探讨内窥镜采集大隐静脉(EVH)在微创冠状动脉旁路移植术(MICABG)患者中对下肢手术切口及术后早期生活质量的影响。方法 分析2022年1月至12月我院及北京安贞医院单医疗组行微创冠状动脉旁路移植术患者共82例,内窥镜采集大隐静脉组(EVH)36例,开放采集大隐静脉组(OVH)46例。比较两组患者一般情况及术后下肢切口愈合不良、感染等方面的差异;应用SF-36生活质量量表比较两组患者术后早期生活质量的变化。结果 EVH组下肢手术切口愈合不良等并发症较少,在躯体疼痛、总体健康两个维度方面的改善率均优于OVH组(所有P<0.05)。结论 对于行微创冠状动脉旁路移植术的患者,内窥镜采集大隐静脉可减少下肢切口相关并发症,并能更好地提高患者术后早期的生活质量。

不接触获取大隐静脉技术应用于非体外循环冠状动脉旁路移植术的早期临床效果

目的:评价不接触获取技术与常规获取技术应用于非体外循环冠状动脉旁路移植术的早期临床效果。方法:回顾性分析南京医科大学第一附属医院心脏大血管外科2020年7月—2022年7月行非体外循环冠状动脉旁路移植术的120例患者的临床资料,其中50例采用不接触获取技术(No-touch组),70例采用常规获取技术(CVH组)。观察指标包括手术时间、静脉桥血管数量、静脉桥血管平均流量、机械通气时间、ICU监护时间和术后下肢切口愈合不良、术后急性肾损伤等并发症,以及随访1年后的心脏超声指标和冠状动脉CT血管成像结果。结果:两组患者手术时间、静脉桥血管数量、静脉桥血管平均流量、机械通气时间、ICU监护时间等比较差异均无统计学意义(P> 0.05)。No-touch组术后主动脉内球囊反搏(intra-aortic balloon pump,IABP)支持5例,下肢切口愈合不良2例,术后突发心血管事件1例。CVH组术后IABP支持2例,术后急性肾损伤1例。两组均无二次开胸探查和二次气管插管情况,且术后各并发症发生率比较差异无统计学意义(P> 0.05)。两组患者术后1年心脏超声指标差异无统计学意义(P> 0.05)。No-touch组术后1年静脉桥血管闭塞率低于CVH组(P <0.05)。结论:与常规获取技术相比,在非体外循环冠状动脉旁路移植手术中采用不接触技术获取大隐静脉不增加手术风险,术后1年桥血管通畅率较高。

Experimental study on autogenous vein cuff alleviating arterial intimal hyperplasia

Objective: To explore the alleviation of arterial intimal hyperplasia and improvement of outflow by inserting an autogenous vein cuff between poly tetraflu oroethylene (PTFE) graft and arteri al an astomosis. Methods: Twenty-four hindlimbs of 12 mongrel dogs were randomly divided into control group and experimental group. Sole PTFE bypasses were made in the control group, an autologous vein cuff was inserted in the distal anastomosis in the experimental group. Eight weeks after operation, angiography was made and specimens were harvested, histomorphological studies under microscope and picture analysis with computer were carried out, scanning electromicroscopy on the vein cuff was made. Results: Angiography demonstrated the patency of control and experimental group was 16. 7% and 66. 7%, respectively; Computer gave the intimal thickness: (483. 5 ± 67. 3) μm and (147. 4 ± 38. 6) μm, respectively; no obvious change was seen in medial thickness; area of intimal hyperplasia was (5217 ± 1 123) (pixel) and (31 17 ± 890) (pixel), respectively, accounting (80. 9 ± 17. 2)% and (47. 7 ± 13. 7)% of the sectional area of vessel lumen. The interpositional vein was arteriolization. Conclusion: The interpositional autologous vein cuff can obviously mitigate the arterial intimal hyperplasia after PTFE bypasses, improving postoperative patency of vascular surgery.

A Single Center Experience with Coronary Endarterectomy and Vein Patch Reconstruction

Background: To evaluate the medium and late term outcomes of coronary artery bypass grafting with pull-through coronary endarterectomy using a saphenous vein patch for bypass distal anastomosis site. Methods: Retrospective review of all coronary artery bypass graft (CABG) procedures performed from January 1, 2000 through June 30, 2013 with and without concomitant coronary endarterectomy (CE), was carried out at the Veterans Affairs Medical Center in Washington DC. Patients who underwent concomitant valve operations were excluded. Primary outcome was overall survival, with analyses performed examining CE as well as the use of cardiopulmonary bypass. Secondary outcomes included 30-day mortality and post-operative MI. Results: 1255 CABG operations were performed, 10 of which included CE. All CE procedures were performed with saphenous vein patch. 7 involved left anterior descending artery (LAD) CE with left internal mammary artery (LIMA) conduits. The remaining 3 were diagonal branch artery (D1) CE with saphenous vein bypass conduits. 1-year survival was 70%. 5-year survival was 43% out of 7 patients. Conclusions: Pull-through CE with saphenous vein patch is a safe alternative technique for patients with diffuse coronary artery disease. Perioperative events and intermediate outcomes are favorable, although long-term survival is less than patients without CE.

Morbidity of Open Saphenous Vein Harvesting after Preoperative Ultrasonic Mapping

Preoperative echography of a saphenous vein graft (SVG) was studied. In 58 cases of consecutive coronary artery bypass grafting, 31 patients underwent SVG echography. Preoperative assessment revealed vein caliber, branching, or varicose saphenous veins. The location of the saphenous vein was marked. Saphenous veins were harvested by the open harvest technique, and the caliber of the veins and the availability of the anastomosis device were recorded. Postoperative morbidity was recorded. Preoperative findings revealed that four (6.5%) of 62 femoral saphenous veins were estimated as “not graftable” because of being a varicose vein or having a small caliber. Seven of 32 lower saphenous veins were estimated as “not graftable”. The mean discrepancy of the caliber was 0.6 mm undersized with preoperative estimation. During harvesting, one of 31 patients had a wrong marking. We were able to use all harvested veins. The morbidity of saphenous harvesting was observed in two (6.5%) of 31 patients. One patient whose marking was wrong had minor skin necrosis. Another patient experienced a hematoma because of the excess effect of warfarin. Preoperative ultrasonic mapping of the saphenous vein reduced useless harvesting, provided information concerning anastomosis device availability, and seemed to reduce morbidity because dissection can be minimal.

屈膝屈髋、髋关节内旋体位在小隐静脉取材术中的应用

目的探讨屈膝屈髋、髋关节内旋体位进行小隐静脉(lesser saphenous vein,LSV)取材的安全性和可行性。方法2014年1月~2022年10月,我们对11例非体外循环冠状动脉旁路移植术(off-pump coronary artery bypass graft,OPCABG)施行LSV取材,采用仰卧位,屈膝90°,屈髋45°,借助弹力绷带缠绕膝关节下部并向对侧牵拉,形成髋关节内旋30°~45°体位。从外踝后方切口找到LSV后,沿其走行向小腿后方中线延长切口,查验LSV的长度和质量后,移植血管分别与升主动脉和靶血管行端侧吻合,完成OPCABG。测量LSV的长度和直径,流量仪测量桥路流量值和搏动指数(Pulsatility Index,PI)。结果11例均顺利完成单侧LSV取材术,血管长度17~26 cm,(22.5±2.8)cm,血管直径2.0~3.7 mm,(3.1±0.5)mm。1例女性患者因LSV管径过细而放弃使用;余10例以LSV完成单根血管吻合:1例对角支、3例后降支和6例回旋支。9例用流量仪测量LSV桥路流量和PI:流量25~58 ml/min,(39.4±11.2)ml/min;PI 1.1~2.0,(1.52±0.30)。11例LSV取材部位切口愈合良好,顺利康复出院。10例LSV取材术后3个月电话随访,均恢复良好,心肌缺血症状消失,纽约心脏协会(New York Heart Association,NYHA)心脏功能分级,Ⅰ级8例,Ⅱ级2例。结论屈膝屈髋、髋关节内旋体位可以安全、便捷地用于LSV取材术。

非接触与裸取大隐静脉在糖尿病冠状动脉移植围术期疗效对比

目的:比较在冠心病合并糖尿病患者中常规获取与非接触(No-touch)获取大隐静脉桥血管在冠状动脉旁路移植术(coronary artery bypass grafting, CABG)中的应用效果。方法:将2020年1月至2021年12月,邯郸市第一医院就诊的88例冠心病合并糖尿病患者随机分为常规组(47例)和No-touch组(41例)。No-touch组使用No-touch技术获取大隐静脉桥血管,常规组采用常规切口采集大隐静脉。比较两组围手术期相关指标及术后并发症情况。结果:两组手术时间、术后48h引流量、呼吸机辅助通气时间、住院时间等,差异均无统计学意义(P>0.05)。两组患者术后低心排血量综合征、死亡、心房颤动、中风、心肌梗死、术后应用主动脉内球囊反搏(intra-aortic balloon pump,IABP)、切口感染发生率等均差异无统计学意义(P>0.05)。结论:在冠心病合并糖尿病患者CABG术中,No-touch技术获取大隐静脉桥血管与常规切口法获取具有同样的安全性,不会增加手术风险,可推广使用。

不接触获取大隐静脉技术应用于冠状动脉旁路移植术的临床效果分析

目的评价不接触获取大隐静脉技术(no-touch saphenous vein grafting,NT-SVG)与传统获取大隐静脉技术(conventional saphenous vein grafting,CV-SVG)应用于冠状动脉旁路移植术的效果。方法2018年1月~2020年12月,应用NT-SVG或CV-SVG同期行CABG术的病人238例,NTSVG组112例,CV-SVG组126例。比较两种获取方式术后并发症和大隐静脉桥血管通畅情况。结果NT-SVG组术后3个月大隐静脉桥血管闭塞率为2.5%,CV-SVG组为6.5%,两组比较,差异有统计学意义(P<0.05),NT-SVG组术后12个月大隐静脉桥血管闭塞率为4.2%,CV-SVG组为9.0%,两组比较,差异有统计学意义(P<0.05)。NT-SVG组和CV-SVG组术后30天内死亡率分别为0.9%和0.8%,二次开胸止血率分别为0.9%和1.6%、心肌梗死率分别为0和0.8%,脑部并发症发生率分别为0.9%和0,肺部感染发生率分别为6.25%和6.3%,肾衰竭需要透析比例分别为1.8%和2.4%,消化道出血发生率分别为0.9%和1.6%,两组比较,差异无统计学意义(P>0.05)。NT-SVG组腿部伤口愈合延迟发生率7.1%,腿部皮肤感觉异常发生率18.8%,CV-SVG组分别为1.6%和9.5%,两组比较,差异有统计学意义(P<0.05)。结论NT-SVG组较CV-SVG组术后3个月和12个月大隐静脉桥通畅率明显提高,术后主要严重并发症无明显增加。

急性心肌梗死桥血管病变急诊介入治疗的临床研究——年龄组对比分析

目的 评价包括 ST段抬高性和非抬高性急性心肌梗死 (AMI)患者在急诊冠状动脉 (冠脉 )造影明确其梗塞相关血管为静脉搭桥血管 (SVBG)后 ,进行急诊直接经皮血管成型术 (PCI)的临床有效性及安全性 ;比较≥ 70岁与 <70岁两组患者 SVBG病变再通的临床效果和不良事件。方法 分析 2 0 0 3年 1月—2 0 0 4年 11月在解放军总医院和德国海德堡大学附属海德堡医院行急诊介入治疗的连续 AMI患者 30 9例 ,其梗塞相关血管为 SVBG患者。全部患者行急诊冠脉造影 ,根据造影显示梗塞相关 SVBG血流为心肌梗死溶栓治疗临床试验 (TIMI) 级以下 ,或同时伴有较明显胸痛 ,梗塞对应心电图导联 ST段仍抬高或压低 ,并均在确认无介入治疗禁忌证后行急诊 PCI治疗 (包括球囊成型术或支架术 )。比较两组患者即刻 SVBG再通效果、血管有效再通成功率、住院期间病死率及短期临床效果。结果 急诊 PCI治疗 SVBG罪犯血管共 30 9例支 ,≥ 70岁组 2 13例 ,<70岁组 96例。两组患者中应用各种血管远端保护器者 4 7例 ,其比例两组间差异无显著性。两组患者行球囊扩张术和支架植入术的技术成功率、急性再闭塞率差异均无显著性。≥ 70岁组 SVBG直接 PCI后发生慢血流或无血流现象明显增多 ,住院期间绝对死亡数多 (2 0 /2 4例 ) ,均较 <70岁组明显?

内镜下与常规切开法采集大隐静脉在冠状动脉旁路移植术中应用的比较

目的 探讨内镜下采集大隐静脉应用于冠状动脉旁路移植术（coronary artery bypass grafting, CABG）中的早期临床效果. 方法 2004年4月～2005年5月,对89例采用内镜下取大隐静脉行CABG（内镜组）,在膝关节中部做2 cm切口,应用VasoView 5内镜血管采集系统游离获取大隐静脉,并与2003年4月～2005年3月38例采用传统切开法取大隐静脉行CABG（常规组）进行比较,比较2组术后下肢切口并发症、恢复行走时间、患肢疼痛麻木感及肿胀、术后6个月通畅率.结果 内镜组取大隐静脉2～3支,平均2.6支;内镜组下肢并发症（6例）与常规组（8例）相比明显减少（χ^2=4.197,P＝0.040）;内镜组患肢疼痛、麻木感7例及肿胀9例与常规组（分别为36、30例）相比明显减少（χ^2=89.740,P＝0.000;χ^2=59.299;P＝0.000）;内镜组恢复行走时间（2.3±0.9） d比常规组（3.4±1.6） d明显缩短（t=-4.952,P=0.000）;内镜组术后6个月通畅率96.0%（48/50）与常规组95.3%（19/20）相比无明显差别（χ2=0.000,P=1.000）. 结论 CABG中应用内镜下采集大隐静脉能够减少创伤,明显降低术后下肢并发症,减轻术后下肢切口疼痛.

内窥镜下取小腿大隐静脉用于冠状动脉搭桥的临床效果

目的:评价内窥镜下采集小腿大隐静脉,用于非体外循环冠状动脉搭桥术(off pump coronary artery bypass grafting,OPCABG)的临床效果。方法:选取OPCABG患者269例,根据小腿大隐静脉取材方式将患者分为,内窥镜血管采集(endoscopic vein harvesting,EVH)组和全程切开(open vein harvesting,OVH)组,比较两组取材时间、取材质量、切口并发症、围术期和术后近期随访时的临床效果及患者评价。结果:EVH组取材长度、血管质量和取材时间可满足冠状动脉搭桥手术需要。与OVH组相比,EVH组术后切口并发症发生率和下肢水肿发生率显著降低,且差异有统计学意义,但皮下组织瘀斑发生率较OVH组高。取材时间EVH组平均35 min,OVH组平均45 min,差异有统计学意义。远端吻合口数目EVH组3.2个/例,OVH组3.1个/例,差异无统计学意义。两组围术期心肌梗死发生率差异无统计学意义。本研究中,所有患者均痊愈出院,术后平均随访4～5个月,均无心绞痛再发。结论:CABG术中采取EVH取小腿大隐静脉的方法有效可行。其作为一种微创取血管的方法,取材质量良好、切口小、并发症更少,得到了医生和患者的认可。

微创内镜切取大隐静脉在冠状动脉搭桥术中的应用(附63例报告)

目的介绍微创内镜切取大隐静脉(MIEVH)在冠状动脉搭桥术(CABG)中应用的方法与临床效果。方法在连续CABG患者中,79例采用传统全程皮肤切口切取大隐静脉,63例采用MIEVH。结果微创术后腿部并发症明显减少,最显著的是切口无感染,下肢的疼痛和水肿明显减轻,切口小美容效果显著,优于传统全程SVG切口(P<0.05)。随访4～13个月(平均8.6个月),搭桥术后效果好。结论MIEVH安全可行,并发症少,美容效果显著,值得推广。

内窥镜辅助下国产大隐静脉采集系统在冠脉旁路移植术中的应用

目的:总结内窥镜辅助下国产大隐静脉采集系统采集大隐静脉(endoscopic vein harvestingEVH)在冠脉旁路移植术(CABG)中应用的早期临床效果。方法:自2010年1-12月84例连续进行冠脉旁路移植术的患者中,36例采用EVH,48例采用间断皮肤切口采集大隐静脉。结果:两组所采集的大隐静脉长度差异无统计学意义(P>0.05)。EVH组较间断切口组的大隐静脉采集时间长(P<0.05),但切口总长度(P<0.05),切口缝合时间明显缩短。在术后1个月内,EVH组和间断切口组分别有13.9%(5/36)和37.5%(18/48)发生下肢切口脂肪液化、红肿、感染等并发症。EVH并发症发生率低于间断切口组切口组,差异有统计学意义(P<0.05)。结论:EVH是冠状动脉微创手术的一个组成部分,是安全和值得推荐的可选择的大隐静脉采集方法。

内窥镜获取大隐静脉在冠状动脉旁路移植术中的中期效果分析

目的探讨内窥镜获取大隐静脉在冠状动脉旁路移植术中的中期临床效果。方法选取2012年7月～2013年4月在郑州大学第一附属医院心外科接受不停跳冠状动脉旁路移植术的205例患者为研究对象。内窥镜获取大隐静脉（EVH）66例为研究组,男性35例,女性31例,年龄60.30±7.92岁,体质量69.77±10.66 kg;同期行开放获取大隐静脉（OVH）的139例为对照组,男性109例,女性30例,年龄59.20±8.37岁,体质量71.16±9.91 kg。结果 205例患者均顺利完成手术。EVH组围术期死亡2例,死亡率为3.03%;OVH组死亡5例,死亡率为3.60%,两组围术期死亡率差异无统计学意义（P=1.00）。OVH组围术期发生急性心梗3例,发生率为2.16%,EVH组1例,发生率1.52%,亦无统计学差异;低心排综合征OVH组4例（2.88%）,EVH组2例（3.03%）,无统计学差异。术后随访OVH组有8例再发心绞痛,发生率为8.80%;EVH组5例,发生率为8.06%,差异无统计学意义（P=0.93）。两组患者随访期间均无再发心梗;2年静脉桥血管通畅率,OVH组为83.59%,EVH组为82.22%,差异也无统计学意义（P=0.73）。结论 EVH在减低术后下肢伤口并发症上具有明显的优势,中期通畅率同常规手术组无统计学差异,而远期临床效果仍需进一步临床随访研究。

灯盏花素对冠脉搭桥术移植静脉保护作用的实验

目的探索灯盏花素对冠脉搭桥术移植静脉的保护作用。方法选择家兔建立动物模型,分3组,生理盐水组、传统静脉保护液组、灯盏花素组,3组移植静脉分别在生理盐水、传统静脉保护液、传统保护液加入灯盏花素处理后移植,移植后1个月、1 a后取出移植静脉,病理切片量化管腔狭窄程度,免疫组化检测细胞增殖程度活性,进行对比分析。结果灯盏花素组的管腔狭窄程度和细胞增殖程度均显著低于对照组(P<0.05)。结论灯盏花素在冠脉搭桥术中对移植静脉有一定保护作用。