Objectives To investigate the relation between hypertrophied myocardium and ventricular fibrillation threshold in spontaneously hypertensive rats （SHR）. Methods 20 male SHR were randomly divided into two groups： 10...Objectives To investigate the relation between hypertrophied myocardium and ventricular fibrillation threshold in spontaneously hypertensive rats （SHR）. Methods 20 male SHR were randomly divided into two groups： 10 week group （n= 10） and 18 week group （n=10）. 10 week male Wistar rats were controlled group （n=10）. The systolic blood pressure （SBP）, heart mass index （HMI）, ventricular effective refractory period （VERP） and ventricular fibrillation threshold（VFT） were measured respectively.① The SBP and HMI of SHR were significantly higher than those of Wistar rats（P 〈 0.001）. The VFT of SHR were significantly lower than that of Wistar rats （P 〈 0.001）.②In SHR, the SBP and HMI of 18 week SHR were significantly higher than those of 10 week SHR （P 〈 0.001）. The VFT of 18 week SHR were significantly lower than that of 10 week SHR （P 〈 0.001）. ③There were no significant difference of VERP among 10 week SHR, 18 week SHR and Wistar rats（P 〉 0.05）. ④There was no relationship between HMI and VFT or SBP in Wistar rats. There was significant relationship between HMI and VFT or SBP in different age spontaneously hypertensive rats. ⑤HMI, age and species of animal were the major influent factors of VFT. Conclusions The VFT of hypertrophied myocardium decreased. The higher the degree of hypertrophy of myocardium and the higher the systolic blood pressure were, the lower the ventricular fibrillation threshold was.展开更多
Long-duration ventricular fibrillation (LDVF) often occurring out-of-hospital has been presented several minutes before electrical shocks. It is important to understand the mechanism by which LDVF is maintained and de...Long-duration ventricular fibrillation (LDVF) often occurring out-of-hospital has been presented several minutes before electrical shocks. It is important to understand the mechanism by which LDVF is maintained and defibrillated. Purkinje fibers (PFs) have been demonstrated to play a key role in the onset of certain types of ventricular fibrillation. In this review, we discuss the electrophysiological difference between PFs and working myocardium, and the role of the PFs in the maintenance and termination of LDVF.展开更多
文摘Objectives To investigate the relation between hypertrophied myocardium and ventricular fibrillation threshold in spontaneously hypertensive rats （SHR）. Methods 20 male SHR were randomly divided into two groups： 10 week group （n= 10） and 18 week group （n=10）. 10 week male Wistar rats were controlled group （n=10）. The systolic blood pressure （SBP）, heart mass index （HMI）, ventricular effective refractory period （VERP） and ventricular fibrillation threshold（VFT） were measured respectively.① The SBP and HMI of SHR were significantly higher than those of Wistar rats（P 〈 0.001）. The VFT of SHR were significantly lower than that of Wistar rats （P 〈 0.001）.②In SHR, the SBP and HMI of 18 week SHR were significantly higher than those of 10 week SHR （P 〈 0.001）. The VFT of 18 week SHR were significantly lower than that of 10 week SHR （P 〈 0.001）. ③There were no significant difference of VERP among 10 week SHR, 18 week SHR and Wistar rats（P 〉 0.05）. ④There was no relationship between HMI and VFT or SBP in Wistar rats. There was significant relationship between HMI and VFT or SBP in different age spontaneously hypertensive rats. ⑤HMI, age and species of animal were the major influent factors of VFT. Conclusions The VFT of hypertrophied myocardium decreased. The higher the degree of hypertrophy of myocardium and the higher the systolic blood pressure were, the lower the ventricular fibrillation threshold was.
基金Supported by National Natural Science Foundation of China (81000081,81070266)
文摘Long-duration ventricular fibrillation (LDVF) often occurring out-of-hospital has been presented several minutes before electrical shocks. It is important to understand the mechanism by which LDVF is maintained and defibrillated. Purkinje fibers (PFs) have been demonstrated to play a key role in the onset of certain types of ventricular fibrillation. In this review, we discuss the electrophysiological difference between PFs and working myocardium, and the role of the PFs in the maintenance and termination of LDVF.
