Vertebral artery orifice stenting may improve blood supply of the posterior circulation of the brain to regions such as the cerebellum and brainstem. However, previous studies have mainly focused on recovery of cerebr...Vertebral artery orifice stenting may improve blood supply of the posterior circulation of the brain to regions such as the cerebellum and brainstem. However, previous studies have mainly focused on recovery of cerebral blood flow and perfusion in the posterior circulation after interventional therapy. This study examined the effects of functional recovery of local brain tissue on cerebellar function remodeling using blood oxygen level-dependent functional magnetic reso- nance imaging before and after interventional therapy. A total of 40 Chinese patients with severe unilateral vertebral artery orifice stenosis were enrolled in this study. Patients were equally and randomly assigned to intervention and control groups. The control group received drug treat- ment only. The intervention group received vertebral artery orifice angioplasty and stenting ＋ identical drug treatment to the control group. At 13 days after treatment, the Dizziness Handicap Inventory score was compared between the intervention and control groups. Cerebellar function remodeling was observed between the two groups using blood oxygen level-dependent functional magnetic resonance imaging. The improvement in dizziness handicap and cerebellar function was more obvious in the intervention group than in the control group. Interventional therapy for severe vertebral artery orifice stenosis may effectively promote cerebellar function remodeling and exert neuroprotective effects.展开更多
The role of intercalatus nucleus of Staderini(INS),the most caudal of the perihypoglossal nuclei,is much debated.Last research seems to suggest that this nucleus plays a role as a vertical eyes movements integrator.Th...The role of intercalatus nucleus of Staderini(INS),the most caudal of the perihypoglossal nuclei,is much debated.Last research seems to suggest that this nucleus plays a role as a vertical eyes movements integrator.The few clinical reports present in the literature that describe isolated lesions of the INS have described patients presenting in acute with up-beating vertical spontaneous nystagmus.Isolated acute lesion of INS is,in fact,much rare,and,without other neurological signs,is exceptional.We present a case of acute isolated vertigo with no other neurological signs or symptoms,due to INS ischemia provoked by vertebral artery stenosis.The patient presented with spontaneous vertical up-beating nystagmus that showed at videonystagmographic recording,a clear exponential decay of angular slow-phase velocity,that is considered a typical sign of neural integrator impairment.This case seems to represent a further confirm that INS is part,as a vertical-to-position neural integrator,of the neural circuit controlling the vertical eyes movements.展开更多
目的:探讨改良后用于磁共振评分的后循环急性卒中预后早期CT量表(MRI-PC-ASPECTS)联合美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)及变换值预测后循环缺血性脑卒中远期预后的价值。方法:78例南通大...目的:探讨改良后用于磁共振评分的后循环急性卒中预后早期CT量表(MRI-PC-ASPECTS)联合美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)及变换值预测后循环缺血性脑卒中远期预后的价值。方法:78例南通大学附属建湖医院神经内科住院的急性后循环缺血性卒中住院患者,根据患者3个月后改良Rankin量表(modified Rankin scale,MRS)分为好转组和不良转归组。比较2组基线资料、危险因素、NIHSS、T入院NIHSS、最高NIHSS、T最高NIHSS(42-最高NIHSS)及MRI-PC-ASPECTS。结果:2组间性别、年龄、既往病史、血压等差异无统计学意义(P>0.05);2组间入院NIHSS、T入院NIHSS、最高NIHSS、T最高NIHSS、MRI-PC-ASPECTS指标的差异具有统计学意义(P<0.05)。受试者工作特征曲线显示MRI-PC-ASPECTS+T最高NIHSS曲线下面积最大(P<0.05)。结论:改良MRI-PC-ASPECTS,T最高NIHSS可对后循环缺血性脑卒中功能预后进行早期预测,若二者联合则预测的准确性更好。展开更多
基金supported by the Natural Science Foundation of Yongchuan District of Chongqing in China,No.Ycstc,2013nc8031the Foundation of Chongqing Municipal Health Bureau in China,No.2010-2-250+1 种基金the Foundation of Chongqing Health and Family Planning Commission in China,No.20143001the Soft Science Foundation of Yongchuan District of Chongqing in China,No.Ycstc,2011BE5004
文摘Vertebral artery orifice stenting may improve blood supply of the posterior circulation of the brain to regions such as the cerebellum and brainstem. However, previous studies have mainly focused on recovery of cerebral blood flow and perfusion in the posterior circulation after interventional therapy. This study examined the effects of functional recovery of local brain tissue on cerebellar function remodeling using blood oxygen level-dependent functional magnetic reso- nance imaging before and after interventional therapy. A total of 40 Chinese patients with severe unilateral vertebral artery orifice stenosis were enrolled in this study. Patients were equally and randomly assigned to intervention and control groups. The control group received drug treat- ment only. The intervention group received vertebral artery orifice angioplasty and stenting ＋ identical drug treatment to the control group. At 13 days after treatment, the Dizziness Handicap Inventory score was compared between the intervention and control groups. Cerebellar function remodeling was observed between the two groups using blood oxygen level-dependent functional magnetic resonance imaging. The improvement in dizziness handicap and cerebellar function was more obvious in the intervention group than in the control group. Interventional therapy for severe vertebral artery orifice stenosis may effectively promote cerebellar function remodeling and exert neuroprotective effects.
文摘The role of intercalatus nucleus of Staderini(INS),the most caudal of the perihypoglossal nuclei,is much debated.Last research seems to suggest that this nucleus plays a role as a vertical eyes movements integrator.The few clinical reports present in the literature that describe isolated lesions of the INS have described patients presenting in acute with up-beating vertical spontaneous nystagmus.Isolated acute lesion of INS is,in fact,much rare,and,without other neurological signs,is exceptional.We present a case of acute isolated vertigo with no other neurological signs or symptoms,due to INS ischemia provoked by vertebral artery stenosis.The patient presented with spontaneous vertical up-beating nystagmus that showed at videonystagmographic recording,a clear exponential decay of angular slow-phase velocity,that is considered a typical sign of neural integrator impairment.This case seems to represent a further confirm that INS is part,as a vertical-to-position neural integrator,of the neural circuit controlling the vertical eyes movements.
文摘目的:探讨改良后用于磁共振评分的后循环急性卒中预后早期CT量表(MRI-PC-ASPECTS)联合美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)及变换值预测后循环缺血性脑卒中远期预后的价值。方法:78例南通大学附属建湖医院神经内科住院的急性后循环缺血性卒中住院患者,根据患者3个月后改良Rankin量表(modified Rankin scale,MRS)分为好转组和不良转归组。比较2组基线资料、危险因素、NIHSS、T入院NIHSS、最高NIHSS、T最高NIHSS(42-最高NIHSS)及MRI-PC-ASPECTS。结果:2组间性别、年龄、既往病史、血压等差异无统计学意义(P>0.05);2组间入院NIHSS、T入院NIHSS、最高NIHSS、T最高NIHSS、MRI-PC-ASPECTS指标的差异具有统计学意义(P<0.05)。受试者工作特征曲线显示MRI-PC-ASPECTS+T最高NIHSS曲线下面积最大(P<0.05)。结论:改良MRI-PC-ASPECTS,T最高NIHSS可对后循环缺血性脑卒中功能预后进行早期预测,若二者联合则预测的准确性更好。
