Kartagener＇s syndrome （KS） is an autosomal recessive genetic disease accounting for approximately 50% of the cases of primary ciliary dyskinesia （PCD）. As it is accompanied by many complications, PCD/KS severely ...Kartagener＇s syndrome （KS） is an autosomal recessive genetic disease accounting for approximately 50% of the cases of primary ciliary dyskinesia （PCD）. As it is accompanied by many complications, PCD/KS severely affects the patient＇s quality of life. Therapeutic approaches for PCD/KS aim to enhance prevention, facilitate rapid definitive diagnosis, avoid misdiagnosis, maintain active treatment, control infection and postpone the development of lesions. In male patients, sperm flagella may show impairment in or complete absence of the ability to swing, which ultimately results in male infertility. Assisted reproductive technology will certainly benefit such patients. For PCD/KS patients with completely immotile sperm, intracytoplasmic sperm injection may be very important and even indispensable. Considering the number of PCD/KS susceptibility genes and mutations that are being identified, more extensive genetic screening is indispensable in patients with these diseases. Moreover, further studies into the potential molecular mechanisms of these diseases are required. In this review, we summarize the available information on various aspects of this disease in order to delineate the therapeutic objectives more clearly, and clarify the efficacy of assisted reproductive technology as a means of treatment for patients with PCD/KS-associated infertility.展开更多
目的探讨集中培训的方式对基层医院相关专业医生推广睡眠医学诊疗技术的临床效果。方法选择吉林省辖区内23家县医院或县级市医院,从事与睡眠医学相关专业主治医师以上职称的医生,培训前、后分别进行试卷考试,培训前的考试成绩为对照组,...目的探讨集中培训的方式对基层医院相关专业医生推广睡眠医学诊疗技术的临床效果。方法选择吉林省辖区内23家县医院或县级市医院,从事与睡眠医学相关专业主治医师以上职称的医生,培训前、后分别进行试卷考试,培训前的考试成绩为对照组,培训后的考试成绩为观察组,观察培训前、后睡眠医学知识的掌握情况。结果培训后及培训前睡眠知识掌握成绩优的比较,观察组明显高于对照组,χ~2=83.49,P <0.05,差异有统计学意义;培训后及培训前睡眠知识掌握成绩优和良两者总和的比较,观察组明显高于对照组,χ~2=48.15, P <0.05,差异有统计学意义。结论睡眠医学诊疗技术这项适宜技术在基层医院临床的推广取得了较好的效果。展开更多
文摘Kartagener＇s syndrome （KS） is an autosomal recessive genetic disease accounting for approximately 50% of the cases of primary ciliary dyskinesia （PCD）. As it is accompanied by many complications, PCD/KS severely affects the patient＇s quality of life. Therapeutic approaches for PCD/KS aim to enhance prevention, facilitate rapid definitive diagnosis, avoid misdiagnosis, maintain active treatment, control infection and postpone the development of lesions. In male patients, sperm flagella may show impairment in or complete absence of the ability to swing, which ultimately results in male infertility. Assisted reproductive technology will certainly benefit such patients. For PCD/KS patients with completely immotile sperm, intracytoplasmic sperm injection may be very important and even indispensable. Considering the number of PCD/KS susceptibility genes and mutations that are being identified, more extensive genetic screening is indispensable in patients with these diseases. Moreover, further studies into the potential molecular mechanisms of these diseases are required. In this review, we summarize the available information on various aspects of this disease in order to delineate the therapeutic objectives more clearly, and clarify the efficacy of assisted reproductive technology as a means of treatment for patients with PCD/KS-associated infertility.
文摘目的探讨集中培训的方式对基层医院相关专业医生推广睡眠医学诊疗技术的临床效果。方法选择吉林省辖区内23家县医院或县级市医院,从事与睡眠医学相关专业主治医师以上职称的医生,培训前、后分别进行试卷考试,培训前的考试成绩为对照组,培训后的考试成绩为观察组,观察培训前、后睡眠医学知识的掌握情况。结果培训后及培训前睡眠知识掌握成绩优的比较,观察组明显高于对照组,χ~2=83.49,P <0.05,差异有统计学意义;培训后及培训前睡眠知识掌握成绩优和良两者总和的比较,观察组明显高于对照组,χ~2=48.15, P <0.05,差异有统计学意义。结论睡眠医学诊疗技术这项适宜技术在基层医院临床的推广取得了较好的效果。
