Viburnum opulus,belonging to Viburnum of Caprifoliaceae family,is commonly used as a Chinese herbal medicine.Many chemical constituents have been isolated from V.opulus,including flavonoids,flavone glycosides,volatile...Viburnum opulus,belonging to Viburnum of Caprifoliaceae family,is commonly used as a Chinese herbal medicine.Many chemical constituents have been isolated from V.opulus,including flavonoids,flavone glycosides,volatile oils and terpenoids.It has antioxidant,antibacterial,antispasmodic,and anticancer effects.V.opulus,with a variety of chemical constituents and remarkable activities,has attracted wide attention.Hence,this report is presented as a review centered on the chemical constituents and pharmacological activities of V.opulus,in order to provide reference for further research and development of Viburnum opulus.展开更多
Five new terpenoids,including two vibsane-type diterpenoids(1,2)and three iridoid allosides(3-5),together with eight known ones,were isolated from the leaves and twigs of Viburnum odoratissimum var.sessiliflorum.Their...Five new terpenoids,including two vibsane-type diterpenoids(1,2)and three iridoid allosides(3-5),together with eight known ones,were isolated from the leaves and twigs of Viburnum odoratissimum var.sessiliflorum.Their planar structures and relative configurations were determined by spectroscopic methods,especially 2D NMR techniques.The sugar moieties of the iridoids were confirmed asβ-D-allose by GC analysis after acid hydrolysis and acetylation.The absolute configurations of neovibsanin Q(1)and dehydrovibsanol B(2)were determined by quantum chemical calculation of their theoretical electronic circular dichroism(ECD)spectra and Rh2(OCOCF_(3))_(4)-induced ECD analysis.The anti-inflammatory activities of compounds 1,3,4,and 5 were evaluated using an LPS-induced RA W264.7 cell model.Compounds 3 suppressed the release of NO in a dose-dependent manner,with an IC_(50) value of 55.64μmol·L^(-1).The cytotoxicities of compounds 1-5 on HCT-116 cells were assessed and the results showed that compounds 2 and 3 exhibited moderate inhibitory activities with IC_(50) values of 13.8 and 12.3μmol·L^(-1),respectively.展开更多
文摘Viburnum opulus,belonging to Viburnum of Caprifoliaceae family,is commonly used as a Chinese herbal medicine.Many chemical constituents have been isolated from V.opulus,including flavonoids,flavone glycosides,volatile oils and terpenoids.It has antioxidant,antibacterial,antispasmodic,and anticancer effects.V.opulus,with a variety of chemical constituents and remarkable activities,has attracted wide attention.Hence,this report is presented as a review centered on the chemical constituents and pharmacological activities of V.opulus,in order to provide reference for further research and development of Viburnum opulus.
基金supported by the National Natural Science Foundation of China(Nos.22077111,22177016,81872756,and 81901678)Department of Education of Guangdong Province(No.2020KZDZX1203)。
文摘Five new terpenoids,including two vibsane-type diterpenoids(1,2)and three iridoid allosides(3-5),together with eight known ones,were isolated from the leaves and twigs of Viburnum odoratissimum var.sessiliflorum.Their planar structures and relative configurations were determined by spectroscopic methods,especially 2D NMR techniques.The sugar moieties of the iridoids were confirmed asβ-D-allose by GC analysis after acid hydrolysis and acetylation.The absolute configurations of neovibsanin Q(1)and dehydrovibsanol B(2)were determined by quantum chemical calculation of their theoretical electronic circular dichroism(ECD)spectra and Rh2(OCOCF_(3))_(4)-induced ECD analysis.The anti-inflammatory activities of compounds 1,3,4,and 5 were evaluated using an LPS-induced RA W264.7 cell model.Compounds 3 suppressed the release of NO in a dose-dependent manner,with an IC_(50) value of 55.64μmol·L^(-1).The cytotoxicities of compounds 1-5 on HCT-116 cells were assessed and the results showed that compounds 2 and 3 exhibited moderate inhibitory activities with IC_(50) values of 13.8 and 12.3μmol·L^(-1),respectively.
