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Analysis of the Tragedy of Vila Socóin Cubatão (São Paulo, Brazil) Using the Haddon Matrix: A Comprehensive Examination of Socio-Environmental Factors and Risk Mitigation Strategies
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作者 Rubens Martins Santos Nilce Ortiz Sabine Neusatz Guilhen 《Journal of Environmental Protection》 2024年第5期620-639,共20页
The tragedy of Vila Socó epitomizes the socio-environmental repercussions of rapid industrialization in Cubatão. Beginning in the 1940s with the construction of the Anchieta highway, the city experienced an ... The tragedy of Vila Socó epitomizes the socio-environmental repercussions of rapid industrialization in Cubatão. Beginning in the 1940s with the construction of the Anchieta highway, the city experienced an influx of migrants drawn by burgeoning industries, leading to unplanned urban growth and the emergence of vulnerable communities like Vila Socó. This article examines the interconnected factors—such as demographic shifts, inadequate planning, and regulatory oversight—that culminated in the devastating fire of 1984, claiming numerous lives and highlighting systemic failures. Utilizing the Haddon Matrix, this study dissects the Vila Socó incident, emphasizing the roles of human error, infrastructure integrity, and socio-economic disparities in disaster causation. By contextualizing the tragedy within Cubatão’s industrial trajectory, it underscores the urgent need for comprehensive risk assessment and proactive mitigation strategies in rapidly developing regions globally. Beyond its immediate focus, this work offers broader insights into the dynamics of industrial disasters and their socio-economic implications. As pipelines continue to play a vital role in global energy infrastructure, the lessons drawn from Vila Socó’s tragedy resonate deeply, emphasizing the imperative of robust safety protocols and accountable governance to prevent similar catastrophes in the future. 展开更多
关键词 Haddon Matrix vila Socó Accident Risk Analysis Cubatão
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Restoration as a Social Cohesion Instrument:Vila Itororóin Central São Paulo 被引量:1
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作者 Benjamim Saviani 《Built Heritage》 2018年第1期66-76,共11页
Recently,the restoration work of Vila Itororó-an architectural complex in central São Paulo,built around the 1920s,has been carried out,enabling applied field research for restoration as well as for historic... Recently,the restoration work of Vila Itororó-an architectural complex in central São Paulo,built around the 1920s,has been carried out,enabling applied field research for restoration as well as for historical per­spective of the social and cultural development that took place at Vila Itororó.Alongside the restoration work,a cultural centre has been installed on the site,embracing the opportunities of creating a new agenda for Vila Itororówith the community while the restoration takes place.Through this,Vila Itororóhas been able to bring the discus­sion and practise of restoration closer to the civil society,reaching a public beyond the academic circles.The rich environment produced by these efforts has allowed for an outlet of publications and discussions regarding issues that range from architectural prospection to the role that heritage can play with our society in the city of the 21st century.This paper intends to present some of these discussions,their origins,insights and other findings that this experience has fostered. 展开更多
关键词 Brazil São Paulo vila Itororó architectural prospection restoration work
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结肠癌细胞中组织因子/活性凝血因子Ⅶ-表皮生长因子受体通路间交互作用机制 被引量:1
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作者 陈贺凯 戴芸 +3 位作者 吴婷 汪欣 万远廉 汤坚强 《北京大学学报(医学版)》 CAS CSCD 北大核心 2017年第6期931-936,共6页
目的:探讨结肠癌细胞中组织因子/活性凝血因子Ⅶ(tissue factor/active coagulation factorⅦ,TF/FⅦa)通路与表皮生长因子受体(epidermal growth factor receptor,EGFR)通路之间是否存在交互作用。方法:在KRAS野生型的HT-29及KRAS突变... 目的:探讨结肠癌细胞中组织因子/活性凝血因子Ⅶ(tissue factor/active coagulation factorⅦ,TF/FⅦa)通路与表皮生长因子受体(epidermal growth factor receptor,EGFR)通路之间是否存在交互作用。方法:在KRAS野生型的HT-29及KRAS突变型的Lo Vo结肠癌细胞中,以FⅦa活化TF/FⅦa通路,采用qRT-PCR、Western blot检测EGFR配体双调蛋白(amphiregulin,AREG)及表皮调节素(epiregulin,EREG)基因、蛋白表达改变;利用RNA干扰技术敲低TF表达后活化TF/FⅦa通路,检测其对AREG、EREG基因表达的影响,以证实FⅦa对AREG、EREG表达调节作用依赖TF。以表皮生长因子(epidermal growth factor,EGF)激活两细胞EGFR通路后,检测TF/FⅦa通路关键分子TF、FⅦ基因表达改变。结果:TF/FⅦa通路活化后,HT-29细胞AREG、EREG基因表达及EREG蛋白表达水平均较对照组显著下调(AREG、EREG基因表达量分别为0.55±0.09 vs.0.99±0.09、0.67±0.10 vs.1.02±0.02,EREG蛋白表达量0.54±0.09 vs.1.04±0.13,P均<0.05);Lo Vo细胞AREG基因表达及AREG、EREG蛋白表达水平较对照组显著上调(AREG基因表达量1.87±0.39 vs.0.93±0.23,AREG、EREG蛋白表达量3.09±0.73 vs.1.11±0.21、1.53±0.19 vs.0.97±0.23,P均<0.05);TF敲低后均可部分阻断FⅦa对两细胞AREG、EREG表达调节作用;EGFR通路激活后,HT-29细胞TF基因表达较对照组无显著变化,FⅦ基因表达未检测到,而Lo Vo细胞的FⅦ及TF基因表达均较对照组显著上调,表达量分别为1.53±0.23 vs.1.00±0.23、53.20±6.08 vs.1.00±0.15(P均<0.05)。结论:结肠癌Lo Vo细胞TF/FⅦa通路与EGFR通路的活化可分别上调另一通路的关键分子表达并发生交互作用,KRAS基因突变可能对该交互作用的发生发挥关键作用。 展开更多
关键词 结肠肿瘤 凝血致活酶 因子Ⅶa 受体 表皮生长因子
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近现代岭南庭园建筑的地域性表达——以东莞可园和白云山庄旅舍为例 被引量:1
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作者 陈梦君 孙丽君 向科 《广东园林》 2016年第5期46-49,共4页
近现代岭南庭园的发展极具地域性特色。以东莞可园和白云山庄为例,从岭南人文精神、空间模式、气候适应性设计策略和建筑技术四个方面,解析近代岭南园林的发展变革和形成原因。总结岭南近现代庭园建筑地域性表达的个性特征和发展规律,... 近现代岭南庭园的发展极具地域性特色。以东莞可园和白云山庄为例,从岭南人文精神、空间模式、气候适应性设计策略和建筑技术四个方面,解析近代岭南园林的发展变革和形成原因。总结岭南近现代庭园建筑地域性表达的个性特征和发展规律,并对当代岭南建筑创作保持与传承地域性特色进行反思。 展开更多
关键词 岭南庭园 地域性表达 东莞 可园 白云山庄旅舍
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浅议乡村别墅的空间组织
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作者 刘谢江 《城市建筑》 2014年第9期240-240,共1页
近年来,随着别墅市场慢慢地走向成熟,其庭院设计已成为衡量别墅品质的又一新卖点。本文根据笔者对部分别墅庭院项目的工作经验,尝试分析了别墅庭院设计的主要步骤,并对每一步骤中的设计方法进行了初步地探讨。
关键词 乡村别墅 建筑空间 环境
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