The preparation of hitherto unknown steroidal heterocycles containing pyrazole fused to 6,7-position of the steroidal nucleus is described. These heterocycles were prepared by the action of Vilsmeier reagent with ster...The preparation of hitherto unknown steroidal heterocycles containing pyrazole fused to 6,7-position of the steroidal nucleus is described. These heterocycles were prepared by the action of Vilsmeier reagent with steroidal semicarbazones in DMF. The structure of the compounds has been established on the basis of their elemental analysis and spectral data. A general mechanistic scheme for these reactions is also suggested based on current and previous results.展开更多
A series of（Z）-2-chloro-1,3-diarylpropen-1-ones were unexpectedly synthesized in moderate yields by treatment of easily available 2,3-epoxy-1,3-diarylpropan-1-ones with Vilsmeier reagent,which was derived from bis（...A series of（Z）-2-chloro-1,3-diarylpropen-1-ones were unexpectedly synthesized in moderate yields by treatment of easily available 2,3-epoxy-1,3-diarylpropan-1-ones with Vilsmeier reagent,which was derived from bis（trichloromethyl） carbonate（BTC, triphosgene） and DMF.A possible mechanism was also proposed,where sequential ring-opening,halogenation and elimination reactions were involved.展开更多
文摘The preparation of hitherto unknown steroidal heterocycles containing pyrazole fused to 6,7-position of the steroidal nucleus is described. These heterocycles were prepared by the action of Vilsmeier reagent with steroidal semicarbazones in DMF. The structure of the compounds has been established on the basis of their elemental analysis and spectral data. A general mechanistic scheme for these reactions is also suggested based on current and previous results.
基金the National Natural Science Foundation of China(Nos.20806073 and 20876147)the National Key Technology Research and Development Program(No.2007BAI34B06) for financial support
文摘A series of（Z）-2-chloro-1,3-diarylpropen-1-ones were unexpectedly synthesized in moderate yields by treatment of easily available 2,3-epoxy-1,3-diarylpropan-1-ones with Vilsmeier reagent,which was derived from bis（trichloromethyl） carbonate（BTC, triphosgene） and DMF.A possible mechanism was also proposed,where sequential ring-opening,halogenation and elimination reactions were involved.
