Quantification of In Vivo Epidermal Keratinocyte Architecture Associated with the Signs of Skin Aging and the Skin Benefit Evaluation by Application of Galactomyces Ferment Filtrate (Pitera)-Containing Skin Care Product

Background: Aged skin exhibits visual alterations such as wrinkles, rough texture, pore dilation, and dull skin tone, as well as physiological aging, namely, decreased hydration and increased transepidermal water loss (TEWL). Recent advances in coherence tomography have also revealed that skin aging affects in vivo epidermal keratinocyte architecture. However, the interconnectivity between spatial architectural aging and visual/physiological aging parameters remains largely unknown. Purpose: To elucidate whether the tomographic keratinocyte architectural aging is correlated with visual and physiological skin aging parameters and to quantitatively evaluate the improvements of the architectural, visual, and physiological aging parameters by the daily treatment of the skin care formula containing Galactomyces Ferment Filtrate (GFF, 8X PiteraTM). Method: We measured the in vivo keratinocyte cellular architecture with two-photon stereoscopic tomography obtaining by-layer epidermal section images in 78 Asian females of various ages. Visual aging parameters were analyzed using a portable image capture system. Hydration and TEWL were also assessed. The anti-aging effects of GFF-containing skin moisturizer (SK-II LXP CreamTM) were also examined in two studies after twice-daily application for 2 (N = 35) and 4 (N = 32) weeks. Results: As for the keratinocyte cellular architecture, skin aging was significantly associated with decreased cell density and increased cell uniformity. These architectural aging parameters were significantly correlated with visual and physiological aging parameters, namely, rough texture, wrinkles, pore dilation, dull skin tone, dehydration, and increased TEWL. The strong interconnectivity allowed us to develop formulae to estimate the keratinocyte architecture from visual aging parameters. Moreover, twice-daily application of SK-II significantly improved the keratinocyte architecture associated with multiple skin aging visual and physiological parameters. Conclusion: Skin aging is a process involving mutual interconnections among epidermal keratinocyte cellular architecture, visual, and physiological parameters. The GFF-containing moisturizer SK-II effectively improves spatial architecture of keratinocytes in epidermis and these evaluated skin aging parameters in a new trajectory over the course of treatment. .

新型Nd:YAG激光治疗中老年玻璃体混浊患者的视觉质量评价研究

目的通过新型Nd:YAG激光治疗中老年玻璃体混浊患者的视觉质量评价研究,评估新型Nd:YAG激光治疗玻璃体混浊的疗效及应用价值。方法本研究为前瞻性观察性队列研究,本研究共筛选入组47例患者54只眼,其中男性20例,女性27例,年龄30~81岁,平均年龄(58.32±10.38)岁。所有患者术前进行最佳矫正视力(BCVA)、眼压、眼B超、超广角扫描激光眼底照相、裂隙灯散瞳眼底检查、光相干断层扫描(OCT),评估患者玻璃体混浊的位置及玻璃体后脱离情况。术后2周、4周随访,记录BCVA、眼压、眼底情况。采用配对t检验方法比较治疗前后BCVA、眼压的变化,P<0.05为差异有统计学意义的标准。结果Nd:YAG激光术前患者BCVA为0~1.0,平均为(0.18±0.27),眼压为10~20mmHg,平均为(14.84±2.22)mmHg。术后4周患者BCVA为0~1.0,平均为(0.17±0.25),眼压为9~19mmHg,平均为(14.30±2.39)mmHg。统计学分析发现,术前术后视力变化无显著性差异(P=0.129),但术后眼压轻度下降,差异有统计学意义(P=0.015)。术后4周患者视觉质量满意度评价平均分为5~10分,平均为(8.10±1.18)分。82%的患者术后3天内黑点增多,98%的患者术后2周眼前遮挡黑影消失,96%的患者术后4周视觉质量明显改善。结论经新型Nd:YAG激光治疗后的中老年玻璃体混浊患者,飞蚊症症状改善明显,患者视觉质量满意度高,尤其是伴有明显weiss环患者,患者的视觉质量改善显著。

Effects of healthy aging on human primary visual cortex

Aging often results in reduced visual acuity from changes in both the eye and neural circuits [1-4]. In normally aging subjects, primary visual cortex has been shown to have reduced responses to visual stimulation [5]. It is not known, however, to what extent aging affects visual field repre-sentations and population receptive sizes in human primary visual cortex. Here we use func-tional MRI (fMRI) and population receptive field (pRF) modeling [6] to measure angular and ec-centric retinotopic representations and population receptive fields in primary visual cortex in healthy aging subjects ages 57 - 70 and in healthy young volunteers ages 24 - 36 (n = 9). Retinotopic stimuli consisted of black and white, drifting checkerboards comprising moving bars 11 deg in radius. Primary visual cortex (V1) was clearly identifiable along the calcarine sulcus in all hemispheres. There was a significant decrease in the surface area of V1 from 0 to 3 deg eccentricity in the aging subjects with respect to the young subjects (p = 0.039). The coherence of the fMRI% BOLD modulation was significantly decreased in the aging subjects compared to the young subjects in the more peripheral eccentricity band from 7 to 10 deg (p = 0.029). Finally, pRF sizes were significantly increased within the 0 to 3 deg foveal representation of V1 in the aging subjects compared to the young subjects (p = 0.019). Understanding the extent of changes that occur in primary visual cortex during normal aging is essential both for understanding the normal aging process and for comparisons of healthy, aging subjects with aging patients suffering from age-related visual and cortical disorders.

De-aging技术相关专利分析

随着电视、电影特效等技术的快速发展,De-aging(即数字减龄、逆龄、去老化)技术得到了广泛的应用。对De-aging技术相关专利申请进行分析,从全球专利申请趋势、申请地域分布、申请人地域分布、主要申请人、申请人成分构成等方面进行详细阐述,并基于技术分支和重要申请人对重点专利进行梳理,为后续De-aging专利的研发、专利申请或专利分析等提供依据。

Visual problems: a review of prevalence studies on visual impairment in school-age children

Childhood visual impairment(VI) have a significant impact on the educational achievement, career choices and social life of affected individual, and in children, is mainly due to either preventable or treatable causes. Reliable data on the prevalence and causes of VI in children will guide the development of a systematic vision screening program for its early detection and successful treatment of possible causes. The purpose of this literature review is to summarize the available data on prevalence and causes of VI in school-age children from various regions globally. A discussion on the major findings highlighting the definition criteria, classifications and limitations for further studies is also presented.

Epidemiological Study of the Development of Visual Acuity in Preschoolers Aged 3 to 6 in the Shenzhen Area

Purpose: To investigate the visual acuity of preschoolers aged 3 to 6 years in Shenzhen of China. Methods:Visual acuity was measured in preschoolers from eight kindergartens in Shenzhen. Results:A total of 1147 children completed the visual acuity test.There were 77 boys and 62 girls aged 3 years,259 and 216 aged 4,193 and 160 aged 5 and 94 and 86 aged 6. The mean visual acuities of children aged 3,4,5,and 6 years were 0.51±0.10, 0.54±0.13, 0.65±0.14, and 0.71±0.17, respectively. The visual acuity was significantly improved with increasing age (P=0.000). Conclusion:For preschoolers aged 3 to 6, the visual acuity continuously develops and improves. Therefore, age should be considered when diagnosing amblyopia in children.

Bibliometrics of stem cell effects on aging in the last decade based on the Web of Science database

Objective:To summarize the recent 10 years of related literature on stem cell effect on aging and explore the research results and hot topics.Methods:Based on the core databaseof Web of Science,all relevant literature from January 1,2012,to December 31,2021,was screened,and CiteSpace 6.1.R2 software was used to show the intrinsic value of literature.The number of publications,research institutions,research countries,co-cited literature,and keywords was analyzed and visualized.Results:In the past 10 years,the total number of articles published showed an upward trend.The number of articles published by relevant countries was 3,911,and the United States had the most significant number of articles published and the highest centrality.The research institutions were mainly universities,supplemented by research centers,and the quality of articles published by famous foreign universities in this field was high.The most co-cited literature is“Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan”by Darren J Baker,which clarifies the feasibility of cell therapy for aging.The high-frequency keywords are stem cell,senescence,expression,etc.,and the most central ones are cancer cell,migration and DNA repair,etc.In addition,emergent words and clustering show that research hotspots are mainly in the aging mechanism.There are many research entry points,and the pathogenesis and development of senescence,therapeutic targets of ion channels in senescent cells,and their effects on exosomes are the main focus of current research.Conclusion:Literature through the analysis of 10 years of research literature summary suggests that stem cell function in aging still needs further study;the United States is in the leading position in this regard,and the research results also show that research institutions dominate in the developed countries,North America and Europe in the increasing number of papers at the same time,and China should pay attention to the quality of the post,in order to make more progress.The literature of some high-quality scholars can be used as a reference to expand our thinking.The aging mechanism still needs to be many follow-upstudies to clarify the pathway and target in the treatment of more refined Alzheimer’s disease and other age-related diseases need to delve into.Subsequent scholars should study the specific role of stem cells in treating aging;in recent years,hot words,such as exosomes,oxidative stress,etc.,can be used as the thinking of the follow-up study and contribute to the development of the field.

近10年国内老年血液透析研究热点的可视化分析

目的:分析我国老年血液透析患者的研究现状、热点及趋势。方法:检索中国知网(CNKI)、万方数据库、维普数据库、中国生物医学文献数据库近10年发表的老年血液透析相关文献,应用CiteSpace 6.2.R7对相关研究的作者、研究机构、关键词进行可视化分析。结果:检索出符合要求的文献1545篇,文献发文量保持平稳增长,2018年为发文高峰;发文期刊多为医疗类期刊,发文量最多的作者为罗洋、陈文和郭一丹,各6篇;发文量较多的地区集中在北京、上海、南京和四川。老年血液透析研究热点集中在治疗、用药、预后和并发症的管理。结论:老年血液透析研究内容较广泛、热点不突出;研究领域内作者及机构合作不紧密,未形成稳定的核心作者群;目前的研究水平发展较不均衡,护理研究内容和质量有待加强。

学龄前儿童常用视力表的研究进展

学龄前期(3-6岁)是视觉发育的关键时期,及早发现并治疗学龄前儿童视觉问题至关重要。视力表是筛查儿童视觉问题的重要工具,国内常采用标准对数视力表和儿童图形视力表,而国外则常用Lea、HOTV和ETDRS视力表。已经有很多研究报道了这三种视力表在儿童视力检查中的可测性、可重复性及诊断视觉相关问题的敏感性。然而,在国内这三种视力表的应用较为有限,本文就这三种视力表的设计原理、临床中的应用及各自的特点进行综述,以便更好地了解它们在学龄前儿童中的适用性和局限性,从而为未来视力检查方法的选择和改进提供参考。

Corvis ST新参数应力-应变指数的研究进展

可视化角膜生物力学分析仪(Corvis ST)是目前评估在体角膜生物力学最常用的临床设备。新参数应力-应变指数(SSI)是近年来临床研究的热点,其不仅可以直接反映角膜生物材料刚度,而且与某些疾病的进展密切相关。SSI是基于使用有限元(FE)数值建模模拟眼内压和Corvis ST喷气效果的角膜行为预测生成的。SSI算法不随着本身中央角膜厚度(CCT)、眼内压以及生物力学矫正眼压(BIOP)的变化而变化,但明显与角巩膜中的胶原纤维改变有关。本文将从SSI的原理、年龄与SSI的关系、眼轴与SSI的关系、近视程度与SSI的关系、SSI的应用等方面进行归纳和总结。

新生血管性年龄相关性黄斑变性中视网膜下高反射物质的研究进展

视网膜下高反射物质(SHRM)是光学相干断层扫描中显示的一种高反射性形态学特征,位于神经上皮外层、色素上皮内层。其常见于未经治疗或经抗血管内皮生长因子治疗后的新生血管性年龄相关性黄斑变性(nAMD),也可见于中心性浆液性脉络膜视网膜病变、葡萄膜炎、近视性脉络膜新生血管、近视性黄斑变性、Best病、视网膜营养不良和脂质肉芽肿病等。SHRM与患者眼部椭圆体带缺失、瘢痕形成、外界膜损伤、黄斑萎缩及外层视网膜管型结构等关系密切,并与视力损害显著相关。抗血管内皮生长因子治疗可显著消退部分SHRM,不同成分及特征的SHRM对治疗有不同的预后反应。明确nAMD中SHRM的形态特征及其功能后果,进一步加深临床对SHRM的认识。

含分层损伤AGS起裂和扩展过程数值模拟

建立了在压缩荷载下先进复合材料格栅加筋结构(AGS)后屈曲阶段的分层起裂和扩展过程的数值模拟方法.首先,基于一阶剪切变形理论和Von Karman几何非线性关系,提出了AGS结构后屈曲有限元分析模型;其次,采用总能量释放率准则,并利用虚裂纹闭合法(VCCT)及自适应网格的生成和移动技术分析了分层损伤的扩展过程,在分析过程中考虑了分层前缘的接触效应;最后,应用OpenGL实现了分层损伤的扩展动态可视化过程.通过典型算例,讨论了肋骨与分层中心的相对位置,以及蒙皮的铺层方式对AGS结构的分层起裂和扩展过程的影响.所提方法和所得结论对AGS结构的承载能力预测将具有参考价值.

超声乳化术联合SBL-3区域折射型非球面IOL治疗年龄相关白内障的效果及对视觉质量的影响

目的 探究超声乳化术联合SBL-3区域折射型非球面人工晶状体(IOL)治疗年龄相关白内障的效果及对视觉质量的影响。方法 选取2022年1—12月收治的年龄相关白内障110例,采用随机数字表法分为单焦点组55例和SBL-3组55例,单焦点组予超声乳化术联合ADAPT AO非球面单焦点IOL植入,SBL-3组给予超声乳化术联合SBL-3区域折射型非球面IOL植入。比较2组术后3个月对比敏感度[明光、暗光、明光炫光、暗光炫光],术前和术后3个月视觉质量[客观散射指数(OSI)、斯特列尔比(SR)、调制传递函数截止频率(MTF cut off)]、视力[最佳矫正近视力(BCNVA)、最佳矫正远视力(BCDVA)、远视矫正下的近视力(DCNVA)]及生活质量[视功能与生存质量问卷(VF-QOL)]。结果 术后3个月,SBL-3组对比敏感度高于单焦点组(P<0.05);术后3个月,2组OSI、BCNVA、BCDVA、DCNVA水平均较术前降低,SBL-3组低于单焦点组(P<0.05);术后3个月,2组SR、MTF cut off水平及VF-QOL评分均较术前升高,SBL-3组高于单焦点组(P<0.05)。结论 超声乳化术联合SBL-3区域折射型非球面IOL能够提高年龄相关白内障患者对比敏感度及视觉质量,改善视力水平及生活质量。

老年人自我报告视力和听力功能障碍及其交互作用与衰弱的相关性研究

目的探讨基于老年人群自我报告的视力障碍和听力障碍及其交互作用与衰弱的关联。方法2022年10月至2023年3月采用便利抽样方法选取遵义市6所医疗机构共5925例老年人进行调查。收集病人一般临床资料,采用衰弱筛查量表评估衰弱情况,感官功能自评表评价其视听功能。采用多因素Logistic回归分析探究视力和听力障碍与老年人衰弱的关联强度和交互作用。结果控制混杂因素后,Logistic回归分析结果显示,视力障碍(OR=2.814,95%CI:2.422~3.270)、听力障碍(OR=1.899,95%CI:1.603~2.249)是老年人发生衰弱的影响因素。交互作用结果显示,视力障碍与听力障碍对老年人衰弱的发生具有相加交互作用(OR=5.709,95%CI:4.507~7.231),相对超额危险度(RERI)=2.515(95%CI:1.241~3.790),归因比(AP)=0.441(95%CI:0.298~0.583),交互作用指数(S)=2.147(95%CI:1.532~3.008)。结论视力障碍、听力障碍是老年人发生衰弱的影响因素,且二者对老年人衰弱的发生具有相加交互作用,提示应重视老年人视听功能的筛查和管理,尽早采取针对性的干预,可有助于预防或延缓老年人衰弱进程,促进健康老龄化。

视觉传达设计的适老性研究

随着人民生活水平的提高,老年群体对养老服务的质量提出了更高要求,对于养老产品的适老性需求越来越强烈。视觉传达设计的适老性不仅要凸显在电子产品设备方面,还需要凸显在图书的设计上,在开本、周边配套设施、制作材料、内容元素等设计时充分考虑老年群体的视觉需求,从视觉传达设计的角度让老年群体更好地享受晚年生活。

Research on the Hotspots and Development of“Internet+Nursing Services”in China:A Bibliometric Analysis Based on CiteSpace

Objective:This study aims to explore the current research status,hotspots,and trends of the emerging nursing model of“Internet+nursing service”in China,and to provide theoretical references for further research and development.Methods:The literature related to“Internet+nursing service”was retrieved from the China National Knowledge Infrastructure(CNKI),Wanfang database,VIP database,and SinoMed.Subsequently,visual analysis was performed using the CiteSpace scientific knowledge mapping software.Results:A total of 1223 articles were included.The number of papers published in this field has been increasing yearly,and a core group of authors has been formed.Research institutions are mainly comprised of universities and hospitals and a high percentage of projects were funded provincially and municipally,while the least percentage of projects were funded nationally.The main research hotspots include the nurse standardized management for online appointments,the current application situation for the nursing model,and factors influencing its application amongst the elderly and also in women and children’s groups.Conclusion:Although the“Internet+nursing service”in China is still in its early stages,considerable progress has been made in relevant research.Future research should focus on identifying and omitting factors that hinder the industry’s growth,thereby establishing an effective long-term model of care.

2003年—2023年老年人主观认知下降的研究热点和护理启示

目的老年人群中主观认知下降(Subjective Cognitive Decline,SCD)的研究显著增加。本研究采用文献计量学的方法分析近20年老年人SCD研究的热点和趋势,旨在为研究者开展该领域的研究提供参考。方法本研究选择Web of Science核心合集中2003年至2023年发表的关于老年人SCD的研究,初步检索获得1502篇,最终纳入1436篇。采用CiteSpace软件对国家、机构、作者、期刊、关键词和突现词等进行分析。结果老年人SCD研究整体呈现上升趋势。美国在该研究领域占据主导地位,其次为中国和法国;加州大学系统、法国国家健康与医学研究院及UDICE法国研究型大学联盟是发文量处于前3位的研究机构;Frank Jessen、韩瑛和Kathryn Ellis是发文量处于前3位的研究者;被引频次处于前3位的期刊为Neurology、Alzheimers&Dementia、Journal of Alzheimer’s Disease。关键词聚类分析显示关注热点涉及“抑郁”“功能连接”“认知储备”“认知功能”“身体活动”、“痴呆症预防”“行为障碍”“初级保健”和“早期诊断”等;关键词的突现词包括“身体活动”“临床前阿尔茨海默病”“框架”“未来痴呆症”和“老年抑郁症”。结论老年人SCD的研究逐年增长,成为研究者关注的热点,其研究范围和主题也逐渐扩大,重点关注早期筛查和预防、负性情绪及症状管理,可为后期护理研究者开展相关研究提供借鉴和参考。

智能时代下专题数据的可视化

智能化时代背景下,海量数据、算力增长为专题制图带来了新的数据源,但也为数据可视化工作带来了新的挑战,传统专题制图可视化手段已无法满足爆炸增长的专题数据需要。通过对比传统专题数据与智能时代下专题数据的可视化,得出了数据驱动、计算决定、粒度影响3种智能时代下专题数据可视化的新特征,并据此为智能时代下专题数据可视化提出了图表形式与量化策略。以《广东省地图集》为例,验证了该方式的可行性。

面向老年用户的药品外包装信息可视化设计路径研究

目的实现向老年用户准确传达药品信息的目的,提高老年人安全、科学、规范用药的能力,满足老年人阅读药品信息时的功能需要及审美需求。增强视读体验,构建层次分析法(AHP)-逼近理想解排序法(TOPSIS)融合模型,对老年常用药品外包装信息可视化进行深入探讨。方法利用AHP法搭建老年用户需求层级模型,并采用几何平均法进行计算,得到各指标的权重,依据权重的排序结果构思方案。基于TOPSIS法对设计方案进行综合评价,得到最佳的设计方案。对设计方案进行深入优化,并完成设计方案的评估与验证。结果融合AHP-TOPSIS构建的适老化药品包装可视化设计模型,能够更准确地分析用户的实际需求和权重,规范设计方案流程。对最佳设计方案进行了优化和验证,确保最终设计结果能够有效提高老年用户对药品包装信息的阅读准确度和速度。结论使用AHP和TOPSIS组合模型,可避免因设计师个人主观因素及用户年龄差较大而忽略老年用户的实际需求,提升了设计方案的合理性。该方法可为同类适老化产品包装信息可视化设计提供参考。

邦纳综合征研究进展

邦纳综合征(CBS)描述了在没有神经精神障碍的人群中,由于视觉通路损害而出现的幻视。CBS患者通常能洞察到幻觉不是真实的,该病可能是偶发性的、周期性的或者慢性的。由于CBS缺乏统一的诊断标准,加上部分患者对承认幻视存在顾虑,该病的患病率存在差异,从0.4%到30%不等。大量研究表明CBS可能与许多眼部疾病有关,如年龄相关性黄斑变性、青光眼等。除此之外,也有继发于眼科手术或药物治疗的CBS相关报道,因此临床医生应提高对该病的重视,及时诊断并缓解患者情绪。目前有关CBS的眼科学文献资料较少,有必要对其进行总结分析,以探讨其发病机制和诊疗方案。本文就以近年来一些与CBS有关的研究做一综述。