Background With the development of information technology,there is a significant increase in the number of network traffic logs mixed with various types of cyberattacks.Traditional intrusion detection systems(IDSs)are...Background With the development of information technology,there is a significant increase in the number of network traffic logs mixed with various types of cyberattacks.Traditional intrusion detection systems(IDSs)are limited in detecting new inconstant patterns and identifying malicious traffic traces in real time.Therefore,there is an urgent need to implement more effective intrusion detection technologies to protect computer security.Methods In this study,we designed a hybrid IDS by combining our incremental learning model(KANSOINN)and active learning to learn new log patterns and detect various network anomalies in real time.Conclusions Experimental results on the NSLKDD dataset showed that KAN-SOINN can be continuously improved and effectively detect malicious logs.Meanwhile,comparative experiments proved that using a hybrid query strategy in active learning can improve the model learning efficiency.展开更多
BACKGROUND Mesenchymal stem cells(MSCs)are capable of self-renewal and differentiation,and extensive studies have demonstrated their therapeutic potential in atherosclerosis(AS).AIM To conduct a bibliometric analysis ...BACKGROUND Mesenchymal stem cells(MSCs)are capable of self-renewal and differentiation,and extensive studies have demonstrated their therapeutic potential in atherosclerosis(AS).AIM To conduct a bibliometric analysis of studies on the use of MSC therapy for AS over the past two decades,assess key trends and provide insights for future research directions.METHODS We systematically searched the Web of Science Core Collection database for articles published between 1999 and 2023,yielding a total of 556 articles.Visual representation and bibliometric analysis of information and trends were facilitated using CiteSpace,the R package‘bibliometrix’and VOSviewer.RESULTS The analyzed articles were predominantly from 52 countries/regions,with prominent contributions from China and the United States.A cohort of 3057 authors contributed to these publications,with the works of Libby P distinguished by their influence and citation count.Int J Mol Sci has emerged as the journal with the highest publication volume,prominently disseminating influential papers and identifying citation outbreaks.Furthermore,our analysis identified current research hotspots within the field,focusing on vascular progenitor cells,inflammatory mechanisms,and extracellular vesicles.Emerging research frontiers,such as extracellular vesicles and oxidative stress,have been highlighted as areas of burgeoning interest.Finally,we offer perspectives on the status of research and future directions of MSC therapy in AS.CONCLUSION This comprehensive analysis provides valuable insights for advancing scientific research on MSC therapy for AS.By elucidating pivotal trends and research directions,this study aimed to foster innovation and promote the progress of disciplines in this field,thereby contributing to advancing scientific knowledge and clinical practice.展开更多
The Chinese traditional medicine,agarwood,is a commonly used medicine for regulating qi,which has many clinical applications because of its unique curative effect.In this study,CiteSpace software was used to visually ...The Chinese traditional medicine,agarwood,is a commonly used medicine for regulating qi,which has many clinical applications because of its unique curative effect.In this study,CiteSpace software was used to visually analyze the application and development trend of agarwood in the literature from CNKI website in the period of 2007-2022.The analysis results showed that the research on agarwood has basically formed core groups of authors,and universities and their affiliated hospitals are main publishing institutions.Moreover,in this study,several research directions of agarwood were also summarized,including clinical research,chemical composition,structural identification and quality standards,showing that agarwood has rich and flexible application prospects in many aspects.On this basis,several suggestions were put forward:strengthening the cooperation between universities and research institutes and building a scientific research cooperation community,and promoting the combination of clinical research and laboratory research.展开更多
Groundwater is a vital component of the hydrological cycle and essential for the sustainable development of ecosystems.Numerical simulation methods are key tools for addressing scientific challenges in groundwater res...Groundwater is a vital component of the hydrological cycle and essential for the sustainable development of ecosystems.Numerical simulation methods are key tools for addressing scientific challenges in groundwater research.This study uses bibliometric visualization analysis to examine the progress and trends in groundwater numerical simulation methods.By analyzing literature indexed in the Web of Science database from January 1990 to February 2023,and employing tools such as Citespace and VOSviewer,we assessed publication volume,research institutions and their collaborations,prolific scholars,keyword clustering,and emerging trends.The findings indicate an overall upward trend in both the number of publications and citations concerning groundwater numerical simulations.Since 2010,the number of publications has tripled compared to the total before 2010,underscoring the increasing significance and potential of numerical simulation methods in groundwater science.China,in particular,has shown remarkable growth in this field over the past decade,surpassing the United States,Canada,and Germany.This progress is closely linked to strong national support and active participation from research institutions,especially the contributions from teams at Hohai University,China University of Geosciences,and the University of Science and Technology of China.Collaboration between research teams is primarily seen between China and the United States,with less noticeable cooperation among other countries,resulting in a diverse and dispersed development pattern.Keyword analysis highlights that international research hotspots include groundwater recharge,karst water,geothermal water migration,seawater intrusion,variable density flow,contaminant and solute transport,pollution remediation,and land subsidence.Looking ahead,groundwater numerical simulations are expected to play a more prominent role in areas such as climate change,surface water-groundwater interactions,the impact of groundwater nitrates on the environment and health,submarine groundwater discharge,ecological water use,groundwater management,and risk prevention.展开更多
Objective:To explore the development and hotspots in the field of traditional Chinese medicine(TCM)constitution identification since the year 2000.Methods:Using CiteSpace and VOSviewer software,literature from five pr...Objective:To explore the development and hotspots in the field of traditional Chinese medicine(TCM)constitution identification since the year 2000.Methods:Using CiteSpace and VOSviewer software,literature from five prominent databases including VIP,WanFang,China National Knowledge Infrastructure(CNKI),PubMed,and Web ofScience was analyzed.Visual methods were used to examine the annual publications,keywords,authors,and collaborative networks.Results:After deduplication with EndNotes,a total of 5,747 articles meeting the criteria were included.Since 2000,the publications of TCM constitution identification shown three major stages:a significant increasing trend with the year before 2016,a fluctuating trend from 2016 to 2021,and a decreasing trend with the year after 2021.The co-occurrence analysis ofkeywords revealed health management,hypertension,and constitution as hot directions in this field of research.CiteSpace was used for keyword clustering and burst analysis,health management,medical life,and constitution emerged as the latest hotspots in the past three years,which will be the main development directions in the future.Clusters such as hypertension,preventive treatment,and health management were identified,representing the main research themes at present.VOSviewer and CiteSpace were used for co-occurrence and clustering analysis of authors,revealing collaborative research networks,with prominent groups represented by WANG Qi,WANG Ji,LI Lingru,HOU Shujuan,ZHU Yanbo,etc.Conclusion:Research related to TCM constitution identification is developing rapidly,involving various aspects of medical care and daily life.However,there is still a need to build an extensive academic platform,strengthen the dissemination of Chinese medicine culture,standardize,intellectualize and universalize the identification of TCM constitution assessments,and construct a health service system with Chinese characteristics.展开更多
Objective:To evaluate the current state of research and areas of interest for traditional Chinese medicine(TCM)in the field of colorectal cancer treatment.Methods:Related papers published between January 1,2012,and No...Objective:To evaluate the current state of research and areas of interest for traditional Chinese medicine(TCM)in the field of colorectal cancer treatment.Methods:Related papers published between January 1,2012,and November 27,2021,were found using the Web of Science Core Collection Science Citation Index Expanded.Using CiteSpace's network map generation capability,we then determined the top writers,organizations,countries,keywords,co-cited writers,journals,references,and research trends.Results:This investigation yielded a total of 336 relevant papers.China is the most productive country.Shanghai University of Traditional Chinese Medicine is the leading institution.The journal with the most popularity and publishing volume is Evidence-based Complementary and Alternative Medicine.The author with the most citations and centrality is Lin JM.The terms"epithelial-mesenchymal transition,""cell cycle arrest,""apoptosis,"and"autophagy"are highly frequent and have a high betweenness centrality.Conclusion:According to the results,research on natural products,traditional Chinese medicine(TCM)extracts,and the molecular mechanisms of TCM chemical constituents constitutes the primary focus within TCM cancer treatment investigations.In recent years,there has been a surge of interest in exploring the role of gut microbiota in TCM chemical constituents research,particularly in its ability to induce apoptosis and autophagy in tumor cells,thereby suppressing tumor cell proliferation,metastasis,and invasion.However,due to the intricate composition of TCM and existing technical limitations,the underlying principles guiding TCM's efficacy in treating colorectal cancer remain unclear and warrant further investigation.展开更多
Objective:The purpose of this study is to use CiteSpace software to examine the development patterns and hotspots in post-stroke hemiplegia research during the last 20 years.Methods:Articles about post-stroke hemipleg...Objective:The purpose of this study is to use CiteSpace software to examine the development patterns and hotspots in post-stroke hemiplegia research during the last 20 years.Methods:Articles about post-stroke hemiplegia from January 2005 to December 2024 were analyzed in the Web of Science database.CiteSpace software was used to conduct co-citation analysis of the articles about post-stroke hemiplegia as well as cooperative network analyses of authors,countries,and institutions,as well as keyword co-occurrence,clustering,emergence,and time line analyses.The results were displayed in a visual atlas.Result:A total of 2625 papers were obtained,and there were more publications overall.China and the United States had the most number of articles,while Chae,John was the author with the most number of articles.Capital Med University and Ohio State University had the most articles among their agencies.The keywords"stroke"and"rehabilitation"were used the most.The key word analysis indicates that the present study focus is on exercise rehabilitation measures and post-stroke treatment.Conclusion:Using CiteSpace software to analyze the literature on post-stroke hemiplegia,it is discovered that the use of new technologies in the field of mechanical thrombectomy and the effectiveness of rehabilitation techniques like mirror treatment are the key areas of study attention.This study has positive significance for finding safer and more effective treatments for post-stroke hemiplegia.展开更多
Since the new century,China’s mathematics curriculum reform in basic education has continued to move forward in attempts and explorations,presenting many new changes,trends,movements,and developments.Sorting out,anal...Since the new century,China’s mathematics curriculum reform in basic education has continued to move forward in attempts and explorations,presenting many new changes,trends,movements,and developments.Sorting out,analyzing,and summarizing the achievements,experiences,problems,and challenges in this journey are conducive to providing insights for the reform and development of the Chinese basic education mathematics curriculum in the new era.This paper analyses the research on mathematics education in China(1999-2024)using the visual measurement of CiteSpace knowledge mapping,hoping to provide directions for the future of mathematics education in China.展开更多
A real-time monitoring and 3D visualization analysis system is proposed for dam foundation curtain grouting. Based on the real-time control technology, the optimization method and the set theory, a mathematical model ...A real-time monitoring and 3D visualization analysis system is proposed for dam foundation curtain grouting. Based on the real-time control technology, the optimization method and the set theory, a mathematical model of the system is established. The real-time collection and transmission technology of the grouting data provides a data foundation for the system. The real-time grouting monitoring and dynamic alarming method helps the system control the grouting quality during the grouting process, thus, the abnormalities of grouting, such as jacking and hydraulic uplift, can be effectively controlled. In addition, the 3D grouting visualization analysis technology is proposed to establish the grouting information model(GIM). The GIM provides a platform to visualize and analyze the grouting process and results. The system has been applied to a hydraulic project of China as a case study, and the application results indicate that the real-time grouting monitoring and 3D visualization analysis for the grouting process can help engineers control the grouting quality more efficiently.展开更多
Background:This paper uses information visualization software to sort out the relevant research of Neuman systems model at home and abroad in the past 20 years,and discusses the research hotspots and development trend...Background:This paper uses information visualization software to sort out the relevant research of Neuman systems model at home and abroad in the past 20 years,and discusses the research hotspots and development trend in the field of Neuman systems model,so as to provide scientific and reliable reference for the future work and research.Methods:By using CiteSpace V software,this paper analyzes the literatures about the Neuman systems model collected in the core web of science database and CNKI database from 2001 to 2020,and analyzes the time distribution,research power distribution,research hotspots,research frontier and development trend of the Neuman systems model at home and abroad in the past 20 years.Results:The development trend of research in this field in foreign countries is relatively stable.The core strength of research is mainly in the United States,and the research hotspots are health,quality of life,caregivers,spirituality,etc;the research in this field in China is gradually on the rise,and there is no obvious research force,and the research hotspots are mainly quality of life,complications,anxiety,stressors,perioperative period,hypertension,etc.Conclusions:It has been proved that the model has a certain guiding effect on the development of nursing discipline in China.In China,there is still room for development in the research of this model.It is suggested that Chinese scholars can learn from foreign leading research forces to carry out in-depth research and expand its application scope.展开更多
Mitigating increasing cyberattack incidents may require strategies such as reinforcing organizations’ networks with Honeypots and effectively analyzing attack traffic for detection of zero-day attacks and vulnerabili...Mitigating increasing cyberattack incidents may require strategies such as reinforcing organizations’ networks with Honeypots and effectively analyzing attack traffic for detection of zero-day attacks and vulnerabilities. To effectively detect and mitigate cyberattacks, both computerized and visual analyses are typically required. However, most security analysts are not adequately trained in visualization principles and/or methods, which is required for effective visual perception of useful attack information hidden in attack data. Additionally, Honeypot has proven useful in cyberattack research, but no studies have comprehensively investigated visualization practices in the field. In this paper, we reviewed visualization practices and methods commonly used in the discovery and communication of attack patterns based on Honeypot network traffic data. Using the PRISMA methodology, we identified and screened 218 papers and evaluated only 37 papers having a high impact. Most Honeypot papers conducted summary statistics of Honeypot data based on static data metrics such as IP address, port, and packet size. They visually analyzed Honeypot attack data using simple graphical methods (such as line, bar, and pie charts) that tend to hide useful attack information. Furthermore, only a few papers conducted extended attack analysis, and commonly visualized attack data using scatter and linear plots. Papers rarely included simple yet sophisticated graphical methods, such as box plots and histograms, which allow for critical evaluation of analysis results. While a significant number of automated visualization tools have incorporated visualization standards by default, the construction of effective and expressive graphical methods for easy pattern discovery and explainable insights still requires applied knowledge and skill of visualization principles and tools, and occasionally, an interdisciplinary collaboration with peers. We, therefore, suggest the need, going forward, for non-classical graphical methods for visualizing attack patterns and communicating analysis results. We also recommend training investigators in visualization principles and standards for effective visual perception and presentation.展开更多
Stem cells have been confirmed to be involved in the occurrence and development of diabetic retinopathy;however,the underlying mechanisms remain unclear.In this study,we used Citespace software to visually analyze 552...Stem cells have been confirmed to be involved in the occurrence and development of diabetic retinopathy;however,the underlying mechanisms remain unclear.In this study,we used Citespace software to visually analyze 552 articles exploring the stem cell-based treatment of diabetic retinopathy over the past 20 years,which were included in the Web of Science Core Collection.We found the following:(1)a co-citation analysis of the references cited by all 552 articles indicated 15 clusters.In cluster#0,representing the stem cell field,some highly cited landmark studies emerged between 2009–2013.For example,endothelial progenitor cells and diabetic retinopathy gradually received the full attention of scholars,in terms of their relationship and therapeutic prospects.Some researchers also verified the potential of adipose-derived stem cells to differentiate into stable retinal perivascular cells,using a variety of animal models of retinal vascular disease.All of these achievements provided references for the subsequent stem cell research.(2)An analysis of popular keywords among the 552 articles revealed that,during the past 20 years,a relative increase in basic research articles examining stem cells and endothelial progenitor cells for the treatment of diabetic retinopathy was observed.The contents of these articles primarily involved the expression of vascular endothelial growth factor,vascular regeneration,oxidative stress,and inflammatory response.(3)A burst analysis of keywords used in the 552 articles indicated that genetic and cytological research regarding the promotion of angiogenesis was an issue of concern from 2001 to 2012,including several studies addressing the expression of various growth factor genes;from 2014 to 2020,mouse models of diabetic retinopathy were recognized as mature animal models,and the most recent research has focused on macular degeneration,macular edema,neurodegeneration,and inflammatory changes in diabetic animal models.(4)Globally,the current authoritative studies have focused on basic research towards the stem cell treatment of diabetic retinopathy.Existing clinical studies are of low quality and have insufficient evidence levels,and their findings have not yet been widely accepted in clinical practice.Major challenges during stem cell transplantation remain,including stem cell heterogeneity,cell delivery,and the effective homing of stem cells to damaged tissue.However,clinical trials examining potential stem cell-based treatments of diabetic retinopathy,including the use of pluripotent stem cells,retinal pigment epithelial cells,bone marrow mesenchymal stem cells,and endothelial progenitor cells,are currently ongoing,and high-quality clinical evidence is likely to appear in the future,to promote clinical transformation.展开更多
Objective:The objective of this study is to explore the current situation,clinical research hot spots,and trends of traditional Chinese medicine(TCM)nursing technology in rheumatoid arthritis(RA),to draw a panorama of...Objective:The objective of this study is to explore the current situation,clinical research hot spots,and trends of traditional Chinese medicine(TCM)nursing technology in rheumatoid arthritis(RA),to draw a panorama of clinical research,to provide the basis and clues for subsequent high-level evidence integration and further in-depth research.Materials and Methods:Seven databases including China National Knowledge Infrastructure,Chinese Scientific Journal Database(VIP),Wanfang Database,Chinese Biomedical Literature Database(Sino-Med),PubMed,Embase,and the Cochrane Library were searched.The bibliometric method and visualization software CiteSpace were used to conduct a multi-dimensional analysis of the included literature.Results:A total of 805 pieces of literature were included(of them,one was written in German and four in English),and the number of published literature showed an increasing trend year by year.There were only 30(3.73%)pieces of literature published in nursing journals.The hot spots of the co-occurrence map were concentrated in:(1)the nursing of fumigation in RA;(2)the efficacy evaluation of TCM nursing technology on pain,joint malformation,and joint dysfunction caused by RA.The included literature themes focused on five TCM technologies:fumigation,moxibustion,acupoint patching,acupoint injection,and Chinese herbal soaking.The beginning year and strength in TCM fumigation were 2012 and 5.2,and those in moxibustion were 2011 and 3.38.Conclusion:The related studies are on the rise.It has entered the field of international readers with clear research hot spots.However,there are still shortcomings such as little literature published in Chinese nursing core journals,few non-Chinese-related documents,and a lack of international exchanges and cooperation.The current research hot spots in this field are TCM fumigation,and the cutting-edge trend of future research may be fumigation and moxibustion technology.It is suggested that further research can focus on evidence integration and original research on the self-optimization of these two techniques.展开更多
Fast and high-throughput determination of drugs is a key trend in clinical medicine.Single particles have increasingly been adopted in a variety of photoanalytical and electroanalytical applications,and microscopic an...Fast and high-throughput determination of drugs is a key trend in clinical medicine.Single particles have increasingly been adopted in a variety of photoanalytical and electroanalytical applications,and microscopic analysis has been a hot topic in recent years,especially for electrochemiluminescence(ECL).This paper describes a simple ECL method based on single gold microbeads to image lecithin.Lecithin reacts to produce hydrogen peroxide under the successive enzymatic reaction of phospholipase D and choline oxidase.ECL was generated by the electrochemical reaction between a luminol analog and hydrogen peroxide,and ECL signals were imaged by a camera.Despite the heterogeneity of single gold microbeads,their luminescence obeyed statistical regularity.The average luminescence of 30 gold microbeads is correlated with the lecithin concentration,and thus,a visualization method for analyzing lecithin was established.Calibration curves were constructed for ECL intensity and lecithin concentration,achieving detection limits of 0.05 m M lecithin.This ECL imaging platform based on single gold microbeads exhibits outstanding advantages,such as high throughput,versatility and low cost,and holds great potential in disease diagnostics,environmental monitoring and food safety.展开更多
Objective This study examined the research status and development process of FU Qingzhu’s Obstetrics and Gynecology(Fu Qing Zhu Nv Ke,《傅青主女科》,FQZNK)in the past 40 years with bibliometrics and visual analysis.M...Objective This study examined the research status and development process of FU Qingzhu’s Obstetrics and Gynecology(Fu Qing Zhu Nv Ke,《傅青主女科》,FQZNK)in the past 40 years with bibliometrics and visual analysis.Methods Retrieved all related literature in the research field of FQZNK from the domestic and foreign databases:China National Knowledge Infrastructure(CNKI),China Science and Technology Journal Database(VIP),Wanfang Database,and Web of Science(WOS)core database,including Science Citation Index Expanded(SCIE),Social Sciences Citation Index(SSCI),and Arts&Humanities Citation Index(A&HCI).The search range was from January 1,1980 to March 10,2021.In addition,bibliometrics and CiteSpace 5.7.R2 software were used to analyze literature types,published journals,cited literature,the number of author publica-tions,co-author networks,co-institution networks,keyword co-occurrence networks,keyword clusters,and keyword bursts.Results A total of 678 valid records were included in the final dataset.Literature types,high publication journals,highly cited literature,high-yield institutions,high-yield research teams,and high-productivity scholars in this research field were found through bibliometrics.Liter-ature types can be divided into four categories,among which 451 are theoretical studies on academic thoughts of FQZNK,accounting for 66.5%of the included journals.The Journal of Shanxi Traditional Chinese Medicine had the largest volume of published articles(61),ac-counting for 9.0%of the total number of the included journals.The most cited literature was ZHOU Mingxin’s article“Using the quantitative method to discuss author’s authenticity and formula characteristics of FU Qingzhu’s Obstetrics and Gynecology”,which was cited 94 times.Hunan University of Chinese Medicine,the institution with the most publications,published 45 articles,and YOU Zhaoling,the most published author,published 33 articles.Moreover,it was found that most high-yield researchers came from high-yield institutions and that Hun-an University of Chinese Medicine had the most research on FQZNK.Keyword co-occur-rence analysis revealed that the keyword“FQZNK”had the highest frequency(597 times)and the highest centrality(1.00).Keyword cluster analysis used the Log-Likelihood Ratio(LLR)al-gorithm to form eleven important clusters:#0 treatment aiming at its root causes,#1 gynecopathy,#2 Siwu Decoction(四物汤),#3 FU Qingzhu,#4 post-partum,#5 infertility,#6 dysmenorrhea,#7 sterility,#8 coordinate the heart and kidney,#9 Danggui Buxue Decoction(当归补血汤),and#10 treatment.It was found that the prescriptions of FQZNK were studied mainly before 2000,the theoretical studies were mainly conducted before 2010,and its clinic-al application was mainly explored from 2010 until now.Diseases such as dysmenorrhea,morbid vaginal discharge,infertility,metrorrhagia,and polycystic ovarian syndrome(PCOS)have recently become popular topics in this field.Conclusion The current study provides more scientific,accurate,and comprehensive sci-entific support for further research and development of traditional Chinese medicine(TCM)in FQZNK.With this foundation,people can use burst detection to ascertain the current hot-spots in research,get their development trends,and forecast future research directions.In ad-dition,infertility,morbid vaginal discharge,flooding,and PCOS treatments based on TCM syndrome differentiation are currently popular research topics for FQZNK.展开更多
Objective Through bibliometrics and visual analysis of the related studies on traditional Chinese medicine(TCM)treatment of immune thrombocytopenia(ITP),this study aims to sort out the overall research progress,hotspo...Objective Through bibliometrics and visual analysis of the related studies on traditional Chinese medicine(TCM)treatment of immune thrombocytopenia(ITP),this study aims to sort out the overall research progress,hotspots,and trends in this field,and provide reference for further research in ITP.Methods The articles on ITP treated by TCM were retrieved from China National Knowledge Infrastructure(CNKI),Wanfang Database,China Science and Technology Journal Database(VIP),Web of Science Core Collection(WOSCC),and PubMed.The retrieval time was from the establishment of the databases to July 31,2022.VOSviewer,CiteSpace,Carrot2,and Note-Express were used for data analysis of the articles in terms of their quantities,types,and journals,and for visualization of research hotspots,authors,institutions,and keywords.Results 1493 Chinese articles and 40 English articles were included.The articles in Chinese mainly focus on clinical trial research and clinical experience summary,while the English articles mainly focus on clinical trial research and animal research.The Chinese articles were published in 317 Chinese journals,while English articles were published in 29 English journals.Research hotspots include the clinical syndrome differentiation of ITP,the therapeutic effect of TCM compounds on ITP,and the mechanism of ITP treatment.Keyword analysis shows that there are many research achievements in integrated traditional Chinese and western medicine treatment,clinical research,famous doctors’experience,TCM treatment,cellular immunity,and humoral immunity.The authors with the most articles in Chinese and English are Professor CHEN Xinyi and Professor MA Rou,respectively,and the research institutions with the most articles are Dongzhimen Hospital of Beijing University of Chinese Medicine and Xiyuan Hospital of China Academy of Chinese Medical Sciences.Chinese herbs often used to treat ITP clinically include Xianhecao(Agrimoniae Herba),Nvzhenzi(Ligustri Lucidi Fructus),Mohanlian(Ecliptae Herba),Zhongjiefeng(Sarcandrae Herba),etc.,and the prescription usually used to treat ITP include Guipi Decoction(归脾汤),Xijiao Dihuang Decoction(犀角地黄汤),Bazhen Decoction(八珍汤),Erzhi Pill(二至丸),and Xiaochaihu De-coction(小柴胡汤).The main development trends toward retrospective study,TCM treatment mechanism,and data mining.展开更多
Dear Sir,Triamcinolone acetonide(TA)is worldwide available therapeutic agent that is commonly used throughout medicine.TA remains a safe and important ophthalmic therapeutic agent even after the advent of angiogenes...Dear Sir,Triamcinolone acetonide(TA)is worldwide available therapeutic agent that is commonly used throughout medicine.TA remains a safe and important ophthalmic therapeutic agent even after the advent of angiogenesis inhibitors[1-2].展开更多
Objective: To describe the revolution and research status of Advances in Psychological Science. Methods: A total of 3060 articles published in Advances in Psychological Science from 1983 to 2014 were analyzed with t...Objective: To describe the revolution and research status of Advances in Psychological Science. Methods: A total of 3060 articles published in Advances in Psychological Science from 1983 to 2014 were analyzed with the information visualization method using Citespace software from the aspects of pub- lications, cited frequency and downloads, funding, organizations, authors and keywords. Results: The results showed that the amount of literature published annually had an upward tendency, and 49.4% of the papers were supported by national or provincial projects. Institutions such as the Chinese Academy of Sciences (CAS) and the normal universities were rated in the forefront of the sci- entific research output. Xiting Huang, Hong Li and Yuejia Luo were at the top of the list of prolific authors. Conclusions: A new pattern of cooperative development of the theory and application in the field of psychological research is forming.展开更多
Objective: The aims of this study were to understand the status quo of authors, collaborations between institutions, research hotspots, and research frontiers of fund-sponsored clinical nursing papers and to ...Objective: The aims of this study were to understand the status quo of authors, collaborations between institutions, research hotspots, and research frontiers of fund-sponsored clinical nursing papers and to provide a reference for Chinese scholars to conduct clinical nursing studies in the future.Methods: The visualization software CiteSpace was used to analyze fund-sponsored clinical nursing papers published between 2012 and 2016 in 12 core journals of nursing.Results: In the clinical nursing field, there are many co叩erative author groups; however, the collaborations between institu加 not close and exist mainly within the same province or city. High-frequency keywords have revealed the four clinical nursing research hotspots of population, diseases, nursing intervention, and others. Chinese medicine nursing, prevention, treatment and nursing, and new technology-aided nursing of ventilator-associated pneumonia are the study frontiers of clinical nursing.Conclusions: Clinical nursing studies are rich in content and cover a wide range of areas, and their hotspots and frontiers are closely related to the requirements of clinical nursing. Collaborations across regions, provinces, and cities are not adequate; there is an urgent need to strengthen the cross-regional exchanges and collaborations to promote the further development of clinical nursing.展开更多
It is difficult to analyze the inter-relationship for the construction layout of a reservoir project scientifically and intuitively.According to the characteristics of broad field and huge information,the modeling met...It is difficult to analyze the inter-relationship for the construction layout of a reservoir project scientifically and intuitively.According to the characteristics of broad field and huge information,the modeling methods of digital terrain and solid model as well as the techniques of texture mapping and scene navigation are adopted.The simulation system is developed by C program language,which includes the functions of the interactive navigation of 3D scene,the visual inquiry of project digital model information,the storage and management of project information.A certain reservoir is taken as a case.The 3D visual analysis for the construction layout and engineering information are obtained.The proposed system is of great advantages in dealing with large amount of information and the method provides a theoretical basis and technical support for the construction layout of a reservoir project.展开更多
基金Supported by SJTU-HUAWEI TECH Cybersecurity Innovation Lab。
文摘Background With the development of information technology,there is a significant increase in the number of network traffic logs mixed with various types of cyberattacks.Traditional intrusion detection systems(IDSs)are limited in detecting new inconstant patterns and identifying malicious traffic traces in real time.Therefore,there is an urgent need to implement more effective intrusion detection technologies to protect computer security.Methods In this study,we designed a hybrid IDS by combining our incremental learning model(KANSOINN)and active learning to learn new log patterns and detect various network anomalies in real time.Conclusions Experimental results on the NSLKDD dataset showed that KAN-SOINN can be continuously improved and effectively detect malicious logs.Meanwhile,comparative experiments proved that using a hybrid query strategy in active learning can improve the model learning efficiency.
基金Supported by the Regional Cooperation Program of Shanxi Province,China,No.202204041101038the Construction and Demonstration of the Molecular Diagnosis and Treatment Platform for Vascular Diseases in Shanxi Province,China,No.SCP-2023-17Translational Medicine Engineering Research Center for Vascular Diseases of Shanxi Province,China,No.2022017.
文摘BACKGROUND Mesenchymal stem cells(MSCs)are capable of self-renewal and differentiation,and extensive studies have demonstrated their therapeutic potential in atherosclerosis(AS).AIM To conduct a bibliometric analysis of studies on the use of MSC therapy for AS over the past two decades,assess key trends and provide insights for future research directions.METHODS We systematically searched the Web of Science Core Collection database for articles published between 1999 and 2023,yielding a total of 556 articles.Visual representation and bibliometric analysis of information and trends were facilitated using CiteSpace,the R package‘bibliometrix’and VOSviewer.RESULTS The analyzed articles were predominantly from 52 countries/regions,with prominent contributions from China and the United States.A cohort of 3057 authors contributed to these publications,with the works of Libby P distinguished by their influence and citation count.Int J Mol Sci has emerged as the journal with the highest publication volume,prominently disseminating influential papers and identifying citation outbreaks.Furthermore,our analysis identified current research hotspots within the field,focusing on vascular progenitor cells,inflammatory mechanisms,and extracellular vesicles.Emerging research frontiers,such as extracellular vesicles and oxidative stress,have been highlighted as areas of burgeoning interest.Finally,we offer perspectives on the status of research and future directions of MSC therapy in AS.CONCLUSION This comprehensive analysis provides valuable insights for advancing scientific research on MSC therapy for AS.By elucidating pivotal trends and research directions,this study aimed to foster innovation and promote the progress of disciplines in this field,thereby contributing to advancing scientific knowledge and clinical practice.
基金Supported by Undergraduate Training Program for Innovation and Entrepreneurship of Guangxi University of Chinese Medicine (S202310600135S202310600049).
文摘The Chinese traditional medicine,agarwood,is a commonly used medicine for regulating qi,which has many clinical applications because of its unique curative effect.In this study,CiteSpace software was used to visually analyze the application and development trend of agarwood in the literature from CNKI website in the period of 2007-2022.The analysis results showed that the research on agarwood has basically formed core groups of authors,and universities and their affiliated hospitals are main publishing institutions.Moreover,in this study,several research directions of agarwood were also summarized,including clinical research,chemical composition,structural identification and quality standards,showing that agarwood has rich and flexible application prospects in many aspects.On this basis,several suggestions were put forward:strengthening the cooperation between universities and research institutes and building a scientific research cooperation community,and promoting the combination of clinical research and laboratory research.
基金supported by the Institute of Hydrogeology and Environmental Geology,China Geological Survey"Coupling analysis of groundwater and land subsidence in typical cities of the North China Plain based on InSAR-GRACE technology"project under Grant No.KY202302the China Geological Survey"Research and promotion of digital water resources survey technology"project under Grant No.DD20230427the"Cloud platform geological survey node operation and maintenance and network security guarantee(Institute of Hydrogeology and Environmental Geology)"project under Grant No.DD20230719.
文摘Groundwater is a vital component of the hydrological cycle and essential for the sustainable development of ecosystems.Numerical simulation methods are key tools for addressing scientific challenges in groundwater research.This study uses bibliometric visualization analysis to examine the progress and trends in groundwater numerical simulation methods.By analyzing literature indexed in the Web of Science database from January 1990 to February 2023,and employing tools such as Citespace and VOSviewer,we assessed publication volume,research institutions and their collaborations,prolific scholars,keyword clustering,and emerging trends.The findings indicate an overall upward trend in both the number of publications and citations concerning groundwater numerical simulations.Since 2010,the number of publications has tripled compared to the total before 2010,underscoring the increasing significance and potential of numerical simulation methods in groundwater science.China,in particular,has shown remarkable growth in this field over the past decade,surpassing the United States,Canada,and Germany.This progress is closely linked to strong national support and active participation from research institutions,especially the contributions from teams at Hohai University,China University of Geosciences,and the University of Science and Technology of China.Collaboration between research teams is primarily seen between China and the United States,with less noticeable cooperation among other countries,resulting in a diverse and dispersed development pattern.Keyword analysis highlights that international research hotspots include groundwater recharge,karst water,geothermal water migration,seawater intrusion,variable density flow,contaminant and solute transport,pollution remediation,and land subsidence.Looking ahead,groundwater numerical simulations are expected to play a more prominent role in areas such as climate change,surface water-groundwater interactions,the impact of groundwater nitrates on the environment and health,submarine groundwater discharge,ecological water use,groundwater management,and risk prevention.
基金supported by the National Natural Science Foundation of China Youth Program(81904324)。
文摘Objective:To explore the development and hotspots in the field of traditional Chinese medicine(TCM)constitution identification since the year 2000.Methods:Using CiteSpace and VOSviewer software,literature from five prominent databases including VIP,WanFang,China National Knowledge Infrastructure(CNKI),PubMed,and Web ofScience was analyzed.Visual methods were used to examine the annual publications,keywords,authors,and collaborative networks.Results:After deduplication with EndNotes,a total of 5,747 articles meeting the criteria were included.Since 2000,the publications of TCM constitution identification shown three major stages:a significant increasing trend with the year before 2016,a fluctuating trend from 2016 to 2021,and a decreasing trend with the year after 2021.The co-occurrence analysis ofkeywords revealed health management,hypertension,and constitution as hot directions in this field of research.CiteSpace was used for keyword clustering and burst analysis,health management,medical life,and constitution emerged as the latest hotspots in the past three years,which will be the main development directions in the future.Clusters such as hypertension,preventive treatment,and health management were identified,representing the main research themes at present.VOSviewer and CiteSpace were used for co-occurrence and clustering analysis of authors,revealing collaborative research networks,with prominent groups represented by WANG Qi,WANG Ji,LI Lingru,HOU Shujuan,ZHU Yanbo,etc.Conclusion:Research related to TCM constitution identification is developing rapidly,involving various aspects of medical care and daily life.However,there is still a need to build an extensive academic platform,strengthen the dissemination of Chinese medicine culture,standardize,intellectualize and universalize the identification of TCM constitution assessments,and construct a health service system with Chinese characteristics.
基金funded by the National Natural Science Foundation of China(82122075,82074232)Shanghai Frontier Research Base of Disease and Syndrome Biology of Inflammatory Cancer Trans-formation(2021KJ03-12)"Shu Guang"project supported by Shanghai Municipal Education Commission and Shanghai Education Development Foundation(21SG43).
文摘Objective:To evaluate the current state of research and areas of interest for traditional Chinese medicine(TCM)in the field of colorectal cancer treatment.Methods:Related papers published between January 1,2012,and November 27,2021,were found using the Web of Science Core Collection Science Citation Index Expanded.Using CiteSpace's network map generation capability,we then determined the top writers,organizations,countries,keywords,co-cited writers,journals,references,and research trends.Results:This investigation yielded a total of 336 relevant papers.China is the most productive country.Shanghai University of Traditional Chinese Medicine is the leading institution.The journal with the most popularity and publishing volume is Evidence-based Complementary and Alternative Medicine.The author with the most citations and centrality is Lin JM.The terms"epithelial-mesenchymal transition,""cell cycle arrest,""apoptosis,"and"autophagy"are highly frequent and have a high betweenness centrality.Conclusion:According to the results,research on natural products,traditional Chinese medicine(TCM)extracts,and the molecular mechanisms of TCM chemical constituents constitutes the primary focus within TCM cancer treatment investigations.In recent years,there has been a surge of interest in exploring the role of gut microbiota in TCM chemical constituents research,particularly in its ability to induce apoptosis and autophagy in tumor cells,thereby suppressing tumor cell proliferation,metastasis,and invasion.However,due to the intricate composition of TCM and existing technical limitations,the underlying principles guiding TCM's efficacy in treating colorectal cancer remain unclear and warrant further investigation.
基金Research topics in key areas of Tianjin Administration of Traditional Chinese Medicine:"Establishment of quantitative model of Chinese medicine syndrome of swallowing dysfunction after stroke based on multi-dimensional item response theory and acupuncture intervention"(2023003)Hospital funded project of Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital:"To investigate the mechanism of acupuncture regulating endometrial receptivity from IL-10/HOXA10 axis"(2022002).
文摘Objective:The purpose of this study is to use CiteSpace software to examine the development patterns and hotspots in post-stroke hemiplegia research during the last 20 years.Methods:Articles about post-stroke hemiplegia from January 2005 to December 2024 were analyzed in the Web of Science database.CiteSpace software was used to conduct co-citation analysis of the articles about post-stroke hemiplegia as well as cooperative network analyses of authors,countries,and institutions,as well as keyword co-occurrence,clustering,emergence,and time line analyses.The results were displayed in a visual atlas.Result:A total of 2625 papers were obtained,and there were more publications overall.China and the United States had the most number of articles,while Chae,John was the author with the most number of articles.Capital Med University and Ohio State University had the most articles among their agencies.The keywords"stroke"and"rehabilitation"were used the most.The key word analysis indicates that the present study focus is on exercise rehabilitation measures and post-stroke treatment.Conclusion:Using CiteSpace software to analyze the literature on post-stroke hemiplegia,it is discovered that the use of new technologies in the field of mechanical thrombectomy and the effectiveness of rehabilitation techniques like mirror treatment are the key areas of study attention.This study has positive significance for finding safer and more effective treatments for post-stroke hemiplegia.
文摘Since the new century,China’s mathematics curriculum reform in basic education has continued to move forward in attempts and explorations,presenting many new changes,trends,movements,and developments.Sorting out,analyzing,and summarizing the achievements,experiences,problems,and challenges in this journey are conducive to providing insights for the reform and development of the Chinese basic education mathematics curriculum in the new era.This paper analyses the research on mathematics education in China(1999-2024)using the visual measurement of CiteSpace knowledge mapping,hoping to provide directions for the future of mathematics education in China.
基金Supported by the Innovative Research Groups of the National Natural Science Foundation of China(No.51321065)the National Natural Science Foundation of China(No.51339003 and No.51439005)
文摘A real-time monitoring and 3D visualization analysis system is proposed for dam foundation curtain grouting. Based on the real-time control technology, the optimization method and the set theory, a mathematical model of the system is established. The real-time collection and transmission technology of the grouting data provides a data foundation for the system. The real-time grouting monitoring and dynamic alarming method helps the system control the grouting quality during the grouting process, thus, the abnormalities of grouting, such as jacking and hydraulic uplift, can be effectively controlled. In addition, the 3D grouting visualization analysis technology is proposed to establish the grouting information model(GIM). The GIM provides a platform to visualize and analyze the grouting process and results. The system has been applied to a hydraulic project of China as a case study, and the application results indicate that the real-time grouting monitoring and 3D visualization analysis for the grouting process can help engineers control the grouting quality more efficiently.
基金This study was supported by Reform Research of Education and Teaching in Tianjin University of Traditional Chinese Medicine(No.2016JYF09).
文摘Background:This paper uses information visualization software to sort out the relevant research of Neuman systems model at home and abroad in the past 20 years,and discusses the research hotspots and development trend in the field of Neuman systems model,so as to provide scientific and reliable reference for the future work and research.Methods:By using CiteSpace V software,this paper analyzes the literatures about the Neuman systems model collected in the core web of science database and CNKI database from 2001 to 2020,and analyzes the time distribution,research power distribution,research hotspots,research frontier and development trend of the Neuman systems model at home and abroad in the past 20 years.Results:The development trend of research in this field in foreign countries is relatively stable.The core strength of research is mainly in the United States,and the research hotspots are health,quality of life,caregivers,spirituality,etc;the research in this field in China is gradually on the rise,and there is no obvious research force,and the research hotspots are mainly quality of life,complications,anxiety,stressors,perioperative period,hypertension,etc.Conclusions:It has been proved that the model has a certain guiding effect on the development of nursing discipline in China.In China,there is still room for development in the research of this model.It is suggested that Chinese scholars can learn from foreign leading research forces to carry out in-depth research and expand its application scope.
文摘Mitigating increasing cyberattack incidents may require strategies such as reinforcing organizations’ networks with Honeypots and effectively analyzing attack traffic for detection of zero-day attacks and vulnerabilities. To effectively detect and mitigate cyberattacks, both computerized and visual analyses are typically required. However, most security analysts are not adequately trained in visualization principles and/or methods, which is required for effective visual perception of useful attack information hidden in attack data. Additionally, Honeypot has proven useful in cyberattack research, but no studies have comprehensively investigated visualization practices in the field. In this paper, we reviewed visualization practices and methods commonly used in the discovery and communication of attack patterns based on Honeypot network traffic data. Using the PRISMA methodology, we identified and screened 218 papers and evaluated only 37 papers having a high impact. Most Honeypot papers conducted summary statistics of Honeypot data based on static data metrics such as IP address, port, and packet size. They visually analyzed Honeypot attack data using simple graphical methods (such as line, bar, and pie charts) that tend to hide useful attack information. Furthermore, only a few papers conducted extended attack analysis, and commonly visualized attack data using scatter and linear plots. Papers rarely included simple yet sophisticated graphical methods, such as box plots and histograms, which allow for critical evaluation of analysis results. While a significant number of automated visualization tools have incorporated visualization standards by default, the construction of effective and expressive graphical methods for easy pattern discovery and explainable insights still requires applied knowledge and skill of visualization principles and tools, and occasionally, an interdisciplinary collaboration with peers. We, therefore, suggest the need, going forward, for non-classical graphical methods for visualizing attack patterns and communicating analysis results. We also recommend training investigators in visualization principles and standards for effective visual perception and presentation.
基金This study was supported by the Natural Science Foundation of Jilin Province of China,No.20200201495JCJilin Province Health Technology Innovation Project,No.2017J089。
文摘Stem cells have been confirmed to be involved in the occurrence and development of diabetic retinopathy;however,the underlying mechanisms remain unclear.In this study,we used Citespace software to visually analyze 552 articles exploring the stem cell-based treatment of diabetic retinopathy over the past 20 years,which were included in the Web of Science Core Collection.We found the following:(1)a co-citation analysis of the references cited by all 552 articles indicated 15 clusters.In cluster#0,representing the stem cell field,some highly cited landmark studies emerged between 2009–2013.For example,endothelial progenitor cells and diabetic retinopathy gradually received the full attention of scholars,in terms of their relationship and therapeutic prospects.Some researchers also verified the potential of adipose-derived stem cells to differentiate into stable retinal perivascular cells,using a variety of animal models of retinal vascular disease.All of these achievements provided references for the subsequent stem cell research.(2)An analysis of popular keywords among the 552 articles revealed that,during the past 20 years,a relative increase in basic research articles examining stem cells and endothelial progenitor cells for the treatment of diabetic retinopathy was observed.The contents of these articles primarily involved the expression of vascular endothelial growth factor,vascular regeneration,oxidative stress,and inflammatory response.(3)A burst analysis of keywords used in the 552 articles indicated that genetic and cytological research regarding the promotion of angiogenesis was an issue of concern from 2001 to 2012,including several studies addressing the expression of various growth factor genes;from 2014 to 2020,mouse models of diabetic retinopathy were recognized as mature animal models,and the most recent research has focused on macular degeneration,macular edema,neurodegeneration,and inflammatory changes in diabetic animal models.(4)Globally,the current authoritative studies have focused on basic research towards the stem cell treatment of diabetic retinopathy.Existing clinical studies are of low quality and have insufficient evidence levels,and their findings have not yet been widely accepted in clinical practice.Major challenges during stem cell transplantation remain,including stem cell heterogeneity,cell delivery,and the effective homing of stem cells to damaged tissue.However,clinical trials examining potential stem cell-based treatments of diabetic retinopathy,including the use of pluripotent stem cells,retinal pigment epithelial cells,bone marrow mesenchymal stem cells,and endothelial progenitor cells,are currently ongoing,and high-quality clinical evidence is likely to appear in the future,to promote clinical transformation.
基金supported by the Research Project on Medical Education launched by the Medical Education Branch of the Chinese Medical Association and the Medical Education Professional Committee of the Chinese Society of Higher Education in 2018(2018B-N18075)the Education Science Research Project of Beijing University of Chinese Medicine(XJYB2029)the Fundamental Research Funds for the Central Universities(2020-JYB-ZDGG-082).
文摘Objective:The objective of this study is to explore the current situation,clinical research hot spots,and trends of traditional Chinese medicine(TCM)nursing technology in rheumatoid arthritis(RA),to draw a panorama of clinical research,to provide the basis and clues for subsequent high-level evidence integration and further in-depth research.Materials and Methods:Seven databases including China National Knowledge Infrastructure,Chinese Scientific Journal Database(VIP),Wanfang Database,Chinese Biomedical Literature Database(Sino-Med),PubMed,Embase,and the Cochrane Library were searched.The bibliometric method and visualization software CiteSpace were used to conduct a multi-dimensional analysis of the included literature.Results:A total of 805 pieces of literature were included(of them,one was written in German and four in English),and the number of published literature showed an increasing trend year by year.There were only 30(3.73%)pieces of literature published in nursing journals.The hot spots of the co-occurrence map were concentrated in:(1)the nursing of fumigation in RA;(2)the efficacy evaluation of TCM nursing technology on pain,joint malformation,and joint dysfunction caused by RA.The included literature themes focused on five TCM technologies:fumigation,moxibustion,acupoint patching,acupoint injection,and Chinese herbal soaking.The beginning year and strength in TCM fumigation were 2012 and 5.2,and those in moxibustion were 2011 and 3.38.Conclusion:The related studies are on the rise.It has entered the field of international readers with clear research hot spots.However,there are still shortcomings such as little literature published in Chinese nursing core journals,few non-Chinese-related documents,and a lack of international exchanges and cooperation.The current research hot spots in this field are TCM fumigation,and the cutting-edge trend of future research may be fumigation and moxibustion technology.It is suggested that further research can focus on evidence integration and original research on the self-optimization of these two techniques.
基金supported by Anhui Provincial Natural Science Foundation(Grant Nos.2008085QB68 and 1808085QB29)Key Project of Provincial Natural Science Research Foundation of Anhui Universities(Grant Nos.KJ2018A0675 and KJ2018A0389)+1 种基金Foundation of State Key Laboratory of Analytical Chemistry for Life Science(Grant No.SKLACLS2003)Foundation of Henan Key Laboratory of Biomolecular Recognition and Sensing(Grant No.HKLBRSK1905)。
文摘Fast and high-throughput determination of drugs is a key trend in clinical medicine.Single particles have increasingly been adopted in a variety of photoanalytical and electroanalytical applications,and microscopic analysis has been a hot topic in recent years,especially for electrochemiluminescence(ECL).This paper describes a simple ECL method based on single gold microbeads to image lecithin.Lecithin reacts to produce hydrogen peroxide under the successive enzymatic reaction of phospholipase D and choline oxidase.ECL was generated by the electrochemical reaction between a luminol analog and hydrogen peroxide,and ECL signals were imaged by a camera.Despite the heterogeneity of single gold microbeads,their luminescence obeyed statistical regularity.The average luminescence of 30 gold microbeads is correlated with the lecithin concentration,and thus,a visualization method for analyzing lecithin was established.Calibration curves were constructed for ECL intensity and lecithin concentration,achieving detection limits of 0.05 m M lecithin.This ECL imaging platform based on single gold microbeads exhibits outstanding advantages,such as high throughput,versatility and low cost,and holds great potential in disease diagnostics,environmental monitoring and food safety.
基金National Key R&D Program of China-Science and Technology Innovation 2030-"New Generation of Artificial Intelligence"Major Project(2018AAA0102100)Postgraduate Research Innovation Project of Hunan Province(CX2018B465)2011 Digital Chinese Medicine Innovation Research Platform of Hunan Digital Chinese Medicine Collaborative Innovation Center。
文摘Objective This study examined the research status and development process of FU Qingzhu’s Obstetrics and Gynecology(Fu Qing Zhu Nv Ke,《傅青主女科》,FQZNK)in the past 40 years with bibliometrics and visual analysis.Methods Retrieved all related literature in the research field of FQZNK from the domestic and foreign databases:China National Knowledge Infrastructure(CNKI),China Science and Technology Journal Database(VIP),Wanfang Database,and Web of Science(WOS)core database,including Science Citation Index Expanded(SCIE),Social Sciences Citation Index(SSCI),and Arts&Humanities Citation Index(A&HCI).The search range was from January 1,1980 to March 10,2021.In addition,bibliometrics and CiteSpace 5.7.R2 software were used to analyze literature types,published journals,cited literature,the number of author publica-tions,co-author networks,co-institution networks,keyword co-occurrence networks,keyword clusters,and keyword bursts.Results A total of 678 valid records were included in the final dataset.Literature types,high publication journals,highly cited literature,high-yield institutions,high-yield research teams,and high-productivity scholars in this research field were found through bibliometrics.Liter-ature types can be divided into four categories,among which 451 are theoretical studies on academic thoughts of FQZNK,accounting for 66.5%of the included journals.The Journal of Shanxi Traditional Chinese Medicine had the largest volume of published articles(61),ac-counting for 9.0%of the total number of the included journals.The most cited literature was ZHOU Mingxin’s article“Using the quantitative method to discuss author’s authenticity and formula characteristics of FU Qingzhu’s Obstetrics and Gynecology”,which was cited 94 times.Hunan University of Chinese Medicine,the institution with the most publications,published 45 articles,and YOU Zhaoling,the most published author,published 33 articles.Moreover,it was found that most high-yield researchers came from high-yield institutions and that Hun-an University of Chinese Medicine had the most research on FQZNK.Keyword co-occur-rence analysis revealed that the keyword“FQZNK”had the highest frequency(597 times)and the highest centrality(1.00).Keyword cluster analysis used the Log-Likelihood Ratio(LLR)al-gorithm to form eleven important clusters:#0 treatment aiming at its root causes,#1 gynecopathy,#2 Siwu Decoction(四物汤),#3 FU Qingzhu,#4 post-partum,#5 infertility,#6 dysmenorrhea,#7 sterility,#8 coordinate the heart and kidney,#9 Danggui Buxue Decoction(当归补血汤),and#10 treatment.It was found that the prescriptions of FQZNK were studied mainly before 2000,the theoretical studies were mainly conducted before 2010,and its clinic-al application was mainly explored from 2010 until now.Diseases such as dysmenorrhea,morbid vaginal discharge,infertility,metrorrhagia,and polycystic ovarian syndrome(PCOS)have recently become popular topics in this field.Conclusion The current study provides more scientific,accurate,and comprehensive sci-entific support for further research and development of traditional Chinese medicine(TCM)in FQZNK.With this foundation,people can use burst detection to ascertain the current hot-spots in research,get their development trends,and forecast future research directions.In ad-dition,infertility,morbid vaginal discharge,flooding,and PCOS treatments based on TCM syndrome differentiation are currently popular research topics for FQZNK.
基金Jiangxi Traditional Chinese Medicine Administration Clinical Research Base Construction Project(Jiangxi TCM Science and Education Letter[2021]No.3)Jiangxi Traditional Chinese Medicine Young and Middle-aged Backbone Talents(First Batch)Training Program Project(Jiangxi TCM Science and Education Letter[2020]No.2)Jiangxi Traditional Chinese Medicine Administration Science and Technology Program Project(2021B050).
文摘Objective Through bibliometrics and visual analysis of the related studies on traditional Chinese medicine(TCM)treatment of immune thrombocytopenia(ITP),this study aims to sort out the overall research progress,hotspots,and trends in this field,and provide reference for further research in ITP.Methods The articles on ITP treated by TCM were retrieved from China National Knowledge Infrastructure(CNKI),Wanfang Database,China Science and Technology Journal Database(VIP),Web of Science Core Collection(WOSCC),and PubMed.The retrieval time was from the establishment of the databases to July 31,2022.VOSviewer,CiteSpace,Carrot2,and Note-Express were used for data analysis of the articles in terms of their quantities,types,and journals,and for visualization of research hotspots,authors,institutions,and keywords.Results 1493 Chinese articles and 40 English articles were included.The articles in Chinese mainly focus on clinical trial research and clinical experience summary,while the English articles mainly focus on clinical trial research and animal research.The Chinese articles were published in 317 Chinese journals,while English articles were published in 29 English journals.Research hotspots include the clinical syndrome differentiation of ITP,the therapeutic effect of TCM compounds on ITP,and the mechanism of ITP treatment.Keyword analysis shows that there are many research achievements in integrated traditional Chinese and western medicine treatment,clinical research,famous doctors’experience,TCM treatment,cellular immunity,and humoral immunity.The authors with the most articles in Chinese and English are Professor CHEN Xinyi and Professor MA Rou,respectively,and the research institutions with the most articles are Dongzhimen Hospital of Beijing University of Chinese Medicine and Xiyuan Hospital of China Academy of Chinese Medical Sciences.Chinese herbs often used to treat ITP clinically include Xianhecao(Agrimoniae Herba),Nvzhenzi(Ligustri Lucidi Fructus),Mohanlian(Ecliptae Herba),Zhongjiefeng(Sarcandrae Herba),etc.,and the prescription usually used to treat ITP include Guipi Decoction(归脾汤),Xijiao Dihuang Decoction(犀角地黄汤),Bazhen Decoction(八珍汤),Erzhi Pill(二至丸),and Xiaochaihu De-coction(小柴胡汤).The main development trends toward retrospective study,TCM treatment mechanism,and data mining.
文摘Dear Sir,Triamcinolone acetonide(TA)is worldwide available therapeutic agent that is commonly used throughout medicine.TA remains a safe and important ophthalmic therapeutic agent even after the advent of angiogenesis inhibitors[1-2].
基金supported by MOE(Ministry of Education of China)the research projects of Humanities and Social Sciences(No.13YJCZH239)Project of innovation and entrepreneurship for undergraduates in Shanxi Medical University(No.20160311)
文摘Objective: To describe the revolution and research status of Advances in Psychological Science. Methods: A total of 3060 articles published in Advances in Psychological Science from 1983 to 2014 were analyzed with the information visualization method using Citespace software from the aspects of pub- lications, cited frequency and downloads, funding, organizations, authors and keywords. Results: The results showed that the amount of literature published annually had an upward tendency, and 49.4% of the papers were supported by national or provincial projects. Institutions such as the Chinese Academy of Sciences (CAS) and the normal universities were rated in the forefront of the sci- entific research output. Xiting Huang, Hong Li and Yuejia Luo were at the top of the list of prolific authors. Conclusions: A new pattern of cooperative development of the theory and application in the field of psychological research is forming.
基金supported by scientific research project of the Health Department of Shanxi Province(No.201301008)
文摘Objective: The aims of this study were to understand the status quo of authors, collaborations between institutions, research hotspots, and research frontiers of fund-sponsored clinical nursing papers and to provide a reference for Chinese scholars to conduct clinical nursing studies in the future.Methods: The visualization software CiteSpace was used to analyze fund-sponsored clinical nursing papers published between 2012 and 2016 in 12 core journals of nursing.Results: In the clinical nursing field, there are many co叩erative author groups; however, the collaborations between institu加 not close and exist mainly within the same province or city. High-frequency keywords have revealed the four clinical nursing research hotspots of population, diseases, nursing intervention, and others. Chinese medicine nursing, prevention, treatment and nursing, and new technology-aided nursing of ventilator-associated pneumonia are the study frontiers of clinical nursing.Conclusions: Clinical nursing studies are rich in content and cover a wide range of areas, and their hotspots and frontiers are closely related to the requirements of clinical nursing. Collaborations across regions, provinces, and cities are not adequate; there is an urgent need to strengthen the cross-regional exchanges and collaborations to promote the further development of clinical nursing.
基金Supported by the Science Fund for Creative Research Groups of National Natural Science Foundation of China(No.51021004)Tianjin Research Program of Application Foundation and Advanced Technology(No.12JCZDJC29200)National Key Technology R and D Program in the 12th Five-Year Plan of China(No.2011BAB10B06)
文摘It is difficult to analyze the inter-relationship for the construction layout of a reservoir project scientifically and intuitively.According to the characteristics of broad field and huge information,the modeling methods of digital terrain and solid model as well as the techniques of texture mapping and scene navigation are adopted.The simulation system is developed by C program language,which includes the functions of the interactive navigation of 3D scene,the visual inquiry of project digital model information,the storage and management of project information.A certain reservoir is taken as a case.The 3D visual analysis for the construction layout and engineering information are obtained.The proposed system is of great advantages in dealing with large amount of information and the method provides a theoretical basis and technical support for the construction layout of a reservoir project.