Visual function and vision-related quality of life after vitrectomy for idiopathic macular hole: a 12mo followup study

· AIM: To investigate the visual function and the relationship with vision-related quality of life(VRQOL)after macular hole repair surgery.· METHODS: Prospective case series. Thirty-six consecutive eyes in 36 patients who underwent pars plana vitrectomy(PPV) and internal limiting membrane(ILM) peeling were included. The 25-item National Eye Institute Visual Function Questionnaire(VFQ-25) was answered by the participants before and 3 and 12 mo after operation. Follow-up visits examinations included best-corrected visual acuity(BCVA), clinical examination,and central macular thickness(CMT) measured by optical coherence tomography(OCT).·RESULTS: Macular-hole closure was achieved in 35 of36 eyes(97.2%). At baseline and months 3 and 12, the log MAR BCVAs(mean±SD) were 1.15±0.47, 0.68±0.53(P 【0.0001 versus baseline), and 0.55 ±0.49(P 【0.001 versus baseline, P =0.273 versus month 3), respectively; the CMTs(μm) were 330 ±81, 244 ±62(P 【0.001 versus baseline), and 225±58(P 【0.001 versus baseline, P =0.222 versus month 3), respectively; the median preoperative VFQ-25 composite score of 73.50(63.92-81.13) increased postoperatively to 85.50(80.04-89.63) at 3mo(P 【0.001)and 86.73(82.50-89.63) at 12mo(P 【0.001) respectively.The improved BCVA was correlated with improvements in five subscales(r =-0.605 to-0.336, P 【0.001 to P =0.046) at 12 mo.· CONCLUSION: PPV with ILM peeling improved anatomic outcome, visual function, and VRQOL. Theimproved BCVA was an important factor related to the improved VRQOL.

AB088.Quality of life and visual function in patients with Boston type I keratoprosthesis

Background:To determine patient-reported vision-related quality of life(VR-QoL)following Boston type I keratoprosthesis(BI-KPro)surgery and its association with postoperative best-corrected visual acuity(BCVA).Methods:Descriptive cross-sectional study.Consecutive consenting patients with BI-KPro were included.The French National Eye Institute Visual Function Questionnaire-25 administered at 51±18 months postoperatively measured VR-QoL.Clinical charts were reviewed for demographics,indications for BI-KPro,baseline and postoperative(at time of interview)BCVA.For patients operated unilaterally,stratification of VR-QoL scores based on BCVA in the non-operated eye was performed.Multivariate linear regression was carried out,using VR-QoL scores as dependent variables,and demographics and postoperative BCVA as covariates.For patients operated bilaterally,Spearman correlation between VR-QoL scores and BCVA was performed.P<0.05 indicated statistical significance.Results:Sixty-four patients,aged 59±14 years,52%male,with a follow-up of 54±19 months,were included.Postoperative BCVA increased from baseline in all operated eyes(P=0.000).In patients with unilateral BI-KPro(n=52),the VR-QoL overall score was 70.7±25.1.Scores on all questionnaire subscales were greater when BCVA in the non-operated eye was>20/200 compared to 20/200(P=0.000).BCVA in the non-operated eye was positively associated with all subscales(P<0.01)independently of age,sex,follow-up duration and postoperative BCVA in the operated eye.In patients with bilateral BI-KPro(n=12)the VR-QoL overall score was 63.0±18.7.BCVA in the best eye positively correlated with Near/Distance activities,and social functioning subscales(P<0.05).There was no significant difference between VR-QoL scores of patients operated unilaterally vs.bilaterally.Conclusions:We describe VR-QoL more than 4 years after BI-KPro surgery.Compared to data at 1 year previously reported,our results suggest that,as vision progressively deteriorates in the operated eye,patients increasingly rely on their non-operated eye.VR-QoL after bilateral BI-KPro is assessed for the first time,and appears comparable to that after unilateral surgery.Larger,prospective,long-term studies,with assessment at baseline,are warranted.

Health-related quality of life evaluated by tumor node metastasis staging system in patients with hepatocellular carcinoma

AIM: To investigate and evaluate the change in healthrelated quality of life (HRQoL) by tumor node metastasis (TNM) staging system in patients with hepatocellular carcinoma (HCC). METHODS: A total of 140 patients diagnosed with HCC between June 2008 and April 2009 in our department were enrolled to this study. One hundred and thirty-five (96.5%) patients had liver cirrhosis secondary to hepatitis B virus (HBV) infection, 73 (54.07%) of them being HBV DNA positive; the other etiologies of liver cirrhosis were alcoholic liver disease (1.4%), hepatitis C (1.4%) or cryptogenic (0.7%). All subjects were fully aware of their diagnosis and provided informed consent. HRQoL was assessed before treatment using the functional assessment of cancer therapy-hepatobiliary (FACT-Hep) questionnaire. Descriptive statistics were used to evaluate demographics and disease-specific characteristics of the patients. One-way analysis of variance and independent samples t tests were used to compare the overall FACT-Hep scores and clinically distinct TNM stages. Scores for all FACT-Hep items were analyzed by frequency analyses. The mean scores obtained from the FACT-Hep in different Child-Pugh classes were also evaluated. RESULTS: The mean FACT-Hep scores were reduced significantly from TNM StageⅠto Stage Ⅱ, Stage ⅢA, Stage ⅢB group (687 ± 39.69 vs 547 ± 42.57 vs 387 ± 51.24 vs 177 ± 71.44, P = 0.001). Regarding the physical and emotional well-being subscales, scores decreased gradually from Stage Ⅰ to Stage ⅢB (P = 0.002 vs Stage Ⅰ; P = 0.032 vs Stage Ⅱ; P = 0.033 vs Stage ⅢA). Mean FACT-Hep scores varied by Child-Pugh class, especially in the subscales of physical well-being, functional well-being and the hepatobiliary cancer (P = 0.001 vs Stage I; P = 0.036 vs Stage Ⅱ; P = 0.032 vs Stage ⅢA). For the social and family well-being subscale, only Stage ⅢB scores were significantly lower as compared with Stage Ⅰ scores (P = 0.035). For the subscales of functional well-being and hepatobiliary cancer, there were significant differences for Stages ⅡΙ, ⅢA and ⅢB (P = 0.002vs StageⅠ). CONCLUSION: HRQoL of patients with HCC worsens gradually with progression of TNM stages. The most impaired subscales of HRQoL, as measured by FACT-Hep, were physical and emotional well-being.

Health Evaluation for Hypertensive Population Using Exercise Testing and Health-related Quality of Life Questionnaire

Objectives This study aims to assess the impacts of hypertension on health-related quality of life (HRQOL), as well as cardiovascular functional status (CVFS). Methods An instrument was presented based on WHOQOL-BREF and SP-16 questionnaire and exercise testing. 57 normotensive and 76 hypertensive subjects aged 35-65 year-old participated the health survey using this instrument. Based on the exercise testing results of the two groups, a discriminate function was established and used to investigate cardiovascular risk factors for hypertensive population. Results The results showed that persons with hypertension rated significantly lower scores on physical health (i.e. limitation in performing daily activities and problems with work or mobility) than did normotensives (P < 0.01). The discriminant score obtained from the exercise testing results was capable of reflecting the impacts of hypertension on CVFS. Conclusions The method presented in this paper provides a more powerful tool to estimate the effects of health interventions and medical therapy for hypertensive population than just self-rated HRQOL questionnaire.

Value of quality of life analysis in liver cancer: A clinician's perspective

Health related quality of life(HRQOL) is increasingly recognized as an important clinical parameter and research endpoint in patients with hepatocellular carcinoma(HCC). HRQOL in HCC patients is multifaceted and affected by medical factor which encompasses HCC and its complications, oncological and palliative treatment for HCC, underlying liver disease, as well as the psychological, social or spiritual reaction to the disease. Many patients presented late with advanced disease and limited survival, plagued with multiple symptoms, rendering QOL a very important aspect in their general well being. Various instruments have been developed and validated to measure and report HRQOL in HCC patients, these included general HRQOL instruments, e.g., Short form(SF)-36, SF-12, Euro Qo L-5D, World Health Organization Quality of Life Assessment 100(WHOQOL-100), World Health Organization Quality of Life Assessment abbreviated version; general cancer HRQOL instruments, e.g., the European Organisation for Research and Treatment of Cancer(EORTC) QLQ-C30, Functional Assessment of Cancer Therapy(FACT)-General, Spitzer Quality of Life Index; and liver-cancer specific HRQOL instruments, e.g., EORTC QLQ-HCC18, FACT-Hepatobiliary(FACT-Hep), FACT-Hep Symptom Index, Trial Outcome Index. Important utilization of HRQOL in HCC patients included description of symptomatology and HRQOL of patients, treatment endpoint in clinical trial, prognostication of survival, benchmarking of palliative care service and health care valuation. In this review, difficulties regarding the use of HRQOL data in research and clinical practice, including choosing a suitable instrument, problems of missing data, data interpretation, analysis and presentation are examined. Potential solutions are also discussed.

An enhanced functional ability questionnaire(faVIQ) to measure the impact of rehabilitation services on the visually impaired

AIM: To develop a short,enhanced functional ability Quality of Vision(faVIQ) instrument based on previous questionnaires employing comprehensive modern statistical techniques to ensure the use of an appropriate response scale,items and scoring of the visual related difficulties experienced by patients with visual impairment. · METHODS: Items in current quality-of-life questionnaires for the visually impaired were refined by a multi-professional group and visually impaired focus groups. The resulting 76 items were completed by 293 visually impaired patients with stable vision on two occasions separated by a month. The faVIQ scores of 75 patients with no ocular pathology were compared to 75 age and gender matched patients with visual impairment. ·RESULTS: Rasch analysis reduced the faVIQ items to 27. Correlation to standard visual metrics was moderate(r =0.32-0.46) and to the NEI-VFQ was 0.48. The faVIQ was able to clearly discriminate between age and gender matched populations with no ocular pathology and visual impairment with an index of 0.983 and 95% sensitivity and 95% specificity using a cut off of 29.·CONCLUSION: The faVIQ allows sensitive assessment of quality-of-life in the visually impaired and should support studies which evaluate the effectiveness of low vision rehabilitation services.

Translation and validation of the Nepean Dyspepsia Index for functional dyspepsia in China

AIM:To assess the reliability and validity of the translated version of Nepean Dyspepsia Index (NDI) in Chinese patients with documented functional dyspepsia (FD).METHODS: The translation process included forward translation, back translation, pretest and cross-cultural adaptation. Reliability and validity of the translated version were examined by asking 300 subjects to complete the Chinese version of the NDI. The mean age of subjects was 39.24 years and 68.7% of the subjects were women. Internal consistency analysis with Cronbach's α was performed to test the reliability. Correlation analysis was used to assess the content validity. Factor analysis and structural equation models were used to assess the construct validity.RESULTS: The Cronbach's α coefficients ranged 0.833-0.960, well above the acceptable level of 0.70. Correlation analysis showed that each item had a strong correlation with the corresponding domain, but a weak correlation with other domains. Confi rmatory factor analysis indicated that the comparative fit index was 0.94, higher than the acceptable level of 0.90.CONCLUSION: The Chinese version of the NDI is a reliable and valid scale for measuring health-related quality of life and disease severity in Chinese patients with FD.

眼科康复训练对斜视治疗的影响

目的评估眼科康复训练对斜视治疗的影响。方法120例斜视患者,根据治疗方法不同分为实验组和对照组,各60例。实验组在常规治疗的基础上实行眼科康复训练,而对照组则仅接受常规治疗。比较两组患者视觉功能、视轴偏移角度、生活质量。结果实验组患者视觉功能评分为(90.17±2.13)分,而对照组为(78.28±3.81)分,实验组视觉功能明显优于对照组(P<0.05)。实验组的视轴偏移角度为(12.2±3.2)°,对照组为(20.4±3.9)°,实验组视轴偏移角度小于对照组(P<0.05)。实验组的生活质量评分为(93.65±1.99)分,对照组为(84.56±3.17)分,实验组生活质量评分高于对照组(P<0.05)。结论眼科康复训练对斜视治疗具有积极的影响,可提高患者视觉功能,减小视轴偏移角度,改善生活质量,该训练方法可成为治疗斜视患者的有效手段。

超声乳化术联合SBL-3区域折射型非球面IOL治疗年龄相关白内障的效果及对视觉质量的影响

目的 探究超声乳化术联合SBL-3区域折射型非球面人工晶状体(IOL)治疗年龄相关白内障的效果及对视觉质量的影响。方法 选取2022年1—12月收治的年龄相关白内障110例,采用随机数字表法分为单焦点组55例和SBL-3组55例,单焦点组予超声乳化术联合ADAPT AO非球面单焦点IOL植入,SBL-3组给予超声乳化术联合SBL-3区域折射型非球面IOL植入。比较2组术后3个月对比敏感度[明光、暗光、明光炫光、暗光炫光],术前和术后3个月视觉质量[客观散射指数(OSI)、斯特列尔比(SR)、调制传递函数截止频率(MTF cut off)]、视力[最佳矫正近视力(BCNVA)、最佳矫正远视力(BCDVA)、远视矫正下的近视力(DCNVA)]及生活质量[视功能与生存质量问卷(VF-QOL)]。结果 术后3个月,SBL-3组对比敏感度高于单焦点组(P<0.05);术后3个月,2组OSI、BCNVA、BCDVA、DCNVA水平均较术前降低,SBL-3组低于单焦点组(P<0.05);术后3个月,2组SR、MTF cut off水平及VF-QOL评分均较术前升高,SBL-3组高于单焦点组(P<0.05)。结论 超声乳化术联合SBL-3区域折射型非球面IOL能够提高年龄相关白内障患者对比敏感度及视觉质量,改善视力水平及生活质量。

白内障超声乳化联合AcrySof IQ人工晶状体植入术的临床研究

目的:应用临床客观指标和视功能生存质量指标评价白内障超声乳化联合AcrySof IQ人工晶状体植入术的临床效果。方法:选择老年性白内障患者86例89眼,按随机数字表进行随机分为A(AcrySof IQ),B(KS-1)人工晶状体组,均行白内障超声乳化联合人工晶状体植入术。观察患者术前、术后1d;1wk;1mo裸眼远视力和最佳矫正远视力,计算安全指数和有效指数。术后1mo进行视功能和生存质量调查问卷。结果:A,B两组的手术安全指数、有效指数、术中和术后并发症、术前、术后裸眼视力和最佳矫正远视力均无显著性差异(P>0.05)。A组患者在术后视功能调查问卷中的感觉适应(P<0.01)和立体觉(P<0.01)上明显优于B组,具有显著性差异。结论:白内障超声乳化联合AcrySof IQ人工晶状体植入术的临床效果良好,具有手术安全指数和有效指数高、术中和术后并发症少等优点;AcrySof IQ非球面人工晶状体能提高患者术后感觉适应和立体觉,改善患者术后视觉质量,值得在临床推广;视功能和生存质量指标是评价白内障手术效果的有力工具,可以提供临床客观指标所不能反映的信息。白内障超声乳化联合AcrySof IQ人工晶状体植入术的临床效果良好,值得在临床推广;视功能和生存质量指标是评价白内障手术效果的有力工具,可以提供临床客观指标所不能反映的信息。

标准化护理对白内障超声乳化手术患者康复效果的影响

目的:分析标准化护理对白内障超声乳化手术患者康复效果的影响。方法:选取兰州大学第二医院2021年1月—2023年1月间400例接受超声乳化手术的白内障患者作为观察对象,按照入院时间顺序分组,分为对照组(常规护理)和观察组(标准化护理),各200例,比较应用效果。结果:观察组并发症发生率低于对照组(P<0.05);观察组各维度视功能生存质量评分高于对照组(P<0.05);观察组生理应激反应指标优于对照组(P<0.05)。结论:针对接受白内障超声乳化手术的患者,采取标准化护理可提高术后康复效果,减轻应激反应,减少并发症,改善视功能生存质量。

KANO模型护理对玻璃体积血患者术后生活质量及心理健康的影响

目的分析卡诺(KANO)模型护理对玻璃体积血患者术后生活质量及心理健康的影响。方法选择2021年1月至2023年1月安徽医科大学附属六安医院治疗的100例玻璃体积血患者为研究对象,所有患者均行玻璃体切割术治疗,根据随机数字表法将其分为对照组和观察组,各50例。对照组在术后给予常规护理干预,观察组在对照组基础上进行KANO模型护理干预。比较两组干预前后眼压及视觉模拟评分法(VAS)评分、国家眼科研究所视功能问卷-25(NEI VFQ-25)、抑郁自评量表(SDS)、焦虑自评量表(SAS)评分及护理满意度。结果干预后,两组眼压及VAS评分均低于干预前,且观察组低于对照组(P<0.05);干预后,两组NEI VFQ-25评分高于干预前,且观察组高于对照组(P<0.05);干预后,两组SDS、SAS评分均低于干预前,且观察组低于对照组(P<0.05);观察组护理满意度优于对照组(P<0.05)。结论KANO模型护理在手术治疗基础上显著改善进一步患者的视功能生活质量,缓解抑郁、焦虑等不良心理,进一步促进患者恢复,降低眼压及疼痛程度,提高护理满意度,具有较高的推广价值。

基于Peplau人际关系理论的出院计划对甲状腺癌手术患者心理健康、社会功能及生存质量的影响

目的:探讨基于Peplau人际关系理论的出院计划对甲状腺癌手术患者心理健康、社会功能及生存质量的影响。方法:将2022年1月—2023年6月在大冶市人民医院甲乳胸外科接受治疗的186例患者作为研究对象,按随机数表法将患者分为对照组和观察组,各93例。对照组接受常规院外护理,观察组接受基于Peplau人际关系理论的出院计划干预,比较两组心理健康、社会功能、生存质量和护理满意度的差异。结果:护理前,两组心理健康测试问卷(DCL-90)评分比较,差异无统计学意义(P>0.05);护理后,两组DCL-90评分较护理前降低,且观察组低于对照组,差异有统计学意义(P<0.05)。护理前,两组生活质量综合评价量表(GQOLI-74)各维度评分比较,差异无统计学意义(P>0.05);护理后,两组躯体功能、社会功能、心理功能、角色功能评分较护理前升高,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组服务态度、护理技能、沟通情况、疾病相关知识掌握情况评分高于对照组,差异有统计学意义(P<0.05)。结论:基于Peplau人际关系理论的出院计划应用于甲状腺手术患者,能改善心理健康状态,提高社会功能和生存质量,还可提高护理满意度。

神经内镜下经鼻蝶垂体瘤切除术治疗垂体瘤患者的效果

目的:观察神经内镜下经鼻蝶垂体瘤切除术治疗垂体瘤患者的效果。方法:选取2018年2月至2023年2月该院收治的86例垂体瘤患者进行前瞻性研究,按随机数字表法将其分为对照组和观察组各43例。对照组行显微镜下经鼻蝶垂体瘤切除术治疗,观察组行神经内镜下经鼻蝶垂体瘤切除术治疗,比较两组手术相关指标(术中出血量、手术时间、住院时间),手术前后嗅觉、视觉功能恢复情况[视野平均缺损值(MD)、视野模式标准差(PSD)、视野指数(VFI)]、垂体相关激素指标[促肾上腺皮质激素(ACTH)、生长激素(GH)、泌乳素(PRL)、促甲状腺素(TSH)]水平、生命质量[健康调查简表(SF-36)]评分和术后1个月内并发症发生率。结果:观察组术中出血量少于对照组,手术时间和住院时间均短于对照组,差异有统计学意义(P<0.05);术后,观察组嗅觉阈评分低于对照组,MD和PSD均小于对照组,VFI高于对照组,差异有统计学意义(P<0.05);术后,观察组ACTH、GH、PRL、TSH水平均低于对照组,差异有统计学意义(P<0.05);术后,观察组生理机能、生理职能、躯体疼痛、一般健康状况、精力、社会功能、情感职能、精神健康等SF-36评分均高于对照组,差异有统计学意义(P<0.05);观察组并发症发生率为4.65%(2/43),低于对照组的18.60%(8/43),差异有统计学意义(P<0.05)。结论:神经内镜下经鼻蝶垂体瘤切除术治疗垂体瘤患者可提高生命质量,改善嗅觉、视觉功能恢复情况,降低手术相关指标、垂体相关激素指标水平和并发症发生率,效果优于显微镜下经鼻蝶垂体瘤切除术治疗。

阅读疗法联合呼吸功能训练对食管癌手术患者心理状态、癌因性疲乏的影响

目的:探索阅读疗法联合呼吸功能训练对食管癌手术患者心理状态、癌因性疲乏的影响。方法:以2021年8月-2023年8月于某院行手术治疗的76例食管癌患者为研究对象,随机分为两组各38例。对照组采取常规临床干预,研究组在此基础上采取阅读疗法联合呼吸功能训练。评价两组的心理状态、应对方式、癌因性疲乏、肺功能及生活质量。结果:研究组干预后的焦虑自评量表(SAS)、抑郁自评量表(SDS)评分低于对照组(t=-5.381,-7.310,P<0.05);干预后,研究组的简易应对方式问卷(SCSQ)中积极应对评分高于对照组,消极应对评分低于对照组(t=5.106,-5.561,P<0.05);干预后,研究组的Piper疲乏修订量表(RPFS)中情感、感觉、行为、认知各维度评分均低于对照组(t=-12.407,-7.595,-7.544,-7.458,P<0.05);干预后,研究组的最大通气量(MVV)、用力肺活量(FVC)、第1秒用力呼气容积(FEV1)较对照组升高(t=5.302,4.007,5.168,P<0.05);干预后,研究组的生活质量测定量表(WHOQOL-BREF)中各维度评分高于对照组(t=6.614,7.963,5.333,6.488,P<0.05)。结论:对食管癌手术患者施于阅读疗法联合呼吸功能训练干预可有效改善患者的心理状态及应对方式,减轻其癌因性疲乏,提高其肺功能及生活质量。

归脾汤加味治疗癌因性疲乏脾气虚证临床研究

目的:观察归脾汤加味治疗癌因性疲乏(CRF)脾气虚证的临床疗效,以及对患者血红蛋白(Hb)、白蛋白(Alb)、CD4^(+)CD25^(hi)CD127^(low)、CD4^(+)细胞绝对计数水平的影响。方法:选取60例CRF脾气虚证患者,按随机数字表法分为对照组和治疗组各30例。对照组给予音乐放松疗法和心理辅导等干预,治疗组在对照组基础上给予归脾汤加味治疗。2组均治疗2周。比较2组治疗前后简易疲劳量表中文版(BFI-C)评分、中医症状积分、匹兹堡睡眠质量指数(PSQI)评分、Karnofsky (KPS)评分,以及Hb、Alb、CD4^(+)CD25^(hi)CD127^(low)、CD4^(+)细胞绝对计数水平,记录2组不良反应。结果:治疗后,2组现疲乏程度,过去24 h疲乏程度,过去24 h最严重疲乏程度,情绪、工作、生活乐趣、一般活动、行走能力及人际关系影响评分均较治疗前降低(P<0.05),治疗组上述9项BFI-C细则评分均低于对照组(P<0.05)。2组饮食减少、食后胃脘不舒、倦怠乏力、大便溏薄、面色萎黄积分均较治疗前降低(P<0.05),治疗组上述5项中医症状积分均低于对照组(P<0.05)。2组PSQI评分均较治疗前降低(P<0.05),治疗组PSQI评分低于对照组(P<0.05)。2组KPS评分均较治疗前升高(P<0.05),治疗组KPS评分高于对照组(P<0.05)。治疗组Hb、Alb水平均较治疗前升高,且均高于对照组(P<0.05)。对照组Hb、Alb水平治疗前后比较,差异均无统计学意义(P>0.05)。治疗组CD4^(+)CD25^(hi)CD127^(low)水平较治疗前降低,且低于对照组(P<0.05)。治疗组CD4^(+)细胞绝对计数水平较治疗前升高,且高于对照组(P<0.05)。对照组治疗前后CD4^(+)CD25^(hi)CD127^(low)及CD4^(+)细胞绝对计数水平比较,差异均无统计学意义(P>0.05)。治疗期间,2组均未出现明显不良反应。结论:归脾汤加味治疗能有效改善CRF脾气虚证患者的临床症状及营养状况,提高其睡眠和生活质量,改善机体的免疫功能。

中药熏蒸治疗绝经后骨质疏松症腰背痛临床研究

目的:观察中药熏蒸治疗绝经后骨质疏松症腰背痛的临床疗效。方法:选取120例绝经后骨质疏松症腰背痛患者作为研究对象,以随机数字表法分为对照组及观察组各60例。对照组给予常规治疗(钙剂、维生素D、注射鲑鱼降钙素),观察组在对照组基础上联合中药熏蒸治疗。比较2组治疗前后疼痛视觉模拟评分法(VAS)评分、腰椎功能评分(JOA)、生活质量综合评定问卷-74 (GQOLI-74)评分、腰椎骨密度,并比较2组临床疗效及不良反应。结果:治疗后,2组VAS评分均降低(P<0.05),且观察组低于对照组(P<0.05)。观察组治疗总有效率96.67%,高于对照组83.33%(P<0.05)。治疗后,2组JOA评分均升高(P<0.05),且观察组高于对照组(P<0.05)。随访3个月,2组GQOLI-74评分均升高(P<0.05),且观察组躯体功能、心理功能维度GQOLI-74评分高于对照组(P<0.05)。治疗后,2组腰椎骨密度均升高(P<0.05),且观察组高于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:中药熏蒸可提升绝经后骨质疏松症腰背痛患者的临床疗效,且能进一步改善患者腰背疼痛症状,帮助患者恢复腰椎功能,增加骨密度,提高生活质量。

Association between functional abdominal pain disorders and asthma in adolescents: A cross-sectional study

AIM To find the association between asthma and different types of functional abdominal pain disorders(FAPDs) among teenagers. METHOD A cross-sectional study was conducted among 13 to 15-year-old children from six randomly selected schools in Anuradhapura district of Sri Lanka. Data were collected using translated and validated selfadministered questionnaires(Rome Ⅲ questionnaire, International Study on Asthma and Allergies in Childhood questionnaire, and Pediatric Quality of Life Inventory 4.0) and administered under an examination setting after obtaining parental consent and assent.RESULTS Of the 1101 children included in the analysis, 157(14.3%) had asthma and 101(9.2%) had at least one FAPDs. Of children with asthma, 19.1% had at least one type of FAPDs. Prevalence rates of functional abdominal pain(FAP)(8.9% vs 3.3% in nonasthmatics), functional dyspepsia(FD)(2.5% vs 0.7%), and abdominal migraine(AM)(3.2% vs 0.4%) were higher in those with asthma(P < 0.05, multiple logistic regression analysis), but not in those with irritable bowel syndrome(4.5% vs 3.1%, P = 0.2). Severe abdominal pain(10.8% vs 4.6%), bloating(16.6% vs 9.6%), nausea(6.4% vs 2.9%), and anorexia(24.2% vs 16.2%) were more prevalent among asthmatics(P < 0.05). Lower gastrointestinal symptoms did not show a significant difference. Scores obtained for health related quality of life(HRQoL) were lower in those with asthma and FAPDs(P < 0.05, unpaired t-test).CONCLUSION Asthma is associated with three different types of FAPDs, namely, FD, AM, and FAP. HRQoL is significantly impaired in teenagers with asthma and FAPDs.

Single-site Baseline and Short-term Outcomes of Clinical Characteristics and Life Quality Evaluation of Chinese Wet Age-related Macular Degeneration Patients in Routine Clinical Practice

Background：Age-related macular degeneration （AMD） is the leading cause of irreversible vision loss among the older population.In China,treatment of age-related ocular diseases is becoming a priority in eye care services.This study was to investigate the clinical characteristics and quality of life of Chinese patients with wet AMD and current treatment types,to evaluate short-term gains in different treatments,and to investigate associations between visual function and vision-related quality of life （VRQoL）.Methods：A prospective,observational,noninterventional study was conducted.Basic data were collected from patients with clinical diagnoses of wet AMD before clinical assessments at baseline.VRQoL was measured with the Chinese version of the National Eye Institute Visual Function Questionnaire-25 （NEI VFQ-25）.Correlations of the NEI VFQ-25 subscale scores with best-corrected visual acuity （BCVA） and between-group differences were analyzed.Results：A total of 80 wet AMD patients were enrolled,with the mean age of 68.40 years.About one-quarter ofwetAMD patients received intravitreal （IVT） ranibizumab treatment,and 67％ of them were treated on apro re nata basis.The visual acuity of patients treated with IVT ranibizumab at month 3 after treatment was significantly increased,whereas patients treated with traditional Chinese medicine achieved no significant improvement.Cronbach＇s α for the NEI VFQ-25 subscales ranged from 0.697 to 0.843.Eight subscale and overall composite scores were moderately correlated with the BCVA of the better-seeing eye.Significant differences in the overall NEI VFQ-25 scores and other subscales were observed between patients with BCVA in the better-seeing eye of less than 50 letters and the others.Conclusions：Patients treated with IVT ranibizumab experienced better vision improvement at short-term follow-up.The Chinese version of the NEI VFQ-25 is a valid and reliable tool for assessing the VRQoL of Chinese wet AMD patients.

Cross-Validation of the Turkish Version of the 28-Item Impact of Vision Impairment Profile Test

Purpose: To translate the original 28-item Impact of Vision Impairment Profile into Turkish and to investigate its validity and reliability. Methods: Patients with no limitations to respond and affected by a chronic eye disease including retinitis pigmentosa (RP), age-related macular degeneration (ARMD) and diabetic macular edema which cause low vision were enrolled. The Turkish version of the IVI test was administered to all participants. The linguistic translation followed the international guidelines of forward and backward translation. 256 subjects who had a Snellen visual acuity of 6/12 or worse in the eye with best corrected visual acuity (BCVA) completed the Turkish version of the IVI-28 item. Psychometric evaluation of the Turkish IVI test involved the assessment of internal consistency, test-retest reliability, convergent and known-groups validity. Results: The mean (±SD) age of the participants was 53.67 ± 17.22 years. There were 256 patients with one of the following conditions: 105 RP (41%), 77 ARMD (30%), 74 DME (29%). Patients with lower visual acuity (VA) had lower index scores than those with higher VA (p = 0.001), which showed a sufficient responsiveness. Conclusion: Statistical analysis showed that Turkish version of the IVI-28 item is a valid and reliable instrument to measure vision-related quality of life (VRQoL) in patients with low vision.