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Analysis of the Erosion-Corrosion Mechanism of the Air Cooler in a Hydrocracking Unit:A Numerical and Experimental Study
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作者 Su Guoqing Li Yan +1 位作者 Guo Hongli Zhang Jianwen 《China Petroleum Processing & Petrochemical Technology》 SCIE CAS CSCD 2024年第1期126-138,共13页
Corrosion leakages often occur in the air cooler of a hydrocracking unit,with the failure sites mainly located in the entrance area of the tubes.An analysis of the macroscopic morphology and corrosion products confirm... Corrosion leakages often occur in the air cooler of a hydrocracking unit,with the failure sites mainly located in the entrance area of the tubes.An analysis of the macroscopic morphology and corrosion products confirmed that the damage was caused by erosion-corrosion(E-C).Numerical and experimental methods were applied to investigate the E-C mechanism in the air cooler.Computational fluid dynamics(CFD)was used to calculate the hydrodynamic parameters of the air cooler.The results showed that there was a biased flow in the air cooler,which led to a significant increase in velocity,turbulent kinetic energy and wall shear within 0.2 m of the tube entrance.A visualization experiment was then performed to determine the principles of migration and transformation of multiphase flow in the air cooler tubes.Various flow patterns(pure droplet flow,mist flow,and annular flow)and their evolutionary processes were clearly depicted experimentally.The initiation mechanism and processes leading to the development of E-C in the air cooler were also determined.This study provided a comprehensive explanation for the E-C failures that occur in air coolers during operation. 展开更多
关键词 air cooler hydrocracking unit EROSION-CORROSION SIMULATION visualization experiment multiphase flow
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Experimental and Numerical Analysis of the Influence ofMicrochannel Size and Structure on Boiling Heat Transfer
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作者 Ningbo Guo Xianming Gao +3 位作者 Duanling Li Jixing Zhang Penghui Yin Mengyi Hua 《Computer Modeling in Engineering & Sciences》 SCIE EI 2023年第9期3061-3082,共22页
Computational fluid dynamics was used and a numerical simulation analysis of boiling heat transfer in microchannels with three depths and three cross-sectional profiles was conducted.The heat transfer coefficient and ... Computational fluid dynamics was used and a numerical simulation analysis of boiling heat transfer in microchannels with three depths and three cross-sectional profiles was conducted.The heat transfer coefficient and bubble generation process of three microchannel structures with a width of 80μm and a depth of 40,60,and 80μm were compared during the boiling process,and the factors influencing bubble generation were studied.A visual test bench was built,and test substrates of different sizes were prepared using a micro-nano laser.During the test,the behavior characteristics of the bubbles on the boiling surface and the temperature change of the heated wall were collected with a high-speed camera and a temperature sensor.It was found that the microchannel with a depth of 80μm had the largest heat transfer coefficient and shortest bubble growth period,the rectangular channel had a larger peak heat transfer coefficient and a lower frequency of bubble occurrence,while the V-shaped channel had the shortest growth period,i.e.,the highest frequency of bubble occurrence,but its heat transfer coefficient was smaller than that of the rectangular channel. 展开更多
关键词 MICROCHANNEL boiling heat transfer BUBBLE numerical simulation visual experiment
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Experimental and Numerical Analysis of Particle Migration and Patterning Behavior in a Gravel Pack
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作者 Bobo Luo Yunbin Xiong +5 位作者 Zhuoyi Li Zhanqing Qu Fenggang Liu Tiankui Guo Zugui Yang Yina Shi 《Fluid Dynamics & Materials Processing》 EI 2023年第4期911-928,共18页
Due to its long lifespan and high sand-removal efficiency,gravel packing is one of the most applied sand control methods during the recovery of reservoirs with sanding problems.The blockage and retention of injected s... Due to its long lifespan and high sand-removal efficiency,gravel packing is one of the most applied sand control methods during the recovery of reservoirs with sanding problems.The blockage and retention of injected sand in a gravel pack is a complex process affected by multiple mechanisms.The majority of existing studies based on the phenomenological deep bed filtration(DBF)theory focused on the gravel pack’s overall permeability damage and failed to obtain the inner-pore particle distribution pattern.In this work,experiments and simulations were carried out to reveal the particle distribution in a gravel pack during flooding.In particular,through real-time monitoring of particle migration,the penetration depth and distribution pattern of invaded particles with different gravel-sand particle ratios,fluid viscosities and injection rates could be determined.By simplifying each unit bed element(UBE)into a pore-throat structure with four tunnels(two horizontals for discharge and two verticals for sedimentation),a new network simulation method,which combines deep bed filtration with a particle trajectory model,was implemented.Cross comparison of experimental and numerical results demonstrates the validity and accuracy of the model. 展开更多
关键词 Gravel pack sand control deep bed filtration visual experiment particle trajectory
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Visualization of Water Plugging Displacement with Foam/Gel Flooding in Internally Heterogeneous Reservoirs 被引量:3
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作者 Jialiang Zhang Shumei He +3 位作者 Tongjing Liu Tianlu Ni Jian Zhou Fang Huang 《Fluid Dynamics & Materials Processing》 EI 2021年第5期931-946,共16页
During the displacement of water plugging with binary flooding in internally heterogeneous reservoirs,it is essential to understand the distributions of remaining oil as well as the oil displacement mechanisms at diff... During the displacement of water plugging with binary flooding in internally heterogeneous reservoirs,it is essential to understand the distributions of remaining oil as well as the oil displacement mechanisms at different stages.In this study,two types of internally heterogeneous systems,i.e.,vertical and horizontal wells are investigated experimentally through a microscopic approach.The results show that plugging agent types have a greater impact on oil recovery than well types,and foam injection can enhance oil recovery more effectively than gel injection.Additionally,the injection sequence of plugging agents significantly affects oil displacement efficiency.Injecting gel after foam is more beneficial.According to the present results,the main formation mechanisms of remaining oil in each displacement stage are influenced by:capillary force,viscous force,inertial force,shear force,microscopic fingering&channeling. 展开更多
关键词 Microscopic visualization experiment internally heterogeneous reservoir remaining oil foam GEL
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Visual Passive Ranging Method Based on Re-entrant Coaxial Optical Path and Experimental Verification
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作者 杨金宝 刘建国 +1 位作者 祝宁华 于丽娟 《Chinese Physics Letters》 SCIE CAS CSCD 2017年第12期32-36,共5页
To overcome the shortcomings of the traditional passive ranging technology based on image, such as poor ranging accuracy, low reliability and complex system, a new visual passive ranging method based on re-entrant coa... To overcome the shortcomings of the traditional passive ranging technology based on image, such as poor ranging accuracy, low reliability and complex system, a new visual passive ranging method based on re-entrant coaxial optical path is presented. The target image is obtained using double cameras with coaxial optical path. Since there is imaging optical path difference between the cameras, the images are different. In comparison of the image differences, the target range could be reversed. The principle of the ranging method and the ranging model are described. The relationship among parameters in the ranging process is analyzed quantitatively. Meanwhile,the system composition and technical realization scheme are also presented. Also, the principle of the method is verified by the equivalent experiment. The experimental results show that the design scheme is correct and feasible with good robustness. Generally, the ranging error is less than 10% with good convergence. The optical path is designed in a re-entrant mode to reduce the volume and weight of the system. Through the coaxial design,the visual passive range of the targets with any posture can be obtained in real time. The system can be widely used in electro-optical countermeasure and concealed photoelectric detection. 展开更多
关键词 Visual Passive Ranging Method Based on Re-entrant Coaxial Optical Path and experimental Verification
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Investigation of Movement and Deposition Behaviors of Solid Particles in Hydraulic Water Reservoir via the CFD‑DEM Coupling Method
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作者 Mandi Li Decai Kong +4 位作者 Qi Guo Xiangyu Liu Jing Yao Jianjun Hu Lijuan Chen 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2022年第6期286-297,共12页
Solid contamination existing as solid particles in power fluid transmission systems may lead to transmission performance reduction,system failures,and component damage.The hydraulic reservoir will deposit the contamin... Solid contamination existing as solid particles in power fluid transmission systems may lead to transmission performance reduction,system failures,and component damage.The hydraulic reservoir will deposit the contamination and store hydraulic fluid.To investigate its purification ability for solid contamination,experiments and simulations for the motion and deposition status of the typical hydraulic system particles are carried out to reveal the interaction of particles and fluid in hydraulic water reservoirs.The results show that the CFD-DEM coupling method could predict the accurate deposition position of iron particles and sand particles when ignoring the small-scale turbulence effect in the flow field.Besides,the particle motion traces and deposition patterns in the reservoir illustrate that the flow development on the bottom surface results in the particles turning,and particles tend to settle in the low flow energy position.The motion of particles is also linked to particles Stokes number,and the same-size sand particles are easily driven by the fluid.The contribution of this paper could provide a guide for predicting the particle motion and deposition pattern in the hydraulic reservoir. 展开更多
关键词 Solid contamination CFD-DEM simulation Motion and deposition of solid particles Hydraulic reservoir visualization experiment
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Mechanisms of water block removal by surfactant micellar solutions in low permeability reservoirs
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作者 LI Junjian LIU Ben +5 位作者 GUO Cheng SU Hang YU Fuwei MA Mengqi WANG Lida JIANG Hanqiao 《Petroleum Exploration and Development》 CSCD 2022年第2期394-405,共12页
The existing researches on surfactant micellar solutions mainly focus on the formulation optimization and core flooding test, and the types and mechanisms of cleanup additives suitable for low permeability reservoir r... The existing researches on surfactant micellar solutions mainly focus on the formulation optimization and core flooding test, and the types and mechanisms of cleanup additives suitable for low permeability reservoir remain unclear. The flowback efficiencies of different types of surfactant micellar solutions were evaluated by core experiments, a multi-level pore-throat system micromodel characterizing pore-throat structures of low permeability reservoir was made, and flooding and flowback experiments of brine and surfactant micellar solutions of different salinities were conducted with the micromodel to show the oil flowback process in micron pores under the effect of surfactant micellar solution visually and reveal the mechanisms of enhancing displacement and flowback efficiency of surfactant micellar solution. During the displacement and flowback of brine and low salinity surfactant micellar solution, many small droplets were produced, when the small droplets passed through pore-throats, huge percolation resistance was created due to Jamin’s effect, leading to the rise of displacement and flowback pressure differences and the drop of flowback efficiency. The surfactant micellar solutions with critical salinity and optimal salinity that were miscible with crude oil to form Winsor Ⅲ micro-emulsion didnot produce mass small droplets, so they could effectively reduce percolation resistance and enhance oil displacement and flowback efficiency. 展开更多
关键词 low permeability reservoir cleanup additive cleanup mechanism SURFACTANT microfluidic visualization experiment crude flowback
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Comparative investigation on the heat transfer performance of an energy storage system with a spiral tube and straight tube:An experimental approach
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作者 MAO QianJun CAO Yan LI Tao 《Science China(Technological Sciences)》 SCIE EI CAS CSCD 2023年第1期71-85,共15页
Latent heat thermal energy storage systems can effectively fill the gap between energy storage and application, and phase-change materials(PCMs) are crucial media for storing thermal energy. Therefore, how to maximize... Latent heat thermal energy storage systems can effectively fill the gap between energy storage and application, and phase-change materials(PCMs) are crucial media for storing thermal energy. Therefore, how to maximize the utilization efficiency of PCMs has attracted widespread attention. In this study, the thermal behavior of two thermal storage units employing a spiral tube and straight tube as heat transfer tubes was experimentally researched and comprehensively compared. Stefan numbers were used to investigate the impact of the heat transfer fluid temperature on the PCM melting process. The temperature distribution of PCMs,temporal evolution of the melting front, and temperature variations of measurement points in both tanks were compared. The average temperature and energy storage of PCMs were calculated to evaluate the thermal performance of different configurations. The results indicate that compared to cylinder B(with a straight tube), the energy storage in cylinder A(with a spiral tube)increased by 78.8%, 38.5%, and 19.6% at Stefan numbers of 1.08, 1.28, and 1.48, respectively. Moreover, the increase in the Stefan number simultaneously ascended the average temperature and energy storage of PCMs in containers A and B, causing the shortening of the melting time. When the Stefan number was increased from 1.28 to 1.48, the storage capacity was raised from3233.18 to 3463.8 k J, and the total melting time was decreased by 34.2% from 547.5 to 360 min after the PCM was loaded in cylinder A. The research results lay a certain foundation for a deeper study of enhanced heat transfer in spiral tubes. 展开更多
关键词 thermal energy storage visualization experiment PCM spiral tube straight tube
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Experimental investigation of thermal effect on cavitation characteristics in a liquid rocket engine turbopump inducer 被引量:8
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作者 Chunmin WANG Le XIANG +2 位作者 Yonghua TAN Hui CHEN Kaifu XU 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2021年第8期48-57,共10页
The objective of this paper is to investigate the effect of water temperature on cavitation characteristics in a turbopump inducer,a series of experiments at different temperatures have been conducted in a newly devel... The objective of this paper is to investigate the effect of water temperature on cavitation characteristics in a turbopump inducer,a series of experiments at different temperatures have been conducted in a newly developed visualization test facility.It is found that higher temperature shows little influence on the non-cavitation performance and breakdown characteristic in the investigated range.The relationship between cavitation development and pressure fluctuation has been discussed in detail.Higher temperature displays a remarkable stabilization effect on the cavitation excited pressure.In particular,the inception cavitation numbers of both the super-synchronous rotating cavitation and synchronous rotating cavitation are decreased at higher temperatures,and the corresponding frequencies are not affected,while the amplitudes are distinctly reduced,and the occurrence range of synchronous rotating cavitation is significantly narrowed.A generalized RayleighPlesset equation has been employed to account for the thermal effect on the bubble development,which may provide a deep insight in understanding the experimental results.Thermal effect is found to act as a remarkable dissipation mechanism to suppress the bubble growth,smooth the collapse.In particular,the excited pressure during collapse is smaller at higher temperatures,which may lead to the stabilization effect of high temperature in this study. 展开更多
关键词 Bubble dynamic Cavitation instability INDUCER Thermal effect visualization experiment
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Experimental and numerical investigations of cavitation evolution in a high-speed centrifugal pump with inducer 被引量:7
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作者 Yu-ying Huan Yao-yao Liu +4 位作者 Xiao-jun Li Zu-chao Zhu Jing-tian Qu Lin Zhe An-da Han 《Journal of Hydrodynamics》 SCIE EI CSCD 2021年第1期140-149,共10页
Along with the anti-cavitation performance,the high speed and the high power density,are the main trends in the development of centrifugal pumps.At present,the most effective method is to install an inducer in front o... Along with the anti-cavitation performance,the high speed and the high power density,are the main trends in the development of centrifugal pumps.At present,the most effective method is to install an inducer in front of the impeller.However,the tip leakage of the inducer results in the vortex cavitation at the blade leading edge of the inducer,and the cavitating flow inside the inducer seriously interferes with the hydraulic behavior of the inducer as well as the impeller with the development of the cavitation,thus to badly affect the operational reliability of the high-speed centrifugal pump.In the present paper,the cavitating flow in a high-speed centrifugal pump with an inducer is investigated by numerical simulations and visual experiments for different cavitation numbers.A typical evolution process of the cavitation is shown,including the inception,the development and the deterioration.A general description of the pump head-drop phenomenon is made through the study of the local and global flow fields,and the relationship between the vapor distribution and the static pressure distribution along the inducer is determined to describe the evolution of the cavitation.This paper intends to provide the foundation for studying the overall cavitation state of a high-speed centrifugal pump,and designing the inducer with a better cavitation resistance. 展开更多
关键词 Centrifugal pump INDUCER cavitation evolution visualization experiment
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Research on bubble trajectory and flow structure in helical-axial multiphase pump 被引量:1
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作者 Hui Quan Chen-xi Sun +4 位作者 Kai Song Ya-nan Li Xiao-yi Liu Xue-ling Yang Liang Wang 《Journal of Hydrodynamics》 SCIE EI CSCD 2023年第3期533-548,共16页
The oil-gas two-phase hybrid transportation technology is one of the innovative technology directions for the exploitation and transportation of marginal and deep ocean oilfields.The helical-axial multiphase pump is a... The oil-gas two-phase hybrid transportation technology is one of the innovative technology directions for the exploitation and transportation of marginal and deep ocean oilfields.The helical-axial multiphase pump is a key equipment for oil and gas extraction.At this stage,most of the research on this kind of pump focuses on the improvement of the structure and conveying performance.However,because of insufficient understanding of the flow behavior and mechanism of bubbles,it is easy to cause the gas-liquid separation.In this paper,the numerical simulation and test are combined to explore the changes in the bubble trajectory and flow structure of the helical-axial multiphase pump.The results shown that when the speed is lower than 1200 r/min,the bubble reaches the maximum volume at 1/2 of the midline of the impeller blade and it contact with the pressure surface,broken to the suction surface.When the rotation speed is higher than 1450 r/min,the number of bubbles in the impeller increases and the size decreases.The backflow occurs in the tip clearance and strength increases continuously.The research results have important significance for the theoretical design and engineering application of the helical-axial multiphase pump. 展开更多
关键词 Helical-axial multiphase pump gas-liquid two-phase flow visualization experiment bubble trajectory flow structure
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Mixing processes and patterns of fluids in alkane-CO_(2)-water systems under high temperature and high pressure——Microscopic visual physical thermal simulations and molecular dynamics simulations
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作者 Guanghui YUAN Shuqi WU +3 位作者 Yingchang CAO Zihao JIN Keyu LIU Yanzhong WANG 《Science China Earth Sciences》 SCIE EI CAS CSCD 2023年第7期1622-1646,共25页
Various types of geofluids exist in deep and ultra-deep layers in petroliferous basins.The geofluids are much more active under high-temperature and high-pressure(HTHP)conditions,but their properties are unclear.We si... Various types of geofluids exist in deep and ultra-deep layers in petroliferous basins.The geofluids are much more active under high-temperature and high-pressure(HTHP)conditions,but their properties are unclear.We simulated the mixing of different fluids in CH_(4)/C_(3)H_(8)/C_(6)H_(14)/C_(8)H_(18)-water systems and C_(6)H_(14)/C_(8)H_(18)-CO_(2)-H_(2)O systems at temperatures of 25℃ to 425℃ and pressures of 5 MPa to 105 MPa,using an in-situ micron quartz capillary tube thermal simulation system and molecular dynamics numerical simulation software.The mixing processes,patterns,and mechanisms of various fluids were analyzed at microscale under increasing temperature and pressure conditions.The results show that the miscibility of fluids in the different alkane-H_(2)O and alkane-CO_(2)-H_(2)O systems is not instantaneous,but the miscibility degree between different fluid phases increases as the temperature and pressure rise during the experiments.The physical thermal experiments(PTEs)show that the mixing process can be divided into three stages:initial miscibility,segmented dynamic miscibility,and complete miscibility.The molecular dynamics numerical simulations(MDNSs)indicate that the mixing process of fluids in the alkane-H_(2)O and alkane CO_(2)-H_(2)O systems can be divided into seven and eight stages,respectively.The carbon number affects the miscibility of alkanes and water,and the temperature and pressure required to reach the same miscibility stage with water increase with the carbon number(C_(3)H_(8),C_(6)H_(14),CH_(4),C_(8)H_(18)).CO_(2) has a critical bridge role in the miscibility of alkanes and water,and its presence significantly reduces the temperatures required to reach the initial,dynamic,and complete miscibility of alkanes and water.The results are of great significance for analyzing and understanding the miscibility of geofluids in deep and ultra-deep HTHP systems. 展开更多
关键词 High temperature high pressure(HTHP) Alkane-H_(2)O-CO_(2)system Mixing of geofluids In-situ visualization thermal experiments Molecular dynamics numerical simulation
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Study on attached ventilation based on inclined walls
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作者 Yicun Hou Angui Li +2 位作者 Jing Yang Yu Tian Dingmeng Wu 《Building Simulation》 SCIE EI CSCD 2021年第3期667-679,共13页
In practical engineering,inclined building walls are often presented due to their functional and aesthetic needs.A reasonable air distribution design is essential for creating a satisfactory indoor environment in such... In practical engineering,inclined building walls are often presented due to their functional and aesthetic needs.A reasonable air distribution design is essential for creating a satisfactory indoor environment in such buildings.In the present study,inclined walls with a variable inclination angle β were used as the research object to explore a novel air supply mode.Visualization experiments and numerical simulations were conducted to investigate the induced airflow,such as the airflow pattern,the airflow characteristics(maximum jet velocity decay and jet spreading rate)and the ventilation effect(vertical air temperature difference,draft rate,air diffusion performance index).The results show that the"air lake"phenomena occurred over the floor,which resembles the displacement ventilation to some extent.The proposed air supply mode has a good ventilation effect and could be applied to building spaces with inclined walls.The current study can be used as a reference for ventilation design in buildings with inclined walls. 展开更多
关键词 attached ventilation inclined wall numerical simulation visualization experiments
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FRACTAL CHARACTERISTICS OF AERODYNAMIC FIELD AT OUTLET OF LOW-NO_x COAXIAL SWIRLING BURNER 被引量:1
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作者 WUJiang TIANFeng-guo +3 位作者 ZHANGMing-chuan SONGYu-bao GAOMao YINBin 《Journal of Hydrodynamics》 SCIE EI CSCD 2004年第1期67-73,共7页
The primary wind of a low-NO_x coaxial swirling burner was visualized byusing glycol as smog tracer. The information of the visual flow field was input into a computerthrough image-capturing card with CCD camera as th... The primary wind of a low-NO_x coaxial swirling burner was visualized byusing glycol as smog tracer. The information of the visual flow field was input into a computerthrough image-capturing card with CCD camera as the image-capturing element. The boundary of thevisual zone, i. e. , the interface of the primary wind and secondary wind was obtained by imageprocessing. The fractal dimension (FD) of the boundary was examined and found to vary from 1. 10 to1. 40 with S_1, S_2 and ζ_1 . It is concluded that when FD is small, the complex level of theinterface is low, and mixture between the primary and secondary wind is weak near the exit of theburner at the initial phase of combustion resulting in stratified flow; when FD is big, mixturebecomes strong near the exit of the burner. It is showed that the flow with FD ranging from 1.10 to1. 20 is stratified flow, which is benefical to reduce NO_x yield and the flow with FD from 1. 25 to1. 40 is mixed flow, producing much NO_x. The mechanism of the forming of stratified flow and mixedflow was theoretically analyzed. The corresponding S_1 , S_2 and ζ_1 of these flows were given. 展开更多
关键词 low-NO_x burner aerodynamic field visual experiment image processing fractal characteristics stratified flow
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Ground-based investigations on phase-moving phenomenon with space sublimation cooling for lunar exploration missions 被引量:1
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作者 Enhui LI Yunze LI +5 位作者 Jixiang WANG Man YUAN Jingyan XIE Yuehang SUN Lizhu YANG Xianwen NING 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2022年第8期65-74,共10页
The lunar surface is a typical vacuum environment,and its harsh heat rejection conditions bring great challenges to the thermal control technology of the exploration mission.In addition to the radiator,the sublimator ... The lunar surface is a typical vacuum environment,and its harsh heat rejection conditions bring great challenges to the thermal control technology of the exploration mission.In addition to the radiator,the sublimator is recommended as one of the promising options for heat rejection.The sublimator makes use of water to freeze and sublimate in a porous medium,rejecting heat to the vacuum environment.The complex heat and mass transfer process involves many physical phenomena such as the freezing and sublimation phase change of water in the porous medium and the movement of the phase-change interface.In this paper,the visualized ground-based experimental approaches of space sublimation cooling were presented to reveal the moving law of threephase point and the growth phenomenon of ice-peak and icicle in microchannels under vacuum conditions.The visualized experiments and results prove that the freezing ice is divided into the porous ice-peak and the transparent icicle.As the sublimation progresses,the phase-change interface moves downward steadily,the length of the ice-peak increases,but the icicle decreases.The visualized experiments of space sublimation cooling in the capillary have guiding significance to reveal the sublimation cooling mechanism of water in the sublimator for lunar exploration missions. 展开更多
关键词 Lunar vacuum environment Phase-change flow Space sublimation cooling Unsteady phase-moving phenomenon Visualized ground-based experimental approaches
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Short-Term Visual Experience Leads to Potentiation of Spontaneous Activity in Mouse Superior Colliculus
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作者 Qingpeng Yu Hang Fu +2 位作者 Gang Wang Jiayi Zhang Biao Yan 《Neuroscience Bulletin》 SCIE CAS CSCD 2021年第3期353-368,共16页
Spontaneous activity in the brain maintains an internal structured pattern that reflects the external environment,which is essential for processing information and developing perception and cognition.An essential prer... Spontaneous activity in the brain maintains an internal structured pattern that reflects the external environment,which is essential for processing information and developing perception and cognition.An essential prerequisite of spontaneous activity for perception is the ability to reverberate external information,such as by potentiation.Yet its role in the processing of potentiation in mouse superior colliculus(SC)neurons is less studied.Here,we used electrophysiological recording,optogenetics,and drug infusion methods to investigate the mechanism of potentiation in SC neurons.We found that visual experience potentiated SC neurons several minutes later in different developmental stages,and the similarity between spontaneous and visually-evoked activity increased with age.Before eye-opening,activation of retinal ganglion cells that expressed ChR2 also induced the potentiation of spontaneous activity in the mouse SC.Potentiation was dependenton stimulus number and showed feature selectivity for direction and orientation.Optogenetic activation of parvalbumin neurons in the SC attenuated the potentiation induced by visual experience.Furthermore,potentiation in SC neurons was blocked by inhibiting the glutamate transporter GLT1.These results indicated that the potentiation induced by a visual stimulus might play a key role in shaping the internal representation of the environment,and serves as a carrier for short-term memory consolidation. 展开更多
关键词 Spontaneous activity Visual experience POTENTIATION Superior colliculus Feature selectivity Glutamate homeostasis
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Effect of intravenous sedation on patients’ visual experience and vital signs during cataract surgery under topical anesthesia: A randomized controlled trial
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作者 Rengaraj Venkatesh Hemal Kenia +2 位作者 Sabyasachi Sengupta Megha Gopalakrishna Kah-Guan Au Eong 《Advances in Ophthalmology Practice and Research》 2021年第1期32-38,共7页
Purpose:Effect of intravenous sedation on patients’visual experience and vital signs during cataract surgery under topical anesthesia:a randomized controlled trial.Design:Prospective,double masked,randomized controll... Purpose:Effect of intravenous sedation on patients’visual experience and vital signs during cataract surgery under topical anesthesia:a randomized controlled trial.Design:Prospective,double masked,randomized controlled trial.Methods:150 eyes of 150 patients undergoing phacoemulsification and IOL implantation under topical anesthesia were randomized to receive either intravenous midazolam(0.015 mg/kg)or normal saline.The patients’experience was evaluated using a questionnaire.Vital signs including blood pressure and heart rate were measured before,during and after surgery.Mean arterial pressure(MAP)was calculated.Results:Both groups were comparable except that fewer patients in the control group were pseudophakic in the fellow eye(25.3%vs.41.3%).More patients in the control group perceived hand movements(p<0.01),surgeon/medical staff(p?0.04)and sudden increase in vision during surgery(p<0.01)compared to midazolam group.More control group patients experienced fear(p<0.001),pain(p=0.06)and unpleasant surgical experience(20.3%vs.1.3%,p<0.001).They also experienced greater fluctuation in MAP(16.9±7.9 vs.7.2±5.3,p<0.001)and this was accentuated in hypertensives.After adjusting for age,gender,hypertension status and other eye lens status,multivariable logistic regression analysis revealed that subjects in the control arm(OR=11.7,95%[CI]=1.3-108,p=0.03),had a longer duration of surgery,experienced pain and more likely to report unpleasant experience.Adjusting for similar covariates,multivariable linear regression analysis showed that control group patients(β=8.5 mmHg,95%CI=6.2-10.8,p=0.03)had hypertension,experienced fear during surgery and greater fluctuations in the MAP.Conclusions:A sedative dose of intravenous midazolam during phacoemulsification under topical anesthesia significantly reduces patients’visual experience,fear and fluctuations in MAP and improves overall surgical experience. 展开更多
关键词 MIDAZOLAM Visual experience PHACOEMULSIFICATION Cataract surgery SEDATION
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