目的:探究布地奈德联合维生素K_(3)注射液治疗小儿毛细支气管炎的效果。方法:选择2022年1—12月黔西市人民医院收治的70例毛细支气管炎患儿作为研究对象,采用随机数表法将其分为对照组和观察组,各35例。对照组采用布地奈德治疗,观察组...目的:探究布地奈德联合维生素K_(3)注射液治疗小儿毛细支气管炎的效果。方法:选择2022年1—12月黔西市人民医院收治的70例毛细支气管炎患儿作为研究对象,采用随机数表法将其分为对照组和观察组,各35例。对照组采用布地奈德治疗,观察组采用布地奈德联合维生素K_(3)注射液治疗。比较两组治疗前后白细胞介素-6(interleukin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)、γ干扰素(interferon-γ,IFN-γ)炎症因子水平,用力肺活量(forced vital capacity,FVC)、第1秒用力呼气容积(forced expiratory volume in one second,FEV_(1))等肺功能指标及效果。结果:两组治疗前IL-6、CRP、IFN-γ、FVC、FEV_(1)水平比较,差异无统计学意义(P>0.05);观察组治疗后IL-6、CRP水平低于对照组,IFN-γ、FVC、FEV_(1)高于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论:布地奈德联合维生素K_(3)注射液治疗小儿毛细支气管炎的效果显著,不仅能有效降低机体炎症因子水平,还能改善肺功能。展开更多
BACKGROUND Vitamin K1(phytomenadione)is a fat-soluble naturally occurring vitamin that is widely used to treat certain coagulation disorders.Adverse cutaneous reactions to vitamin K1 can occur;however,owing to its low...BACKGROUND Vitamin K1(phytomenadione)is a fat-soluble naturally occurring vitamin that is widely used to treat certain coagulation disorders.Adverse cutaneous reactions to vitamin K1 can occur;however,owing to its low incidence and considerable variability in presentation and morphology,its diagnosis can be easily overlooked.Managing these reactions may be challenging for patients and clinicians.Therefore,reviewing the adverse cutaneous reactions to vitamin K1 is important.CASE SUMMARY Here we report the case of a 50-year-old woman with no pre-existing hepatic disease who developed a cutaneous allergic reaction to subcutaneous vitamin K1 that presented as localized eczematous plaques at the vitamin K1 injection site.The eruption developed within 5 d of the injection and persisted for 32 mo despite treatment with topical and intralesional steroids.Eczema was diagnosed based on the results of the pathological examination,immunohistochemical staining,and a skin biopsy.The patient was advised to take herbal medicines orally twice daily.After treatment and follow-up,the patient’s eczematous urticarial plaques improved and her condition stabilized.CONCLUSION Here we present the first case of a cutaneous allergic reaction to subcutaneous vitamin K1 that was successfully treated with Chinese medicine.展开更多
目的 分析维生素K_(1)治疗血清异常凝血酶原(proteinin-duced by vitamin K absence or antagonistⅡ,PIVKA-Ⅱ)升高的不同肝病患者的疗效。方法 回顾性分析2017年1月~2020年7月在首都医科大学附属北京佑安医院收治的经维生素K_(1)治疗...目的 分析维生素K_(1)治疗血清异常凝血酶原(proteinin-duced by vitamin K absence or antagonistⅡ,PIVKA-Ⅱ)升高的不同肝病患者的疗效。方法 回顾性分析2017年1月~2020年7月在首都医科大学附属北京佑安医院收治的经维生素K_(1)治疗的PIVKA-Ⅱ升高的230例患者。其中肝癌组86例,亚急性肝衰竭组69例,胆汁淤积性肝病组75例,比较3组患者入院时的PIVKA-Ⅱ水平;3组患者应用维生素K_(1)治疗7天后PIVKA-Ⅱ和凝血酶原活动度(PTA)的变化。结果 原发性肝癌组患者PIVKA-Ⅱ值明显高于亚急性肝衰竭组、胆汁淤积性肝病组。亚急性肝衰竭组患者PTA水平明显低于原发性肝癌组、胆汁淤积性肝病组(P<0.001),经维生素K_(1)治疗后,原发性肝癌组PIVKA-Ⅱ、PTA水平较入院时变化不明显,差异无统计学意义(P>0.05)。胆汁淤积性肝病组PIVKA-Ⅱ明显下降,PTA明显升高,差异有统计学意义(P<0.001)。亚急性肝衰竭组,根据出院方式分为存活组及死亡组,死亡组患者PIVKA-Ⅱ下降不明显,PTA略有增加或无变化;存活组患者PIVKA-Ⅱ明显下降,PTA明显升高,差异有统计学意义(P<0.01)。结论 临床上对亚急性肝衰竭及胆汁淤积明显患者给予维生素K_(1)治疗,如果PIVKA-Ⅱ降低、PTA在短时间内增加,患者更有可能存活。展开更多
[Objectives]To make simultaneous determination of vitamin K_(1)(VK_(1))and vitamin K_(2)(VK_(2),mainly MK-4,MK-7 and MK-9)in milk and dairy products.[Methods]A high performance liquid chromatographic method was develo...[Objectives]To make simultaneous determination of vitamin K_(1)(VK_(1))and vitamin K_(2)(VK_(2),mainly MK-4,MK-7 and MK-9)in milk and dairy products.[Methods]A high performance liquid chromatographic method was developed for the simultaneous determination of vitamin K_(1)(VK_(1))and vitamin K_(2)(VK_(2),mainly MK-4,MK-7 and MK-9)in milk and dairy products.After enzymatic digestion,the samples were extracted with hexane for VK_(1),MK-4,MK-7 and MK-9,subjected to gradient elution at excitation wavelength 243 nm and emission wavelength 430 nm,detected by high performance liquid chromatography with fluorescence detector and quantified by external standard method.[Results]The linearity of VK_(1),MK-4,MK-7 and MK-9 was good in the concentration range of 2.5-1000 ng/mL with the correlation coefficients greater than 0.999;The relative standard deviations(RSD)of VK_(1),MK-4,MK-7 and MK-9 in milk powder,liquid milk and yogurt were 1.32%-5.05%,1.10%-2.48% and 2.20%-3.47%,respectively;the recovery rates of VK_(1),MK-4,MK-7 and MK-9 at different levels in milk powder,liquid milk and yogurt were 81.1%-108%,81.8%-103%and 82.1%-99.2%,respectively.[Conclusions]The method is rapid,accurate,reproducible and capable of simultaneous determination of VK_(1),MK-4,MK-7 and MK-9.展开更多
文摘目的:探究布地奈德联合维生素K_(3)注射液治疗小儿毛细支气管炎的效果。方法:选择2022年1—12月黔西市人民医院收治的70例毛细支气管炎患儿作为研究对象,采用随机数表法将其分为对照组和观察组,各35例。对照组采用布地奈德治疗,观察组采用布地奈德联合维生素K_(3)注射液治疗。比较两组治疗前后白细胞介素-6(interleukin-6,IL-6)、C反应蛋白(C-reactive protein,CRP)、γ干扰素(interferon-γ,IFN-γ)炎症因子水平,用力肺活量(forced vital capacity,FVC)、第1秒用力呼气容积(forced expiratory volume in one second,FEV_(1))等肺功能指标及效果。结果:两组治疗前IL-6、CRP、IFN-γ、FVC、FEV_(1)水平比较,差异无统计学意义(P>0.05);观察组治疗后IL-6、CRP水平低于对照组,IFN-γ、FVC、FEV_(1)高于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论:布地奈德联合维生素K_(3)注射液治疗小儿毛细支气管炎的效果显著,不仅能有效降低机体炎症因子水平,还能改善肺功能。
文摘BACKGROUND Vitamin K1(phytomenadione)is a fat-soluble naturally occurring vitamin that is widely used to treat certain coagulation disorders.Adverse cutaneous reactions to vitamin K1 can occur;however,owing to its low incidence and considerable variability in presentation and morphology,its diagnosis can be easily overlooked.Managing these reactions may be challenging for patients and clinicians.Therefore,reviewing the adverse cutaneous reactions to vitamin K1 is important.CASE SUMMARY Here we report the case of a 50-year-old woman with no pre-existing hepatic disease who developed a cutaneous allergic reaction to subcutaneous vitamin K1 that presented as localized eczematous plaques at the vitamin K1 injection site.The eruption developed within 5 d of the injection and persisted for 32 mo despite treatment with topical and intralesional steroids.Eczema was diagnosed based on the results of the pathological examination,immunohistochemical staining,and a skin biopsy.The patient was advised to take herbal medicines orally twice daily.After treatment and follow-up,the patient’s eczematous urticarial plaques improved and her condition stabilized.CONCLUSION Here we present the first case of a cutaneous allergic reaction to subcutaneous vitamin K1 that was successfully treated with Chinese medicine.
文摘目的 分析维生素K_(1)治疗血清异常凝血酶原(proteinin-duced by vitamin K absence or antagonistⅡ,PIVKA-Ⅱ)升高的不同肝病患者的疗效。方法 回顾性分析2017年1月~2020年7月在首都医科大学附属北京佑安医院收治的经维生素K_(1)治疗的PIVKA-Ⅱ升高的230例患者。其中肝癌组86例,亚急性肝衰竭组69例,胆汁淤积性肝病组75例,比较3组患者入院时的PIVKA-Ⅱ水平;3组患者应用维生素K_(1)治疗7天后PIVKA-Ⅱ和凝血酶原活动度(PTA)的变化。结果 原发性肝癌组患者PIVKA-Ⅱ值明显高于亚急性肝衰竭组、胆汁淤积性肝病组。亚急性肝衰竭组患者PTA水平明显低于原发性肝癌组、胆汁淤积性肝病组(P<0.001),经维生素K_(1)治疗后,原发性肝癌组PIVKA-Ⅱ、PTA水平较入院时变化不明显,差异无统计学意义(P>0.05)。胆汁淤积性肝病组PIVKA-Ⅱ明显下降,PTA明显升高,差异有统计学意义(P<0.001)。亚急性肝衰竭组,根据出院方式分为存活组及死亡组,死亡组患者PIVKA-Ⅱ下降不明显,PTA略有增加或无变化;存活组患者PIVKA-Ⅱ明显下降,PTA明显升高,差异有统计学意义(P<0.01)。结论 临床上对亚急性肝衰竭及胆汁淤积明显患者给予维生素K_(1)治疗,如果PIVKA-Ⅱ降低、PTA在短时间内增加,患者更有可能存活。
文摘[Objectives]To make simultaneous determination of vitamin K_(1)(VK_(1))and vitamin K_(2)(VK_(2),mainly MK-4,MK-7 and MK-9)in milk and dairy products.[Methods]A high performance liquid chromatographic method was developed for the simultaneous determination of vitamin K_(1)(VK_(1))and vitamin K_(2)(VK_(2),mainly MK-4,MK-7 and MK-9)in milk and dairy products.After enzymatic digestion,the samples were extracted with hexane for VK_(1),MK-4,MK-7 and MK-9,subjected to gradient elution at excitation wavelength 243 nm and emission wavelength 430 nm,detected by high performance liquid chromatography with fluorescence detector and quantified by external standard method.[Results]The linearity of VK_(1),MK-4,MK-7 and MK-9 was good in the concentration range of 2.5-1000 ng/mL with the correlation coefficients greater than 0.999;The relative standard deviations(RSD)of VK_(1),MK-4,MK-7 and MK-9 in milk powder,liquid milk and yogurt were 1.32%-5.05%,1.10%-2.48% and 2.20%-3.47%,respectively;the recovery rates of VK_(1),MK-4,MK-7 and MK-9 at different levels in milk powder,liquid milk and yogurt were 81.1%-108%,81.8%-103%and 82.1%-99.2%,respectively.[Conclusions]The method is rapid,accurate,reproducible and capable of simultaneous determination of VK_(1),MK-4,MK-7 and MK-9.
