With the changes in trends of disease pattern from infectious to chronic degenerative disease, cardiovascular disease has been considered as the major cause of death in Korea.Numerous studies have been done on the ant...With the changes in trends of disease pattern from infectious to chronic degenerative disease, cardiovascular disease has been considered as the major cause of death in Korea.Numerous studies have been done on the antioxidant effects of some vitamins in the prevention of chronic illness, but not many in relation to the cardiovascular disease.Therefore, the relation between antioxidant vitamins, mainly α-tocopherol (α-T) and B-carotene (B-C), and coronary artery disease (CAD) such as angina pectoris and myocardial infarction has been investigated in this study.The blood samples were obtained from the CAD patients who were angiographically diagnosed within a month (100 case group). Patients who had an experience of PTCA or CABG were excluded from the study. Control subjects were healthy adults who had normal EKG values, no chest pain and no past history of cardiac disease (100 control group). All subjects were free of serum lipid lowering drugs. Serum α-T and B-C were analysed using HPLC. In addition to antioxidant vitamins, serum lipids (total cholesterol, HDL, TG) were also measured. Each case and control was matched in terms of age and sex. And all the CAD risk factors such as blood pressure, smoking, alcohol, serum lipid profile and BMI were adjusted to determine pure effect(s) of α-T and B-C on the CAD.The concentrations of both α-T and B-C were significantly lower in the CAD group than those in control group (P<0.05); in CAD group, mean values of α-T and B-C were 11.9±7.2 (μg/ml), 35.8±3.1 (μg/dl) respectively. As for the levels of B-C, it shows inverse relation with age, but not for the α-T Ievels. Serum levels of both vitamins did not show any significant differences in terms of sex, but men have a tendency o higher levels of B-C,but lower levels of α-T展开更多
BACKGROUND Many epidemiologic investigations have explored the relationship between viatmins and polycystic ovary syndrome(PCOS).However,the effectiveness of vitamin,vitamin-like nutrient,or mineral supplementation in...BACKGROUND Many epidemiologic investigations have explored the relationship between viatmins and polycystic ovary syndrome(PCOS).However,the effectiveness of vitamin,vitamin-like nutrient,or mineral supplementation in reducing the risk of PCOS remains a subject of debate.AIM To investigate the impact of plasma levels of vitamins A,B12,D,E,and K on PCOS and key pathways implicated in its development,namely,insulin resistance,hyperlipidemia,and obesity,through Mendelian randomization(MR)analysis.METHODS Single nucleotide polymorphisms associated with vitamin levels were selected from genome-wide association studies.The primary analysis was performed using the random-effects inverse-variance-weighted approach.Complementary analyses were conducted using the weighted median,MR-Egger,MR-robust adjusted profile score,and MR-PRESSO approaches.RESULTS The results provided suggestive evidence of a decreased risk of PCOS with genetically predicted higher levels of vitamin E(odds ratio[OR]=0.118;95%confidence interval[CI]:0.071–0.226;P<0.001)and vitamin B12(OR=0.753,95%CI:0.568–0.998,P=0.048).An association was observed between vitamin E levels and insulin resistance(OR=0.977,95%CI:0.976–0.978,P<0.001).Additionally,genetically predicted higher concentrations of vitamins E,D,and A were suggested to be associated with a decreased risk of hyperlipidemia.Increased vitamins K and B12 levels were linked to a lower obesity risk(OR=0.917,95%CI:0.848–0.992,P=0.031).CONCLUSION The findings of this MR study suggest a causal relationship between increased vitamins A,D,E,K,and B12 levels and a reduced risk of PCOS or primary pathways implicated in its development.展开更多
在翘嘴鲌（Culter alburnus）鱼种基础饲料中添加相当于抗坏血酸含量为0mg／kg、25mg／kg、50mg／kg、100mg／kg、150mg／kg、200mg／kg和400mg／kg的包膜维生素C（Vc），制成7种实验饲料，饲养初始体质量为（3．71±0．11）g的7组...在翘嘴鲌（Culter alburnus）鱼种基础饲料中添加相当于抗坏血酸含量为0mg／kg、25mg／kg、50mg／kg、100mg／kg、150mg／kg、200mg／kg和400mg／kg的包膜维生素C（Vc），制成7种实验饲料，饲养初始体质量为（3．71±0．11）g的7组翘嘴鲌鱼种8周，每个实验组包含3个重复。结果表明，摄食不添加Vc饲料的实验鱼成活率显著低于其他Vc添加组（P〈0．05）。饲料中Vc添加量为0-50mg／kg时，对鱼体增重有显著影响（P〈0．05），鱼体增重随添加量的增加而上升。但添加量继续增大，对鱼体增重不再有显著影响（P〉0．05）。饲料中维生素C添加量为。和25mg／kg时，饲料效率和蛋白质效率低于其他各组（P〈0．05）。试验饲料中Vc不同添加量对肝体指数和全鱼体成分无显著影响（P〉0．05）。肌肉中抗坏血酸含量随饲料中Vc添加量加大而不断上升，二者呈正相关关系（P〈0．05）。肝胰脏抗坏血酸含量在Vc添加量≤100mg／kg时，随饲料中Vc添加量加大而不断上升（P〈0．05），但高于此添加量时，则肝胰脏中抗坏血酸不再随添加量的上升而有显著变化（P〉0．05）。分别以鱼体增质量和肝胰脏中抗坏血酸为指标，经折线模型（Broken line model）回归分析求得翘嘴铂鱼种饲料中Vc的适宜添加量分别为53mg／kg和97mg／kg。展开更多
文摘With the changes in trends of disease pattern from infectious to chronic degenerative disease, cardiovascular disease has been considered as the major cause of death in Korea.Numerous studies have been done on the antioxidant effects of some vitamins in the prevention of chronic illness, but not many in relation to the cardiovascular disease.Therefore, the relation between antioxidant vitamins, mainly α-tocopherol (α-T) and B-carotene (B-C), and coronary artery disease (CAD) such as angina pectoris and myocardial infarction has been investigated in this study.The blood samples were obtained from the CAD patients who were angiographically diagnosed within a month (100 case group). Patients who had an experience of PTCA or CABG were excluded from the study. Control subjects were healthy adults who had normal EKG values, no chest pain and no past history of cardiac disease (100 control group). All subjects were free of serum lipid lowering drugs. Serum α-T and B-C were analysed using HPLC. In addition to antioxidant vitamins, serum lipids (total cholesterol, HDL, TG) were also measured. Each case and control was matched in terms of age and sex. And all the CAD risk factors such as blood pressure, smoking, alcohol, serum lipid profile and BMI were adjusted to determine pure effect(s) of α-T and B-C on the CAD.The concentrations of both α-T and B-C were significantly lower in the CAD group than those in control group (P<0.05); in CAD group, mean values of α-T and B-C were 11.9±7.2 (μg/ml), 35.8±3.1 (μg/dl) respectively. As for the levels of B-C, it shows inverse relation with age, but not for the α-T Ievels. Serum levels of both vitamins did not show any significant differences in terms of sex, but men have a tendency o higher levels of B-C,but lower levels of α-T
基金Supported by the Huzhou Science and Technology Plan,No.2022GY27.
文摘BACKGROUND Many epidemiologic investigations have explored the relationship between viatmins and polycystic ovary syndrome(PCOS).However,the effectiveness of vitamin,vitamin-like nutrient,or mineral supplementation in reducing the risk of PCOS remains a subject of debate.AIM To investigate the impact of plasma levels of vitamins A,B12,D,E,and K on PCOS and key pathways implicated in its development,namely,insulin resistance,hyperlipidemia,and obesity,through Mendelian randomization(MR)analysis.METHODS Single nucleotide polymorphisms associated with vitamin levels were selected from genome-wide association studies.The primary analysis was performed using the random-effects inverse-variance-weighted approach.Complementary analyses were conducted using the weighted median,MR-Egger,MR-robust adjusted profile score,and MR-PRESSO approaches.RESULTS The results provided suggestive evidence of a decreased risk of PCOS with genetically predicted higher levels of vitamin E(odds ratio[OR]=0.118;95%confidence interval[CI]:0.071–0.226;P<0.001)and vitamin B12(OR=0.753,95%CI:0.568–0.998,P=0.048).An association was observed between vitamin E levels and insulin resistance(OR=0.977,95%CI:0.976–0.978,P<0.001).Additionally,genetically predicted higher concentrations of vitamins E,D,and A were suggested to be associated with a decreased risk of hyperlipidemia.Increased vitamins K and B12 levels were linked to a lower obesity risk(OR=0.917,95%CI:0.848–0.992,P=0.031).CONCLUSION The findings of this MR study suggest a causal relationship between increased vitamins A,D,E,K,and B12 levels and a reduced risk of PCOS or primary pathways implicated in its development.
文摘在翘嘴鲌（Culter alburnus）鱼种基础饲料中添加相当于抗坏血酸含量为0mg／kg、25mg／kg、50mg／kg、100mg／kg、150mg／kg、200mg／kg和400mg／kg的包膜维生素C（Vc），制成7种实验饲料，饲养初始体质量为（3．71±0．11）g的7组翘嘴鲌鱼种8周，每个实验组包含3个重复。结果表明，摄食不添加Vc饲料的实验鱼成活率显著低于其他Vc添加组（P〈0．05）。饲料中Vc添加量为0-50mg／kg时，对鱼体增重有显著影响（P〈0．05），鱼体增重随添加量的增加而上升。但添加量继续增大，对鱼体增重不再有显著影响（P〉0．05）。饲料中维生素C添加量为。和25mg／kg时，饲料效率和蛋白质效率低于其他各组（P〈0．05）。试验饲料中Vc不同添加量对肝体指数和全鱼体成分无显著影响（P〉0．05）。肌肉中抗坏血酸含量随饲料中Vc添加量加大而不断上升，二者呈正相关关系（P〈0．05）。肝胰脏抗坏血酸含量在Vc添加量≤100mg／kg时，随饲料中Vc添加量加大而不断上升（P〈0．05），但高于此添加量时，则肝胰脏中抗坏血酸不再随添加量的上升而有显著变化（P〉0．05）。分别以鱼体增质量和肝胰脏中抗坏血酸为指标，经折线模型（Broken line model）回归分析求得翘嘴铂鱼种饲料中Vc的适宜添加量分别为53mg／kg和97mg／kg。
