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Abnormalities of interhemispheric functional connectivity in individuals with acute eye pain: a resting-state fMRI study 被引量:3
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作者 Zhi-Zhang Dong Fei-Yin Zhu +9 位作者 Wen-Qing Shi Yong-Qiang Shu Lin-Long Chen Qing Yuan Qi Lin Pei-Wen Zhu Kang-Cheng Liu You-Lan Min Lei Ye Yi Shao 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2019年第4期634-639,共6页
AIM: To study the changes of the resting state functional connectivity(rsFC) between acute eye pain(EP) subjects and healthy controls(HCs) in the two hemispheres by using voxel-mirrored homotopic connectivity(VMHC) me... AIM: To study the changes of the resting state functional connectivity(rsFC) between acute eye pain(EP) subjects and healthy controls(HCs) in the two hemispheres by using voxel-mirrored homotopic connectivity(VMHC) method.METHODS: Totally 20 patients with EP and 20 HCs were enrolled, sex, age, and education were matched, and all subjects were examined by functional magnetic resonance imaging(fMRI) scans at resting-state. The changes of rs FC between the hemispheres were evaluated by the VMHC method according to Gaussian random field(GRF) theory. In order to identify the VMHC, as biomarkers for distinguishing EP and from HC, the receiver operating characteristic curves(ROC) had been analyzed. The relationships were evaluated with Pearson correlation analysis between the mean VMHC signal values and clinical features in these patients.RESULTS: By comparing with health subjects, the significant decreased VMHC values was observed in lingual/calcarine(Brodmann area, BA 30), precentral/postcentral gyrus(PreCG/PosCG; BA 4) and medial frontal gyrus(MFG; BA 8)(false discovery rate corrected <0.01) in the acute EP individuals. The accuracy of area under curve was excellent indicated by the ROC curve analysis of each brain regions.CONCLUSION: Our study demonstrates preliminary evidence of disrupted interhemispheric rsFC in acute EP in sensorimotor and limbic system and somatosensory cortex, which might give some useful information for understanding the neurological mechanisms in acute EP individuals. 展开更多
关键词 ACUTE eye PAIN voxel-mirrored homotopic connectivity functional magnetic resonance imaging RESTING state
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单侧颞叶癫痫患者双侧大脑半球间的功能协同性研究 被引量:4
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作者 刘慧华 郑金瓯 《中国神经精神疾病杂志》 CAS CSCD 北大核心 2016年第10期616-622,共7页
目的研究单侧颞叶癫痫患者双侧大脑半球间同伦功能连接的变化。方法纳入左侧颞叶癫痫(left temporal lobe epilepsy,LTLE)21例、右侧颞叶癫痫患者(right temporal lobe epilepsy,RTLE)22例以及正常对照(normal control,NC)20例。采用体... 目的研究单侧颞叶癫痫患者双侧大脑半球间同伦功能连接的变化。方法纳入左侧颞叶癫痫(left temporal lobe epilepsy,LTLE)21例、右侧颞叶癫痫患者(right temporal lobe epilepsy,RTLE)22例以及正常对照(normal control,NC)20例。采用体素-镜像同伦功能连接(voxel-mirrored homotopic connectivity,VMHC)方法分析数据,计算出各组VMHC改变的脑区。结果与NC组相比较,LTLE组双侧辅助运动区(t=-3.35)、颞中回(t=-3.50)、内侧额上回(t=-3.20)、顶下小叶(t=-3.66)VMHC值降低;双侧角回(t=3.03)、枕下回(t=4.25)、顶上回(t=3.62)VMHC值升高(P<0.05,alphasim校正)。与NC组相比较,RTLE组双侧颞中回(t=-4.26)、中央前回(t=-3.29)VMHC值减低;双侧枕下回(t=3.22)、海马旁脑回(t=3.32)和小脑(t=3.50)VMHC值升高(P<0.05,alphasim校正)。结论单侧颞叶癫痫患者两侧半球间部分脑区的功能协同性发生了变化。 展开更多
关键词 单侧颞叶癫痫 静息态功能磁共振 体素-镜像同伦功能连接
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基于磁共振脑成像的自闭症儿童镜像同伦功能连接异常研究 被引量:7
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作者 刘梦婉 卢虹冰 +6 位作者 徐守军 杨春兰 李佳铭 郑凯中 燕宝玉 刘健 李宝娟 《医疗卫生装备》 CAS 2019年第10期13-18,共6页
目的:基于磁共振成像探究大脑镜像同伦脑区的功能连接强度在自闭症(autism spectrum disorder,ASD)儿童与正常儿童间的差异性,寻找潜在的ASD神经生物学机制。方法:募集83例年龄在2~6岁的ASD患儿(ASD组)和70例相同年龄的典型发育(typical... 目的:基于磁共振成像探究大脑镜像同伦脑区的功能连接强度在自闭症(autism spectrum disorder,ASD)儿童与正常儿童间的差异性,寻找潜在的ASD神经生物学机制。方法:募集83例年龄在2~6岁的ASD患儿(ASD组)和70例相同年龄的典型发育(typically developing,TD)儿童(TD组)。对2组分别进行睡眠状态下功能磁共振成像扫描,分析体素镜像同伦连接(voxel-mirrored homotopic connectivity,VMHC)强度。使用单样本t检验分别得到2组的VMHC强度图谱,最后通过双样本t检验方法研究2组间大脑半球间连接的差异。结果:经错误发现率(false discovery rate,FDR)控制校正后,与TD组相比,ASD组在颞上回、楔前叶、内侧额叶、尾状核的VMHC强度显著降低(P<0.05)。结论:ASD患儿在静息状态下大脑两半球间功能连接降低,交互沟通能力下降。该研究为理解ASD的神经生物学机制提供了新视角。 展开更多
关键词 功能磁共振成像 自闭症 体素镜像同伦连接 功能连接 社会认知
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双侧强化训练对痉挛型偏瘫儿童粗大运动功能和步行功能的影响 被引量:1
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作者 邵鹤 都修波 +3 位作者 马丙祥 李海峰 常琳琳 米雪 《中国中西医结合儿科学》 2020年第6期502-505,共4页
目的观察双侧强化训练对痉挛型偏瘫儿童粗大运动和步行功能的疗效。方法以2014年2月至2019年12月河南中医药大学第一附属医院儿童脑病康复诊疗中心诊断收治的30例偏瘫患儿为研究对象,随机分为对照组和观察组各15例。对照组应用常规康复... 目的观察双侧强化训练对痉挛型偏瘫儿童粗大运动和步行功能的疗效。方法以2014年2月至2019年12月河南中医药大学第一附属医院儿童脑病康复诊疗中心诊断收治的30例偏瘫患儿为研究对象,随机分为对照组和观察组各15例。对照组应用常规康复治疗,观察组应用常规康复治疗的基础上,运动疗法应用双侧强化训练,两组均治疗3个疗程。治疗前后对患儿分别采用粗大运动功能评定量表(GMFM-88项)、足印分析法、10 m步行测试、1 min步行测试进行评定。结果两组治疗后GMFM-88项测试评分、步长和步宽、10 m步行时间及1 min步行距离均优于治疗前,差异有统计学意义(P<0.05),且观察组优于对照组,差异有统计学意义(P<0.05)。结论双侧强化训练结合常规康复治疗可以改善痉挛型偏瘫儿童的粗大运动功能,纠正异常步态,提高步行的速度、耐力和稳定性。 展开更多
关键词 痉挛型偏瘫 同伦功能连接 双侧强化训练 粗大运动功能 步行功能
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Interhemispheric functional connectivity for Alzheimer's disease and amnestic mild cognitive impairment based on the triple network model 被引量:1
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作者 Zheng-luan LIAO Yun-fei TAN +8 位作者 Ya-ju QIU Jun-peng ZHU Yan CHEN Si-si LIN Ming-hao WU Yan-ping MAO Jiao-jiao HU Zhong-xiang DING En-yan YU 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2018年第12期924-934,共11页
The purpose of this study was to explore the differences in interhemispheric functional connectivity in patients with Alzheimer’s disease(AD) and amnestic mild cognitive impairment(aMCI) based on a triple network mod... The purpose of this study was to explore the differences in interhemispheric functional connectivity in patients with Alzheimer’s disease(AD) and amnestic mild cognitive impairment(aMCI) based on a triple network model consisting of the default mode network(DMN), salience network(SN), and executive control network(ECN). The technique of voxel-mirrored homotopic connectivity(VMHC) analysis was applied to explore the aberrant connectivity of all patients. The results showed that:(1) the statistically significant connections of interhemispheric brain regions included DMN-related brain regions(i.e. precuneus, calcarine, fusiform, cuneus, lingual gyrus, temporal inferior gyrus, and hippocampus), SN-related brain regions(i.e. frontoinsular cortex), and ECN-related brain regions(i.e. frontal middle gyrus and frontal inferior);(2) the precuneus and frontal middle gyrus in the AD group exhibited lower VMHC values than those in the aMCI and healthy control(HC) groups, but no significant difference was observed between the a MCI and HC groups; and(3) significant correlations were found between peak VMHC results from the precuneus and Mini Mental State Examination(MMSE) and Montreal Cognitive Scale(MOCA) scores and their factor scores in the AD, a MCI, and AD plus aMCI groups, and between the results from the frontal middle gyrus and MOCA factor scores in the a MCI group. These findings indicated that impaired interhemispheric functional connectivity was observed in AD and could be a sensitive neuroimaging biomarker for AD. More specifically, the DMN was inhibited, while the SN and ECN were excited. VMHC results were correlated with MMSE and MOCA scores, highlighting that VMHC could be a sensitive neuroimaging biomarker for AD and the progression from aMCI to AD. 展开更多
关键词 voxel-mirrored homotopic connectivity Alzheimer's disease Amnestic mild cognitive impairment Default mode network Salience network Executive control network
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