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ITIC:一种高效的k-影响社区top-r查询算法
1
作者
谭玉婷
王习特
+2 位作者
白梅
周虹宇
朱斌
《计算机应用与软件》
北大核心
2023年第9期30-36,共7页
k-影响社区(k-Influential Community, k-IC)是网络中具有较大影响值且无包含关系的最大连通k-core。k-IC的top-r查询的目标是返回影响值较大的前r个k-IC。针对此问题,提出W-D(Weight-Degree)索引用于管理网络。提出k-IC的top-r查询优...
k-影响社区(k-Influential Community, k-IC)是网络中具有较大影响值且无包含关系的最大连通k-core。k-IC的top-r查询的目标是返回影响值较大的前r个k-IC。针对此问题,提出W-D(Weight-Degree)索引用于管理网络。提出k-IC的top-r查询优化算法ITIC(Index-based Top-r Query Algorithm for k-Influential Community),该算法无须频繁计算连通分量,并且从权重较大的节点开始处理,一般只对部分节点进行处理即可求得结果。同时,该算法是渐进输出k-IC,可根据用户需求随时终止算法。通过实验验证所提算法的有效性。实验结果表明,相对于现有算法,ITIC可以显著提高计算效率。
展开更多
关键词
k-影响社区
k-core
w-d
索引
Top-r
网络
下载PDF
职称材料
基质金属蛋白酶-9抑制剂对犬体外循环肺损伤的影响
被引量:
4
2
作者
龚文辉
葛圣林
+3 位作者
张成鑫
张胜权
冯俊波
张雷
《中国胸心血管外科临床杂志》
CAS
2010年第1期36-40,共5页
目的研究外源性基质金属蛋白酶-9(matrix metalloproteinases-9,MMP-9)抑制剂多西环素(Doxycycline)对体外循环(CPB)引起肺损伤的保护作用。方法将20只健康杂种幼犬(体重10~12kg),采用随机数字表法随机分为对照组(n=10)和实验组(n=10)...
目的研究外源性基质金属蛋白酶-9(matrix metalloproteinases-9,MMP-9)抑制剂多西环素(Doxycycline)对体外循环(CPB)引起肺损伤的保护作用。方法将20只健康杂种幼犬(体重10~12kg),采用随机数字表法随机分为对照组(n=10)和实验组(n=10);对照组:CPB前后不采取任何肺保护措施;实验组:CPB术前3d每天饲料拌食多西环素(30mg/kg体重)。采用酶联免疫吸附(ELISA)法检测血浆MMP-9浓度;监测两组犬血流动力学和呼吸参数,计算术前和术后肺泡-动脉氧分压差(A-aDO2)和呼吸指数(RI);比色法测定支气管肺泡灌洗液(BALF)髓过氧化物酶(MPO)活性;考马斯亮蓝G-250法测定BALF总蛋白。CPB后,在光学显微镜和电子显微镜下观察肺组织形态学改变;计算肺组织干湿重系数(W/D)。结果两组犬血浆MMP-9浓度随CPB时间延长而显著增高,CBP150min和270min时实验组血浆中MMP-9含量较对照组显著下降(9.45±5.29ng/mlvs.18.66±5.90ng/ml,t=3.664,P=0.005;16.63±2.90ng/mlvs.26.17±5.96ng/ml,t=5.216,P=0.001)。实验组MPO活性,BALF中总蛋白浓度,肺组织W/D,术后A-aDO2和RI均较对照组均明显减低,差异有统计学意义(t=5.622,P=0.000;t=5.081,P=0.001;t=2.266,P=0.050;t=4.927,P=0.001;t=6.679,P=0.000)。肺组织病理和电子显微镜显示实验组损伤明显减轻。结论多西环素通过抑制MMP-9的分泌,降低细胞基底膜的降解,减轻肺泡白细胞浸润和肺水肿,可起到对肺的保护作用。
展开更多
关键词
体外循环
急性肺损伤
基质金属蛋白酶
多西环素
肺保护
下载PDF
职称材料
题名
ITIC:一种高效的k-影响社区top-r查询算法
1
作者
谭玉婷
王习特
白梅
周虹宇
朱斌
机构
大连海事大学信息科学技术学院
出处
《计算机应用与软件》
北大核心
2023年第9期30-36,共7页
基金
国家自然科学基金项目(61602076,61702072,61976032,62002039)
中国博士后科学基金面上项目(2017M611211,2017M621122,2019M661077)
+1 种基金
辽宁省自然科学基金项目(20180540003)
赛尔网络下一代互联网技术创新项目(NGII20190902)。
文摘
k-影响社区(k-Influential Community, k-IC)是网络中具有较大影响值且无包含关系的最大连通k-core。k-IC的top-r查询的目标是返回影响值较大的前r个k-IC。针对此问题,提出W-D(Weight-Degree)索引用于管理网络。提出k-IC的top-r查询优化算法ITIC(Index-based Top-r Query Algorithm for k-Influential Community),该算法无须频繁计算连通分量,并且从权重较大的节点开始处理,一般只对部分节点进行处理即可求得结果。同时,该算法是渐进输出k-IC,可根据用户需求随时终止算法。通过实验验证所提算法的有效性。实验结果表明,相对于现有算法,ITIC可以显著提高计算效率。
关键词
k-影响社区
k-core
w-d
索引
Top-r
网络
Keywords
K-influential community
K-core
w-d index
Top-r
Network
分类号
TP3 [自动化与计算机技术—计算机科学与技术]
下载PDF
职称材料
题名
基质金属蛋白酶-9抑制剂对犬体外循环肺损伤的影响
被引量:
4
2
作者
龚文辉
葛圣林
张成鑫
张胜权
冯俊波
张雷
机构
安徽医科大学第二附属医院心胸外科
安徽医科大学第一附属医院心血管外科
出处
《中国胸心血管外科临床杂志》
CAS
2010年第1期36-40,共5页
基金
安徽省自然科学基金资助项目(070413070)~~
文摘
目的研究外源性基质金属蛋白酶-9(matrix metalloproteinases-9,MMP-9)抑制剂多西环素(Doxycycline)对体外循环(CPB)引起肺损伤的保护作用。方法将20只健康杂种幼犬(体重10~12kg),采用随机数字表法随机分为对照组(n=10)和实验组(n=10);对照组:CPB前后不采取任何肺保护措施;实验组:CPB术前3d每天饲料拌食多西环素(30mg/kg体重)。采用酶联免疫吸附(ELISA)法检测血浆MMP-9浓度;监测两组犬血流动力学和呼吸参数,计算术前和术后肺泡-动脉氧分压差(A-aDO2)和呼吸指数(RI);比色法测定支气管肺泡灌洗液(BALF)髓过氧化物酶(MPO)活性;考马斯亮蓝G-250法测定BALF总蛋白。CPB后,在光学显微镜和电子显微镜下观察肺组织形态学改变;计算肺组织干湿重系数(W/D)。结果两组犬血浆MMP-9浓度随CPB时间延长而显著增高,CBP150min和270min时实验组血浆中MMP-9含量较对照组显著下降(9.45±5.29ng/mlvs.18.66±5.90ng/ml,t=3.664,P=0.005;16.63±2.90ng/mlvs.26.17±5.96ng/ml,t=5.216,P=0.001)。实验组MPO活性,BALF中总蛋白浓度,肺组织W/D,术后A-aDO2和RI均较对照组均明显减低,差异有统计学意义(t=5.622,P=0.000;t=5.081,P=0.001;t=2.266,P=0.050;t=4.927,P=0.001;t=6.679,P=0.000)。肺组织病理和电子显微镜显示实验组损伤明显减轻。结论多西环素通过抑制MMP-9的分泌,降低细胞基底膜的降解,减轻肺泡白细胞浸润和肺水肿,可起到对肺的保护作用。
关键词
体外循环
急性肺损伤
基质金属蛋白酶
多西环素
肺保护
Keywords
Objective To study the protective effect of exogenous matrix metalloproteinases-9(MMP-9) inhibitor Doxycycline against lung injury during cardiopulmonary bypass(CPB) in dogs. Methods Twenty healthy mongrel puppies(weighed 10 -12 kg) were divided into control group (n=10) and experimental group(n=10) with random number table. In control group, no measure was taken to protect lung before and after CPB. In experimental group, the feeding food was mixed with Doxycycline (30 mg/kg, body weight) daily for three days before operation. Enzyme-linked immunosorbent assay(ELISA) was used to measure the plasma concentration of MMP-9. Hemodynamic and respiratory parameters in two groups were monitored. The preoperative and postoperative alveolar-arterial oxygen partial pressure difference (A-aDO2) and respiratory
index
(RI) were calculated. The myeloperoxidase(MPO)activity of bronchoalveolar lavage fluid(BALF)was determined by colorimetry. The total protein of BALF was measured by Coomassie Brillian...更多t Blue G-250. After CPB, light microscope and electronic microscope were used to observe the morphological changes of lung tissue. The dry to wet weight
index
(W/D) was calculated. Results In both groups, the plasma concentrations of MMP-9 increased significantly as the time of CPB prolonged. The plasma MMP-9 at 150 min and 270 min after CPB in experimental group decreased significantly than those in control group (9.45±5.29 ng/ml vs. 18.66±5.90 ng/ml, t=3.664, P=0.005
16.63±2.90 ng/ml vs. 26.17±5.96 ng/ml, t=5.216, P= 0.001). MPO activity, total protein of BALF, W/D, postoperative A-aDO2 and RI in experimental group decreased significantly than those in control group. There were significant differences between two groups(t=5.622, P=0.000
t=5.081, P=0.001
t=2.266, P=0.050
t=4.927, P=0.001
t=6.679,P=0.000). The lung histopathology and electronic microscope showed that the lung injury reduced significantly. Conclusion Doxycycline plays a role in lung protection by inhibiting the secretion of MMP-9, reducing the degradation of cell basement membrane, pulmonary neutrophil infiltration and pulmonary edema. 还原 Objective To study the protective effect of exogenous matrix metalloproteinases-9(MMP-9) inhibitor Doxycycline against lung injury during cardiopulmonary bypass(CPB) in dogs. Methods Twenty healthy mongrel puppies(weighed 10 -12 kg) were divided into control group (n=10) and experimental group(n=10) with random number table. In control group, no measure was taken to protect lung before and after CPB. In experimental group, the feeding food was mixed with Doxycycline (30 mg/kg, body weight) daily for three days before operation. Enzyme-linked immunosorbent assay(ELISA) was used to measure the plasma concentration of MMP-9. Hemodynamic and respiratory parameters in two groups were monitored. The preoperative and postoperative alveolar-arterial oxygen partial pressure difference (A-aDO2) and respiratory
index
(RI) were calculated. The myeloperoxidase(MPO)activity of bronchoalveolar lavage fluid(BALF)was determined by colorimetry. The total protein of BALF was measured by Coomassie Brillian...更多t Blue G-250. After CPB, light microscope and electronic microscope were used to observe the morphological changes of lung tissue. The dry to wet weight
index
(W/D) was calculated. Results In both groups, the plasma concentrations of MMP-9 increased significantly as the time of CPB prolonged. The plasma MMP-9 at 150 min and 270 min after CPB in experimental group decreased significantly than those in control group (9.45±5.29 ng/ml vs. 18.66±5.90 ng/ml, t=3.664, P=0.005
16.63±2.90 ng/ml vs. 26.17±5.96 ng/ml, t=5.216, P= 0.001). MPO activity, total protein of BALF, W/D, postoperative A-aDO2 and RI in experimental group decreased significantly than those in control group. There were significant differences between two groups(t=5.622, P=0.000
t=5.081, P=0.001
t=2.266, P=0.050
t=4.927, P=0.001
t=6.679,P=0.000). The lung histopathology and electronic microscope showed that the lung injury reduced significantly. Conclusion Doxycycline plays a role in lung protection by inhibiting the secretion of MMP-9, reducing the degradation of cell basement membrane, pulmonary neutrophil infiltration and pulmonary edema. 还原Cardiopulmonary bypass
Acute lung injury
Matrix metalloproteinase
Doxycycline
Lung protection
分类号
R654.1 [医药卫生—外科学]
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ITIC:一种高效的k-影响社区top-r查询算法
谭玉婷
王习特
白梅
周虹宇
朱斌
《计算机应用与软件》
北大核心
2023
0
下载PDF
职称材料
2
基质金属蛋白酶-9抑制剂对犬体外循环肺损伤的影响
龚文辉
葛圣林
张成鑫
张胜权
冯俊波
张雷
《中国胸心血管外科临床杂志》
CAS
2010
4
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