Introduction:Recent studies examining the association of Toll-like receptor 3(TLR3)gene polymorphisms with the risk of developing various types of cancer have reported conflicting results.Clarifying this association c...Introduction:Recent studies examining the association of Toll-like receptor 3(TLR3)gene polymorphisms with the risk of developing various types of cancer have reported conflicting results.Clarifying this association could advance our knowledge of the influence of TLR3 single nucleotide polymorphisms(SNPs)on cancer risk.Methods:We systematically reviewed studies that focused on a collection of 12 SNPs located in the TLR3 gene and the details by which these SNPs influenced cancer risk.Additionally,14 case-control studies comprising a total of7997 cases of cancer and 8699 controls were included in a meta-analysis of 4 highly studied SNPs(rs3775290,rs3775291,rs3775292,and rs5743312).Results:The variant TLR3 genotype rs5743312(C9948T,intron 3,C>T)was significantly associated with an increased cancer risk as compared with the wild-type allele(odds ratio[OR]=1.11,95%confidence interval[CI]=1.00–1.24,P=0.047).No such association was observed with other TLR3 SNPs.In the stratified analysis,the rs3775290(C13766T,C>T)variant genotype was found to be significantly associated with an increased cancer risk in Asian populations.Additionally,the rs3775291(G13909A,G>A)variant genotype was significantly associated with an increased cancer risk in Asians,subgroup with hospital-based controls,and subgroup with a small sample size.Conclusion:After data integration,our findings suggest that the TLR3 rs5743312 polymorphism may contribute to an increased cancer risk.展开更多
Wang Jimin was not only a distinguished medical historian in modem China and an academician of the International Academy of the History of Science but also an originator of the first Museum of Chinese Medical[History ...Wang Jimin was not only a distinguished medical historian in modem China and an academician of the International Academy of the History of Science but also an originator of the first Museum of Chinese Medical[History and of the Chinese Medical History Society.This study briefly introduces Wang’s family academic history,his groundbreaking achievements in studies on medical history and the first monograph of History of Chinese Medicine(English edition)in China.It also reviews the foundation of the first Museum of Chinese Medical History.展开更多
The World Journal of Gastrointestinal Oncology Editorial Board consists of 428 members,representing a team of worldwide experts in gastrointestinal oncology.They are from 40 countries,including Argentina(2),Australia(...The World Journal of Gastrointestinal Oncology Editorial Board consists of 428 members,representing a team of worldwide experts in gastrointestinal oncology.They are from 40 countries,including Argentina(2),Australia(10),Belgium(5),Brazil(2),Canada(4),Chile(2),China(56),Czech Republic(1),Denmark(1),Finland(3),France(7),Germany(24),Greece(13),Hungary(2),India(9),Iran(2),Ireland(2),Israel(4),Italy(41),Japan(47),Kuwait(2),Mexico(1),Netherlands(7),New Zealand(2),Norway(1),Poland(3),Portugal(5),Romania(1),Saudi Arabia(1),Serbia(2),Singapore(4),South Korea(27),Spain(10),Sweden(5),Switzerland(2),Syria(1),Thailand(1),Turkey(6),United Kingdom(15),and United States(95).展开更多
The World Journal of Gastrointestinal Oncology Editorial Board consists of 428 members,representing a team of worldwide experts in gastrointestinal oncology.They are from 40 countries,including Argentina(2),Australia(...The World Journal of Gastrointestinal Oncology Editorial Board consists of 428 members,representing a team of worldwide experts in gastrointestinal oncology.They are from 40 countries,including Argentina(2),Australia(10),Belgium(5),Brazil(2),Canada(4),Chile(2),China(56),Czech Republic(1),Denmark(1),Finland(3),France(7),Germany(24),Greece(13),Hungary(2),India(9),Iran(2),Ireland(2),Israel(4),Italy(41),Japan(47)。展开更多
The World Journal of Gastrointestinal Oncology Editorial Board consists of 428 members,representing a team of worldwide experts in gastrointestinal oncology.They are from 40 countries,including Argentina(2),Australia(...The World Journal of Gastrointestinal Oncology Editorial Board consists of 428 members,representing a team of worldwide experts in gastrointestinal oncology.They are from 40 countries,including Argentina(2),Australia(10),Belgium(5),Brazil(2),Canada(4),Chile(2),China(56),Czech Republic(1),Denmark(1),Finland(3)。展开更多
The World Journal of Gastrointestinal Oncology Editorial Board consists of 404 members,representing a team of worldwide experts in gastrointestinal oncology.They are from 41 countries,including Argentina(1),Australia(9),
The World Journal of Radiology Editorial Board consists of 365 members,representing a team of worldwide experts in radiology.They are from 36 countries,including Afghanistan(1),Argentina(2),Australia(5),Austria(7),Bel...The World Journal of Radiology Editorial Board consists of 365 members,representing a team of worldwide experts in radiology.They are from 36 countries,including Afghanistan(1),Argentina(2),Australia(5),Austria(7),Belgium(2),Brazil(8),Canada(6),Chile(1),China(43),Croatia(1),Denmark(4),Egypt(6),France(5),Germany(22)。展开更多
The World Journal of Diabetes Editorial Board now consists of 713 members,representing a team of worldwide experts in diabetes mellitus.They are from 56 countries,including Argentina(2),Australia(27),Austria(11),
The World Journal of Radiology Editorial Board consists of 319 members,representing a team of worldwide experts in radiology.They are from 40 countries,including Australia(3),Austria(4),Belgium(5),Brazil(3),Canada(9),...The World Journal of Radiology Editorial Board consists of 319 members,representing a team of worldwide experts in radiology.They are from 40 countries,including Australia(3),Austria(4),Belgium(5),Brazil(3),Canada(9),Chile(1),China(25),Czech(1),Denmark(1),Egypt(4),Estonia(1),Finland(1),France(6),Germany(17),Greece(8),Hungary(1),India(9),Iran(5),Ireland(1),Israel(4),Italy(28),Japan(14),Lebanon(1),Libya(1),Malaysia(2),展开更多
The World Journal of Gastrointestinal Pathophysiology Editorial Board consists of 523 members,representing a team of worldwide experts in gastrointestinal pathophysiology.They are from 45 countries,including Argentina...The World Journal of Gastrointestinal Pathophysiology Editorial Board consists of 523 members,representing a team of worldwide experts in gastrointestinal pathophysiology.They are from 45 countries,including Argentina(2),Australia(14),Austria(3),Belgium(9),Brazil(10),Brunei Darussalam(1),Canada(20),China(30),Croatia(1),Czech Republic(2),Denmark(4),Egypt(1),Estonia(1),Finland(1),France(8),Germany(22),Greece(7)。展开更多
文摘Introduction:Recent studies examining the association of Toll-like receptor 3(TLR3)gene polymorphisms with the risk of developing various types of cancer have reported conflicting results.Clarifying this association could advance our knowledge of the influence of TLR3 single nucleotide polymorphisms(SNPs)on cancer risk.Methods:We systematically reviewed studies that focused on a collection of 12 SNPs located in the TLR3 gene and the details by which these SNPs influenced cancer risk.Additionally,14 case-control studies comprising a total of7997 cases of cancer and 8699 controls were included in a meta-analysis of 4 highly studied SNPs(rs3775290,rs3775291,rs3775292,and rs5743312).Results:The variant TLR3 genotype rs5743312(C9948T,intron 3,C>T)was significantly associated with an increased cancer risk as compared with the wild-type allele(odds ratio[OR]=1.11,95%confidence interval[CI]=1.00–1.24,P=0.047).No such association was observed with other TLR3 SNPs.In the stratified analysis,the rs3775290(C13766T,C>T)variant genotype was found to be significantly associated with an increased cancer risk in Asian populations.Additionally,the rs3775291(G13909A,G>A)variant genotype was significantly associated with an increased cancer risk in Asians,subgroup with hospital-based controls,and subgroup with a small sample size.Conclusion:After data integration,our findings suggest that the TLR3 rs5743312 polymorphism may contribute to an increased cancer risk.
文摘Wang Jimin was not only a distinguished medical historian in modem China and an academician of the International Academy of the History of Science but also an originator of the first Museum of Chinese Medical[History and of the Chinese Medical History Society.This study briefly introduces Wang’s family academic history,his groundbreaking achievements in studies on medical history and the first monograph of History of Chinese Medicine(English edition)in China.It also reviews the foundation of the first Museum of Chinese Medical History.
文摘The World Journal of Gastrointestinal Oncology Editorial Board consists of 428 members,representing a team of worldwide experts in gastrointestinal oncology.They are from 40 countries,including Argentina(2),Australia(10),Belgium(5),Brazil(2),Canada(4),Chile(2),China(56),Czech Republic(1),Denmark(1),Finland(3),France(7),Germany(24),Greece(13),Hungary(2),India(9),Iran(2),Ireland(2),Israel(4),Italy(41),Japan(47),Kuwait(2),Mexico(1),Netherlands(7),New Zealand(2),Norway(1),Poland(3),Portugal(5),Romania(1),Saudi Arabia(1),Serbia(2),Singapore(4),South Korea(27),Spain(10),Sweden(5),Switzerland(2),Syria(1),Thailand(1),Turkey(6),United Kingdom(15),and United States(95).
文摘The World Journal of Gastrointestinal Oncology Editorial Board consists of 428 members,representing a team of worldwide experts in gastrointestinal oncology.They are from 40 countries,including Argentina(2),Australia(10),Belgium(5),Brazil(2),Canada(4),Chile(2),China(56),Czech Republic(1),Denmark(1),Finland(3),France(7),Germany(24),Greece(13),Hungary(2),India(9),Iran(2),Ireland(2),Israel(4),Italy(41),Japan(47)。
文摘The World Journal of Gastrointestinal Oncology Editorial Board consists of 428 members,representing a team of worldwide experts in gastrointestinal oncology.They are from 40 countries,including Argentina(2),Australia(10),Belgium(5),Brazil(2),Canada(4),Chile(2),China(56),Czech Republic(1),Denmark(1),Finland(3)。
文摘The World Journal of Gastrointestinal Oncology Editorial Board consists of 404 members,representing a team of worldwide experts in gastrointestinal oncology.They are from 41 countries,including Argentina(1),Australia(9),
文摘The World Journal of Radiology Editorial Board consists of 365 members,representing a team of worldwide experts in radiology.They are from 36 countries,including Afghanistan(1),Argentina(2),Australia(5),Austria(7),Belgium(2),Brazil(8),Canada(6),Chile(1),China(43),Croatia(1),Denmark(4),Egypt(6),France(5),Germany(22)。
文摘The World Journal of Diabetes Editorial Board now consists of 713 members,representing a team of worldwide experts in diabetes mellitus.They are from 56 countries,including Argentina(2),Australia(27),Austria(11),
文摘The World Journal of Radiology Editorial Board consists of 319 members,representing a team of worldwide experts in radiology.They are from 40 countries,including Australia(3),Austria(4),Belgium(5),Brazil(3),Canada(9),Chile(1),China(25),Czech(1),Denmark(1),Egypt(4),Estonia(1),Finland(1),France(6),Germany(17),Greece(8),Hungary(1),India(9),Iran(5),Ireland(1),Israel(4),Italy(28),Japan(14),Lebanon(1),Libya(1),Malaysia(2),
文摘The World Journal of Gastrointestinal Pathophysiology Editorial Board consists of 523 members,representing a team of worldwide experts in gastrointestinal pathophysiology.They are from 45 countries,including Argentina(2),Australia(14),Austria(3),Belgium(9),Brazil(10),Brunei Darussalam(1),Canada(20),China(30),Croatia(1),Czech Republic(2),Denmark(4),Egypt(1),Estonia(1),Finland(1),France(8),Germany(22),Greece(7)。
