目的观察肝豆灵片联合推拿手法治疗痰瘀互结型肝豆状核变性(WD)肌张力障碍的临床疗效。方法选取于2021年9月-2023年2月安徽中医药大学第一附属医院脑病科住院治疗的肌张力障碍的痰瘀互结型WD患者40例,随机分为对照组和观察组,每组各20...目的观察肝豆灵片联合推拿手法治疗痰瘀互结型肝豆状核变性(WD)肌张力障碍的临床疗效。方法选取于2021年9月-2023年2月安徽中医药大学第一附属医院脑病科住院治疗的肌张力障碍的痰瘀互结型WD患者40例,随机分为对照组和观察组,每组各20例。对照组采用二巯丙磺酸钠祛铜联合推拿手法治疗,观察组在对照组的基础上加用肝豆灵片治疗,8 d 1个疗程,共治疗4个疗程。治疗前后采用日常生活能力量表(ADL)、改良Ashworth肌张力分级评分、中医证候积分、有效率评价两组治疗效果。结果治疗后两组ADL量表评分均高于治疗前(P<0.01),改良Ashworth肌张力分级评分、中医证候积分均低于治疗前(P<0.01),观察组治疗后ADL量表评分高于对照组(P<0.01),Ashworth肌张力分级评分低于对照组(P<0.05),中医证候分低于对照组(P<0.01),观察组临床疗效高于对照组,差异无统计学意义(P>0.05)。结论肝豆灵片联合推拿手法可有效改善痰瘀互结型WD患者肌张力障碍,提高患者的生活质量,为临床治疗带来新思路。展开更多
We have found that the expression of ring finger and WD repeat domain 3(RFWD3)is significantly higher in unpaired and paired hepatocellular carcinoma(HCC)tissues than in normal tissues.Moreover,this expression has a s...We have found that the expression of ring finger and WD repeat domain 3(RFWD3)is significantly higher in unpaired and paired hepatocellular carcinoma(HCC)tissues than in normal tissues.Moreover,this expression has a significant correlation with the infiltration level of 14 immune cell types and when the detected RFWD3 expression levels were grouped as high and low,a prominent difference was revealed for overall survival,disease-specific survival,and progression-free interval.Through statistical analysis(univariate Cox),we were also able to identify RFWD3 as an independent prognostic element for HCC,with RFWD3 having an ability to accurately predict HCC prognosis(area under the curve of 0.863).Finally,we have generated prognostic nomograms for probabilities of 1-,3-and 5-year overall survival in HCC via integrating the factors of age,pathologic stage,alpha-fetoprotein level,and RFWD3 expression.展开更多
今年初,西数(WD)更新了My Book台式硬盘产品线,推出My Book台式硬盘22TB版本,容量得到进一步提升,覆盖到更多用户群体。WD My Book 22TB版本仍旧采用单盘设计,具有小体积、大容量等特点,实际传输速度和综合体验怎样?消费电子编辑部拿到...今年初,西数(WD)更新了My Book台式硬盘产品线,推出My Book台式硬盘22TB版本,容量得到进一步提升,覆盖到更多用户群体。WD My Book 22TB版本仍旧采用单盘设计,具有小体积、大容量等特点,实际传输速度和综合体验怎样?消费电子编辑部拿到了这款产品,我们一起来了解下。展开更多
文摘目的观察肝豆灵片联合推拿手法治疗痰瘀互结型肝豆状核变性(WD)肌张力障碍的临床疗效。方法选取于2021年9月-2023年2月安徽中医药大学第一附属医院脑病科住院治疗的肌张力障碍的痰瘀互结型WD患者40例,随机分为对照组和观察组,每组各20例。对照组采用二巯丙磺酸钠祛铜联合推拿手法治疗,观察组在对照组的基础上加用肝豆灵片治疗,8 d 1个疗程,共治疗4个疗程。治疗前后采用日常生活能力量表(ADL)、改良Ashworth肌张力分级评分、中医证候积分、有效率评价两组治疗效果。结果治疗后两组ADL量表评分均高于治疗前(P<0.01),改良Ashworth肌张力分级评分、中医证候积分均低于治疗前(P<0.01),观察组治疗后ADL量表评分高于对照组(P<0.01),Ashworth肌张力分级评分低于对照组(P<0.05),中医证候分低于对照组(P<0.01),观察组临床疗效高于对照组,差异无统计学意义(P>0.05)。结论肝豆灵片联合推拿手法可有效改善痰瘀互结型WD患者肌张力障碍,提高患者的生活质量,为临床治疗带来新思路。
文摘We have found that the expression of ring finger and WD repeat domain 3(RFWD3)is significantly higher in unpaired and paired hepatocellular carcinoma(HCC)tissues than in normal tissues.Moreover,this expression has a significant correlation with the infiltration level of 14 immune cell types and when the detected RFWD3 expression levels were grouped as high and low,a prominent difference was revealed for overall survival,disease-specific survival,and progression-free interval.Through statistical analysis(univariate Cox),we were also able to identify RFWD3 as an independent prognostic element for HCC,with RFWD3 having an ability to accurately predict HCC prognosis(area under the curve of 0.863).Finally,we have generated prognostic nomograms for probabilities of 1-,3-and 5-year overall survival in HCC via integrating the factors of age,pathologic stage,alpha-fetoprotein level,and RFWD3 expression.
