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PBMC中PD-L1、HLA-B、MRP5在晚期乳腺癌放疗过程中的动态表达及意义
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作者 寸倩滢 张思荣 唐恩跃 《分子诊断与治疗杂志》 2021年第11期1735-1739,共5页
目的探究外周血单个核细胞(PBMC)中程序性细胞死亡配体1(PD-L1)、人类白细胞抗原-B(HLA-B)、多药耐药相关蛋白5(MRP5)在晚期乳腺癌放疗过程中的动态表达及意义。方法选取保山市人民医院122例晚期乳腺癌患者,根据放疗结束后4周评估疗效,... 目的探究外周血单个核细胞(PBMC)中程序性细胞死亡配体1(PD-L1)、人类白细胞抗原-B(HLA-B)、多药耐药相关蛋白5(MRP5)在晚期乳腺癌放疗过程中的动态表达及意义。方法选取保山市人民医院122例晚期乳腺癌患者,根据放疗结束后4周评估疗效,分为有效组(74例)与无效组(48例),放疗过程中动态监测PBMC中PD-L1、HLA-B、MRP5 mRNA水平,分析其临床意义。结果放疗1个疗程、放疗结束后PBMC中PD-L1、MRP5 mRNA水平低于放疗前,HLA-B mRNA水平高于放疗前(P<0.05);有效组放疗1个疗程、放疗结束后PBMC中PD-L1、MRP5 mRNA水平低于无效组,HLA-B mRNA水平高于无效组,放疗前与放疗结束后PBMC中PD-L1、MRP5、HLA-B mRNA水平差值绝对值高于无效组(P<0.05);PBMC中PD-L1、HLA-B、MRP5 mRNA水平放疗前与放疗结束后差值绝对值呈正相关(P<0.05);放疗前与放疗结束后PBMC中PD-L1、MRP5、HLA-B mRNA水平差值绝对值与疗效呈正相关(P<0.05);PBMC中PD-L1、HLA-B、MRP5 m RNA差值绝对值联合预测疗效的AUC为0.951,95%CI为0.906~0.996,敏感度为91.67%,特异度为91.89%,优于各指标单独预测(P<0.05)。结论晚期乳腺癌放疗过程中动态监测PBMC中PD-L1、MRP5、HLA-B mRNA水平变化情况能作为临床预测疗效的潜在途径,有助于及时调整放疗方案、提高疗效。 展开更多
关键词 晚期乳腺癌 放疗 外周血单个核细胞 程序性细胞死亡配体1 人类白细胞抗原-b 多药耐药相关蛋白5
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Constitutive equation and hot processing maps of Al-5Ti-1B master alloy 被引量:1
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作者 Fu-Wei Kang Jie Zhou +3 位作者 Zhi-Wei Wang Xue-Min Zhang Yi-Cheng Feng Er-Jun Guo 《Rare Metals》 SCIE EI CAS CSCD 2018年第8期668-674,共7页
The isothermal compression tests of A1-5Ti- 1B master alloy were conducted on the thermal mechanical simulator Gleeble-1500D at the deformation temperature range of 300-450 ℃,the strain rate range of 0.01- 10.00 s^-l... The isothermal compression tests of A1-5Ti- 1B master alloy were conducted on the thermal mechanical simulator Gleeble-1500D at the deformation temperature range of 300-450 ℃,the strain rate range of 0.01- 10.00 s^-l, and the engineering strain of 50 %. The effects of deformation temperatures and strain rates on the flow stress were analyzed by the true stress-true strain curves. The result indicates that the flow stress increases with the increase of strain rate, while it decreases with the increase of temperature. The hot deformation activation energy of A1-5Ti-IB master alloy is calculated to be 250.9 kJ.mol^-1, and the constitutive equation is established as ε=1.97 x lO^19[sinh(O.O15δ)^11.14exp(-250.9/RT), and the validity of this constitutive equation is verified. Based on dynamic material model (DMM) criterion, the hot processing map of AI-5Ti-1B master alloy is obtained. The optimum hot extrusion conditions are determined as deformation temperature of 400℃ and strain rate of 1.00 s^-1, and the flow instability only appears at the temperature range of 300-340℃ at the base of the hot processing map. 展开更多
关键词 Al-5Ti-1b master alloy Flow stress constitutive equation Hot processing map
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