The view of life and death is the fundamental in human’s life, is a nation’s, or a country’s most intrinsic and most profound value about human life, it is also an important theme of ethics and philosophy. The cele...The view of life and death is the fundamental in human’s life, is a nation’s, or a country’s most intrinsic and most profound value about human life, it is also an important theme of ethics and philosophy. The celebration of life and for centuries, they all take life and death seriously, but they also have different views towards death and life. This article will center on major American poets such as Henry Wadsworth Longfellow Emily Dickinson, Robert Frost, Walt Whitman and so on. This article will try to have a discussion on the basis of ethical review and interpretation about the view of life and death, to reveal the similarities and differences about the view of life and death in different poets’ poems, to find a method for us to learn about how to adapt to the modern civilization on the basis of ethical review and interpretation, how to understand human life and death how to face life and death, how to survive beyond life and death how to live a wonderful life through understanding human life and death in a proper way.展开更多
以3-异丙基苯乙酮(1)为原料,经3步反应合成了花青醛[3-(3-异丙基苯基)丁醛(4)],并优化了反应条件。确定合成3-(3-异丙基苯基)-2-丁烯酸乙酯(2)的最优条件为:n(1)/n(磷酰基乙酸三乙酯)/n(氢化钠)=5/6/6,于室温反应12 h,收率84.5%;合成3-...以3-异丙基苯乙酮(1)为原料,经3步反应合成了花青醛[3-(3-异丙基苯基)丁醛(4)],并优化了反应条件。确定合成3-(3-异丙基苯基)-2-丁烯酸乙酯(2)的最优条件为:n(1)/n(磷酰基乙酸三乙酯)/n(氢化钠)=5/6/6,于室温反应12 h,收率84.5%;合成3-(3-异丙基苯基)-1-丁醇(3)的最佳条件为:n(2)/n(硼氢化钠)/n(六水合二氯化钴)/n(二异丙基胺)=10/20/1/2,于55℃反应24 h,收率87.8%;合成4的最优条件为:n(3)/n(乙酸酐)/n(亚硝酸钠)=5/4/15,投料顺序为:乙酸酐、3、亚硝酸钠,反应时间为2 min,收率91.0%。产物结构经1 H NMR,13 C NMR和MS(ESI)确证。展开更多
The present paper deals with the facile synthesis of 6 E geranylgeraniol 19 oic acid(1), a naturally occuring alicyclic diterpene acid, by a Horner Wadsworth Emmons olefination of two readily available fragments 7 and 3.
Facile synthesis of 6(E)-geranylgeraniol-19-oic acid 1, a naturally occurring alicyclic diterpene acid, by a Horner-Wadsworth-Emmons olefination of two readily available fragments 2 and 3, is described.
The sequential oxidation-Horner-Wadsworth-Emmons reaction of alcohols to prepare α-Halo-α,β-unsaturated esters （halo =F, Cl） with middle to excellent （Z）-selectivity was developed.
A novel and efficient synthetic method of atorvastatin was described.The key step of the synthesis was the construction of the olefin linkage between the chiral side chain and skeleton via a Horner-Wadsworth-Emmons re...A novel and efficient synthetic method of atorvastatin was described.The key step of the synthesis was the construction of the olefin linkage between the chiral side chain and skeleton via a Horner-Wadsworth-Emmons reaction,resulting in the advanced intermediate of atorvastatin under hydrogenation of the olefin over Pd/C.This novel method is more useful for the practical synthesis of atorvastatin than its document reported methods.展开更多
This work presents expeditious synthesis of C-glycoside amphiphiles in aqueous media from unprotected di-or mono-saccharides.A Horner-Wadsworth-Emmons/Michael addition/Barbier allylation sequence led to C-glycosides t...This work presents expeditious synthesis of C-glycoside amphiphiles in aqueous media from unprotected di-or mono-saccharides.A Horner-Wadsworth-Emmons/Michael addition/Barbier allylation sequence led to C-glycosides that exhibit hydrotropic properties.The hydrotropic and solubilizing properties of these homoallylic alcohols including a β-C-glycoside moiety as well as additional β-C-glycosidic ketones with a short(C7) alkyl chain are also described and compared with those of commercial O-glucoside references.展开更多
Three two-photon absorption （TPA） tribranched chromophores were successfully prepared, in which 1,3,5-triazine is been as electron deficient core, 1,4-phenylenedivinylene as conjugated bridge, 3,4-ethylenedioxy- thi...Three two-photon absorption （TPA） tribranched chromophores were successfully prepared, in which 1,3,5-triazine is been as electron deficient core, 1,4-phenylenedivinylene as conjugated bridge, 3,4-ethylenedioxy- thiophene （EDOT） （T1）, N-methylpyrrole （T2） or triphenylamine （T3） as electron-donating end-groups. Their pho- tophysical properties were studied by absorption, one- and two-photon fluorescence and TPA cross-section deter- mination. The nonlinear transmission （NLT） measurement in femtoseconds （fs） regime at 800 nm indicates that TPA cross-section σ2 values of T1, T2 and T3 with extended π-conjugated bridge are much larger than the corresponding chromophore T4 with a short length bridge, and TPA cross-section of T1 with end-groups EDOT exhibits a remarkable enhancement compared with T2 and T3 having the same length It-system. The chromophores T1, T2 and T3 show also remarkable up-converted luminescence and optical limiting activity.展开更多
文摘The view of life and death is the fundamental in human’s life, is a nation’s, or a country’s most intrinsic and most profound value about human life, it is also an important theme of ethics and philosophy. The celebration of life and for centuries, they all take life and death seriously, but they also have different views towards death and life. This article will center on major American poets such as Henry Wadsworth Longfellow Emily Dickinson, Robert Frost, Walt Whitman and so on. This article will try to have a discussion on the basis of ethical review and interpretation about the view of life and death, to reveal the similarities and differences about the view of life and death in different poets’ poems, to find a method for us to learn about how to adapt to the modern civilization on the basis of ethical review and interpretation, how to understand human life and death how to face life and death, how to survive beyond life and death how to live a wonderful life through understanding human life and death in a proper way.
文摘以3-异丙基苯乙酮(1)为原料,经3步反应合成了花青醛[3-(3-异丙基苯基)丁醛(4)],并优化了反应条件。确定合成3-(3-异丙基苯基)-2-丁烯酸乙酯(2)的最优条件为:n(1)/n(磷酰基乙酸三乙酯)/n(氢化钠)=5/6/6,于室温反应12 h,收率84.5%;合成3-(3-异丙基苯基)-1-丁醇(3)的最佳条件为:n(2)/n(硼氢化钠)/n(六水合二氯化钴)/n(二异丙基胺)=10/20/1/2,于55℃反应24 h,收率87.8%;合成4的最优条件为:n(3)/n(乙酸酐)/n(亚硝酸钠)=5/4/15,投料顺序为:乙酸酐、3、亚硝酸钠,反应时间为2 min,收率91.0%。产物结构经1 H NMR,13 C NMR和MS(ESI)确证。
基金Supported bytheNational Natural Science Foundation of China( No.2 0 0 72 0 12 ) and the Special Research Grant forDoctoral Sites in Chinese U niversities( No.2 0 0 10 730 0 0 1)
文摘The present paper deals with the facile synthesis of 6 E geranylgeraniol 19 oic acid(1), a naturally occuring alicyclic diterpene acid, by a Horner Wadsworth Emmons olefination of two readily available fragments 7 and 3.
基金supported by the National Natural Science Foundation of China(Grant No.20072012)the Foundation for University Key Teacher by the Ministry of Education of China
文摘Facile synthesis of 6(E)-geranylgeraniol-19-oic acid 1, a naturally occurring alicyclic diterpene acid, by a Horner-Wadsworth-Emmons olefination of two readily available fragments 2 and 3, is described.
文摘The sequential oxidation-Horner-Wadsworth-Emmons reaction of alcohols to prepare α-Halo-α,β-unsaturated esters （halo =F, Cl） with middle to excellent （Z）-selectivity was developed.
基金Project supported by the National Natural Science Foundation of China(Nos.21462056,21801261)the Science and Technology Foundation of Guizhou Province(No.[2014]7542)he Zunyi Medical University(Nos.20163715,F-627)~~
基金the financial supports from the National Key Project for Basic Research(No.2010CB 11261 02)the Outstanding Youth Foundation of Heilongjiang Province(No.JC200706)
文摘A novel and efficient synthetic method of atorvastatin was described.The key step of the synthesis was the construction of the olefin linkage between the chiral side chain and skeleton via a Horner-Wadsworth-Emmons reaction,resulting in the advanced intermediate of atorvastatin under hydrogenation of the olefin over Pd/C.This novel method is more useful for the practical synthesis of atorvastatin than its document reported methods.
基金the ANRT (Association Nationale de la Recherche et de la Technologie) and the Armor Protéines Company for a grant to AR and for funding
文摘This work presents expeditious synthesis of C-glycoside amphiphiles in aqueous media from unprotected di-or mono-saccharides.A Horner-Wadsworth-Emmons/Michael addition/Barbier allylation sequence led to C-glycosides that exhibit hydrotropic properties.The hydrotropic and solubilizing properties of these homoallylic alcohols including a β-C-glycoside moiety as well as additional β-C-glycosidic ketones with a short(C7) alkyl chain are also described and compared with those of commercial O-glucoside references.
基金Project supported by the National Natural Science Foundation of China （No. 20774039） and the National Basic Research （No. 2007CB925103）.
文摘Three two-photon absorption （TPA） tribranched chromophores were successfully prepared, in which 1,3,5-triazine is been as electron deficient core, 1,4-phenylenedivinylene as conjugated bridge, 3,4-ethylenedioxy- thiophene （EDOT） （T1）, N-methylpyrrole （T2） or triphenylamine （T3） as electron-donating end-groups. Their pho- tophysical properties were studied by absorption, one- and two-photon fluorescence and TPA cross-section deter- mination. The nonlinear transmission （NLT） measurement in femtoseconds （fs） regime at 800 nm indicates that TPA cross-section σ2 values of T1, T2 and T3 with extended π-conjugated bridge are much larger than the corresponding chromophore T4 with a short length bridge, and TPA cross-section of T1 with end-groups EDOT exhibits a remarkable enhancement compared with T2 and T3 having the same length It-system. The chromophores T1, T2 and T3 show also remarkable up-converted luminescence and optical limiting activity.
