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基于改进Kruskal-Wallis检验的低压开关电器状态表征参数选择
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作者 刘洋 曹云东 刘树鑫 《高电压技术》 EI CAS CSCD 北大核心 2024年第2期535-542,共8页
由于状态数据的多属性、高维度和大数据量,以及特征参数难以满足正态性和方差齐性检验的事实,低压开关电器的状态表征参数难于选择。针对该问题,基于非参数单体多状态样本的分组状态间秩差异性,以及特征参数Kruskal-Wallis(KW)检验统计... 由于状态数据的多属性、高维度和大数据量,以及特征参数难以满足正态性和方差齐性检验的事实,低压开关电器的状态表征参数难于选择。针对该问题,基于非参数单体多状态样本的分组状态间秩差异性,以及特征参数Kruskal-Wallis(KW)检验统计量的计算规则和变化趋势,研究论证了单体样本特征参数表征显著性鉴别机理。同时,基于状态序列斜率变化增量和子序列变异增量,提出样本状态时序分类算法,并将该算法与参数鉴别机理相结合,形成单体多状态样本改进KW检验理论。最后,基于改进理论提出低压开关电器状态表征参数选择新方法。以交流接触器为例进行验证,结果表明该文方法适用于具有非线性、非平稳、动态随机分布等特点的低压开关电器状态表征参数选择。实例证明,基于该方法获得状态表征曲线的拟合优度可达0.91,状态划分显著性P值可达8.42848×10–266,表征与分类精度较参数选择前及同类方法提升明显,为下一步研究低压开关电器状态的精确划分与识别奠定了理论基础。 展开更多
关键词 低压开关电器 状态表征 参数选择 Kruskal-wallis检验 状态划分
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Wallis动态稳定系统治疗腰椎退行性疾病的研究进展
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作者 李继胜 王秉翔 +1 位作者 冯盛华 牛光峰 《中国骨伤》 CAS CSCD 2023年第5期495-498,共4页
Wallis动态稳定系统作为腰椎非融合技术中的一种手术方式,是由棘间阻滞剂和涤纶人造韧带构成,在保持脊柱稳定的同时保留病变节段一定的活动度。近年来,研究发现Wallis动态稳定系统对腰椎退行性疾病治疗具有重要意义,既能改善临床症状,... Wallis动态稳定系统作为腰椎非融合技术中的一种手术方式,是由棘间阻滞剂和涤纶人造韧带构成,在保持脊柱稳定的同时保留病变节段一定的活动度。近年来,研究发现Wallis动态稳定系统对腰椎退行性疾病治疗具有重要意义,既能改善临床症状,也能有效延缓邻近节段退变等并发症。本文通过综述Wallis动态稳定系统与腰椎退行性疾病相关的文献,阐述了Wallis动态稳定系统治疗腰椎退行性疾病的远期预后效果,为治疗腰椎退行性疾病的术式选择提供理论依据及参考。 展开更多
关键词 wallis动态稳定系统 腰椎 非融合 腰椎退行性疾病 综述
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A Construction That Produces Wallis-Type Formulas 被引量:1
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作者 Joshua M. Fitzhugh David L. Farnsworth 《Advances in Pure Mathematics》 2013年第6期579-585,共7页
Generalizations of the geometric construction that repeatedly attaches rectangles to a square, originally given by Myerson, are presented. The initial square is replaced with a rectangle, and also the dimensionality o... Generalizations of the geometric construction that repeatedly attaches rectangles to a square, originally given by Myerson, are presented. The initial square is replaced with a rectangle, and also the dimensionality of the construction is increased. By selecting values for the various parameters, such as the lengths of the sides of the original rectangle or rectangular box in dimensions more than two and their relationships to the size of the attached rectangles or rectangular boxes, some interesting formulas are found. Examples are Wallis-type infinite-product formulas for the areas of p-circles with p > 1. 展开更多
关键词 wallis’s formula Unit p-Circle INFINITE Product Π GAMMA Function
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Fanlian Huazhuo Formula alleviates high-fat diet-induced nonalcoholic fatty liver disease by modulating autophagy and lipid synthesis signaling pathway 被引量:1
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作者 Meng-Yuan Niu Geng-Ting Dong +9 位作者 Yi Li Qing Luo Liu Cao Xi-Min Wang Qi-Wen Wang Yi-Ting Wang Zhe Zhang Xi-Wen Zhong Wei-Bo Dai Le-Yu Li 《World Journal of Gastroenterology》 SCIE CAS 2024年第30期3584-3608,共25页
BACKGROUND Fanlian Huazhuo Formula(FLHZF)has the functions of invigorating spleen and resolving phlegm,clearing heat and purging turbidity.It has been identified to have therapeutic effects on type 2 diabetes mellitus... BACKGROUND Fanlian Huazhuo Formula(FLHZF)has the functions of invigorating spleen and resolving phlegm,clearing heat and purging turbidity.It has been identified to have therapeutic effects on type 2 diabetes mellitus(T2DM)in clinical application.Non-alcoholic fatty liver disease(NAFLD)is frequently diagnosed in patients with T2DM.However,the therapeutic potential of FLHZF on NAFLD and the underlying mechanisms need further investigation.AIM To elucidate the effects of FLHZF on NAFLD and explore the underlying hepatoprotective mechanisms in vivo and in vitro.METHODS HepG2 cells were treated with free fatty acid for 24 hours to induce lipid accumulation cell model.Subsequently,experiments were conducted with the different concentrations of freeze-dried powder of FLHZF for 24 hours.C57BL/6 mice were fed a high-fat diet for 8-week to establish a mouse model of NAFLD,and then treated with the different concentrations of FLHZF for 10 weeks.RESULTS FLHZF had therapeutic potential against lipid accumulation and abnormal changes in biochemical indicators in vivo and in vitro.Further experiments verified that FLHZF alleviated abnormal lipid metabolism might by reducing oxidative stress,regulating the AMPKα/SREBP-1C signaling pathway,activating autophagy,and inhibiting hepatocyte apoptosis.CONCLUSION FLHZF alleviates abnormal lipid metabolism in NAFLD models by regulating reactive oxygen species,autophagy,apoptosis,and lipid synthesis signaling pathways,indicating its potential for clinical application in NAFLD. 展开更多
关键词 Fanlian Huazhuo formula Nonalcoholic fatty liver disease AUTOPHAGY Apoptosis AMPKα/SREBP-1C signal pathway Oxidative stress
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A Cauchy integral formula for(p,q)-monogenic functions withα-weight
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作者 GAO Long DU Xiao-jing +1 位作者 LIU Yue XIE Yong-hong 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2024年第3期545-553,共9页
Firstly,some properties for(p,q)-monogenic functions withα-weight in Clifford analysis are given.Then,the Cauchy-Pompeiu formula is proved.Finally,the Cauchy integral formula and the Cauchy integral theorem for(p,q)-... Firstly,some properties for(p,q)-monogenic functions withα-weight in Clifford analysis are given.Then,the Cauchy-Pompeiu formula is proved.Finally,the Cauchy integral formula and the Cauchy integral theorem for(p,q)-monogenic functions withα-weight are given. 展开更多
关键词 (p q)-monogenic functions with-weight Cauchy-Pompeiu formula Cauchy integral formula Cauchy integral theorem
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Trace formula of the integro-differential operator on a quantum graph
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作者 WEI Li-xiao YANG Chuan-fu 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 2024年第2期311-318,共8页
In this paper we study the eigenvalue problem for integro-differential operators on a lasso graph.The trace formula of the operator is established by applying the residual technique in complex analysis.
关键词 integro-differential operators EIGENVALUE trace formula
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Improved nuclear mass formula with an additional term from the Fermi gas model
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作者 Xiao-Yu Xu Li Deng +3 位作者 Ai-Xi Chen Hang Yang Amir Jalili Han-Kui Wang 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第5期131-138,共8页
Nuclear mass is a fundamental property of nuclear physics and a necessary input in nuclear astrophysics.Owing to the complexity of atomic nuclei and nonperturbative strong interactions,conventional physical models can... Nuclear mass is a fundamental property of nuclear physics and a necessary input in nuclear astrophysics.Owing to the complexity of atomic nuclei and nonperturbative strong interactions,conventional physical models cannot completely describe nuclear binding energies.In this study,the mass formula was improved by considering an additional term from the Fermi gas model.All nuclear masses in the Atomic Mass Evaluation Database were reproduced with a root-mean-square deviation(RMSD)of -1.86 MeV(1.92 MeV).The new mass formula exhibits good performance in the neutron-rich nuclear region.The RMSD decreases to 0.393 MeV when the ratio of the neutron number to the proton number is≥1.6. 展开更多
关键词 Nuclear mass formula Neutron-rich nuclei Fermi-gas model
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Analytical Solution and Simplified Formula for Added Mass of Horizontal and Vertical Motions of Truncated Cylinders Under Earthquake Action
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作者 WANG Pi-guang LYU Si-yu +2 位作者 QU Yang ZHAO Mi DU Xiu-li 《China Ocean Engineering》 SCIE EI CSCD 2024年第1期54-67,共14页
This paper investigates the hydrodynamic characteristics of floating truncated cylinders undergoing horizontal and vertical motions due to earthquake excitations in the finite water depth.The governing equation of the... This paper investigates the hydrodynamic characteristics of floating truncated cylinders undergoing horizontal and vertical motions due to earthquake excitations in the finite water depth.The governing equation of the hydrodynamic pressure acting on the cylinder is derived based on the radiation theory with the inviscid and incompressible assumptions.The governing equation is solved by using the method of separating variables and analytical solutions are obtained by assigning reasonable boundary conditions.The analytical result is validated by a numerical model using the exact artificial boundary simulation of the infinite water.The main variation and distribution characteristics of the hydrodynamic pressure acting on the side and bottom of the cylinder are analyzed for different combinations of wide-height and immersion ratios.The added mass coefficient of the cylinder is calculated by integrating the hydrodynamic pressure and simplified formulas are proposed for engineering applications.The calculation results show that the simplified formulas are in good agreement with the analytical solutions. 展开更多
关键词 EARTHQUAKE hydrodynamic pressure truncated cylinder added mass simplified formula
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Examining the Use of Scott’s Formula and Link Expiration Time Metric for Vehicular Clustering
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作者 Fady Samann Shavan Askar 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第3期2421-2444,共24页
Implementing machine learning algorithms in the non-conducive environment of the vehicular network requires some adaptations due to the high computational complexity of these algorithms.K-clustering algorithms are sim... Implementing machine learning algorithms in the non-conducive environment of the vehicular network requires some adaptations due to the high computational complexity of these algorithms.K-clustering algorithms are simplistic,with fast performance and relative accuracy.However,their implementation depends on the initial selection of clusters number(K),the initial clusters’centers,and the clustering metric.This paper investigated using Scott’s histogram formula to estimate the K number and the Link Expiration Time(LET)as a clustering metric.Realistic traffic flows were considered for three maps,namely Highway,Traffic Light junction,and Roundabout junction,to study the effect of road layout on estimating the K number.A fast version of the PAM algorithm was used for clustering with a modification to reduce time complexity.The Affinity propagation algorithm sets the baseline for the estimated K number,and the Medoid Silhouette method is used to quantify the clustering.OMNET++,Veins,and SUMO were used to simulate the traffic,while the related algorithms were implemented in Python.The Scott’s formula estimation of the K number only matched the baseline when the road layout was simple.Moreover,the clustering algorithm required one iteration on average to converge when used with LET. 展开更多
关键词 CLUSTERING vehicular network Scott’s formula FastPAM
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Modified Sadowski formula-based model for the slope shape amplification effect under multistage slope blasting vibration
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作者 Xiaogang Wu Mingyang Wang +2 位作者 Hao Lu Yongjun Zhang Wen Nie 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2024年第5期631-641,共11页
Blasting operations,which are crucial to open-pit mine production due to their simplicity and efficiency,require precise control through accurate vibration velocity calculations.The conventional Sadowski formula mainl... Blasting operations,which are crucial to open-pit mine production due to their simplicity and efficiency,require precise control through accurate vibration velocity calculations.The conventional Sadowski formula mainly focuses on blast center distance but neglects the amplification effect of blasting vibration waves by terraced terrain,from which the calculated blasting vibration velocities are smaller than the actual values,affecting the safety of the project.To address this issue,our model introduces the influences of slope and time into Sadowski formula to measure safety through blast vibration displacement.In the northern section of the open-pit quartz mine in Jinchang City,Gansu Province,China,the data of a continuous blasting slope project are referred to.Our findings reveal a noticeable vibration amplification effect during blasting when a multi-stage slope platform undergoes a sudden cross-sectional change near the upper overhanging surface.The amplification vibration coefficient increases with height,while vibration waves within rocks decrease from bottom to top.Conversely,platforms without distinct crosssectional changes exhibit no pronounced amplification during blasting.In addition,the vibration intensity decreases with distance as the rock height difference change propagates.The results obtained by the proposed blast vibration displacement equation incorporating slope shape influence closely agree with real-world scenarios.According to Pearson correlation coefficient(PPMCC)analysis,the average accuracy rate of our model is 88.84%,which exceeds the conventional Sadowski formula(46.92%). 展开更多
关键词 Multistage slope Slope shape influence factor Continuous blasting Sadowski formula Amplification effect
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Jianpi Qinghua Formula Alleviates Diabetic Myocardial Injury Through Inhibiting JunB/c-Fos Expression
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作者 Lin WANG Qing-guang CHEN Hao LU 《Current Medical Science》 SCIE CAS 2024年第1期144-155,共12页
Objective Diabetic cardiomyopathy(DCM)represents a substantial risk factor for heart failure and increased mortality in individuals afflicted with diabetes mellitus(DM).DCM typically manifests as myocardial fibrosis,m... Objective Diabetic cardiomyopathy(DCM)represents a substantial risk factor for heart failure and increased mortality in individuals afflicted with diabetes mellitus(DM).DCM typically manifests as myocardial fibrosis,myocardial hypertrophy,and impaired left ventricular diastolic function.While the clinical utility of the Jianpi Qinghua(JPQH)formula has been established in treating diabetes and insulin resistance,its potential efficacy in alleviating diabetic cardiomyopathy remains uncertain.This study aims to investigate the impact and underlying molecular mechanisms of the JPQH formula(JPQHF)in ameliorating myocardial injury in nonobese diabetic rats,specifically focusing on apoptosis and inflammation.Methods Wistar rats were assigned as the normal control group(CON),while Goto-Kakizaki(GK)rats were randomly divided into three groups:DM,DM treated with the JPQHF,and DM treated with metformin(MET).Following a 4-week treatment regimen,various biochemical markers related to glucose metabolism,cardiac function,cardiac morphology,and myocardial ultrastructure in GK rats were assessed.RNA sequencing was utilized to analyze differential gene expression and identify potential therapeutic targets.In vitro experiments involved high glucose to induce apoptosis and inflammation in H9c2 cells.Cell viability was evaluated using CCK-8 assay,apoptosis was monitored via flow cytometry,and the production of inflammatory cytokines was measured using quantitative real-time PCR(qPCR)and ELISA.Protein expression levels were determined by Western blotting analysis.The investigation also incorporated the use of MAPK inhibitors to further elucidate the mechanism at both the transcriptional and protein levels.Results The JPQHF group exhibited significant reductions in interventricular septal thickness at end-systole(IVSs)and left ventricular internal diameter at end-systole and end-diastole(LVIDs and LVIDd).JPQHF effectively suppressed high glucose-induced activation of IL-1βand caspase 3 in cardiomyocytes.Furthermore,JPQHF downregulated the expression of myocardial JunB/c-Fos,which was upregulated in both diabetic rats and high glucose-treated H9c2 cells.Conclusion The JPQH formula holds promise in mitigating diabetic myocardial apoptosis and inflammation in cardiomyocytes by inhibiting JunB/c-Fos expression through suppressing the MAPK(p38 and ERK1/2)pathway. 展开更多
关键词 Jianpi Qinghua formula diabetic cardiomyopathy AP-1 transcription factor apoptosis inflammation
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A Generalized Wallis Formula
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作者 Javad Namazi 《Applied Mathematics》 2018年第3期207-209,共3页
This article generalizes the famous Wallis’s formula for k ≥ 0 , to an integral over the unit sphere Sn-1. An application to the integral of polynomials over Sn-1 is discussed.
关键词 WILLIS formula UNIT SPHERE
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Antidepressant effects of Peiyuan Jieyu formula in a mouse model of chronic stress in conjunction with lipopolysaccharide-induced depression
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作者 Qin Tang Yu Li +3 位作者 Tao Yang Xiaoxu Fan Lina Li Hongsheng Chang 《Journal of Traditional Chinese Medical Sciences》 CAS 2024年第1期111-119,共9页
Objective:To explore the mechanism of the Peiyuan Jieyu formula in treating depression by assessing its impact on a lipopolysaccharide-induced(LPS-induced)depression mouse model.Methods:We created a mouse model of dep... Objective:To explore the mechanism of the Peiyuan Jieyu formula in treating depression by assessing its impact on a lipopolysaccharide-induced(LPS-induced)depression mouse model.Methods:We created a mouse model of depression by exposing mice that had previously received chronic stress to intraperitoneal LPS injections.The mice were divided into the following groups:control,model,fluoxetine,Tiansi Yin,Sini powder,and low-,medium-,and high-dose Peiyuan Jieyu formula groups.Forced swim and tail suspension tests were used to assess the efficacy of the depression(despair)model,and weight gain rates were also measured.Furthermore,serum levels of various depression and inflammation-associated molecules,including tumor necrosis factor-a(TNF-a),interferon-γ(IFN-γ),tryptophan,5-hydroxytryptamine,kynurenine(KYN),and kynurenic acid(KA)were assessed.Furthermore,the expression levels of ionic calcium-binding adaptor molecule-1(IBA-1)and indoleamine 2,3-dioxygenase(IDO)mRNA in hippocampal microglia were measured.Results:The model group displayed greater despair-associated immobility,which was shortened in response to various doses of Peiyuan Jieyu formula.Furthermore,formula administration significantly reduced serum TNF-a levels and hippocampal IDO mRNA expression.The high formula dose also reduced IFN-γand IBA-1 levels,the latter was also decreased in response to the medium formula dose.However,the low formula dose reduced serum KYN level and KYN/tryptophan(TRP)and KYN/KA ratios.Conclusion:The Peiyuan Jieyu formula holds immense potential in treating depression in a mouse model,potentially inhibiting inflammation and improving TRP-KYN metabolic disorders. 展开更多
关键词 Peiyuan Jieyu formula DEPRESSION Chronic stress LIPOPOLYSACCHARIDE Inflammation Tryptophan pathway
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Gastrointestinal tolerability of organic infant formula compared to traditional infant formula: A systematic review
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作者 Mohammed Al-Beltagi Nermin Kamal Saeed +2 位作者 Adel Salah Bediwy Reem Elbeltagi Mohamed Basiony Hamza 《World Journal of Clinical Pediatrics》 2024年第1期125-140,共16页
BACKGROUND Infants'nutrition significantly influences their growth,development,and overall well-being.With the increasing demand for organic infant formula driven by the perception of health benefits and growing a... BACKGROUND Infants'nutrition significantly influences their growth,development,and overall well-being.With the increasing demand for organic infant formula driven by the perception of health benefits and growing awareness of natural feeding options,it is crucial to conduct a comparative analysis of the gastrointestinal tolerability between organic and traditional infant formulas.AIM To provide a concise and precise analysis of the gastrointestinal tolerability of organic infant formula compared to traditional infant formula.Due to limited direct comparisons,the review synthesizes available literature on each formula type,presenting insights into their potential effects on infants'digestive health.METHODS An extensive literature search was conducted,compiling studies on organic and traditional infant formulas,their compositions,and reported effects on gastrointestinal tolerability.We searched academic databases such as PubMed and Google Scholar and specialized nutrition,paediatrics,and infant health journals using relevant keywords till October 1,2023.RESULTS Although specific comparative studies are scarce and formula heterogeneity is a significant limitation,this systematic review provides an in-depth understanding of organic infant formulas'composition and potential benefits.While scientific evidence directly comparing gastrointestinal tolerability is limited,organic formulas strive to use carefully selected organic ingredients to imitate breast milk composition.Potential benefits include improved lipid profiles,higher methionine content,and decreased antibiotic-resistant bacteria levels.Understanding the gastrointestinal tolerability of organic and traditional infant formulas is crucial for parents and healthcare providers to make informed decisions.CONCLUSION Despite limitations in direct comparisons,this systematic review provides insights into the composition and potential benefits of organic infant formulas.It emphasizes the need for further research to elucidate their gastrointestinal effects comprehensively. 展开更多
关键词 Organic infant formula Traditional infant formula Gastrointestinal tolerability formula ingredients Digestive health Infant nutrition Organic farming
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Evaluation of the famous classic formula Sanhua decoction based on network pharmacology and multi-component quantitative analysis
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作者 Xin Zhang Wan-Cui Wang +6 位作者 Jin-Kui Zhang Wei-Mei Zhang Peng-Wang Wang Peng-Cheng Lin Yong-Chang Lu Xia Li Wen-Yuan Gao 《Traditional Medicine Research》 2024年第1期1-13,共13页
Background:Sanhua decoction has significant effects in the treatment of stroke.The study of the Sanhua decoction material benchmark was carried out to analyze the value transfer relationship between the Chinese herbal... Background:Sanhua decoction has significant effects in the treatment of stroke.The study of the Sanhua decoction material benchmark was carried out to analyze the value transfer relationship between the Chinese herbal pieces and the substance benchmark.Methods:Network pharmacology was employed to investigate the potential active components and molecular mechanisms of Sanhua decoction in the treatment of stroke.15 batches of Sanhua decoction lyophilized powder were prepared using traditional formulas and subjected to high-performance liquid chromatography analysis to generate fingerprints of the Sanhua decoction substance benchmarks.Then,a multi-component quantitative analysis method was established,allowing for the simultaneous determination of ten components,to study the transfer of quantity values between pieces and substance benchmarks.Results:60 active ingredients were screened from Sanhua decoction by network pharmacology,of which gallic acid,magnolol honokiol,physcion,and aloe-emodin may have a greater effect than other active components.63 key targets and 134 pathways were predicted as the potential mechanism of Sanhua decoction in treating stroke.The fingerprint similarity of the Sanhua decoction substance benchmarks was found to be good among the 15 batches,confirming the 19 common peaks.The content of the 10 components was basically consistent.The components’transfer rates were within 30%of their respective means.Conclusions:This study provided a comprehensive and reliable strategy for the quality evaluation of Sanhua decoction substance benchmarks and held significant importance in improving its application value. 展开更多
关键词 Sanhua decoction classic famous formula HPLC fingerprinting value transfer network pharmacology
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Effect of Luhong formula on the cardiac rehabilitation of patients with chronic heart failure
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作者 Ji-Jie Xu Jian Dai +3 位作者 Qi-Hai Xie Pei-Chao Du Cha Li Hua Zhou 《World Journal of Clinical Cases》 SCIE 2024年第17期3027-3034,共8页
BACKGROUND Current treatments for chronic heart failure(CHF)are therapeutically ineffective.The optimization of treatments for this disease needs to be explored and analyzed.AIM To analyze the effect of using Luhong F... BACKGROUND Current treatments for chronic heart failure(CHF)are therapeutically ineffective.The optimization of treatments for this disease needs to be explored and analyzed.AIM To analyze the effect of using Luhong Formula in the cardiac rehabilitation of patients with CHF and its influence on cardiopulmonary function(CPF)and prognosis.METHODS In total,160 patients with CHF admitted between June 2022 and June 2023 were selected,including 75 receiving perindopril(control group)and 85 receiving Luhong Formula(research group).We conducted comparative analyses on the curative effects of traditional Chinese medicine(TCM)syndromes and cardiac function,CPF[oxygen consumption at the anaerobic threshold(VO2 AT)and at peak exercise(peak VO2)],echocardiographic indexes[left atrial volume index(LAVI),left ventricular muscle mass index(LVMI),left ventricular ejection fraction(LVEF)],and prognosis[major adverse cardiovascular events(MACEs)at 6 months follow-up].RESULTS The research group showed markedly higher curative effects of TCM syndromes and cardiac function than the control group.In addition,post-treatment VO2 AT,peak VO2,LVMI and LVEF in the research group were significantly higher,whereas LAVI was significantly lower,than those of the control group.Furthermore,fewer patients in the research group developed MACEs at the 6-month follow-up.CONCLUSION Luhong Formula is more therapeutically effective than perindopril for the cardiac rehabilitation of patients with CHF,specifically in enhancing CPF and prognosis. 展开更多
关键词 Luhong formula Chronic heart failure Cardiopulmonary function Cardiac rehabilitation PROGNOSIS
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Optimal traditional Chinese medicine formulas in treating ulcerative colitis:Choose one or take it all?
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作者 Yan Zeng Jun-Wen Zhang Jian Yang 《World Journal of Clinical Cases》 SCIE 2024年第32期6570-6574,共5页
Ulcerative colitis(UC)is a chronic inflammatory bowel disease that presents significant treatment challenges due to its complexity,especially in terms of the various side effects that traditional medications may bring... Ulcerative colitis(UC)is a chronic inflammatory bowel disease that presents significant treatment challenges due to its complexity,especially in terms of the various side effects that traditional medications may bring during the chronic course of the disease.Traditional Chinese medicine(TCM)has emerged as a promising complementary therapy for UC.Based on the latest research,our editorial explored the current issues and potential essential research directions for TCM in treating UC.We anticipate that future high-quality research will pave the way for the optimization of TCM formulas for UC and their broader global application. 展开更多
关键词 Traditional Chinese medicine Ulcerative colitis Inflammatory bowel disease formula Treatment
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Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach
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作者 Xia-Jie Quan Hao Liang +5 位作者 Yong-Hong Tang Li Jiang Xiong-Ying Ji Feng-Ying Zhang Ping Zhang Bo Ouyang 《Traditional Medicine Research》 2025年第2期16-29,共14页
Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of treatment.Nevertheless,the specific mechanism of action of SXLJF remains unclear.Methods:The mou... Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of treatment.Nevertheless,the specific mechanism of action of SXLJF remains unclear.Methods:The mouse model of insomnia was established by intraperitoneal injection of para-chlorophenylalanine.Forty-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive days.The open field test and pentobarbital-induced sleeping test were conducted.LC-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating insomnia.Finally,key targets were validated using RT-qPCR.Results:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep duration.Metabolomics and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of SXLJF.Specifically,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,respectively.RT-qPCR results supported the role of TH in the mechanism of SXLJF in treating insomnia.Conclusion:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia. 展开更多
关键词 Shangxia Liangji formula INSOMNIA metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism
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Goat milk-based infant formula regulates intestinal barrier function and promotes the production of short-chain fatty acids
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作者 Qingxue Chen Ting Cao +5 位作者 Hongwei Tang Linyi Zhou Yuxuan Zheng Jinju Cheng Bailiang Li Song Wang 《Food Science and Human Wellness》 SCIE CAS CSCD 2024年第6期3150-3158,共9页
Infant formula(IF)based on cow milk and goat milk is a substitute food for infants who are underfed with human milk.In our previous study,we reported the composition and physicochemical stability of IF based on milk f... Infant formula(IF)based on cow milk and goat milk is a substitute food for infants who are underfed with human milk.In our previous study,we reported the composition and physicochemical stability of IF based on milk from cows and goats and a combination of both milks.Here,we investigated the effects of these 3 IFs on intestinal immunity and short-chain fatty acid production(SCFAs)using human microbiota-associated(HMA)mice and selected human milk as a positive control.The results showed that goat milk-based IF is associated with a functional immune advantage,due to the rise in the levels of immune-related cytokines interleukin(IL)-2 and IL-10,decreased levels of intestinal permeability markers D-lactic acid and endotoxin,and increased mRNA levels of intestinal tight junction proteins occludin and claudin.In addition,the intestine of mice fed with goat milk-based IF contained 12.06μmol/g acetate,2.42μmol/g propionate,and 1.72μmol/g butyrate,which reached 69%,79%,and 60%of the levels in human milk,respectively.Our results indicate that goat milk-based IF improves intestinal immune function and promotes the production of intestinal SCFAs. 展开更多
关键词 Goat milk-based infant formula Immune function Short-chain fatty acid Human microbiota associated mice
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Study of the Lift Force Induced by An Interceptor on A High-Speed Mono-Hull:The Affecting Factors and Estimation Formula
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作者 DENG Rui HU Yu-xiao +3 位作者 HUANG Si-chong SONG Zhi-jie WANG Shi-gang WU Tie-cheng 《China Ocean Engineering》 SCIE EI CSCD 2024年第4期557-571,共15页
To find a better way to estimate the lift force induced by an interceptor on a high-speed mono-hull ship,a series of high-speed mono-hull ship models are designed and investigated under different conditions.Different ... To find a better way to estimate the lift force induced by an interceptor on a high-speed mono-hull ship,a series of high-speed mono-hull ship models are designed and investigated under different conditions.Different lift forces are obtained by numerical calculations and validated by a model test in a towing tank.The factors that influence the force are the interceptor height,velocity,draft,and deadrise angle.The relationship between each factor and the induced lift force is investigated and obtained.We found that the induced lift mainly depends on the interceptor height and advancing velocity,and is proportional to the square of the interceptor height and velocity.The results also showed that the effects of the draft and deadrise angle are relatively less important,and the relationship between the induced lift and these two factors is generally linear.Based on the results,a formula including the combined effect of all factors used to estimate the lift force induced by the interceptor is developed based on systematic analysis.The proposed formula could be used to estimate the lift force induced by interceptors,especially under high-speed condition. 展开更多
关键词 high-speed mono-hull ship INTERCEPTOR lift force formula lift force towing tank test computational fluid dynamics
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