基于SD-WAN混合链路实现规模无关快速路由切换的设计

软件定义广域网(Software Defined Wide Area Network,SD-WAN)作为被应用于广域网连接的新型网络技术,使用混合链路为广域网流量提供多条Overlay转发路径,配合智能应用选路等技术为网络流量提供最优路径动态选择的能力。提出了一种基于混合链路多Overlay隧道实现网络规模解耦下快速路由切换的新型设计,在广域网链路中断后提供路由收敛时间确定性上界保证,给出关键的数据结构及工作流程,对相关工程实施具备较好的指导作用。

Network pharmacology to decipher the mechanism of Danggui Longhui Wan against chronic myeloid leukemia

Chronic myeloid leukemia(CML)is a hematopoietic myeloproliferative disorder.The Chinese prescription Danggui Longhui Wan(DGLHW)has been utilized in CML treatment,but its underlying mechanisms remain unclear.In this study,we gathered 794 constituents,1249 drug targets,1654 disease genes and 129 intersection genes.GO and KEGG were used to analyze the function of these genes.Compatibility of prescription study showed that monarch drug,minister drug,assistant and guide drug played a synergistic role in the treatment of CML.In addition,we obtained 20 hub genes and 12 key components.Molecular docking indicated that the main compounds and core proteins had good binding ability.The results of this study also showed that DGLHW might play a role in the treatment of CML by affecting MAPK,PI3K/AKT,FoxO and p53 signaling pathways.

Network pharmacology and molecular docking analysis reveal insights into the molecular mechanism of Gualou Qumai Wan in clear cell renal cell carcinoma

Background:To initially clarify the potential therapeutic targets and pharmacological mechanism regarding Gualou Qumai Wan(GQW),a kind of traditional Chinese medicine(TCM),in clear cell renal cell carcinoma(ccRCC)by virtue of the network pharmacology analysis and molecular docking analysis.Methods:The screening of bioactive components and targets of GQW was based on the Traditional Chinese Medicine System Pharmacology(TCMSP)and the UniProt platform served for standardizing their targets.Online Mendelian Inheritance in Man(OMIM),PharmGkb,TTD,DrugBank and GeneCards databases were searched to collect the disease targets of ccRCC.Cytoscape assisted in constructing herb-compound-target(H-C-T)networks.The STRING database was searched for constructing the target protein-protein interaction(PPI)networks,while the R programming language served for analyzing GO functional terms and the KEGG pathways related to potential targets.Analyses of core genes related to survival and tumor microenvironment(TME)were conducted respectively based on the GEPIA2 database and TIMER 2.0 database.Human Protein Atlas(HPA)and The Cancer Genome Atlas(TCGA)helped to obtain core genes’protein expression as well as transcriptome expression level.Autodock Vina software validated the molecular docking regarding GQW components and pivotal targets.Results:The constructed H-C-T networks mainly had 33 compounds and 65 targets.A topological analysis of the PPI network identified that ESR1,AKT1,HIF1A,PTGS2,TP53 and VEGFA serve as core targets in the way GQW affects ccRCC.According to the GO and KEGG pathway enrichment analyses,the effects of GQW are mediated by genes related to hypoxia and oxidative stress as well as the Chemical carcinogenesis-receptor activation and PI3K-Akt signaling pathways.AKT1 shows a close relation to the recruitment of various immune cells and can remarkably affect disease prognosis according to reports.Molecular docking and molecular dynamics simulations showed that diosgenin has higher affinity with core targets.Conclusion:The study makes a comprehensive explanation of the biological activity,potential targets,as well as molecular mechanism regarding GQW against ccRCC,which promisingly assists in revealing the action mechanism of TCM formulae in disease treatment and the respective and scientific basis.

基于SD-WAN的企业快速组网探究与应用

企业广域网组网技术,具有传输效率不高、网络延迟大等缺陷,不能满足现代企业高效率传输要求。SD-WAN是当前较为先进的企业组网技术,优势颇多,将其应用在企业中,不仅可以和现有的多协议标记交换(Multi-Protocol Lab Switching,MPLS)实现无缝对接,保证业务的连续性,还能在端到端监控网络状态。鉴于此,本文即围绕SD-WAN展开,对基于SD-WAN的企业快速组网深入研究。

SD-WAN结合边缘智能在纸板生产车间的研究和实践

文章研究了软件定义广域网(Software-Defined Wide Area Networking,SD-WAN)结合边缘智能在瓦楞纸板生产车间中的应用。该研究的目标是提升瓦楞纸板生产车间的网络性能、安全性和管理效率。通过使用SD-WAN技术,该车间可以实现网络虚拟化、智能路由和实时监控,从而提高网络通信的可靠性和稳定性。SD-WAN与边缘智能的结合使网络资源得以高效利用,优化路由决策,并实现主动的网络管理。该研究对于推动工业环境中的网络技术发展具有重要意义,为瓦楞纸板制造业提供了提高生产效率、降低成本以及提升运营灵活性的机遇。

面向运营商的SD-WAN演进思考

SD-WAN(Software Defined Wide Area Network,软件定义广域网)自2012年问世以来迅速发展。2019年8月,MEF发布了MEF70,推出了SD-WAN的第一个标准化定义。SDWAN凭借敏捷性、安全性、灵活性、多样性等特点在全球备受推崇,尤其是在疫情的影响下,众多企业加速数字化转型,SD-WAN服务将成为产业数字化时代融合通信的必然发展趋势。

SD-WAN技术在图书馆馆际组网中的应用

【目的】分析VPN技术、专线技术及SD-WAN等组网技术特点,选用SD-WAN技术来组建图书馆馆际网络,可实现不同图书馆间的数字资源共建共享、信息系统良好复用。【方法】以国家图书馆、省级图书馆为例,提出组网原则、网络架构、地址规划等,以福建省图书馆为例进行组网实践。【结果】对国家图书馆、福建省图书馆网络连通性进行测试,无网络丢包现象,可相互访问,运行结果正常,组网成功。【结论】SD-WAN技术可用于图书馆馆际间的组网,接入到SDWAN专网的节点间,可实现网络资源的稳定传输。

Zuo Gui Wan Promotes Osteogenesis via PI3K/AKT Signaling Pathway:Network Pharmacology Analysis and Experimental Validation

Objective Osteogenesis is vitally important for bone defect repair,and Zuo Gui Wan(ZGW)is a classic prescription in traditional Chinese medicine(TCM)for strengthening bones.However,the specific mechanism by which ZGW regulates osteogenesis is still unclear.The current study is based on a network pharmacology analysis to explore the potential mechanism of ZGW in promoting osteogenesis.Methods A network pharmacology analysis followed by experimental validation was applied to explore the potential mechanisms of ZGW in promoting the osteogenesis of bone marrow mesenchymal stem cells(BMSCs).Results In total,487 no-repeat targets corresponding to the bioactive components of ZGW were screened,and 175 target genes in the intersection of ZGW and osteogenesis were obtained.And 28 core target genes were then obtained from a PPI network analysis.A GO functional enrichment analysis showed that the relevant biological processes mainly involve the cellular response to chemical stress,metal ions,and lipopolysaccharide.Additionally,KEGG pathway enrichment analysis revealed that multiple signaling pathways,including the phosphatidylinositol-3-kinase/protein kinase B(PI3K/AKT)signaling pathway,were associated with ZGW-promoted osteogensis.Further experimental validation showed that ZGW could increase alkaline phosphatase(ALP)activity as well as the mRNA and protein levels of ALP,osteocalcin(OCN),and runt related transcription factor 2(Runx 2).What’s more,Western blot analysis results showed that ZGW significantly increased the protein levels of p-PI3K and p-AKT,and the increases of these protein levels significantly receded after the addition of the PI3K inhibitor LY294002.Finally,the upregulated osteogenic-related indicators were also suppressed by the addition of LY294002.Conclusion ZGW promotes the osteogenesis of BMSCs via PI3K/AKT signaling pathway.

基于SD-WAN技术的企业组网研究

企业广域网组网技术,一直受到传输效率低、网络延迟大、组网成本高等问题的制约。为此,该文将软件定义网络和广域网技术结合运用,为企业广域网设计基于SD-WAN(软件定义广域网)的架构模式。在这种架构中,充分运用SD-WAN技术,通过控制器单元、CPE单元、POP单元的配置,实现企业网和公共网络的高效对接。为了进一步提高传输效率,提出一种新的加速方案。实验结果表明,在该文构建的企业广域网架构下,经过该文提出的加速方案处理,视频信息流和文本信息流的传输实时性都得到明显改善。

基于5G网络与SD-WAN技术的政企专线应急保障方案

政企专线是面向政府、企业提供的高价值通信服务,往往具备较高的保障要求。由于市政施工等外部因素对光缆线路的破坏,导致政企专线中断且抢修时长不可控,通过结合5G网络与SD-WAN技术,提出了一种适用多种政企专线业务的应急保障方案,引入云端交换设备与运营商网络对接,并通过VLAN隔离与路由疏导技术实现政企业务的快速抢通。

基于LoRaWAN的机场跑道警戒灯运行状态监视系统的设计与应用

随着物联网技术的快速发展,为解决无法及时监控反馈跑道警戒灯工作状态的问题,切实提高机场的运行安全裕度,完善跑道安全管理,文章在运用LoRaWAN技术手段实时监控远端警示灯工作状态的同时,通过统筹考虑软硬件设计提出充分利用无线广域网技术的解决方案。

SD-WAN在企业组网中的运用

随着云计算、物联网等新兴技术的不断发展,传统企业网络已经无法满足大规模数据传输和处理的需求。软件定义广域网络(Software-Defined networking in a Wide Area Network,SD-WAN)作为一种新型的企业网络架构方案,具有较高的可扩展性、灵活性和可管理性,成为企业网络升级的重要选择。通过对SD-WAN技术在不同企业组网中的应用和SD-WAN网络设计关键技术的介绍,深入剖析其优势和特点,并分析SD-WAN应用过程面临的挑战和解决方案,探讨未来SD-WAN技术的趋势和发展方向。

Preparation of Dashanzha Wan by three-dimensional printing

Objective:To use three-dimensional(3D)printing technology to prepare Dashanzha Wan.Methods:The standard formula proportion of Dashanzha Wan was used to prepare printable materials(normally called the ink)for 3D printing,and different doses and shapes of Dashanzha Wan were prepared.Then,the rheological properties,texture characteristics,scanning electron microscopy,and content of ursolic acid were evaluated.Results:Dashanzha Wan ink showed good shear thinning properties,which is very suitable for 3D printing.The printed sample had a beautiful and regular shape with high resolution.Meanwhile,ursolic acid content in 3D-printed Dashanzha Wan aligned with the ursolic acid content shown in the Pharmacopoeia of the People's Republic of China 2020.Conclusion:The 3D-printed Dashanzha Wan has a better texture,and can be shaped into various shapes according to individual needs,which would increase patients’interest when taking medicine.Moreover,3D printing of Dashanzha Wan could be easily integrated into the digital life system,enabling online customization or use at home.This study reveals that 3D printing technology is a promising method for the production of traditional Chinese medicine with personalized appearance,dosage,and texture,which is suitable for a broader population.

Simiao Wan alleviates obesity-associated insulin resistance via PKCε/IRS-1/PI3K/Akt signaling pathway based on network pharmacology analysis and experimental validation

Background:The purpose of the study was to investigatethe active ingredients and potential biochemicalmechanisms of Simiao Wan(SMW)in obesity-associated insulin resistance.Methods:An integrated network pharmacology method to screen the active compoundsand candidate targets,construct the protein-protein-interaction network,and ingredients-targets-pathways network was constructed for topological analysis to identify core targets and main ingredients.To find the possible signaling pathways,enrichment analysis was performed.Further,a model of insulin resistance in HL-7702 cells was established to verify the impact of SMW and the regulatory processes.Results:An overall of 63 active components and 151 candidate targets were obtained,in which flavonoids were the main ingredients.Enrichment analysis indicated that the PI3K-Akt signaling pathway was the potential pathway regulated by SMW in obesity-associated insulin resistance treatment.The result showed that SMW could significantly ameliorate insulin sensitivity,increase glucose synthesis and glucose utilization and reduce intracellular lipids accumulation in hepatocytes.Also,SMW inhibited diacylglycerols accumulation-induced PKCεactivity and decreased its translocation to the membrane.Conclusion:SMW ameliorated obesity-associated insulin resistance through PKCε/IRS-1/PI3K/Akt signaling axis in hepatocytes,providing a new strategy for metabolic disease treatment.

The Governing Philosophy,Institutional Building and Policy Choice of the Rwanda Patriotic Front

The sound economic and governance performance in Rwanda has attracted wide attention in the international community.A lot of research into its specific policies has been done to look at the reasons behind the success of Rwanda.From the perspective of party politics,its success can be equated with that of the governance model of a party-centered country.

软件定义广域网络(SD-WAN)2.0测试方法

以产业共性需求为基准,结合技术更迭的具体特征,构建了设备、方案和服务3个维度的软件定义广域网络(SD-WAN)2.0测试规范体系。该体系从不同维度抽象出测试工作的方向和范围,明确了相应的测试评估指标。该测试方法体系将为进一步的SD-WAN 2.0测试研究工作提供重要参考。

Classification of Villages in Wan’an County under the Background of Rural Revitalization

Rural revitalization strategy is an important strategic layout of rural development in the new era of the CPC Central Committee,and scientific and reasonable determination of village types is an important measure to promote rural revitalization by classification.The villages of Wan’an County were selected as the research object.Firstly,the factors that have a key impact on the development of the villages were extracted and qualitatively analyzed to preliminarily screen and judge their types.Secondly,the evaluation index system of development potential of the villages was constructed to quantitatively evaluate and reasonably classify the villages.Finally,the spatial distribution characteristics and quantity of different villages were revealed,and differentiated development strategies were proposed.

SD-WAN部署中的安全问题及应对措施

相较于传统的WAN,SD-WAN提高了部署效率,降低了成本,并降低了网络管理和运维的复杂程度,但却存在连接不稳定、数据易泄露、身份认证和访问控制难度大、网络攻击增多等4个方面安全问题.对此,结合现有的网络安全技术提出应对措施,即采用加密和隧道技术、部署威胁检测系统和入侵防御系统、采用身份认证和访问控制机制,以及加强安全监控和日志管理.这些措施有效保护了SD-WAN的数据传输安全.

The Problems and Measures for Small Tourism Town Development in China:A Case Study of Wan Town

With the rapid development of tourism and urbanization in China,small tourism towns gradually grow toward prosperity.This paper takes Wan Town as an example to analyze the problem and countermeasures concerning the development of small tourism towns in China.There are a series of issues in the process of development of Wan Town,which includes uncoordinated architectural style,inaccurate market positioning,repeated cultural themes,and vulnerable linkage of the industrial chain.Based on the factor analysis,these development issues were classified into three categories:confusing architectural style,repetitive cultural theme,and weak linkage of industrial chain.To achieve the goal of sustainable development of small tourism towns,some countermeasures must be taken which include promoting the development of small tourism towns with the new rural revitalization,strengthening services improvement in small tourism towns,gathering industrial elements related to the tourism industry,and increasing tourism cultural connotation.

基于拥塞及内存感知的SD-WAN故障恢复

在软件定义广域网(SD-WAN)中,链路故障会导致大量丢包,严重时会引起部分网络瘫痪.现有的流量工程方法通过在数据平面提前安装备份路径能够加快故障恢复过程,但在资源受限的情况下难以适应各种网络故障情况,从而使恢复后的网络性能下降.为了保证网络在故障恢复之后的性能并减少备份资源的消耗,本文提出一种基于拥塞及内存感知的主动式故障恢复方案(CAMA),不仅能够将受影响数据流进行快速重定向,还能实现负载均衡避免恢复后潜在的链路拥塞.实验结果表明,与已有方案相比, CAMA能有效利用备份资源,在负载均衡上有较好的性能,且仅需少量备份规则即可覆盖所有单链路故障情况.