Discussion on the Application of Warm Yang to Promote Qi Transformation in Acne Mastitis from“Yang Promotes Qi Transformation and Yin Promotes Forming”

“Yang promotes Qi transformation and Yin promotes forming”maintains the normal progress of human life activities,which is an important embodiment of human vitality.The dysfunction of“Yang promotes Qi transformation and Yin promotes forming”leads to the coagulation of pathological products such as phlegm and blood stasis in the breast meridian,resulting in the occurrence of acne mastitis.In clinical treatment,we should take“warm Yang to promote Qi transformation”as the treatment principle,and add or subtract according to the specific situation.

Effect of Yang-Warming and Kidney-Tonifying Prescription on Expression of Osteogenic and Angiogenic Factors and H-Type Vascular Markers in Steroid-Induced Avascular Necrosis of Femoral Head in Rabbits

Objective: To investigate the effect of Yang-warming and Kidney-tonifying Prescription (YKP) on the treatment of steroid-induced avascular necrosis of the femoral head (SANFH) in rabbits. And to further explore whether its therapeutic mechanism is related to the expression of HIF-1α and VEGF (angiogenic factors), BMP2 and Osterix (osteogenic factor), CD31 (type H vascular marker) and MMP13 (bone destruction-related factor). Methods: Twenty-seven healthy male New Zealand white rabbits were divided into a normal group, model group, traditional Chinese medcine (TCM) group (clinical equivalent dose group of YKP), miR-130a inhibitor group and TCM + inhibitor group. The SANFH model was established by combining horse serum with methylprednisolone. After the model is successfully established, TCM group was given 6.44 g/kg·d YKP by gavage, and the miR-130a gene inhibitor group was intraperitoneally injected with 25 mg/kg miR-130a inhibitor, locked nucleic acid (LNA)-anti-miR-130a. TCM + inhibitor group was treated with YKP intragastrically and miR-130a inhibitor intraperitoneally. The rabbits in the normal group and the model group were intragastrically administered with normal saline 10 ml/d. Once a day for 4 weeks. The avascular necrosis was detected by HE staining. The contents of HIF-1α, VEGF, BMP2 and Osterix in rabbit tissues were detected by qRT-PCR kit, and the expression of CD31 and MMP13 was detected by immunofluorescence staining. Results: In the normal group, the surface of the cartilage layer of the femoral head was smooth, the bone trabeculae were intact and densely arranged, the cells of each layer were neatly arranged, the morphology of the bone cells, the chondrocytes and the adipocytes were normal. In the model group, cartilage surfaces of the femoral head showed exfoliative cracks. The bone trabecular structure was loose and incomplete, chondrocytes, osteoblasts and bone marrow cells were significantly reduced, and the number of empty bone traps was significantly increased. In the TCM-treated group, more chondrocytes, thicker cartilage layer, and more regular bone trabeculae were detected as compared to model rabbits. In contrast, the cartilage layer was thinner, the destruction and fracture of bone trabeculae was more serious, chondrocytes and osteocytes were decreased as compared to model group. The expression of HIF-1α, VEGF, BMP2, and Osterix in the model group decreased significantly as compared to the normal group (P Conclusion: YKP can regulate the expression of angiogenic-related factors (VEGF and HIF-α), osteogenic-related factors (BMP2 and Osterix), and H-type vascular marker CD31, resulting in increased expressions of VEGF, HIF-α, BMP2, and Osterix, which promote intra-femoral head revascularization. Meanwhile, YKP decreased the expression of bone-destruction-related factor MMP13, thus enhancing the ability of bone tissue to repair itself. Regulation of these molecules’ expression may be one of the mechanisms of YKP in the treatment of hormonal femoral head necrosis.

“Warming yang and invigorating qi” acupuncture alters acetylcholine receptor expression in the neuromuscular junction of rats with experimental autoimmune myasthenia gravis

Myasthenia gravis is an autoimmune disorder in which antibodies have been shown to form against the nicotinic acetylcholine nicotinic postsynaptic receptors located at the neuromuscular junction.＂Warming yang and invigorating qi＂ acupuncture treatment has been shown to reduce serum inflammatory cytokine expression and increase transforming growth factor beta expression in rats with experimental autoimmune myasthenia gravis.However,few studies have addressed the effects of this type of acupuncture on the acetylcholine receptors at the neuromuscular junction.Here,we used confocal laser scanning microscopy to examine the area and density of immunoreactivity for an antibody to the nicotinic acetylcholine receptor at the neuromuscular junction in the phrenic nerve of rats with experimental autoimmune myasthenia gravis following ＂warming yang and invigorating qi＂ acupuncture therapy.Needles were inserted at acupressure points Shousanli（LI10）,Zusanli（ST36）,Pishu（BL20）,and Shenshu（BL23） once daily for 7 consecutive days.The treatment was repeated after 1 day of rest.We found that area and the integrated optical density of the immunoreactivity for the acetylcholine receptor at the neuromuscular junction of the phrenic nerve was significantly increased following acupuncture treatment.This outcome of the acupuncture therapy was similar to that of the cholinesterase inhibitor pyridostigmine bromide.These findings suggest that ＂warming yang and invigorating qi＂ acupuncture treatment increases acetylcholine receptor expression at the neuromuscular junction in a rat model of autoimmune myasthenia gravis.

Clinical observation on efficacy of compound of warming yang, descending turbidity and dredging collaterals in the treatment of diabetic kidney disease with Yin-Yang deficiency and blood stasis syndrome

Objective:To observe the clinical efficacy of compound of owarming yang,descending turbidity and dredging collaterals in the treatment of diabetic kidney disease with yin-yang deficiency and blood stasis syndrome.Methods:Seventy-six patients of diabetic kidney disease with yin-yang deficiency and blood stasis syndrome were randomly divided into observation group and control group,thirty-eight cases in each group.The control group was given conventional western medicine treatment,while the observation group took compound of owarming yang,descending turbidity and dredging collaterals orally on the basis of conventional western medicine treatment.The course of treatment covered for one month.Before and after treatment,we observed the scores of traditional Chinese medicine symptoms,indicators of renal function[serum creatinine(Scr),blood urea nitrogen(BUN),microalbuminuria(MALB)],indicators of glucose metabolism[fasting plasma glucose(FPG),2-hour postprandial blood glucose(2hPG),glycosylated hemoglobin(HbAlc)],indicators of hemorheology[plasma viscosity(PV),platelet aggregation rate(PAR),fibrinogen(FIB)],Cystatin-C(Cys-C),C-reactive protein(CRP)in the two groups.Results:After treatment,the clinical effect of the observation group was significantly better than the control group(P<0.05).The scores of traditional Chinese medicine symptoms,indicators of renal function(Scr、BUN、UAER),indicators of glucose metabolism(FPG、2hPG、HbAlc),indicators of hemorheology(PV、PAR、FIB),Cys-C and CRP in the two groups were decreased significantly compared with those before treatment(P<0.05),and the decrease in the observation group was superior to that in the control group(P<0.05).Conclusion:Compound of warming yang,descending turbidity and dredging collaterals has remarkable efficacy in treating of diabetic kidney disease patients with yin-yang deficiency and blood stasis syndrome by alleviating clinical symptoms,glucose metabolism,renal function and microcirculatory disturbance,and the mechanism related to alleviation of microinflammation.

The combined efficacy of warming Yang therapy and Western of dilated cardiomyopathy with heart medicine the treatment failure:a meta-analysis

Background:To evaluate the clinical efficacy of oral administration of Chinese medicines with warming Yang effects and Western medicine in the treatment of heart failure caused by dilated cardiomyopathy.Methods:Seven databases including Chinese National Knowledge Infrastructure,Weipu database,Wanfang database,China Biomedical Literature Service System,Cochrane library,PubMed,and Embase were searched.The search date was from established to October 2019.Randomized clinical trials of dilated cardiomyopathy patients with heart failure under the combination treatment of Chinese medicines with warming Yang effects and Western medicine were included.We then assessed the methodological quality of included literatures,extracted valid data and conducted systematically evaluation according to the Cochrane systematic review method.Outcome index included clinical efficacy,left ventricular ejection fraction,and brain natriuretic peptide.Results:Meta-analysis results showed that the clinical effective rate was higher in the combination group than that in the control group(RR=1.24,95%CI(1.14,1.34),P<0.01).In addition,the combination group could improve left ventricular ejection fraction compared with the control group(Std.MD=0.85,95%CI(0.69,1.01),P<0.01).However,the meta-analysis of brain natriuretic peptide levels showed that the included literatures have higher heterogeneity and the meta-analysis results were unstable.So the results of brain natriuretic peptide were abandoned.Conclusion:Oral administration of Chinese medicines with warming Yang effects combined with Western medicine is better than Western medicine alone in improving clinical effect and left ventricular ejection fraction,but it is not clear whether brain natriuretic peptide can be improved.Because the quality of the included studies is not high and inconsistent outcome index,more standardized and rigorous randomized double-blind controlled trials are needed to validate and guide clinical use.

温阳宣肺祛风法辨治白癜风经验

白癜风是皮肤科较为常见的色素脱失性疾病,易诊难治。作者在总结前人经验的基础上,结合自身多年临床认为,白癜风实为本虚标实之证。于内以“阳虚”体质为发病基础,于外以感受“风邪”为致病关键,提出以“温阳宣肺祛风法”治疗白癜风,并自拟中药方剂“扫白茴风丸”,在临床中取得满意成效。文章从病因病机、治法方药两方面阐释了温阳宣肺祛风法辨治白癜风的经验,并附验案一则,以期为中医药治疗白癜风拓宽思路。

“培土制水”治法的历史源流及其发展初探

“培土制水”渊源于“五行学说”,是对五行制化理论的具体应用,经过历代医家不断发展与完善,已经成为中医治疗疑难杂病的基本治法之一。文章通过文献研究探讨“培土制水”法理论源流以及临床应用,总结认为“培土制水”法首倡于《黄帝内经》,首次应用于《伤寒杂病论》,在北宋时期方书《圣济总录》首次提出,经过宋金元时期的发展,在明清时期逐渐完善,现代医家广泛应用于内伤杂病;“培土制水”理论不仅指狭义的健脾制水,还应包括“宽脾利水”“温阳利水”“摄纳肾气”等。“培土制水”的实际含义是通过调理脾土等脏腑机能,使水液代谢以及肾脏功能恢复正常,拓展了临床治疗的实践思路。

张守琳运用“温阳解毒通络”法治疗糖尿病肾脏病(Ⅳ-Ⅴ期)经验探析

糖尿病肾脏病属中医学的“肾消(消肾)”“下消”“水肿”等范畴,目前已成为终末期肾病的主要原因。张守琳教授认为“阳虚毒瘀肾络”是糖尿病肾脏病(Ⅳ-Ⅴ期)的基本病机,阳气受损为发病之本,毒瘀肾络是发病的关键环节,并确立了“温阳解毒通络”的治疗原则,有效延缓了肾功能损伤的进展和进入透析的进程。

基于郑氏妇科温补理论辨治子宫腺肌病经验撷英

子宫腺肌病是临床常见的难治性妇科疾病,其发病机制较复杂,西医治疗效果欠佳。郑氏妇科在长期医疗实践中逐渐认识到阳气虚弱、寒凝血瘀为本病的核心病机,用药崇尚温补,以温阳益气、化瘀散结为主要治法;并宗“杂合以治”之旨,创立中医综合治疗方案,内服与外治并用,整体与局部相统一,临床屡获良效。对子宫腺肌病病程缠绵日久而正气虚弱、气血耗伤者,采用丸剂或中成药以温补气血、调理善后。附验案1则。

浅谈颜红教授温阳法治疗抑郁症低动力症状

“低动力”为抑郁症的常见特征,表现为精力减退、疲劳感、反应迟缓、性欲减退等,严重影响患者的生活、工作、社交能力。作者随第七批全国老中医药专家学术经验继承老师、天津市名中医颜红教授学习,发现临床上此类症状可归为阳虚证,由于患者长期七情内伤、思虑过度,使情志失遂,进而导致阳气不振、心神失养。治以温阳之法,振奋阳气,可有效改善抑郁症患者低动力症状,值得临床推广使用。

温阳利水法治疗感染性休克液体复苏后患者体液潴留临床研究

目的:分析温阳利水法治疗感染性休克液体复苏后体液潴留的临床效果。方法:选取80例感染性休克患者,患者接受液体复苏后均出现不同程度体液潴留,采用随机数字表法分为对照组(n=40,接受西药治疗)和观察组(n=40,对照组治疗基础上采用加味真武汤治疗),比较两组患者疗效、中医证候积分、中心静脉压(CVP)、氧合指数(PaO_(2)/FiO_(2))、下腔静脉内径(IVC)及呼吸变异度(RVI)。结果:观察组治疗总有效率及各项中医证候积分优于对照组(均P<0.05)。液体复苏后T1、T2、T3观察组CVP水平低于对照组,PaO_(2)/FiO_(2)水平高于对照组(均P<0.05)。治疗后观察组RVI大于对照组,IVC最小内径(IVCmin)小于对照组(均P<0.05)。结论:真武汤治疗感染性休克液体复苏后体液潴留患者效果显著,可改善患者中医症状及容量状态。

“温阳祛瘀”中药熏洗联合复方益母草胶囊对阳虚血瘀型子宫复旧不全产妇早期康复的临床研究

目的:研究分析“温阳祛瘀”中药熏洗联合复方益母草胶囊对阳虚血瘀型子宫复旧不全产妇早期康复的临床效果。方法:前瞻性纳入2021年4月—2023年4月在广东省人民医院赣州医院妇产科住院的阳虚血瘀型子宫复旧不全产妇80例,将患者按照随机数字表法分为治疗组(n=40)和对照组(n=40)。对照组在常规治疗的基础上加用复方益母草胶囊,治疗组在对照组基础上加以“温阳祛瘀”中药熏洗治疗。比较两组临床症状消失时间、子宫恢复情况、疼痛情况、睡眠质量、心理状态、临床疗效。结果:治疗组恶露、腹痛消失时间均早于对照组,子宫底高度、子宫体积均小于对照组,子宫腔积液量少于对照组,视觉模拟评分法(VAS)、抑郁自评量表(SDS)、焦虑自评量表(SAS)、匹兹堡睡眠质量指数(PSQI)评分均低于对照组,临床疗效优于对照组,差异均有统计学意义(P<0.05)。结论:“温阳祛瘀”中药熏洗联合复方益母草胶囊能显著促进阳虚血瘀型子宫复旧不全产妇早期康复,有效提高产妇睡眠质量,改善不良情绪,整体治疗效果较佳。

温阳健脾法联合维生素D调节免疫失衡治疗桥本甲减的研究

目的观察温阳健脾法联合维生素D调节免疫失衡,治疗桥本甲状腺炎(HT)合并甲减的疗效。同时通过检测HT甲减期患者治疗前后Th17和Treg细胞表达的百分率,以评估临床疗效。方法选取收治的住院及门诊病人64例作为研究对象,随机分为对照组和实验组各32例,对照组给予维生素D,试验组给予复方甲减平合剂+维生素D,疗程为8周,比较2组患者的中医证候疗效,血清促甲状腺激素(TSH)、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、甲状腺过氧化物酶抗体(TPO-AB)、甲状腺球蛋白抗体(TGAb)、Th17和Treg细胞表达的百分率及甲状腺体积变化。结果治疗前后中医证候积分改善情况试验组明显优于对照组(P<0.05);2组患者在治疗后FT3、FT4、TSH水平及甲状腺体积对比疗效相当(P>0.05)。2组患者治疗前后甲状腺抗体指标比较,试验组的疗效优于对照组(P<0.05)。结论温阳健脾法联合维生素D治疗桥本甲减安全性较高,不良反应少,值得在临床中广泛应用。

刘小斌运用麻附细辛汤合甘草干姜汤加减治疗先天性肌无力综合征经验

先天性肌无力综合征(congenital myasthenia syndrome,CMS)为临床罕见的遗传性肌病。CMS患者虽与重症肌无力患者的症状相似,均有肌无力、易疲劳等症,但CMS为先天禀赋不足疾病,以肾元亏损为本,而重症肌无力为后天失养疾病,故在辨治侧重上有所区别。刘小斌教授认为,CMS的中医病机特点为“先天不足,肾元亏损”“脾胃虚损,五脏相关”,属于中医“痿病”范畴;根据患者不易出汗、舌淡红苔白、脉细的病症表现,可辨为脾肾阳虚兼寒邪束表证(少阴太阴兼太阳证);治疗可采用温阳补肾、健脾益损法,常以麻附细辛汤合甘草干姜汤加减,可酌加桑螵蛸、紫河车等益精养血之品,可获显效。

基于“阳化气,阴成形”从温阳法论治肺部结节

《素问·阴阳应象大论篇》中记载的“阳化气,阴成形”高度概括了人体脏腑组织的生命活动,阴阳失衡是导致疾病发生的关键。本文通过分析“阳化气,阴成形”理论,发现肺部结节发生和发展的核心机制是“阳化气不足,阴成形太过”。结节乃有形之体,是机体阳气亏虚,精血津液运行障碍,化为痰饮瘀毒,敛聚局部而生;结节本质乃阳虚阴结,本虚标实,本虚即脾肾阳虚,标实即痰饮、瘀血、浊毒。中医学强调治病求本,故基于“阳化气,阴成形”理论,以温阳化气为基本治则,探讨温阳法在肺部结节治疗中的应用,分别从温阳补肾、温阳健脾、温阳化痰、温阳活血、温阳解毒和温阳散结等角度辨证施治,以防“阴成形太过”,使“阳化气”之功能正常发挥,则机体阴阳平衡,百病不生。

毛以林教授运用经络辨证治疗项痹经验

经络辨证是中医学辨证理论体系中重要的辨证方法。毛以林教授临床善于运用经络辨证治疗各种复杂病证,认为项痹的经络辨证多与足太阳膀胱经、手太阳小肠经、足少阳胆经、手少阳三焦经、足少阴肾经及督脉密切相关。基本病机主要有寒侵太阳、营卫凝遏;少阳气郁、气血失和;肾虚失养、髓减骨空;督阳不振,筋懈骨惰。治疗上以祛风散寒、温经止痛;和解气郁、疏利经气;补肾壮骨、填精益髓;温振督阳、益肾补督。随证治之,疗效颇佳。

糖尿病合并肺部感染(气虚阳亏证)证治机理探析

糖尿病合并肺部感染发病率高、死亡率高,严重威胁患者的生活质量及生命安全。中医目前多从清热或者滋阴角度治疗糖尿病合并肺部感染,但此疗法对一些糖尿病后期合并肺部感染患者疗效欠佳甚至无效,从气虚阳亏的思路治疗糖尿病合并肺部感染可以取得满意的疗效。为此,本文探寻糖尿病后期合并肺部感染(气虚阳亏证)的诊治机理,指出其病机是肺脾肾气阳虚衰,尤以脾最为关键,兼寒饮内伏,治疗核心是扶助阳气以温化促气化,以恢复机体平衡。

从脾论治儿童抗生素相关性腹泻

儿童抗生素相关性腹泻(antibiotic-associated diarrhea,AAD)是儿童使用抗菌药后而出现的腹泻,其发病机制与肠道菌群密切相关,抗生素可通过影响肠道菌群的代谢功能及免疫功能导致AAD。中医认为,儿童AAD的病位主要在脾脏,病因不外素体脾胃虚弱、疫毒侵袭、药毒蓄积等,病机以脾虚湿盛、脾气亏虚、脾阳不足为特点。脾虚为小儿AAD发病之本,且脾与肠道菌群具有共通性,故临床治疗小儿AAD可从脾论治。从脾论治儿童ADD以健运脾脏为原则,采用健脾渗湿、健脾益气、健脾温阳等治法,分别以参苓白术散、四君子汤、附子理中丸等为基础方,调理脾脏以达治病求本之目的。

辛丑年运气方治疗皮肌炎相关间质性肺疾病所致难治性咳嗽

基于五运六气理论,从整体恒动的观念出发,分析辛丑年运用五味子汤合备化汤治疗皮肌炎相关间质性肺疾病(DM-ILD)所致难治性咳嗽的疗效。辛丑全年,岁水不及,太阴湿土司天,太阳寒水在泉,整年气化以寒湿为主。寒湿为阴邪,易伤阳气,尤伤肾阳,故辛丑年防治疾病应注重扶阳温中。五味子汤和备化汤是陈无择根据辛丑年运气特点所创的运气方,二者配伍具有温肾健脾散寒、温肺化痰滋阴之效,恰合辛丑年DMILD所致难治性咳嗽的病机特点,故辛丑年以其治疗该病具有良好疗效。

从“阳化气,阴成形”探讨扶阳法在肿瘤临床中的应用

“阳化气,阴成形”源于《素问·阴阳应象大论》。“阳化气”不足而“阴成形”太过会导致气滞血瘀、痰湿凝滞、水饮内停,使病理有形之物积聚而发为肿瘤。因此,“阳化气”不足而“阴成形”太过是肿瘤的核心发病机制。基于此,提出扶阳法为肿瘤的临床防治大法。在预防方面,需强身健体,劳逸结合,饮食有节忌偏嗜,注意调畅情志;在治疗用药方面,可分为温阳法、通阳法、温通法三法。