Systematic review and meta-analysis of endometrial thickening during endocrine therapy combined with Chinese herbal medicine intervention after breast cancer surgery

Objective:To systematically evaluate the endometrial thickening and Chinese herbal medicine intervention effects during endocrine therapy following breast cancer surgery.Methods:Computerized searches were performed on CNKI,CBM,Wanfang,VIP,Pub Med,Embase,and Cochrane to gather randomized controlled trials(RCTs)of endometrial thickening combined with Chinese herbal medicine intervention during endocrine therapy after breast cancer surgery.The meta analysis is done using Rev Man 5.4,and the retrieval range is from the database's creation to January 2023.Results:There were 710 patients enrolled in a total of 12 RCTs.The results of Meta-analysis were as follows:combined with Chinese herbal medicine treatment for 3 months of endometrial thickness(MD=-1.12,95%CI[-1.47,0.77],P<0.00001);6 months endometrial thickness(MD=-1.90,95%CI[-2.38,-1.42],P<0.00001);endometrial thickness at 12 months(MD=-2.24,95%CI[-2.96,-1.52],P<0.00001);modified Kupperman score(MD=-10.45,95%CI[-19.10,-1.80],P=0.02);TCM syndrome score(SMD=-1.53,95%CI[-1.84,-1.22],P<0.00001);KPS score(MD=3.75,95%CI[2.81,4.68],P<0.00001);there was no significant difference in CA153,CEA,FSH and E2 between the two groups.Conclusion:After breast cancer surgery,endocrine therapy combined with Chinese herbal medicine can significantly lessen endometrial thickening and enhance patient quality of life.

Molecular mechanism and research progress of traditional Chinese medicine in the treatment of prostate cancer

Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence worldwide.Traditional Chinese medicine(TCM),as an important component of complementary and alternative medicine,shows unique advantages in cancer treatment.Chinese herbal medicine is usually composed of multiple ingredients and involves multiple signaling pathways,which showed function of inducing apoptosis of cancer cells,arresting the cell cycle,inhibiting invasion and metastasis,reducing drug resistance,and regulating immune function.Physical therapy is also an important treatment of TCM.Currently,Physical therapy such as acupuncture or Tai Chi and Qigong are gaining increased recognition in the management of PCa,particularly in addressing issues like urinary incontinence and bone metastasis-related pain.This article reviews the TCM treatment and therapy of PCa,in order to provide new research avenues and treatment options for the treatment of PCa with TCM and improve the quality of life of patients.

Integration of Chinese herbal medicines and exercise for insomnia:a systematic review and meta-analysis

Background:As a disease,insomnia is often ignored by the general public.Insomnia,which not directly fatal,may be equivalent to chronic suicide if it is not paid attention to.However,there are many theories on how to treat insomnia,and researchers have been searching for a cure.Chinese herbal medicine(CHM)and exercise therapy(ET)are relatively effective,and have been used since ancient times to treat insomnia.This study aimed to examine the effect of CHM combined with ET(CHM-ET)on patients with insomnia.Methods:We searched eight electronic databases including PubMed,Web of Science,EMBASE,the Cochrane Library,the China National Knowledge Infrastructure(CNKI),the China Biology Medicine disc(CBMdisc),the China Science and Technology Journal Database(VIP),the Wanfang Database to find randomized controlled trials(RCTs)evaluating CHM-ET in the treatment of insomnia patients up to September 13,2022.Two researchers read and screened the publications to extract data.We used the pittsburgh sleep quality index(PSQI)as the evaluation indicators for each study,and the other was the total effective rate(TER).The Cochrane risk-of-bias assessment tool was used to assess the risk of bias of the included literature.The level of evidence for this result was assessed by GARDE method.The meta-analysis was performed using STATA 14 software and RevMan 5.3.The research method was registered with PROSPERO(CRD42022350926).Results:We included fourteen randomized controlled trials,which including a total of 1,126 participants.Compared with the control group,the experimental group showed significantly improvements in sleep effect as reflected by the reduced PSQI score[mean difference(MD)=-2.47,95%confidence interval(CI)(-3.15,-1.78),I^(2)=92%]with low quality of evidence,and increased TER[risk ratio(RR)=1.23,95%CI(1.14,1.33),I^(2)=40%]with moderate quality of evidence.Compared with hypnotic drugs,CHM-ET significantly reduced the PSQI score[mean difference(MD)=-3.18,95%CI(-5.48,-0.89),I^(2)=73%]with low quality of evidence.The PSQI of CHM-ET significantly decreased compared with single CHM[mean difference(MD)=-3.04,95%CI(-5.84,-0.25),I^(2)=98%]with low quality of evidence,and ET[mean difference(MD)=-2.44,95%CI(-2.87,-2.02),I^(2)=0%]with moderate quality of evidence.No serious adverse reactions were observed.Conclusion:This review suggested that CHM-ET may be an effective treatment for insomnia.However,given the limited quality of the studies and methodologies included in the trials,further rigorous randomized controlled trials are needed for more accurate results.

Traditional Chinese herbal medicine plus triple therapy in treating Helicobacter pylori-induced chronic atrophic gastritis: a meta-analysis and cumulative meta-analysis

Objectives:To evaluate the benefits of traditional Chinese herbal medicine(TCHM)plus triple therapy(TT)in the management of Helicobacter pylori(H.pylori)-induced chronic atrophic gastritis(CAG).Methods:A comprehensive access and electronic database search were carried out from inception to June 2020.Prospective randomized trials(TCHM plus TT vs.TT)were selected to assess the eradication rate of H.pylori(ER of H.pylori),clinical symptom relief rate(SRR),treatment-related adverse reactions(TRAR)and 95%confidence intervals(CI)in the meta-analysis and cumulative meta-analysis(CMA).Meta-regression analysis was used to analyze heterogeneity between studies and publication bias.Results:33 studies contained 3,226 participants were included.Compared with the TT group,TCHM plus TT group showed a significantly higher ER of H.pylori(OR=4.14,95%CI:3.21-5.35;P=0.000)and SRR(OR=4.50,95%CI:3.59-5.64).Meanwhile,the TRAR of TCHM plus TT remedy was significantly lower than TT monopoly(RR=0.43,95%CI:0.29-0.64;P=0.000).The results of the CMA,sorted by publication year,duration of treatment,and sample size,confirmed that combined treatment remedy was superior to TT monopoly in respect of ER of H.pylori and SRR.Conclusions:The present study obtained reliable and convincing evidence suggesting that TCHM plus TT remedy was efficacious and safe in treating H.pylori-induced CAG.

Integrative techniques using acupuncture,Chinese herbal medicine,diet,and supplements for polycystic ovary syndrome:a case report

Patients with a diagnosis of polycystic ovary syndrome （PCOS） are on the rise. About 4%-12% of women are currently estimated to have this condition. It is hypothesized that PCOS appears in women who have long-standing insulin resistance （1R）, which leads to high androgen and testosterone levels; this ultimately disrupts their menstrual cycles. Some researchers attribute IR to genetic factors, although there have been only minute changes in the human genome in the past 20 000 years. However, even with a stable gene pool, genes can be turned on and offby the environment, food and air quality and toxin exposure.

Use of Chinese Herbal Medicine Therapies in Comprehensive Hospitals in Central China: A Parallel Survey in Cancer Patients and Clinicians

Summary： Chinese herbal medicine （CHM）, as the largest application category of traditional Chinese medicine （TCM）, is widely accepted among cancer patients in China. Herbal slice （HS） and Chinese patent drug （CPD） are commonly used CHM in China. This study aimed to investigate the utilization of CHM among clinicians and cancer patients in central China. Five hundred and twenty-five patients and 165 clinicians in 35 comprehensive hospitals in central China were asked to complete an anonymous questionnaire that was designed to evaluate the use of CHM. The results showed that 90.74% clinicians and 72.24% cancer patients used CHM during cancer treatment. The educational backgrounds of the clinicians and the age, education level, annual income, and cancer stage of the cancer patients were re- lated to use of CHM. More than 90% clinicians and cancer patients had used CPD. Comparatively, the percentage of HS use was 10% lower than that of CPD use among clinicians and cancer patients. More clinicians preferred to use CHM after surgery than cancer patients did （20.41% vs. 5.37%）. Enhancing physical fitness and improving performance status were regarded as the most potential effect of CHM on cancer treatment （85.71% among clinicians and 94.07% among cancer patients）, in comparison with directly killing tumor cells （24.49% among clinicians and 31.36% among patients）. As for refusal rea- sons, imprecise efficacy was the unanimous （100%） reason for clinicians＇ rejection of CHM, and 95.58% patients objected to using CHM also for this reason. Furthermore, the side effects of CHM were more concerned by clinicians than by patients （33.33% vs. 15.81%）. In conclusion, our survey revealed that CHM was popularly accepted by clinicians and cancer patients in central China. The reasons of use and rejection of CHM were different between clinicians and cancer patients.

Therapeutic potential of natural compounds from Chinese medicine in acute and subacute phases of ischemic stroke

Stroke is one of the leading causes of death and disability in adults worldwide,resulting in huge social and financial burdens.Extracts from herbs,especially those used in Chinese medicine,have emerged as new pharmaceuticals for stroke treatment.Here we review the evidence from preclinical studies investigating neuroprotective properties of Chinese medicinal compounds through their application in acute and subacute phases of ischemic stroke,and highlight potential mechanisms underlying their therapeutic effects.It is noteworthy that many herbal compounds have been shown to target multiple mechanisms and in combinations may exert synergistic effects on signaling pathways,thereby attenuating multiple aspects of ischemic pathology.We conclude the paper with a general discussion of the prospects for novel natural compound-based regimens against stroke.

The roles of traditional Chinese herbal medications in regulating mitochondrial activity to reverse cancer

Cancer was gradually regarded as a metabolic disease,which might be linked to impairment of mitochondrial function.There are really some essential differences between the mitochondria of normal and cancer cells,which might become promising target for cancer chemotherapy.According to western pharmacology,a known target was needed for drug development.Unfortunately,the number of therapeutic agents relating to the mitochondrion are severely limited because of lacking of knowledge about mitochondrial biology.Unlike the“Western Medicine”,some traditional Chinese herbal medicine(TCHM)might be prone to targeting mitochondria despite the lack of precise molecular mechanisms.If it is the case,we might be able to screen and identify active anti-cancer drugs from traditional Chinese therapeutics by using mitochondrial functional assay.In this review,we would give an overview of the effect of TCHM on the mitochondrion,and the challenges and breakthroughs remaining in cancer treatment.

改良中药蜡疗在痉挛型脑瘫尖足患儿中的应用

目的探讨改良中药蜡疗对痉挛型脑瘫尖足患儿的临床疗效。方法选取72例痉挛型脑瘫尖足患儿作为研究对象,采用随机数字表法分为观察组和对照组,各36例。对照组在常规综合康复治疗基础上采用传统中药蜡疗,观察组在常规综合康复治疗基础上采用改良中药蜡疗,分别于治疗前、治疗8周后,分析踝关节被动活动范围(PROM)、综合痉挛量表(CSS)与粗大运动功能测试量表(GMFM)评分,对2组患儿PROM值、痉挛程度,站立、行走、跑、跳功能进行评定。结果干预后观察组PROM值、GMFM中D、E功能区评分高于对照组,CSS评分低于对照组,差异均有统计学意义(P<0.01)。结论改良中药蜡疗能有效增加痉挛型脑瘫尖足患儿的踝关节被动活动范围、改善痉挛程度,提高站立、行走、跑、跳功能。

蜡疗技术的临床应用现状及护理

中药蜡疗具有疗效确切、操作简便、方便实用、不良反应少等优势,在缓解诸多疾病症状方面具有较好的效果。本研究就蜡疗的作用原理、蜡疗在临床中的应用现状以及蜡疗相关的护理对策进行总结分析,从而为临床中进一步研究中药蜡疗技术的规范性和可操作性提供依据。

火针疗法联合消疮散中药面膜治疗面部寻常痤疮的疗效观察

目的:观察火针疗法联合消疮散中药面膜治疗面部寻常痤疮的临床疗效和安全性。方法:选取面部寻常痤疮患者66例,根据纳入标准制定随机对照表,随机分为治疗组(针药联合)和对照组(火针),治疗后,两组实际各纳入31例、32例。火针治疗每周1次,中药面膜治疗隔日1次,疗程均为4周,分别于治疗第2周末、第4周末进行疗效判定,并记录治疗过程中发生的不良反应,疗程结束后1个月对患者进行回访。结果:治疗2周后,两组患者的皮损评分均低于治疗前(P<0.05)。且治疗4周后,治疗组皮损评分低于对照组(P<0.05)。治疗组总有效率96.77%,高于对照组的78.13%(P<0.05)。结论:火针疗法联合消疮散中药面膜治疗面部寻常痤疮疗效确切,安全性高,临床可推广应用。

针刺结合中药保留灌肠对溃疡性结肠炎的疗效及免疫功能的影响

目的:探讨针刺结合中药保留灌肠治疗溃疡性结肠炎(UC)的临床疗效及其改善免疫功能的作用。方法:选取符合纳入标准的UC患者70例,依据随机数字表随机分为观察组和对照组,各35例。对照组给予美沙拉嗪缓释片,观察组在对照组基础上加用针刺与中药保留灌肠疗法,两组均治疗8周。比较两组患者治疗前后血清免疫功能指标CD3^(+)、CD4^(+)与CD8^(+)含量、炎症因子指标白细胞介素(IL)-1β、IL-23与转化生长因子-β1(TGF-β1)的改善情况。结果:治疗后,两组患者TGF-β1、CD3^(+)、CD4^(+)含量均较治疗前明显升高(P<0.05),IL-1β、IL-23、CD8^(+)含量下降(P<0.05);且观察组治疗后TGF-β1、CD3^(+)和CD4^(+)水平均高于对照组(P<0.05),IL-1β、IL-23、CD8^(+)水平均低于对照组(P<0.05)。结论:针刺结合中药保留灌肠治疗能显著改善UC患者免疫功能,降低其炎症因子水平。

中药塌渍联合蜡疗治疗多系统萎缩患者排尿障碍临床观察与护理

目的探讨中药塌渍联合蜡疗治疗多系统萎缩患者排尿障碍的效果,总结护理体会。方法选取2023年1月—8月科室收治的30例多系统萎缩伴排尿障碍患者为研究对象,根据入院时间顺序分为观察组和对照组,各15例。对照组给予常规治疗及护理,观察组在对照组的基础上增加中药塌渍联合蜡疗治疗。采用膀胱过度活动症状评分(OABSS)进行疗效评估。结果治疗后两组患者OABSS总分较治疗前降低(P<0.05),且观察组OABSS总分低于对照组(P<0.05)。结论中药塌渍联合蜡疗可进一步改善多系统萎缩患者排尿障碍,有助于提升患者的生活质量。

蜡疗联合中药塌渍在腰椎间盘突出症疼痛护理中的疗效

目的 分析蜡疗联合中药塌渍在腰椎间盘突出症疼痛护理中的效果。方法 选取2022年10月至2023年10月于我院进行治疗的40例腰椎间盘突出症患者为研究对象,采用随机数字表法将其分为联合组与常规组,每组各20例,以中药塌渍+TDP照射治疗对常规组进行干预,以蜡疗联合中药塌渍对联合组进行干预。对比干预后患者组间疗效、疼痛评分(VAS)、舒适度及腰椎功能。结果干预后,联合组患者的临床治疗有效率高于常规组(P <0.05);联合组患者的VAS评分高于常规组(P <0.05);联合组患者舒适度高于常规组(P <0.05);联合组患者干预后3个月与6个月的腰椎功能评分均低于常规组(P <0.05)。结论 在腰椎间盘突出症患者中,蜡疗联合中药塌渍在临床上具有进一步减轻患者疼痛,降低患者腰椎功能障碍,提高患者疗效与舒适度的作用,有一定临床应用价值。

中医适宜技术在产妇分娩疼痛管理中的应用进展

该文从分娩疼痛产生机制,中医适宜技术应用于分娩疼痛管理的理论基础及方式进行综述,分析中医适宜技术在减轻产妇分娩疼痛、增加舒适感方面的应用优势,探讨存在的不足,提出对未来的展望,为今后的研究和临床护理实践提供参考。

Therapeutic potential and mechanism of Chinese herbal medicines in treating fibrotic liver disease

Liver fibrosis is a pathological condition characterized by replacement of normal liver tissue with scar tissue,and also the leading cause of liver-related death worldwide.During the treatment of liver fibrosis,in addition to antiviral therapy or removal of inducers,there remains a lack of specific and effective treatment strategies.For thousands of years,Chinese herbal medicines(CHMs)have been widely used to treat liver fibrosis in clinical setting.CHMs are effective for liver fibrosis,though its mechanisms of action are unclear.In recent years,many studies have attempted to determine the possible mechanisms of action of CHMs in treating liver fibrosis.There have been substantial improvements in the experimental investigation of CHMs which have greatly promoted the understanding of anti-liver fibrosis mechanisms.In this review,the role of CHMs in the treatment of liver fibrosis is described,based on studies over the past decade,which has addressed the various mechanisms and signaling pathways that mediate therapeutic efficacy.Among them,inhibition of stellate cell activation is identified as the most common mechanism.This article provides insights into the research direction of CHMs,in order to expand its clinical application range and improve its effectiveness.

中医药治疗斑秃研究进展

斑秃是一种较为常见的非瘢痕性炎症性脱发,禀赋不足气血空虚、饮食不节湿热内蕴、情志失调瘀阻脉络、腠理不固风袭巅顶等皆可导致斑秃的发生,其病性属本虚标实。本病可从肝肾不足、气血亏虚、血虚风燥、血热动风、肝郁血瘀、湿热蕴蒸6个证型辨治。现从辨证论治、专方治疗、中成药治疗、针药并用以及中西医结合治疗角度概括中医药治疗斑秃的研究进展,以期为临床治疗斑秃提供思路。

中药塌渍联合蜡疗治疗1例项痹病患者的护理体会

本文总结中药塌渍联合蜡疗治疗1例项痹病患者的护理经验。护理人员在护理评估、饮食干预等常规护理基础上,通过辨证分析,采用中药塌渍结合蜡疗干预,有效缓解项痹病患者的疼痛症状,提高患者的生活质量。

中药膏摩治疗腰椎间盘突出症1例的护理

腰椎间盘突出症是骨科常见疾病,下腰痛是患者就诊的主要症状。中医外治疗法缓解腰椎间盘突出症患者疼痛症状效果明确。本文回顾中药膏摩治疗1例腰椎间盘突出综合症患者的效果,总结护理经验。通过对患者精准的护理评估,明确患者的护理目标,在常规护理和健康宣教的基础上,通过实施中药膏摩技术,能够有效改善患者疼痛与下肢无力症状。中药膏摩治疗腰椎间盘突出症效果明确,且不良反应少,易于患者接受。