来自多方的声音:构建中国开放科学创新生态——第十届中国开放获取推介周(China OA Week)会议综述

[目标/意义]2021年第十届中国开放获取推介周(10th China OA Week)的主题为“开放科学的意义和影响”,标志着中国最主要的开放获取平台主题正式转向开放科学,契合形势发展需要。[方法/过程]本届会议邀请到国内外的多方专家与代表,分专题探讨开放科学目标、关键问题、实践案例并提出发展建议。[结果/结论]会议呼吁构建中国开放创新生态,初步勾画出中国开放科学发展现状。响应国家提出的推动开放科学发展要求,China OA Week平台及其研讨成果将持续助力中国开放科学事业的推进。

Once-versus Twice-weekly Bortezomib Induction Therapy with Dexamethasone in Newly Diagnosed Multiple Myeloma

In this study,we administered a modified schedule of weekly intravenous Bortezomib at 1.6 mg/m 2 with dexamethasone(BD) and compared it to the standard 1.3 mg/m 2 twice-weekly BD regimen in Chinese patients with newly diagnosed multiple myeloma(MM).We assessed the difference in efficacy,safety profile and survival between the once-weekly and twice-weekly cohorts(13 vs.24 patients).The over response rate was similar with both arms of the study,being 77% in the once-weekly schedule and 74.9% in the twice-weekly schedule(P=0.690).The median overall survival was not reached in either schedule.Also,the median progression-free survival and duration of response of the once-weekly schedule did not significantly differ from those of the twice-weekly schedule(8 months vs.10 months,P=0.545 and 6 months vs.7 months,P=0.467 respectively).Peripheral sensory neuropathy and grade 3/4 hematologic toxic effects were more frequently reported in the twice-weekly schedule than the once-weekly schedule,but there was no statistically significant difference.This preliminary experience in Chinese patients with newly diagnosed MM indicated that once-weekly infusion of Bortezomib plus dexamethasone may improve safety without affecting outcome.

Prediction Model of Weekly Retail Price for Eggs Based on Chaotic Neural Network

This paper establishes a short-term prediction model of weekly retail prices for eggs based on chaotic neural network with the weekly retail prices of eggs from January 2008 to December 2012 in China.In the process of determining the structure of the chaotic neural network,the number of input layer nodes of the network is calculated by reconstructing phase space and computing its saturated embedding dimension,and then the number of hidden layer nodes is estimated by trial and error.Finally,this model is applied to predict the retail prices of eggs and compared with ARIMA.The result shows that the chaotic neural network has better nonlinear fitting ability and higher precision in the prediction of weekly retail price of eggs.The empirical result also shows that the chaotic neural network can be widely used in the field of short-term prediction of agricultural prices.

Evaluation of an alternative dosing regimen with tadalafil, three times per week, for men with erectile dysfunction： SURE study in Italy

Aim： To examine the preference for two dosing regimens of 20 mg of tadalafil, on demand or three times per week, in men affected with erectile dysfunction （ED） in Italy. Methods： Scheduled Use versus on demand Regimen Evaluation （SURE） is a multicenter, crossover and open-label study, involving 94 urology centers in Italy. Patients aged 18 years or older affected with ED for at least 3 months were enrolled and randomized to 20 mg of tadalafil treatment on demand or three times per week for 5-6 weeks. After a 1-week washout, patients were crossed over to the alternate regimen for 5-6 weeks. A treatment preference question was used to determine the preferred treatment regimen. International Index of Erectile Function （IIEF） and Sexual Encounter Profile （SEP） questionnaire were used as efficacy measures. Results： A total of 1 058 men （mean age 54.8 years）, were randomized to treatment. Overall, 59.1% of patients preferred the on-demand regimen and 41.9% preferred the three times per week dosing. Both regimens were efficacious and well tolerated. Although a statistically higher improvement of the IIEF erectile function （IIEF-EF） domain score and the SEP questionnaire was reported for the three times per week compared to the ondemand treatment regimen, this difference was numerically minimal and lacking in clinical significance. Conclusion： Tadalafil is effective and well tolerated whether used on demand or three times per week. Patients should be given the option to choose the best treatment regimen according to personal needs and preferences.

Weekly pattern of emergency room admissions for peptic ulcers:A population-based study

AIM:To investigate variations in the incidence of peptic ulcers(PUs) in Taiwan by day of the week within age subgroups.METHODS:Ambulatory care data were retrieved from the Longitudinal Health Insurance Database 2000.There were 7204 subjects≥18 years-old with an emergency room admission claim for the treatment of PUs,resulting in a total of 9234 emergency room visits for PUs between 2009 and 2011.Data was divided into the seven days of the week and an additional variable for holidays.One-way analysis of variance was used to examine associations among the daily mean number of PU emergency room admissions and holidays/weekends/weekdays.RESULTS:One-way analysis of variance showed that there was a significant difference in emergency room admissions for PUs by the day of the week(P<0.001),with admission more likely to occur on Sundays or holidays than weekdays within the total and working populations.The weekday patterns of admission were similar for the patients aged 18-64 years and≥65years of age.Holidays,followed by Sundays,had higher PU admissions than the mean daily PU emergency room admissions.Furthermore,inclusion of only those treated for PUs with hemorrhage or perforation,Sundays and holidays had higher mean emergency room admissions than other days.Inclusion of patients who diagnosed with Helicobacter pylori infection,only holidays had higher mean emergency room admissions than other days.Inclusion of patients who had been prescribed non-steroidal anti-inflammatory drugs(NSAIDs)for over30 d,Sundays and holidays had higher mean PU ER admissions than other non-holiday weekdays.CONCLUSION:There is a higher incidence of emergency room admission for PUs on weekends than on weekdays for the total and working populations.

Three Weeks Carboplatin/Paclitaxel versus Weekly Regimen in Egyptian Women Cohort Treated for Ovarian Carcinoma

Introduction: Epithelial Ovarian Carcinoma (EOC) comprises the vast majority (almost 90%) of ovarian carcinomas. Chemotherapy is the main treatment in ovarian cancers. The standard of care in the chemotherapeutic is the combination of a platinum (carboplatin or cisplatin) and a taxane (paclitaxel or docetaxel). Studies were done to determine whether this combination to be given weekly or every 3 weeks. Patient and Method: Inclusion criteria: 1) Female patients between the ages of 17 - 78 years. 2) Baseline hematological, renal and liver laboratory profiles were within accepted ranges. 3) Performance status of the patients was 0-II. 4) Patients were pathologically proven ovarian cancer. 5) A follow-up period for at least 6 months was required. Exclusion criteria: 1) Patients who had double malignancy were excluded. 2) Performance status more than II. 3) Other comorbidity. Results: We reviewed 69 female patients with EOC, with 60% received every three weeks regimen. Mean age was 53.22 years. At a median follow up of 45.9 months, there was no significant different between the two protocols in terms of mean PFS, 62.35 months (95% CI: 50.08 - 74.63 months) for the three-weekly cohort, and 69.25 months (95% CI: 55.24 - 83.26 months) for weekly protocol (p = 0.613). The three weekly regimen patients had a higher incidence of hospital admission (40% vs 18.5% for the weekly protocol patients), but it didn’t reach a statistical significance (p = 0.063). The three weekly protocol had a significantly higher incidence of causing a neutropenic fever (p = 0.003). Conclusion: In our cohort of Egyptian women with EOC, no significant difference in PFS was found when compared the weekly Carboplatin/paclitaxel when compared to the classic three weeks, although the weekly protocol may be causing less febrile neutropenia and fewer hospital admissions.

China Foundry Week 2017 and CHINACAST 2017 open concurrently in Suzhou city

China Foundry Week 2017＆the China Foundry Expo（CHINACAST）2017,hosted by the Foundry Institution of Chinese Mechanical Engineering Society（FICMES）and the State Key Laboratory of Light Aloy Casting Technology for High-end Equipment,were successfully held November 14-17,2017 in Suzhou International Expo Centre,Jiangsu Province, China.

Spectral Analysis of Stock Data Series and Evidence of Day-of-the-Week Effects

Daily return series of Dow Jones Industrial Average Index (DJIA) and Shanghai Conposite Index are investigated using spectral analysis methods. The day of the week effect is found in the frequency domain in both stock markets. Time domain performances of the daily returns are also studied. Although both markets have a clear weekly component in the frequency domain, they show some different behaviors with respect to the day of the week effects.

Evaluating the weekly changes in terrestrial water storage estimated by two different inversion strategies in the Amazon River Basin

In this study,we estimated the weekly Gravity Recovery and Climate Experiment(GRACE)spherical harmonic(SH)solutions and regional mascon solutions using GRACE-based Geopotential Difference(GPD)data and investigated their abilities in retrieving terrestrial water storage(TWS)changes over the Amazon River Basin(ARB)from January 2003 to February 2013.The performance of the weekly GPD-SH and GPDmascon solutions was evaluated by comparing them with the weekly GFZ-SH solutions,Global Land Data Assimilation Systems(GLDAS)-NOAH hydrological model outputs,and monthly GFZ-SH,GPD-SH,and CSRmascon solutions in the spatio-temporal and spectral domains.The results demonstrate that the weekly GPD-SH and GPD-mascon present good consistency with the weekly GFZ-SH solutions and GLDAS-NOAH estimates in the spatio-temporal domains,but GPD-mascon presents stronger signal amplitudes and more spatial details.The comparison of the monthly average of weekly estimates and monthly solutions demonstrates that the weekly GPD-mascon and GFZ-SH with DDK1 filtering are close to the monthly CSRmascon and GFZ-SH solutions,respectively.However,the signal amplitudes of TWS changes from GPD-SH and GFZ-SH with 650 km Gaussian filtering are smaller than the monthly solutions,and the corresponding Root Mean Square Errors between the TWS change time series from the monthly average of weekly solutions and monthly estimates are 18.12 mm(GPD-mascon),18.81 mm(GFZ-SH-DDK1),24.93 mm(GPDSH-G650km),and 33.07 mm(GFZ-SH-G650km),respectively.Additionally,the TWS change time series derived from weekly solutions present more high-frequency time-varying information than monthly solutions.Furthermore,the 300 km Gaussian filtering can improve the signal amplitudes of TWS changes from the weekly GPD-SH solutions more than those with 650 km Gaussian filtering,but the corresponding noise level is higher.The weekly GPD-SH and GPD-mascon solutions can extend the application scopes of GRACE and provide good complements to the current GRACE monthly solutions.

Scheduling Check-in Staff with Hierarchical Skills and Weekly Rotation Shifts

The paper aims to schedule check-in staff with hierarchical skills as well as day and night shifts in weekly rotation.That shift ensures staff work at day in a week and at night for the next week.The existing approaches do not deal with the shift constraint.To address this,the proposed algorithm firstly guarantees the day and night shifts by designing a data copy tactic,and then introduces two algorithms to generate staff assignment in a polynomial time.The first algorithm is to yield an initial solution efficiently,whereas the second incrementally updates that solution to cut off working hours.The key idea of the two algorithms is to utilize a block Gibbs sampling with replacement to simultaneously exchange multiple staff assignment.Experimental results indicate that the proposed algorithm reduces at least 15.6 total working hours than the baselines.

Evaluation of Adherence to Nevirapine for Prevention of Mother-to-Child Transmission amongst Infants of HIV Positive Mothers in the First 6 Weeks of Life in Lagos Nigeria

Background: Over 90% of infection in children is acquired through mother to child transmission (MTCT). Nevirapine’s efficacy, safety and affordable cost make it the most preferred non-nucleoside reverse transcriptase inhibitor (NNRTI) for paediatric prophylactic use in resource limited settings. There are very few studies on pediatric adherence to antiretroviral prophylaxis, especially in very young infants. The objective of the study was to evaluate the adherence to nevirapine for prevention of mother to child transmission (PMTCT) amongst infants of HIV positive mothers in the first 6 weeks of life. Methods: This was a questionnaire based prospective cross-sectional multicenter study initiated in July 2015 and concluded in December 2017. The study was carried out at the Aids Prevention in Nigeria (APIN/HIV) human immunodeficiency paediatric clinics of the Lagos University Teaching Hospital (LUTH), Idi-Araba, Lagos State, 68 Nigerian Army Reference Hospital Yaba (68NARHY) Lagos, Nigeria and the Holy Family Catholic Hospital, Festac Town, Amuwo Odofin, Lagos State. Nevirapine adherence, in infants of 0 - 6 weeks was measured by maternal verbal reports. Results: Eighty-one (81) infants receiving nevirapine within the age of 0 - 6 weeks completed the study. Majority of the infants started treatment at birth (32%) and after 4 weeks (31%). 54% of the 81 respondents do not miss or skip their doses while 46% of respondents skip doses. Majority of the respondents 18 (49%) missed their doses for 24 - 48 hours while 25% missed their doses because they were away from home and 23% ran out of pills. 85.2% took ≥95% of the prescribed medications (good or high adherence ), 8.2% took 80% - 95% of doses (moderate adherence) while 6.2% took 0.05). Conclusions: The adherence rates found in this study are comparable to other studies in developing countries. But these rates are still low for good clinical outcomes. Different levels of adherence were documented with the majority having good or high adherence. Not all of the infants started treatment at birth and Institutional delivery should be encouraged to improve early initiation of prophylaxis. The finding of patients with low adherence rates among the study population calls for intensification of counselling on adherence and should continue to be an integral part of prevention of mother to child transmission. Improved access to antiretroviral agents and improved care delivery systems are important.

International Wedding & Evening Dress Week Inaugurated in Chaozhou

On November 10, China （Chaozhou） International Wedding ＆ Evening Dress Week, sponsored by the China National Garment Association and the China Fashion Association, was inaugurated in Chaozhou.

Did weekly economic index and volatility index impact US food sales during the first year of the pandemic?

We explore the impacts of economic and financial dislocations caused by COVID-19 pandemic shocks on food sales in the United States from January 2020 to January 2021.We use the US weekly economic index(WEI)to measure economic dislocations and the Chicago Board Options Exchange volatility index(VIX)to capture the broader stock market dislocations.We validate the NARDL model by testing a battery of models using the autoregressive distributed lags(ARDL)methodology(ARDL,NARDL,and QARDL specifications).Our study postulates that an increase in WEI has a significant negative long-term effect on food sales,whereas a decrease in WEI has no statistically significant(long-run)effect.Thus,policy responses that ignore asymmetric effects and hidden cointegration may fail to promote food security during pandemics.

Exenatide once weekly combined with metformin reduced glycemic variability in type 2 diabetes by using flash glucose monitoring system

BACKGROUND Multiple studies demonstrate that fluctuating blood glucose level produces greater damage compared with sustained hyperglycemia.Flash glucose monitoring system is an effective method in documenting blood glucose variability,contributing to better glucose management and reduced hypoglycemic event occurrence.AIM To investigate the improvement in glycemic variability(GV),blood glucose level,and metabolic indexes of patients with type 2 diabetes mellitus after combined treatment of exenatide once weekly(EXQW)and metformin.METHODS Twenty-five patients with type 2 diabetes mellitus suffering from poor blood glucose control under metformin treatment were recruited.The recruited patients were prescribed with oral metformin only(maintaining a dosage of metformin at≥1500 mg/day)for 2 wk(screening period),and then given EXQW(2 mg,subcutaneous injection)for 12 wk(experimental period).The flash glucose monitoring system was used to document blood glucose values during the screening period and the last 2 wk of the experimental period.RESULTS Four patients were excluded for various reasons,yielding a total of 21 patients,including 17 males and 4 females,with an average age of 48.8 years,who completed this study.The estimated glycated hemoglobin,mean blood glucose,fasting and postprandial blood glucose levels,and percentage of blood glucose above 7.8 mmol/L decreased compared to those at baseline(P=0.003,0.003,0.008,0.010,0.014,0.017,and 0.005,respectively),while the percentage of blood glucose between 3.9 and 7.8 mmol/L significantly increased(P=0.005).Parameters of GV including standard deviation of blood glucose,mean amplitude of glycemic excursions,mean of daily difference,area under the curve difference between percentiles 25 and 75,and area under the curve difference between percentiles 10 and 90 were significantly lower compared to that of baseline(P=0.017,0.006,0.000,0.024,0.036,respectively).The durations of blood glucose below 3.9 mmol/L during the day and nocturnal periods significantly increased after treatment(P=0.041 and 0.028,respectively),but there was no significant increase in severe hypoglycemia(<3.0 mmol/L)compared with that at baseline(P=0.207).In addition,some metabolic indicators improved after EXQW treatment.CONCLUSION EXQW combined with metformin can effectively improve blood glucose levels,reduce GV,and improve metabolic indicators.However,there is still a risk of nocturnal hypoglycemia,and careful attention should be paid to patients with EXQW treatment.

Swiss Innovation Week 2019:Home of Drones,the New High Flyer of Swiss Industry

Following the successful Swiss Innovation Week(SIW)held in July 2018,the Embassy of Switzerland in China launches its 2nd edition from 12 to 14of June 2019.With Swiss drones as the brand-new theme,Switzerland’s drone ecosystem and innovation in the field of flying robots were present.According to various rankings,Switzerland is one of the most innovative countrie s in the world and also one of the most competitive co untries.

China Beyond Your Imagination Special Event of 2019 China Tourism and Culture Week in Suzhou

Special Event of China Tourism and Culture Week in Suzhou had its official opening at Pan Pacific Suzhou Hotel on the morning of May 1 7, 20 1 9, which was co-sponsored by the Network of International Culturalink Entities and the Center for Establishment & Management of Overseas Cultural Facilities, Ministry of Culture and Tourism, together with the People s Government of Suzhou Municipality and Suzhou Culture, Radio, Television and Tourism Bureau.

China Tourism and Culture Week Kicks off in Toronto

The China Tourism and Culture Week kicked off in Toronto on June 15 to showcase China's landscapes, culture and food, attracting hundreds of visitors.