Objective:To investigate the effect of Wei’s triple nine needling therapy on the N2-P2 wave of the flash visual evoked potential(FVEP)in rats of the of the transverse directional pulling model.Methods:Thirty-six Wist...Objective:To investigate the effect of Wei’s triple nine needling therapy on the N2-P2 wave of the flash visual evoked potential(FVEP)in rats of the of the transverse directional pulling model.Methods:Thirty-six Wistar rats were randomly grouped,nine were in normal control group without any treatment,and the remaining 27 were surgically modelled in the right eyes.Eighteen of these rats were randomly divided into a Wei’s triple nine needling therapy group and a model group of nine rats each after the TON model was made using the transverse quantitative retraction method.The other 9 rats were sham-operated,and only the optic nerve was exposed without retraction.On the next day of modelling,the Wei’s triple nine needling therapy group was treated with Wei’s triple nine needling therapy for 20 minutes/1 time/1 day for 14 days.The model group,sham-operated group and normal control group were not intervened.Wei's triple nine acupoints were represented as follows:1st link:"Jingming"(BL1)and"Chengqi"(ST1);2nd link:"Sizhukong"(SJ23)penetrating"Taiyang"(EX-HN5);and the third:"Fengchi"(GB 20)and"Taichong"(LV3).The FVEP of each group was observed on 1d,7d and 14d.The FVEP of each group was observed on 1d,7d and 14d.Results:Compared with the model group,the N2 wave latency and P2 wave latency were shortened in the Wei’s triple nine needling therapy on 1d(P<0.05,P<0.01);on 7d,their N2 wave latency was shortened(P<0.01)and the N2-P2 wave amplitude was increased compared with the model group(P<0.05);on 14d,their P2 wave latency was shortened(P<0.05)and the N2-P2 wave amplitude was increased.There was no statistical difference in N2 wave latency,P2 wave latency and N2-P2 wave amplitude in the sham-operated group on 1d,7d and 14d(P>0.05).The delayed N2 and P2 wave latencies in the model group did not improve from 1d to 14d(P>0.05)and the amplitude decreased throughout,showing a significant difference on 14d compared to 1d(P<0.05).In contrast,the N2 wave latency in Wei’s triple nine needling therapy group was not significantly different until 7d to 14d(P<0.05);its P2 wave latency,although significantly delayed from 1d to 7d(P<0.05),recovered on 14d and reached a level that was not statistically different from 1d and 7d(P>0.05).There was also no significant decrease in N2-P2 wave amplitude between 1d and 14d in Wei’s triple nine needling therapy group(P>0.05).Conclusion:In this experiment,the TON rat model was successfully established by the transverse quantitative retraction method,and the treatment of TON rats with Wei’s triple nine needling therapy reduced the P2 wave delay of the FVEP electrophysiological signal and increased the N2-P2 amplitude,which had a certain positive effect on the repair of optic nerve injury,probably related to its effect of improving the conduction function of the optic nerve and protecting the retinal ganglion cells that had not been degenerated and necrosed.展开更多
目的:观察中医“三联疗法”治疗中风后假性球麻痹吞咽障碍的临床疗效。方法:将80例中风后假性球麻痹吞咽障碍患者按照随机数字表法分为观察组和对照组,每组各40例。两组患者均给予常规西药治疗,对照组给予康复功能训练,观察组在对照组...目的:观察中医“三联疗法”治疗中风后假性球麻痹吞咽障碍的临床疗效。方法:将80例中风后假性球麻痹吞咽障碍患者按照随机数字表法分为观察组和对照组,每组各40例。两组患者均给予常规西药治疗,对照组给予康复功能训练,观察组在对照组治疗的基础上采用中医“三联疗法”,包括舌根透针法、穴位贴敷、冰片柠檬冰棒咽部冷刺激等。比较两组患者的临床疗效及治疗前后日常生活活动能力(activities of daily living,ADL)评分、标准吞咽功能评定量表(standardized swallowing assessment,SSA)评分、美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)评分、血清前白蛋白水平。结果:观察组有效率为95.0%,对照组有效率为75.0%,两组患者有效率比较,差异具有统计学意义(P<0.05)。两组患者治疗后SSA评分低于本组治疗前,且治疗后观察组低于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后ADL评分高于本组治疗前,且治疗后观察组高于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后NIHSS评分低于本组治疗前,血清前白蛋白水平高于本组治疗前,治疗后观察组NIHSS评分低于对照组,血清前白蛋白水平高于对照组,差异均有统计学意义(P<0.05)。结论:中医“三联疗法”治疗中风后假性球麻痹吞咽障碍,可改善患者的临床症状及营养状况,提高其生活质量,促进神经功能的恢复。展开更多
基金National Natural Science Foundation of China(No.81904258)。
文摘Objective:To investigate the effect of Wei’s triple nine needling therapy on the N2-P2 wave of the flash visual evoked potential(FVEP)in rats of the of the transverse directional pulling model.Methods:Thirty-six Wistar rats were randomly grouped,nine were in normal control group without any treatment,and the remaining 27 were surgically modelled in the right eyes.Eighteen of these rats were randomly divided into a Wei’s triple nine needling therapy group and a model group of nine rats each after the TON model was made using the transverse quantitative retraction method.The other 9 rats were sham-operated,and only the optic nerve was exposed without retraction.On the next day of modelling,the Wei’s triple nine needling therapy group was treated with Wei’s triple nine needling therapy for 20 minutes/1 time/1 day for 14 days.The model group,sham-operated group and normal control group were not intervened.Wei's triple nine acupoints were represented as follows:1st link:"Jingming"(BL1)and"Chengqi"(ST1);2nd link:"Sizhukong"(SJ23)penetrating"Taiyang"(EX-HN5);and the third:"Fengchi"(GB 20)and"Taichong"(LV3).The FVEP of each group was observed on 1d,7d and 14d.The FVEP of each group was observed on 1d,7d and 14d.Results:Compared with the model group,the N2 wave latency and P2 wave latency were shortened in the Wei’s triple nine needling therapy on 1d(P<0.05,P<0.01);on 7d,their N2 wave latency was shortened(P<0.01)and the N2-P2 wave amplitude was increased compared with the model group(P<0.05);on 14d,their P2 wave latency was shortened(P<0.05)and the N2-P2 wave amplitude was increased.There was no statistical difference in N2 wave latency,P2 wave latency and N2-P2 wave amplitude in the sham-operated group on 1d,7d and 14d(P>0.05).The delayed N2 and P2 wave latencies in the model group did not improve from 1d to 14d(P>0.05)and the amplitude decreased throughout,showing a significant difference on 14d compared to 1d(P<0.05).In contrast,the N2 wave latency in Wei’s triple nine needling therapy group was not significantly different until 7d to 14d(P<0.05);its P2 wave latency,although significantly delayed from 1d to 7d(P<0.05),recovered on 14d and reached a level that was not statistically different from 1d and 7d(P>0.05).There was also no significant decrease in N2-P2 wave amplitude between 1d and 14d in Wei’s triple nine needling therapy group(P>0.05).Conclusion:In this experiment,the TON rat model was successfully established by the transverse quantitative retraction method,and the treatment of TON rats with Wei’s triple nine needling therapy reduced the P2 wave delay of the FVEP electrophysiological signal and increased the N2-P2 amplitude,which had a certain positive effect on the repair of optic nerve injury,probably related to its effect of improving the conduction function of the optic nerve and protecting the retinal ganglion cells that had not been degenerated and necrosed.
文摘目的:观察中医“三联疗法”治疗中风后假性球麻痹吞咽障碍的临床疗效。方法:将80例中风后假性球麻痹吞咽障碍患者按照随机数字表法分为观察组和对照组,每组各40例。两组患者均给予常规西药治疗,对照组给予康复功能训练,观察组在对照组治疗的基础上采用中医“三联疗法”,包括舌根透针法、穴位贴敷、冰片柠檬冰棒咽部冷刺激等。比较两组患者的临床疗效及治疗前后日常生活活动能力(activities of daily living,ADL)评分、标准吞咽功能评定量表(standardized swallowing assessment,SSA)评分、美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)评分、血清前白蛋白水平。结果:观察组有效率为95.0%,对照组有效率为75.0%,两组患者有效率比较,差异具有统计学意义(P<0.05)。两组患者治疗后SSA评分低于本组治疗前,且治疗后观察组低于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后ADL评分高于本组治疗前,且治疗后观察组高于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后NIHSS评分低于本组治疗前,血清前白蛋白水平高于本组治疗前,治疗后观察组NIHSS评分低于对照组,血清前白蛋白水平高于对照组,差异均有统计学意义(P<0.05)。结论:中医“三联疗法”治疗中风后假性球麻痹吞咽障碍,可改善患者的临床症状及营养状况,提高其生活质量,促进神经功能的恢复。
