Objective:To explore the effect of Jianpi Wenshen Granules on the Controlling Nutritional Status(CONUT)score in elderly patients undergoing maintenance hemodialysis.Methods:Seventy elderly outpatients undergoing maint...Objective:To explore the effect of Jianpi Wenshen Granules on the Controlling Nutritional Status(CONUT)score in elderly patients undergoing maintenance hemodialysis.Methods:Seventy elderly outpatients undergoing maintenance hemodialysis from January 2023 to January 2024 at the Blood Purification Centers of Taizhou Traditional Chinese Medicine Hospital and Taizhou Second People’s Hospital were selected as the study subjects.The patients were randomly divided into two groups:the study group and the control group,with 35 patients in each group.Both groups received maintenance hemodialysis,while the control group received only conventional Western medicine treatment,and the study group was additionally treated with Jianpi Wenshen Granules.The changes in biochemical and inflammatory markers before and after treatment were compared between the two groups.The nutritional status of the patients was assessed using the Controlling Nutritional Status(CONUT)score,and detailed statistics were gathered on anemia and albumin levels in both groups.Results:After treatment,the CONUT score in the study group significantly decreased compared to the control group,showing a significant correlation(P<0.05).Albumin and hemoglobin levels significantly increased,with a notable difference(P<0.05).There were no significant differences in alanine aminotransferase and aspartate aminotransferase levels between the two groups before and after treatment(P>0.05).Conclusion:In elderly patients undergoing maintenance hemodialysis,Jianpi Wenshen Granules improve the CONUT score and enhance nutritional status,demonstrating potential for clinical application and promotion.展开更多
[Objectives]To establish the quality standard of Fuyang Wenshen Granules and carry out the routine examination of granule type.[Methods]The particle size,water content,solubility,loading difference and microbial limit...[Objectives]To establish the quality standard of Fuyang Wenshen Granules and carry out the routine examination of granule type.[Methods]The particle size,water content,solubility,loading difference and microbial limit of Fuyang Wenshen Granules were examined,and TLC was used for qualitative identification of Astmgali Radix and Notoginseng Radix Et Rhizoma.[Results]The particle size,water content,solubility,loading difference,and microbial limit of Fuyang Wenshen Granules complied with the relevant provisions of the Pharmacopoeia of the People's Republic of China(2020).The TLC spots of Astmgali Radix and Notoginseng Radix Et Rhizoma were clearly colored,and negative had no interference.[Conclusions]The method was simple,accurate,reliable,specific and reproducible,and can effectively control the quality of Fuyang Wenshen Granules.展开更多
目的:探究温肾汤治疗慢性肾功能不全脾肾阳虚证的效果及其对肾脏纤维化的影响。方法:选择符合纳入标准的慢性肾功能不全脾肾阳虚证患者96例,依据随机数字表随机分为对照组和观察组。对照组采用常规西药治疗,观察组在对照组基础上口服温...目的:探究温肾汤治疗慢性肾功能不全脾肾阳虚证的效果及其对肾脏纤维化的影响。方法:选择符合纳入标准的慢性肾功能不全脾肾阳虚证患者96例,依据随机数字表随机分为对照组和观察组。对照组采用常规西药治疗,观察组在对照组基础上口服温肾汤治疗,2周为1个疗程,两组均治疗2个疗程。比较治疗前后两组患者中医症状评分(畏寒肢冷、面浮肢肿、神疲乏力、食少纳呆、腰膝畏寒和脘腹胀痛)、肾功能相关损伤指标(24 h Pro、BUN、Ccr和GFR)及肾纤维化相关指标(CTGF、CIV、PCⅢ和BMP-7)变化情况及临床疗效。结果:对照组临床总有效率为77.1%(37/48),观察组临床总有效率为91.7%(44/48),差异有统计学意义(P<0.05);治疗后两组患者畏寒肢冷、面浮肢肿、神疲乏力、食少纳呆、腰膝畏寒和脘腹胀痛的中医症状评分均较治疗前显著降低(P<0.05),且观察组改善程度优于对照组(P<0.05);治疗后两组患者24 h Pro、BUN水平均较治疗前显著降低(P<0.05),Ccr、GFR水平显著升高(P<0.05),且观察组改善程度优于对照组(P<0.05);治疗后两组患者CTGF、CIV及PCⅢ水平较治疗前明显降低(P<0.05),BMP-7水平明显升高(P<0.05),且观察组改善程度优于对照组(P<0.05)。结论:温肾汤可以有效改善慢性肾功能不全脾肾阳虚证患者的肾功能,降低蛋白尿,显著抑制肾脏纤维化。展开更多
目的探讨温肾强督方对强直性脊柱炎患者骨代谢及炎症细胞因子的影响。方法将医院强直性脊柱炎患者71例随机分组,对照组34例采用柳氮磺吡啶、双氯芬酸钠治疗;在此基础上,观察组37例采用温肾强督方治疗,每日1剂,持续治疗8周。比较两组临...目的探讨温肾强督方对强直性脊柱炎患者骨代谢及炎症细胞因子的影响。方法将医院强直性脊柱炎患者71例随机分组,对照组34例采用柳氮磺吡啶、双氯芬酸钠治疗;在此基础上,观察组37例采用温肾强督方治疗,每日1剂,持续治疗8周。比较两组临床疗效,记录血肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、血沉(erythrocyte sedimentation rate,ESR)、C反应蛋白(C-reactive protein,CRP)、骨钙素(osteocalcin,BGP)、I型胶原C末端肽(C-terminal peptide of type I collagen,CTX)、骨碱性磷酸酶(Bone alkaline phosphatase,BALP)及腰椎L 1-4、股骨颈的骨密度。结果与对照组比,观察组治疗后血TNF-α、ESR及CRP水平较低,血BGP、BALP水平较高,血清CTX水平较低,腰椎、股骨颈骨密度较高,差异有统计学意义(P<0.05)。对照组有效率76.47%低于观察组94.59%,差异有统计学意义(P<0.05)。两组不良反应比较,差异无统计学意义(P>0.05)。结论温肾强督方对强直性脊柱炎患者的疗效显著,通过改善骨代谢和炎症细胞因子,以避免骨质流失,值得推广。展开更多
OBJECTIVE:To primarily explore the effect and mechanism of Wenshen Yangxue decoction(温肾养血方)in promoting follicular development in elderly female mice.METHODS:Fifty Institute of Cancer Research mice were randomly ...OBJECTIVE:To primarily explore the effect and mechanism of Wenshen Yangxue decoction(温肾养血方)in promoting follicular development in elderly female mice.METHODS:Fifty Institute of Cancer Research mice were randomly divided into blank,controlled ovarian hyperstimulation(COH),low-dose Wenshen Yangxue decoction,medium-dose Wenshen Yangxue decoction,and high-dose Wenshen Yangxue decoction groups,with 10 mice in each group.The number of ovulations,number of fertilizations,mitochondrial adenosine triphosphate(ATP)level,and mitochondrial DNA(mt DNA)of oocytes in each group were compared.Reverse transcriptionpolymerase chain reaction and Western blotting were used to detect the m RNA and protein expression levels of silent information regulator 3(Sirt3)and forkhead transcription factor O13a(FOXO3a).RESULTS:Wenshen Yangxue decoction significantly increased the number of ovulations in mice(P<0.05)and promoted the formation of fertilized eggs.The ATP level and mt DNA copy number of mice oocytes in the highdose groups were significantly higher than those in the COH group(P<0.05).Wenshen Yangxue decoction significantly increased the m RNA and protein levels of Sirt3 and FOXO3a in mouse oocytes.CONCLUSION:Wenshen Yangxue decoction promoted the development of follicles in elderly female mice,increased the number of ovulations and improved fertility.Its mechanism may be related to increased mitochondrial energy metabolism and regulation of the Sirt3/FOXO3a pathway.展开更多
基金Taizhou Traditional Chinese Medicine Science and Technology Development Project(Project No.TZ202207)。
文摘Objective:To explore the effect of Jianpi Wenshen Granules on the Controlling Nutritional Status(CONUT)score in elderly patients undergoing maintenance hemodialysis.Methods:Seventy elderly outpatients undergoing maintenance hemodialysis from January 2023 to January 2024 at the Blood Purification Centers of Taizhou Traditional Chinese Medicine Hospital and Taizhou Second People’s Hospital were selected as the study subjects.The patients were randomly divided into two groups:the study group and the control group,with 35 patients in each group.Both groups received maintenance hemodialysis,while the control group received only conventional Western medicine treatment,and the study group was additionally treated with Jianpi Wenshen Granules.The changes in biochemical and inflammatory markers before and after treatment were compared between the two groups.The nutritional status of the patients was assessed using the Controlling Nutritional Status(CONUT)score,and detailed statistics were gathered on anemia and albumin levels in both groups.Results:After treatment,the CONUT score in the study group significantly decreased compared to the control group,showing a significant correlation(P<0.05).Albumin and hemoglobin levels significantly increased,with a notable difference(P<0.05).There were no significant differences in alanine aminotransferase and aspartate aminotransferase levels between the two groups before and after treatment(P>0.05).Conclusion:In elderly patients undergoing maintenance hemodialysis,Jianpi Wenshen Granules improve the CONUT score and enhance nutritional status,demonstrating potential for clinical application and promotion.
基金Supported by Project of Guangxi Clinical Research Center of Traditional Chinese Medicine Encephalopathy(GUIKE AD20238028)High-level Innovation Team and Outstanding Scholar Program of Guangxi Colleges and Universities[GUIJIAORENCAI(2020)6]+1 种基金Academic Team Construction Project of the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine[YUANZI(2018)146]Key Discipline Construction Project of Guangxi Traditional Chinese Medicine(GZXK-Z-20-13)。
文摘[Objectives]To establish the quality standard of Fuyang Wenshen Granules and carry out the routine examination of granule type.[Methods]The particle size,water content,solubility,loading difference and microbial limit of Fuyang Wenshen Granules were examined,and TLC was used for qualitative identification of Astmgali Radix and Notoginseng Radix Et Rhizoma.[Results]The particle size,water content,solubility,loading difference,and microbial limit of Fuyang Wenshen Granules complied with the relevant provisions of the Pharmacopoeia of the People's Republic of China(2020).The TLC spots of Astmgali Radix and Notoginseng Radix Et Rhizoma were clearly colored,and negative had no interference.[Conclusions]The method was simple,accurate,reliable,specific and reproducible,and can effectively control the quality of Fuyang Wenshen Granules.
文摘目的:探究温肾汤治疗慢性肾功能不全脾肾阳虚证的效果及其对肾脏纤维化的影响。方法:选择符合纳入标准的慢性肾功能不全脾肾阳虚证患者96例,依据随机数字表随机分为对照组和观察组。对照组采用常规西药治疗,观察组在对照组基础上口服温肾汤治疗,2周为1个疗程,两组均治疗2个疗程。比较治疗前后两组患者中医症状评分(畏寒肢冷、面浮肢肿、神疲乏力、食少纳呆、腰膝畏寒和脘腹胀痛)、肾功能相关损伤指标(24 h Pro、BUN、Ccr和GFR)及肾纤维化相关指标(CTGF、CIV、PCⅢ和BMP-7)变化情况及临床疗效。结果:对照组临床总有效率为77.1%(37/48),观察组临床总有效率为91.7%(44/48),差异有统计学意义(P<0.05);治疗后两组患者畏寒肢冷、面浮肢肿、神疲乏力、食少纳呆、腰膝畏寒和脘腹胀痛的中医症状评分均较治疗前显著降低(P<0.05),且观察组改善程度优于对照组(P<0.05);治疗后两组患者24 h Pro、BUN水平均较治疗前显著降低(P<0.05),Ccr、GFR水平显著升高(P<0.05),且观察组改善程度优于对照组(P<0.05);治疗后两组患者CTGF、CIV及PCⅢ水平较治疗前明显降低(P<0.05),BMP-7水平明显升高(P<0.05),且观察组改善程度优于对照组(P<0.05)。结论:温肾汤可以有效改善慢性肾功能不全脾肾阳虚证患者的肾功能,降低蛋白尿,显著抑制肾脏纤维化。
文摘目的探讨温肾强督方对强直性脊柱炎患者骨代谢及炎症细胞因子的影响。方法将医院强直性脊柱炎患者71例随机分组,对照组34例采用柳氮磺吡啶、双氯芬酸钠治疗;在此基础上,观察组37例采用温肾强督方治疗,每日1剂,持续治疗8周。比较两组临床疗效,记录血肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、血沉(erythrocyte sedimentation rate,ESR)、C反应蛋白(C-reactive protein,CRP)、骨钙素(osteocalcin,BGP)、I型胶原C末端肽(C-terminal peptide of type I collagen,CTX)、骨碱性磷酸酶(Bone alkaline phosphatase,BALP)及腰椎L 1-4、股骨颈的骨密度。结果与对照组比,观察组治疗后血TNF-α、ESR及CRP水平较低,血BGP、BALP水平较高,血清CTX水平较低,腰椎、股骨颈骨密度较高,差异有统计学意义(P<0.05)。对照组有效率76.47%低于观察组94.59%,差异有统计学意义(P<0.05)。两组不良反应比较,差异无统计学意义(P>0.05)。结论温肾强督方对强直性脊柱炎患者的疗效显著,通过改善骨代谢和炎症细胞因子,以避免骨质流失,值得推广。
基金Supported by Grants from the Beijing Natural Science Foundation:Study on the Effect of Wenshen Yangxue Recipe on Improving the Quality of Oocytes in Aged Female Mice based on Sirt3/FoxO3a Pathway(No.7192068)National Natural Science Foundation of China:Research on the Pathogenesis of Methyl Group Deletion Caused by One Novel Mutation of BRCA2 Gene in Patients from Families at Risk of Hereditary Ovarian Cancer and Breast Cancer(No.8972444)
文摘OBJECTIVE:To primarily explore the effect and mechanism of Wenshen Yangxue decoction(温肾养血方)in promoting follicular development in elderly female mice.METHODS:Fifty Institute of Cancer Research mice were randomly divided into blank,controlled ovarian hyperstimulation(COH),low-dose Wenshen Yangxue decoction,medium-dose Wenshen Yangxue decoction,and high-dose Wenshen Yangxue decoction groups,with 10 mice in each group.The number of ovulations,number of fertilizations,mitochondrial adenosine triphosphate(ATP)level,and mitochondrial DNA(mt DNA)of oocytes in each group were compared.Reverse transcriptionpolymerase chain reaction and Western blotting were used to detect the m RNA and protein expression levels of silent information regulator 3(Sirt3)and forkhead transcription factor O13a(FOXO3a).RESULTS:Wenshen Yangxue decoction significantly increased the number of ovulations in mice(P<0.05)and promoted the formation of fertilized eggs.The ATP level and mt DNA copy number of mice oocytes in the highdose groups were significantly higher than those in the COH group(P<0.05).Wenshen Yangxue decoction significantly increased the m RNA and protein levels of Sirt3 and FOXO3a in mouse oocytes.CONCLUSION:Wenshen Yangxue decoction promoted the development of follicles in elderly female mice,increased the number of ovulations and improved fertility.Its mechanism may be related to increased mitochondrial energy metabolism and regulation of the Sirt3/FOXO3a pathway.
