Objective:To systematically evaluate the effect of Yiqi Wenyang Huoxue therapy in treating diabetic kidney disease(DKD)of stage III-IV.Method:The relevant literature was retrieved by computer from CNKI,Wanfang and VIP...Objective:To systematically evaluate the effect of Yiqi Wenyang Huoxue therapy in treating diabetic kidney disease(DKD)of stage III-IV.Method:The relevant literature was retrieved by computer from CNKI,Wanfang and VIP databases,CBM,PubMed,EMBase,Cochrane Library and Web of Science.Articles screening and data extraction were performed by two researchers separately and independently.The Meta-analysis was conducted with RevMan 5.3.Results:A total of 10 randomized controlled trials were collected,including 778 cases with DKD.Meta-analysis showed that the Yiqi Wenyang Huoxue Method combined with western medicine basic treatment could reduce 24hUTP[MD=-0.36,95%CI(-0.46,-0.26),P<0.00001],UAER[MD=-36.72,95%CI(-47.21,-26.23),P<0.00001],Scr[MD=-16.28,95%CI(-20.59,-11.97),P<0.00001],BUN[MD=-1.45,95%CI(-1.76,-1.14),P<0.00001],TC[MD=-0.64,95%CI(-1.07,-0.21),P=0.004].There was also a reduction in HbA1c[MD=-0.50,95%CI(-0.94,-0.05),P=0.03],but the difference is not significant.Conclusion:Based on the current evidence,for the treatment of DKD of stage III-IV,basic western medicine treatment combined with Yiqi Wenyang Huoxue method may better reduce urine protein,total cholesterol levels and improve renal function.The conclusion of this study needs to be further researched by high-quality studies,because that the quality of the included studies is generally low.展开更多
目的 探讨益气温阳补肾方加减治疗老年高血压脾肾阳虚证的临床效果。方法 选取2021年12月—2022年11月期间青岛市中医医院收治的脾肾阳虚证老年高血压患者98例,采用随机数字表法分为对照组和试验组,每组各49例。对照组给予常规西药降压...目的 探讨益气温阳补肾方加减治疗老年高血压脾肾阳虚证的临床效果。方法 选取2021年12月—2022年11月期间青岛市中医医院收治的脾肾阳虚证老年高血压患者98例,采用随机数字表法分为对照组和试验组,每组各49例。对照组给予常规西药降压治疗,试验组在对照组基础上联合益气温阳补肾方加减治疗,两组患者均治疗4周。观察比较两组患者临床疗效、治疗安全性,治疗前后中医证候积分、血压[收缩压(Systolic blood pressure,SBP)、舒张压(Diastolic blood pressure,DBP)、脉压(Pulse pressure,PP)、24 h SBP、24 h DBP]水平、血管内皮功能指标[内皮素-1(Endothelin-1,ET-1)、一氧化氮(Nitric oxide,NO)、血栓素A2(Thrombin A2,TXA_(2))]水平。结果 (1)临床疗效:治疗后试验组总有效率95.92%(47/49)明显高于对照组81.25%(39/48),差异有统计学意义(P<0.05)。(2)中医证候积分:治疗后两组患者中医证候各项症状积分均较治疗前降低,差异有统计学意义(P<0.05);且试验组中医证候各项症状积分均明显低于对照组,差异有统计学意义(P<0.05)。(3)血压监测水平:治疗后两组患者SBP、DBP、PP、24 h SBP、24 h DBP水平均较治疗前降低,差异有统计学意义(P<0.05);且试验组SBP、DBP、PP、24 h SBP、24 h DBP水平均明显低于对照组,差异有统计学意义(P<0.05)。(4)血管内皮功能水平:治疗后两组患者血清ET-1、TXA_(2)均较治疗前降低,NO较治疗前升高,差异有统计学意义(P<0.05);且试验组ET-1、TXA_(2)均明显低于对照组,NO明显高于对照组,差异有统计学意义(P<0.05)。(5)安全性:治疗期间,两组患者均未发生严重或影响治疗的不良反应,仅对照组出现1例轻度潮红,未给予干预自行缓解。结论 益气温阳补肾方加减治疗老年高血压脾肾阳虚证效果显著,安全性高,有利于控制患者血压水平,且可能与调节血管内皮功能有关。展开更多
目的系统全面地评价益气温阳方治疗变应性鼻炎的临床效果。方法利用个人计算机查询CNKI、万方、维普、Pubmed、Web of science数据库中的资料,再利NoteExpress软件对资料进行整理和筛选,使用Review Manager5.3软件对数据进行Meta分析。...目的系统全面地评价益气温阳方治疗变应性鼻炎的临床效果。方法利用个人计算机查询CNKI、万方、维普、Pubmed、Web of science数据库中的资料,再利NoteExpress软件对资料进行整理和筛选,使用Review Manager5.3软件对数据进行Meta分析。检索时间:数据库建库至今。纳入益气温阳方治疗变应性鼻炎临床疗效的随机对照试验,对纳入文献的总有效率、症状总评分(TNSS)、嗜酸性粒细胞(EOS)表达水平进行Meta分析。结果总共纳入5篇益气温阳方治疗变应性鼻炎的随机对照试验。益气温阳方治疗变应性鼻炎的总有效率[OR=5.25,95%CI:(2.98,9.24),P<0.00001]、症状总评分[MD=-1.51,95%CI:(-2.01,-1.01),P<0.00001]、嗜酸性粒细胞表达水平[MD=-5.12,95%CI:(-13.86,3.62),P=0.25]。结论益气温阳方能够改善变应性鼻炎患者的临床症状,提高治疗总有效率,具有更好的临床疗效。展开更多
基金National Natural Science Foundation of China(No.81973801)。
文摘Objective:To systematically evaluate the effect of Yiqi Wenyang Huoxue therapy in treating diabetic kidney disease(DKD)of stage III-IV.Method:The relevant literature was retrieved by computer from CNKI,Wanfang and VIP databases,CBM,PubMed,EMBase,Cochrane Library and Web of Science.Articles screening and data extraction were performed by two researchers separately and independently.The Meta-analysis was conducted with RevMan 5.3.Results:A total of 10 randomized controlled trials were collected,including 778 cases with DKD.Meta-analysis showed that the Yiqi Wenyang Huoxue Method combined with western medicine basic treatment could reduce 24hUTP[MD=-0.36,95%CI(-0.46,-0.26),P<0.00001],UAER[MD=-36.72,95%CI(-47.21,-26.23),P<0.00001],Scr[MD=-16.28,95%CI(-20.59,-11.97),P<0.00001],BUN[MD=-1.45,95%CI(-1.76,-1.14),P<0.00001],TC[MD=-0.64,95%CI(-1.07,-0.21),P=0.004].There was also a reduction in HbA1c[MD=-0.50,95%CI(-0.94,-0.05),P=0.03],but the difference is not significant.Conclusion:Based on the current evidence,for the treatment of DKD of stage III-IV,basic western medicine treatment combined with Yiqi Wenyang Huoxue method may better reduce urine protein,total cholesterol levels and improve renal function.The conclusion of this study needs to be further researched by high-quality studies,because that the quality of the included studies is generally low.
文摘目的 探讨益气温阳补肾方加减治疗老年高血压脾肾阳虚证的临床效果。方法 选取2021年12月—2022年11月期间青岛市中医医院收治的脾肾阳虚证老年高血压患者98例,采用随机数字表法分为对照组和试验组,每组各49例。对照组给予常规西药降压治疗,试验组在对照组基础上联合益气温阳补肾方加减治疗,两组患者均治疗4周。观察比较两组患者临床疗效、治疗安全性,治疗前后中医证候积分、血压[收缩压(Systolic blood pressure,SBP)、舒张压(Diastolic blood pressure,DBP)、脉压(Pulse pressure,PP)、24 h SBP、24 h DBP]水平、血管内皮功能指标[内皮素-1(Endothelin-1,ET-1)、一氧化氮(Nitric oxide,NO)、血栓素A2(Thrombin A2,TXA_(2))]水平。结果 (1)临床疗效:治疗后试验组总有效率95.92%(47/49)明显高于对照组81.25%(39/48),差异有统计学意义(P<0.05)。(2)中医证候积分:治疗后两组患者中医证候各项症状积分均较治疗前降低,差异有统计学意义(P<0.05);且试验组中医证候各项症状积分均明显低于对照组,差异有统计学意义(P<0.05)。(3)血压监测水平:治疗后两组患者SBP、DBP、PP、24 h SBP、24 h DBP水平均较治疗前降低,差异有统计学意义(P<0.05);且试验组SBP、DBP、PP、24 h SBP、24 h DBP水平均明显低于对照组,差异有统计学意义(P<0.05)。(4)血管内皮功能水平:治疗后两组患者血清ET-1、TXA_(2)均较治疗前降低,NO较治疗前升高,差异有统计学意义(P<0.05);且试验组ET-1、TXA_(2)均明显低于对照组,NO明显高于对照组,差异有统计学意义(P<0.05)。(5)安全性:治疗期间,两组患者均未发生严重或影响治疗的不良反应,仅对照组出现1例轻度潮红,未给予干预自行缓解。结论 益气温阳补肾方加减治疗老年高血压脾肾阳虚证效果显著,安全性高,有利于控制患者血压水平,且可能与调节血管内皮功能有关。
文摘目的系统全面地评价益气温阳方治疗变应性鼻炎的临床效果。方法利用个人计算机查询CNKI、万方、维普、Pubmed、Web of science数据库中的资料,再利NoteExpress软件对资料进行整理和筛选,使用Review Manager5.3软件对数据进行Meta分析。检索时间:数据库建库至今。纳入益气温阳方治疗变应性鼻炎临床疗效的随机对照试验,对纳入文献的总有效率、症状总评分(TNSS)、嗜酸性粒细胞(EOS)表达水平进行Meta分析。结果总共纳入5篇益气温阳方治疗变应性鼻炎的随机对照试验。益气温阳方治疗变应性鼻炎的总有效率[OR=5.25,95%CI:(2.98,9.24),P<0.00001]、症状总评分[MD=-1.51,95%CI:(-2.01,-1.01),P<0.00001]、嗜酸性粒细胞表达水平[MD=-5.12,95%CI:(-13.86,3.62),P=0.25]。结论益气温阳方能够改善变应性鼻炎患者的临床症状,提高治疗总有效率,具有更好的临床疗效。
