BACKGROUND Wernicke's encephalopathy is a disease caused by thiamine deficiency.The lesions usually involve the periphery of the aqueduct,midbrain,tectum,third ventricle,papillary body,and thalamus.It is very rare...BACKGROUND Wernicke's encephalopathy is a disease caused by thiamine deficiency.The lesions usually involve the periphery of the aqueduct,midbrain,tectum,third ventricle,papillary body,and thalamus.It is very rare to affect the vermis and cerebellar hemispheres.CASE SUMMARY We report a 77-year-old female patient admitted to the emergency department of our hospital for 2 d of unconsciousness.Brain magnetic resonance imaging showed increased diffusion weighted imaging signals in the bilateral thalamus,periventricular regions of the third ventricle,corpora quadrigemina,vermis,and cerebellar hemispheres.Wernicke's encephalopathy was considered.She was given thiamine therapy and became conscious after the treatment.CONCLUSION Wernicke's encephalopathy may have various imaging manifestations.Clinicians should keep in mind that Wernicke’s encephalopathy may occur in patients who experience prolonged periods of malnutrition.展开更多
Background:Kashmir has a population that largely consumes polished rice which is deficient in thiamine.Furthermore,lactating women in this region are prone to severe thiamine deficiency because of their traditional fo...Background:Kashmir has a population that largely consumes polished rice which is deficient in thiamine.Furthermore,lactating women in this region are prone to severe thiamine deficiency because of their traditional food avoidance practices.Infantile beriberi is common in exclusively breastfed infants of thiamine deficient mothers in Kashmir.Methods:This was a one year prospective hospitalbased study.We included 50 exclusively breastfed infants in our study.AH patients were evaluated as per unit protocol including complete septic workup and metabolic workup.Most of our patients belonged to low and middle income group families,and mothers were on customary dietary restriction.Demographic and anthropometric data were collected from all the study participants.In addition,data regarding the treatments received by the study population and overall mortality were collected.Results:The mean age,male:female ratio,and mean weight of the study population were 3.15±0.97 months,1.5∶1,and 5.1±1.1 kg,respectively.Traditional food avoidance practices were followed by 80% of the mothers.Irritability was observed in 40 (80%) patients.Blepharoptosis was observed in 30 (60%).Septic workup including cerebro spinal fluid analysis was normal in all patients.Predominant magnetic resonance imaging finding was bilateral basal ganglia hyperintensity.Whole blood thiamine diphosphate levels showed a drastic decrease (10-49 nmol/L).Ten percent of the study infants died.Conclusion:In exclusively breasffed infants,we observed acute infantile encephalopathy with epidemiological,clinical,biochemical,and radiological features suggestive of infantile Wernicke's encephalopathy and a favourable therapeutic response to thiamine supplementation during the acute stage.展开更多
To editor:Wernicke encephalopathy(WE)is an acute neurological disorder caused by a deficiency of vitamin B1(thiamine),with a prevalence of 1.3%in autopsy studies.1 Eighty-four percent of patients with WE will develop ...To editor:Wernicke encephalopathy(WE)is an acute neurological disorder caused by a deficiency of vitamin B1(thiamine),with a prevalence of 1.3%in autopsy studies.1 Eighty-four percent of patients with WE will develop Korsakoff syndrome,which is characterized by amnesia and confusion.2 Although WE is more common in alcoholics,it can also be caused by vomiting,malnourishment,and other situations.展开更多
基金the Hangzhou Science and Technology Bureau,No.20191203B84.
文摘BACKGROUND Wernicke's encephalopathy is a disease caused by thiamine deficiency.The lesions usually involve the periphery of the aqueduct,midbrain,tectum,third ventricle,papillary body,and thalamus.It is very rare to affect the vermis and cerebellar hemispheres.CASE SUMMARY We report a 77-year-old female patient admitted to the emergency department of our hospital for 2 d of unconsciousness.Brain magnetic resonance imaging showed increased diffusion weighted imaging signals in the bilateral thalamus,periventricular regions of the third ventricle,corpora quadrigemina,vermis,and cerebellar hemispheres.Wernicke's encephalopathy was considered.She was given thiamine therapy and became conscious after the treatment.CONCLUSION Wernicke's encephalopathy may have various imaging manifestations.Clinicians should keep in mind that Wernicke’s encephalopathy may occur in patients who experience prolonged periods of malnutrition.
文摘Background:Kashmir has a population that largely consumes polished rice which is deficient in thiamine.Furthermore,lactating women in this region are prone to severe thiamine deficiency because of their traditional food avoidance practices.Infantile beriberi is common in exclusively breastfed infants of thiamine deficient mothers in Kashmir.Methods:This was a one year prospective hospitalbased study.We included 50 exclusively breastfed infants in our study.AH patients were evaluated as per unit protocol including complete septic workup and metabolic workup.Most of our patients belonged to low and middle income group families,and mothers were on customary dietary restriction.Demographic and anthropometric data were collected from all the study participants.In addition,data regarding the treatments received by the study population and overall mortality were collected.Results:The mean age,male:female ratio,and mean weight of the study population were 3.15±0.97 months,1.5∶1,and 5.1±1.1 kg,respectively.Traditional food avoidance practices were followed by 80% of the mothers.Irritability was observed in 40 (80%) patients.Blepharoptosis was observed in 30 (60%).Septic workup including cerebro spinal fluid analysis was normal in all patients.Predominant magnetic resonance imaging finding was bilateral basal ganglia hyperintensity.Whole blood thiamine diphosphate levels showed a drastic decrease (10-49 nmol/L).Ten percent of the study infants died.Conclusion:In exclusively breasffed infants,we observed acute infantile encephalopathy with epidemiological,clinical,biochemical,and radiological features suggestive of infantile Wernicke's encephalopathy and a favourable therapeutic response to thiamine supplementation during the acute stage.
文摘To editor:Wernicke encephalopathy(WE)is an acute neurological disorder caused by a deficiency of vitamin B1(thiamine),with a prevalence of 1.3%in autopsy studies.1 Eighty-four percent of patients with WE will develop Korsakoff syndrome,which is characterized by amnesia and confusion.2 Although WE is more common in alcoholics,it can also be caused by vomiting,malnourishment,and other situations.
