Is tumor necrosis factor-α monoclonal therapy with proactive therapeutic drug monitoring optimized for inflammatory bowel disease? Network meta-analysis

BACKGROUND The efficacy and safety of anti-tumor necrosis factor-α(TNF-α)monoclonal antibody therapy[adalimumab(ADA)and infliximab(IFX)]with therapeutic drug monitoring(TDM),which has been proposed for inflammatory bowel disease(IBD)patients,are still controversial.AIM To determine the efficacy and safety of anti-TNF-αmonoclonal antibody therapy with proactive TDM in patients with IBD and to determine which subtype of IBD patients is most suitable for proactive TDM interventions.METHODS As of July 2023,we searched for randomized controlled trials(RCTs)and observa-tional studies in PubMed,Embase,and the Cochrane Library to compare anti-TNF-αmonoclonal antibody therapy with proactive TDM with therapy with reactive TDM or empiric therapy.Pairwise and network meta-analyses were used to determine the IBD patient subtype that achieved clinical remission and to determine the need for surgery.RESULTS This systematic review and meta-analysis yielded 13 studies after exclusion,and the baseline indicators were balanced.We found a significant increase in the number of patients who achieved clinical remission in the ADA[odds ratio(OR)=1.416,95%confidence interval(CI):1.196-1.676]and RCT(OR=1.393,95%CI:1.182-1.641)subgroups and a significant decrease in the number of patients who needed surgery in the proactive vs reactive(OR=0.237,95%CI:0.101-0.558)and IFX+ADA(OR=0.137,95%CI:0.032-0.588)subgroups,and the overall risk of adverse events was reduced(OR=0.579,95%CI:0.391-0.858)according to the pairwise meta-analysis.Moreover,the network meta-analysis results suggested that patients with IBD treated with ADA(OR=1.39,95%CI:1.19-1.63)were more likely to undergo TDM,especially in comparison with patients with reactive TDM(OR=1.38,95%CI:1.07-1.77).CONCLUSION Proactive TDM is more suitable for IBD patients treated with ADA and has obvious advantages over reactive TDM.We recommend proactive TDM in IBD patients who are treated with ADA.

A Fuzzy Trust Management Mechanism with Dynamic Behavior Monitoring for Wireless Sensor Networks

Traditional wireless sensor networks(WSNs)are typically deployed in remote and hostile environments for information collection.The wireless communication methods adopted by sensor nodes may make the network highly vulnerable to various attacks.Traditional encryption and authentication mechanisms cannot prevent attacks launched by internal malicious nodes.The trust-based security mechanism is usually adopted to solve this problem in WSNs.However,the behavioral evidence used for trust estimation presents some uncertainties due to the open wireless medium and the inexpensive sensor nodes.Moreover,how to efficiently collect behavioral evidences are rarely discussed.To address these issues,in this paper,we present a trust management mechanism based on fuzzy logic and a cloud model.First,a type-II fuzzy logic system is used to preprocess the behavioral evidences and alleviate uncertainty.Then,the cloud model is introduced to estimate the trust values for sensor nodes.Finally,a dynamic behavior monitoring protocol is proposed to provide a balance between energy conservation and safety assurance.Simulation results demonstrate that our trust management mechanism can effectively protect the network from internal malicious attacks while enhancing the energy efficiency of behavior monitoring.

A study on temperature monitoring method for inverter IGBT based on memory recurrent neural network

The power module of the Insulated Gate Bipolar Transistor(IGBT)is the core component of the traction transmission system of high-speed trains.The module's junction temperature is a critical factor in determining device reliability.Existing temperature monitoring methods based on the electro-thermal coupling model have limitations,such as ignoring device interactions and high computational complexity.To address these issues,an analysis of the parameters influencing IGBT failure is conducted,and a temperature monitoring method based on the Macro-Micro Attention Long Short-Term Memory(MMALSTM)recursive neural network is proposed,which takes the forward voltage drop and collector current as features.Compared with the traditional electricalthermal coupling model method,it requires fewer monitoring parameters and eliminates the complex loss calculation and equivalent thermal resistance network establishment process.The simulation model of a highspeed train traction system has been established to explore the accuracy and efficiency of MMALSTM-based prediction methods for IGBT power module junction temperature.The simulation outcomes,which deviate only 3.2% from the theoretical calculation results of the electric-thermal coupling model,confirm the reliability of this approach for predicting the temperature of IGBT power modules.

Well-Drilling and Groundwater Monitoring Network Construction:Taking Changde City as an Example

Entrusted by the Environmental Protection Bureau of Changde City,we conducted drilling,sampling survey and constructed a monitoring network for groundwater in several counties and districts of Changde City.This article introduces the drilling technology,detection method and detection network layout plan adopted in the project,and expounds the problems that occurred while executing the project,in order to provide reference for similar groundwater capacity supervision and construction projects.

A HybridManufacturing ProcessMonitoringMethod Using Stacked Gated Recurrent Unit and Random Forest

This study proposed a new real-time manufacturing process monitoring method to monitor and detect process shifts in manufacturing operations.Since real-time production process monitoring is critical in today’s smart manufacturing.The more robust the monitoring model,the more reliable a process is to be under control.In the past,many researchers have developed real-time monitoring methods to detect process shifts early.However,thesemethods have limitations in detecting process shifts as quickly as possible and handling various data volumes and varieties.In this paper,a robust monitoring model combining Gated Recurrent Unit(GRU)and Random Forest(RF)with Real-Time Contrast(RTC)called GRU-RF-RTC was proposed to detect process shifts rapidly.The effectiveness of the proposed GRU-RF-RTC model is first evaluated using multivariate normal and nonnormal distribution datasets.Then,to prove the applicability of the proposed model in a realmanufacturing setting,the model was evaluated using real-world normal and non-normal problems.The results demonstrate that the proposed GRU-RF-RTC outperforms other methods in detecting process shifts quickly with the lowest average out-of-control run length(ARL1)in all synthesis and real-world problems under normal and non-normal cases.The experiment results on real-world problems highlight the significance of the proposed GRU-RF-RTC model in modern manufacturing process monitoring applications.The result reveals that the proposed method improves the shift detection capability by 42.14%in normal and 43.64%in gamma distribution problems.

Monitoring Peer-to-Peer Botnets:Requirements,Challenges,and Future Works

The cyber-criminal compromises end-hosts(bots)to configure a network of bots(botnet).The cyber-criminals are also looking for an evolved architecture that makes their techniques more resilient and stealthier such as Peer-to-Peer(P2P)networks.The P2P botnets leverage the privileges of the decentralized nature of P2P networks.Consequently,the P2P botnets exploit the resilience of this architecture to be arduous against take-down procedures.Some P2P botnets are smarter to be stealthy in their Commandand-Control mechanisms(C2)and elude the standard discovery mechanisms.Therefore,the other side of this cyberwar is the monitor.The P2P botnet monitoring is an exacting mission because the monitoring must care about many aspects simultaneously.Some aspects pertain to the existing monitoring approaches,some pertain to the nature of P2P networks,and some to counter the botnets,i.e.,the anti-monitoring mechanisms.All these challenges should be considered in P2P botnet monitoring.To begin with,this paper provides an anatomy of P2P botnets.Thereafter,this paper exhaustively reviews the existing monitoring approaches of P2P botnets and thoroughly discusses each to reveal its advantages and disadvantages.In addition,this paper groups the monitoring approaches into three groups:passive,active,and hybrid monitoring approaches.Furthermore,this paper also discusses the functional and non-functional requirements of advanced monitoring.In conclusion,this paper ends by epitomizing the challenges of various aspects and gives future avenues for better monitoring of P2P botnets.

Entropy-Based Approach to Remove Redundant Monitoring Wells from Regional-Scale Groundwater Network

An entropy based approach is applied to identify redundant wells in the network. In the process of this research, groundwater monitoring network is considered as a communication system with a capability to transfer information, and monitoring wells are taken as information receivers. The concepts of entropy and mutual information are then applied to measure the information content of individual monitoring well and information relationship between monitoring well pairs. The efficiency of information transfer among monitoring wells is the basis to judge the redundancy in the network. And the capacity of the monitoring wells to provide information on groundwater is the point of evaluation to identify redundant monitoring wells. This approach is demonstrated using the data from a regional scale groundwater network in Hebei plain, China. The result shows that the entropy based method is recommendable in optimizing groundwater networks, especially for those within media of higher heterogeneities and anisotropies.

Fire monitoring in coal mines using wireless underground sensor network and interval type-2 fuzzy logic controller

From the view of underground coal mining safety system, it is extremely important to continuous monitoring of coal mines for the prompt detection of fires or related problems inspite of its uncertainty and imprecise characteristics. Therefore, evaluation and inferring the data perfectly to prevent fire related accidental risk in underground coal mining (UMC) system are very necessary. In the present article, we have proposed a novel type-2 fuzzy logic system (T2FLS) for the prediction of fire intensity and its risk assessment for risk reduction in an underground coal mine. Recently, for the observation of underground coal mines, wireless underground sensor network (WUSN) are being concerned frequently. To implement this technique IT2FLS, main functional components are sensor nodes which are installed in coal mines to accumulate different imprecise environmental data like, temperature, relative humidity, different gas concentrations etc. and these are sent to a base station which is connected to the ground observation system through network. In the present context, a WUSN based fire monitoring system is developed using fuzzy logic approach to enhance the consistency in decision making system to improve the risk chances of fire during coal mining. We have taken Mamdani IT2FLS as fuzzy model on coal mine monitoring data to consider real-time decision making (DM). It is predicted from the simulated results that the recommended system is highly acceptable and amenable in the case of fire hazard safety with compared to the wired and off-line monitoring system for UMC. Legitimacy of the suggested model is prepared using statistical analysis and multiple linear regression analysis.

Monitoring subsidence rates along road network by persistent scatterer SAR interferometry with high-resolution TerraSAR-X imagery

Ground subsidence is one of the key factors damaging transportation facilities, e.g., road networks consisting of highways and railways. In this paper, we propose to apply the persistent scatterer synthetic aperture radar interferometry （PS-InSAR） approach that uses high- resolution TerraSAR-X （TSX） imagery to extract the regional scale subsidence rates （i.e., average annual sub- sidence in mm/year） along road networks. The primary procedures involve interferometric pair selection, interfer- ogram generation, persistent scatterer （PS） detection, PS networking, phase parameterization, and subsidence rate estimation. The Xiqing District in southwest Tianjin （China） is selected as the study area. This district contains one railway line and several highway lines. A total of 15 TSX images covering this area between April 2009 and June 2010 are utilized to obtain the subsidence rates by using the PS-InSAR （PSI） approach. The subsidence rates derived from PSI range from -68.7 to -1.3 mm/year. These findings show a significantly uneven subsidence pattern along the road network. Comparison between the PSI-derived subsidence rates and the leveling data obtained along the highways shows that the mean and standard deviation （SD） of the discrepancies between the two types of subsidence rates are 0.1 and 4-3.2 mm/year, respectively. The results indicate that the high-resolution TSX PSI is capable of providing comprehensive and detailed subsidence information regarding road networks with millimeter-level accuracy. Further inspections under geo- logical conditions and land-use categories in the study area indicate that the observed subsidence is highly related to aquifer compression due to groundwater pumping. Therefore, measures should be taken to mitigate groundwater extraction for the study area.

SNES: Social-Network-Oriented Public Opinion Monitoring Platform Based on ElasticSearch

With the rapid development of social network,public opinion monitoring based on social networks is becoming more and more important.Many platforms have achieved some success in public opinion monitoring.However,these platforms cannot perform well in scalability,fault tolerance,and real-time performance.In this paper,we propose a novel social-network-oriented public opinion monitoring platform based on ElasticSearch(SNES).Firstly,SNES integrates the module of distributed crawler cluster,which provides real-time social media data access.Secondly,SNES integrates ElasticSearch which can store and retrieve massive unstructured data in near real time.Finally,we design subscription module based on Apache Kafka to connect the modules of the platform together in the form of message push and consumption,improving message throughput and the ability of dynamic horizontal scaling.A great number of empirical experiments prove that the platform can adapt well to the social network with highly real-time data and has good performance in public opinion monitoring.

Development and Field Evaluation of a Low-Cost Wireless Sensor Network System for Hydrological Monitoring of a Small Agricultural Watershed

Hydrological monitoring and real-time access to data are valuable for hydrological research and water resources management. In the recent decades, rapid developments in digital technology, micro-electromechanical systems, low power micro-sensing technologies and improved industrial manufacturing processes have resulted in retrieving real-time data through Wireless Sensor Networks (WSNs) systems. In this study, a remotely operated low-cost and robust WSN system was developed to monitor and collect real-time hydrologic data from a small agricultural watershed in harsh weather conditions and upland rolling topography of Southern Ontario, Canada. The WSN system was assembled using off-the-shelf hardware components, and an open source operating system was used to minimize the cost. The developed system was rigorously tested in the laboratory and the field and found to be accurate and reliable for monitoring climatic and hydrologic parameters. The soil moisture and runoff data for 7 springs, 19 summer, and 19 fall season rainfall events over the period of more than two years were successfully collected in a small experimental agricultural watershed situated near Elora, Ontario, Canada. The developed WSN system can be readily extended for the purpose of most hydrological monitoring applications, although it was explicitly tailored for a project focused on mapping the Variable Source Areas (VSAs) in a small agricultural watershed.

BP-Neural-Network-Based Tool Wear Monitoring by Using Wav elet Decomposition of the Power Spectrum

In a drilling process, the power spectrum of the drilling force is related tothe tool wear and is widely applied in the monitoring of tool wear. But the feature extraction andidentification of the power spectrum have always been an unresolved difficult problem. This papersolves it through decomposition of the power spectrum in multilayers using wavelet transform andextraction of the low frequency decomposition coefficient as the envelope information of the powerspectrum. Intelligent identification of the tool wear status is achieved in the drilling processthrough fusing the wavelet decomposition coefficient of the power spectrum by using a BP (BackPropagation) neural network. The experimental results show that the features of the power spectrumcan be extracted efficiently through this method, and the trained neural networks show highidentification precision and the ability of extension.

On-line Condition Monitoring and Diagnostic Network System for Rotating Machine Set

Several industrial computers and a server are combined to set up the on-line monitoring and diagnostic system of turbo-generator sets. The main function of the system is to monitor machine sets' running condition. Through analyzing running data, technicians can detect whether there exist faults and where they occur. To share and transmit the dynamic information of the turbo-generator sets, a distributed network system is introduced. NetWare network operating system is used in the LAN (Local Area Network) system. The LAN is extended to realize the sharing of data and remote transmission of information. Furthermore, functions of monitoring and diagnostic clients are listed.

Non-derivative solution to nonlinear dynamic optimal design of class two for deformation network monitoring

Based on the nonlinear error equation of deformation network monitoring, the mathematical model of nonlinear dynamic optimal design of class two was put forward for the deformation network monitoring, in which the target function is the accuracy criterion and the constraint conditions are the network’s sensitivity, reliability and observing cost. Meanwhile a new non derivative solution to the nonlinear dynamic optimal design of class two was also put forward. The solving model uses the difference to stand for the first derivative of functions and solves the revised feasible direction to get the optimal solution to unknown parameters. It can not only make the solution to converge on the minimum point of the constraint problem, but decrease the calculating load.

Application of ArtificialNeural Network to Real-Time Condition Monitoring Control and Usual Trouble Diagnosis during Driling

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Groundwater level monitoring-importance global groundwater monitoring network

The paper illustrates the concept, methodology, essential components and importance of groundwater level monitoring in terms of various aquifers such as multiple aquifer, karst aquifer and other aquifers. The groundwater resources in Mekong countries including Cambodia, Laos PDR, Myanmar, Thailand and Vietnam have also been reviewed. Finally, the author briefly presents Global Groundwater Monitoring Network.

Inter-Data Commonality Detection for Spectrum Monitoring in Wireless Sensor Networks

Cooperative spectrum monitoring with multiple sensors has been deemed as an efficient mechanism for improving the monitoring accuracy and enlarging the monitoring area in wireless sensor networks.However,there exists redundancy among the spectrum data collected by a sensor node within a data collection period,which may reduce the data uploading efficiency.In this paper,we investigate the inter-data commonality detection which describes how much two data have in common.We define common segment set and divide it into six categories firstly,then a method to measure a common segment set is conducted by extracting commonality between two files.Moreover,the existing algorithms fail in finding a good common segment set,so Common Data Measurement(CDM)algorithm that can identify a good common segment set based on inter-data commonality detection is proposed.Theoretical analysis proves that CDM algorithm achieves a good measurement for the commonality between two strings.In addition,we conduct an synthetic dataset which are produced randomly.Numerical results shows that CDM algorithm can get better performance in measuring commonality between two binary files compared with Greedy-String-Tiling(GST)algorithm and simple greedy algorithm.

A Novel Outage Capacity Objective Function for Optimal Performance Monitoring and Predictive Fault Detection in Hybrid Free-Space Optical and RF Wireless Networks

This study develops an optimal performance monitoring metric for a hybrid free space optical and radio wireless network, the Outage Capacity Objective Function. The objective function—the dependence of hybrid channel outage capacity upon the error rate, jointly quantifies the effects of atmospheric optical impairments on the performance of the free space optical segment as well as the effect of RF channel impairments on the radio frequency segment. The objective function is developed from the basic information-theoretic capacity of the optical and radio channels using the gamma-gamma model for optical fading and Ricean statistics for the radio channel fading. A simulation is performed by using the hybrid network. The objective function is shown to provide significantly improved sensitivity to degrading performance trends and supports of proactive link failure prediction and mitigation when compared to current thresholding techniques for signal quality metrics.

On-line Tool Condition Monitoring with Improved Fuzzy Neural Network

This paper presents an investigation of tool condition monitoring based on fuzzy neural network for drilling. In this study, five monitoring feature parameters, which will be used to monitor tool condition, are selected by means of vibration signal spectral analysis. In order to meet the need of the system real time, this paper presents a neural network with fuzzy inference. Fuzzy neural network requires less computation than backpropagation neural network, and can easily describe the relationship between the tool conditions and the monitoring indices. The experimental results indicate that the use of vibration signal for on--line drilling condition monitoring is feasible.

A LOCAL DYNAMIC CLUSTER SELF-ORGANIZATION ALGORITHM IN WIRELESS SENSOR NETWORKS FOR RAINFALL MONITORING

Wireless Sensor Networks for Rainfall Monitoring (RM-WSNs) is a sensor network for the large-scale regional and moving rainfall monitoring,which could be controlled deployment. Delivery delay and cross-cluster calculation leads to information inaccuracy by the existing dynamic collabo-rative self-organization algorithm in WSNs. In this letter,a Local Dynamic Cluster Self-organization algorithm (LDCS) is proposed for the large-scale regional and moving target monitoring in RM-WSNs. The algorithm utilizes the resource-rich node in WSNs as the cluster head,which processes target information obtained by sensor nodes in cluster. The cluster head shifts with the target moving in chance and re-groups a new cluster. The target information acquisition is limited in the dynamic cluster,which can reduce information across-clusters transfer delay and improve the real-time of information acquisition. The simulation results show that,LDCS can not only relieve the problem of "too frequent leader switches" in IDSQ,also make full use of the history monitoring information of target and con-tinuous monitoring of sensor nodes that failed in DCS.