Analytic Hierarchy Process for Technological Risks in the Process of Innovative Drug Development in China

Objective To identify the critical risks in the process of innovative drug research and development,and to provide reference for improving the efficiency of innovative drug development and risk control in China.Methods Expert investigation and analytic hierarchy process were used to determine the weights of different risks.Results and Conclusion The research and analysis results showed that the risks at different stages of development had different effects on the success rate of drug development,among which the risk at the drug discovery stage influenced the most.In the drug discovery stage,inappropriate target selection had the greatest impact on the success rate of drug development.The lack of appropriate cell tissue or animal models had the greatest impact on the success rate of drug development from the discovery of a compound to the application for clinical trials.The difference in changes between nonclinical and clinical studies had the greatest impact on the success rate of drug development from early clinical studies to pivotal clinical studies.Incorrect dose selection had the greatest impact on the success rate of drug development from pivotal clinical studies to marketing authorization applications.The biggest impact from the marketing authorization application to the approval stage was inadequate communication with regulators.After investigating the weight of risk factors in the process of innovative drug development based on scientific methods,a new perspective for the risk control of new drug development and improving the research and development efficiency is provided.

How Does Robotics Process Automation (RPA) Affect Project Management Practices

The main purpose of this literature review is to understand the effectiveness and impacts of Robotics Process Automation (RPA) on the practices of Project Management (PM). For attaining the purposes of the research study, an extensive literature review was conducted, which helped in gaining a theoretical understanding. These findings were then justified with the help of current and relevant secondary sources in the analysis section. The findings suggested that RPA is quite advantageous for implementing in varied aspects of a business, especially in the field of project management. However, it can pose several challenges, which need to be taken into due consideration by the organizations during execution such as the capabilities of the employees and the abilities of the existing systems to incorporate automation, among others. It was ultimately concluded that RPA is highly advantageous for project management teams but its effective implementation is the key to success.

Project Management and Coordination of Distributed Cooperative Product Design in a Virtual Enterprise

The architecture of project management of distributed concurrent product design in a virtual enterprise is put forward. T he process of project management and its functions are presented. Product design process coordination is also discussed. First, based on the analysis of traditi onal project management, project management and coordination of distributed coop erative product design in the virtual enterprise is put forward. Then, aiming at the characteristics of a distributed concurrent product design process, the inh erent rules and complex interrelations in product development are studied. Accor dingly, the architecture of project management of distributed cooperative produc t design in a virtual enterprise is presented to adapt to distributed concurrent development of complex products. The main advantages of the architecture are al so discussed. Finally, the emphasis is placed on the project management process. Its main functions are set forth, such as project definition, task decompositio n and distribution, resource constraints and dynamic resource scheduling, proces s fusion, task scheduling and monitoring, project plan, cost and quality evaluat ion, etc.

Enterprise Process Modeling Methodology and Environment Supporting Project Management

Development of the global economy makes modem enterprises confront challenges of efficient managements for large projects and complex processes. Projects are typically managed in rather special manners. On the contrary, there exist many methodologies for product process management to achieve consistency and continuance. However, processes often lack flexibility offered by projects. This paper dis~ the relationship of conceptual characteristics between process and project, gives low-level details to tackle the difference between them, and proposes an enterprise process modeling method for project management. An integrated environment is designed to support the method from which both project management and process management can receive benefits and conform to the limitations.

A Novel Method for Assessing and Optimizing Software Project Process Based Risk Control

A new approach for assessing and optimizing software project process based on software risk control presented, which evaluates and optimizes software project process from the view of controlling the software project risks. A model for optimizing software risk control is given, a discrete optimization algorithm based on dynamic programruing is proposed and an example of using above method to solve a problem is also included in this paper. By improving the old passive post-project control into an active effective preaction, this new method can greatly promote the possibility of success of software projects.

Common Management Process Model of New TQM Based on the Situation Analysis

In the previous study, we suggested the concept of new TQM based on the consideration of basic concept of Quality Control. Also, in the previous study, we suggested the target domains and entities of product and process based on the TQM Matrix and view point of Three Dimensional Unification Value Models for managing quality of organization systems. Furthermore, in the previous study, we suggest the Common Management Process of organizations. Based on the above suggestion, in this paper, we would like to propose the Common Management Process Model of Total Quality Management based on the consideration of situation analysis and more precise definition of TQM Matrix and Three Dimensional Unification Value Model of “Product and Process”. Improvement of quality and efficiency of organization management can be expected by the integration of conventional different management such as quality assurance, quality improvement, risk management, investment individually from the view point of common management process.

Modeling of Business Processes of Project Financing

Need of transformation of means of support of project financing for commercial banks is proved.The analysis and modeling of business processes of project management by the contextual chart and the chart of decomposition is carried out that allowed to describe the main stages of project financing.With use of tools of programming the business application of project management which will promote operational assessment on selection of introduced drafts is created.

Research on Progress Control of Overseas Cement EPC General Contracting Project

The purpose of Engineering Procurement Construction(EPC)general contracting project schedule management is to ensure that the project meets its deadlines,and it plays a critical role in contract performance.In comparison to the domestic general contracting model,project management and coordination are more complex for the general contractor of international EPC projects.As a result,scientific project schedule process control is critical to effectively ensuring project duration,saving project costs,improving project management level,and project quality,and ensuring that the project achieves the promised advantages for both the contractor and the owner.Through the research and analysis of the status of the schedule management of the Indonesia B Project Phase II cement project,corresponding optimization measures are proposed for the project schedule process control.

如何利用Microsoft Project提高工作效率

Microsoft Project除了用于项目管理,对日常工作的安排也非常适用,象每周工作安排、重大会议的筹备等需要多人共同完成的活动,把每一项工作都落实到人头,便于加强过程控制,有利于工作的组织、协调。

Research on Concurrent Engineering Oriented Integrated Product Development Process Management System

In concurrent engineering, effective process management is the key to improve the efficiency and quality of product development. Although in project management system, workflow management system and PDM system, process management functions are provided, they can not meet the needs of product development. In this paper, we integrate the project management, workflow management and product management technique together and a concurrent engineering oriented integrated product development process management system is proposed. The system structure, integrated product development model and running method are introduced. The practice proves this system is powerful in supporting product development process.

单元综合安全项目在呼吸科多重耐药感染防控中的应用

目的 探讨基于单元的综合安全项目在呼吸科多重耐药菌感染防控中的应用价值。方法 以某院呼吸科2019年1—12月在院患者1093例为对照组,实施常规管理方案;2020年4月—2021年4月在院患者1028例为观察组,启动单元的综合安全项目(Comprehensive unit-based safety program, CUSP)计划,将一系列循证干预措施纳入临床管理方案。比较两组患者多重耐药菌(Multi-drug Resistant Organism, MDRO)感染发生率、标本送检正确率、标本送检及时率、抗生素使用规范率、医务人员安全文化、MDRO感染患者住院日数及防控措施落实率。结果 观察组MDRO感染发生率低于对照组(χ^(2)=21.380,P<0.001),患者标本送检正确率、送检及时率及抗菌药物使用规范率高于对照组(χ^(2)=58.039,P<0.001;χ^(2)=64.590,P<0.001;χ^(2)=36.169,P<0.001),医务人员安全文化总评分高于对照组(t=-26.666,P<0.001),MDRO感染患者住院日数低于对照组(Z=-2.866,P=0.004),MDRO防控措施落实率高于对照组(χ^(2)=37.854,P<0.001;χ^(2)=21.328,P<0.001;χ^(2)=4.423,P=0.035;χ^(2)=5.985,P=0.014)。结论 在呼吸内科多重耐药菌感染防控中,开展单元的综合安全项目干预能够有效降低MDRO感染发生率,提高病房管理质量,提升病区患者安全文化,缩短MDRO感染患者住院日数及提高病区MDRO防控措施落实率。

世界一流油公司的开发管理体系与启示

近年来,中国石油企业积极参与国际油气项目合作,与世界一流油公司展开竞争与合作,展示了技术实力,积累了丰富经验。文章研究分析世界一流油公司的先进管理案例,系统总结一流平台在方案设计体系、实施保障体系、科技与人才支撑体系及标准规范体系建设方面的有力措施。方案设计体系建设包括对方案层级、模型迭代和先导试验的管理,实施保障体系建设包括对数据质量、审查机制和油藏健康的优化,科技与人才支撑体系建设包括对数据共享、技术创新和人才培养的完善,标准规范体系包括对管理标准、实施标准和技术标准的建设。建议我国油公司借鉴世界一流油公司先进管理经验,建立适合自身的开发管理体系,通过“1+4+5”的管理框架,建立以开发方案为核心的组织管理体系;通过“1+6+3”的执行方式,形成以油藏模型为核心的方案编制模式,促进企业快速成长为世界一流企业。

水利工程质量监督全过程全方位定量评价模型构建

为促进我国水利工程质量监督管理工作运行的高效化,确保工程监督的有效性和权威性,基于AHP(analytic hierarchy process)原理,针对水利部督查小组的现场检查情况,依据水利部下达的相关文件,结合负分制和一票否决制,将定性问题定量化,构建一套涉及水利工程建设、运行、管理全过程全方位的质量监督管理评价模型,共包含7层2112个指标。在综合试错的基础上,计算得出不同层级和不同指标的权重,然后选用该模型分析评价2020年7个省份受督查水利工程项目的质量管理与安全生产管理监督数据,间接说明模型的实用性和易操作性。评价结果表明:7个省份均在合格以上,整体质量管理情况较好,但得分差异显著,其中最高得分90.6、最低得分65.6,相差25分;不同类型管理评价结果显示,安全生产管理得分普遍高于质量管理得分;各参建单位评价结果显示,建设单位和勘察设计单位的情况最优、评分基本达到满分,而质量检测单位和施工单位得分最低、需重点加强相关监管。评价结果为水利工程监督管理工作提供了科学的数据支撑,构建的评价模型也为水利工程质量监督定量化提供了易实操的普适性工具。

EPC工程总承包模式下发包人管理对策研究

据有关资料统计,目前我国工程总承包产值约占建筑业产值的10%,在工程建设领域,EPC工程总承包模式逐渐成为工程项目管理的主流模式之一。但在发包人的具体应用管理过程中,EPC工程总承包模式存在应用不合理、缺乏与之相配套的计价模式、投资控制难等问题。文章通过对典型问题的梳理,分析业务关键节点,提出在政策性文件的指导下,优化EPC工程总承包应用前提及模式,采取项目需求清单式管理,优化合同计价模式,引入全过程工程咨询等合理化对策与措施,解决EPC工程总承包应用中出现的典型问题,以期为EPC工程总承包更好发展与规范化应用提供参考。

基于Project的虚拟维修拆装过程建模

分析虚拟维修拆装过程描述的复杂性,提出利用项目管理软件Microsoft Project建立维修拆装过程模型的方法。建立的过程模型主要包括:拆装结构模型、拆装资源模型和拆装运动模型。其中,利用了Project中WBS层次管理、设定任务优先级及任务链接等功能建立基于层次关系和关联关系的拆装结构模型;构造用于表现螺旋运动、直线运动和空间运动的三个描述公式,建立拆装运动模型。最后以某型坦克起动电机的拆卸为实例,说明建立的模型能很好地应用于维修拆装过程的描述,并且具有直观性。

建筑施工总承包项目中消防设施施工全过程管理

研究了建筑施工总承包项目中消防设施施工的全过程管理,探讨了设计阶段、施工准备阶段以及施工过程的质量管理策略,阐述了建筑施工总承包项目中,消防设施施工的文档与记录管理,以及风险管理的相关内容。

总承包工程精细管理实践

某7500t/d水泥熟料生产线EPC项目在执行过程中,利用BIM平台,通过实施项目建设总体策划、划分施工与安装区域、模拟施工场地布置和建设、合理布置施工总平面、加强设备质量管理、施工质量与进度控制、实施智慧安全管理,合理安排设备与材料堆存、非标准件制作场地,加强费用成本控制管理等,实现了项目建设年初开工,当年投产,经济效益与社会效益良好。